{"id":"https://openalex.org/W2883484574","doi":"https://doi.org/10.1038/s41598-018-29135-w","title":"Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge","display_name":"Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge","publication_year":2018,"publication_date":"2018-07-19","ids":{"openalex":"https://openalex.org/W2883484574","doi":"https://doi.org/10.1038/s41598-018-29135-w","mag":"2883484574","pmid":"https://pubmed.ncbi.nlm.nih.gov/30046140","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6060117"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-29135-w","doi":"https://doi.org/10.1038/s41598-018-29135-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-29135-w","pdf_url":"https://www.nature.com/articles/s41598-018-29135-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-29135-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100637510","display_name":"Ying Liu","orcid":"https://orcid.org/0000-0001-5783-1284","observed_orcids":["https://orcid.org/0000-0001-5783-1284"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210155662","display_name":"Institute of Special Animal and Plant Sciences","ror":"https://ror.org/04c0a2034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987","https://openalex.org/I4210155662"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA","Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture of China, Institute of Special Economic Animals and Plants, Chinese Academy of Agricultural Sciences CAAS, Changchun, Jilin 130112, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture of China, Institute of Special Economic Animals and Plants, Chinese Academy of Agricultural Sciences CAAS, Changchun, Jilin 130112, P. R. China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210155662"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Ye","raw_affiliation_strings":["Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Fang Lin","raw_affiliation_strings":["Central Laboratory, Tangdu Hospital at the Fourth Military Medical University, Xi'An, 710038, China","Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Tangdu Hospital at the Fourth Military Medical University, Xi'An, 710038, China","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063716846","display_name":"Yasmine A. Gomaa","orcid":"https://orcid.org/0000-0002-4643-4360","observed_orcids":["https://orcid.org/0000-0002-4643-4360"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasmine Gomaa","raw_affiliation_strings":["Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091128747","display_name":"David C. Flyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100774","display_name":"Novavax (United States)","ror":"https://ror.org/01bhs6g30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Flyer","raw_affiliation_strings":["Novavax Inc., 20 Firstfield Road, Gaithersburg, MD, 20878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novavax Inc., 20 Firstfield Road, Gaithersburg, MD, 20878, USA","institution_ids":["https://openalex.org/I4210100774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102967348","display_name":"Ricardo Carrion","orcid":"https://orcid.org/0000-0001-7046-7683","observed_orcids":["https://orcid.org/0000-0001-7046-7683"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Carrion","raw_affiliation_strings":["Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX, 78227, USA"],"raw_orcid":"https://orcid.org/0000-0001-7046-7683","affiliations":[{"raw_affiliation_string":"Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX, 78227, USA","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031670950","display_name":"Jean L. Patterson","orcid":"https://orcid.org/0000-0001-8069-8098","observed_orcids":["https://orcid.org/0000-0001-8069-8098"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean L. Patterson","raw_affiliation_strings":["Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX, 78227, USA"],"raw_orcid":"https://orcid.org/0000-0001-8069-8098","affiliations":[{"raw_affiliation_string":"Texas Biomedical Research Institute, 7620 NW Loop 410, San Antonio, TX, 78227, USA","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030894404","display_name":"Mark R. Prausnitz","orcid":"https://orcid.org/0000-0002-9076-8448","observed_orcids":["https://orcid.org/0000-0002-9076-8448"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Prausnitz","raw_affiliation_strings":["Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000458556","display_name":"Gale Smith","orcid":"https://orcid.org/0000-0002-6482-6026","observed_orcids":["https://orcid.org/0000-0002-6482-6026"]},"institutions":[{"id":"https://openalex.org/I4210100774","display_name":"Novavax (United States)","ror":"https://ror.org/01bhs6g30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gale Smith","raw_affiliation_strings":["Novavax Inc., 20 Firstfield Road, Gaithersburg, MD, 20878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novavax Inc., 20 Firstfield Road, Gaithersburg, MD, 20878, USA","institution_ids":["https://openalex.org/I4210100774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032295889","display_name":"Gregory M. Glenn","orcid":"https://orcid.org/0000-0002-2030-8665","observed_orcids":["https://orcid.org/0000-0002-2030-8665"]},"institutions":[{"id":"https://openalex.org/I4210100774","display_name":"Novavax (United States)","ror":"https://ror.org/01bhs6g30","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Glenn","raw_affiliation_strings":["Novavax Inc., 20 Firstfield Road, Gaithersburg, MD, 20878, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novavax Inc., 20 Firstfield Road, Gaithersburg, MD, 20878, USA","institution_ids":["https://openalex.org/I4210100774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048858926","display_name":"Hua Wu","orcid":"https://orcid.org/0000-0002-4210-2377","observed_orcids":["https://orcid.org/0000-0002-4210-2377"]},"institutions":[{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210155662","display_name":"Institute of Special Animal and Plant Sciences","ror":"https://ror.org/04c0a2034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987","https://openalex.org/I4210155662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Wu","raw_affiliation_strings":["Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture of China, Institute of Special Economic Animals and Plants, Chinese Academy of Agricultural Sciences CAAS, Changchun, Jilin 130112, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture of China, Institute of Special Economic Animals and Plants, Chinese Academy of Agricultural Sciences CAAS, Changchun, Jilin 130112, P. R. China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210155662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064720448","display_name":"Richard W. Compans","orcid":"https://orcid.org/0000-0003-2360-335X","observed_orcids":["https://orcid.org/0000-0003-2360-335X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Compans","raw_affiliation_strings":["Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021227129","display_name":"Chinglai Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chinglai Yang","raw_affiliation_strings":["Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA. chyang@emory.edu","Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA. chyang@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory University School of Medicine, 1518 Clifton Road, Atlanta, GA, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5021227129"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.8338,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90645886,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"11193","last_page":"11193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.8679999709129333},{"id":"https://openalex.org/keywords/microneedle-patch","display_name":"microneedle patch","score":0.9629999995231628},{"id":"https://openalex.org/keywords/intradermal-vaccination","display_name":"intradermal vaccination","score":0.972000002861023},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.8360000252723694},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.765999972820282},{"id":"https://openalex.org/keywords/vaccine-delivery","display_name":"vaccine delivery","score":0.45100000500679016},{"id":"https://openalex.org/keywords/filovirus-vaccines","display_name":"filovirus vaccines","score":0.6990000009536743},{"id":"https://openalex.org/keywords/lethal-challenge-protection","display_name":"lethal challenge protection","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.8678175210952759},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7405825853347778},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.7376521825790405},{"id":"https://openalex.org/C2909623084","wikidata":"https://www.wikidata.org/wiki/Q5331908","display_name":"Ebolavirus","level":4,"score":0.5374259352684021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4486888349056244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4233083426952362},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40235382318496704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37464839220046997},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19076097011566162}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D022223","descriptor_name":"Vaccines, Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022223","descriptor_name":"Vaccines, Subunit","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022223","descriptor_name":"Vaccines, Subunit","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D046129","descriptor_name":"Ebola Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-018-29135-w","doi":"https://doi.org/10.1038/s41598-018-29135-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-29135-w","pdf_url":"https://www.nature.com/articles/s41598-018-29135-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5022102","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6060117","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6060117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6060117","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:30046140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30046140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:edf8a6f6fe824ccd9fdad02e54e89f28","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/edf8a6f6fe824ccd9fdad02e54e89f28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"},{"id":"doi:10.60692/24b56-nnk25","doi":"https://doi.org/10.60692/24b56-nnk25","is_oa":true,"landing_page_url":"https://doi.org/10.60692/24b56-nnk25","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/jd2dz-vep20","doi":"https://doi.org/10.60692/jd2dz-vep20","is_oa":true,"landing_page_url":"https://doi.org/10.60692/jd2dz-vep20","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-29135-w","doi":"https://doi.org/10.1038/s41598-018-29135-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-29135-w","pdf_url":"https://www.nature.com/articles/s41598-018-29135-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2543947341","display_name":null,"funder_award_id":"AI093406","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4373404572","display_name":"A dual vaccine strategy against filovirus infection","funder_award_id":"R01AI093406","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7740234158","display_name":null,"funder_award_id":"AI093406","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883484574.pdf","grobid_xml":"https://content.openalex.org/works/W2883484574.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1814034318","https://openalex.org/W1964672881","https://openalex.org/W1974870628","https://openalex.org/W1982830459","https://openalex.org/W1997677784","https://openalex.org/W2006120701","https://openalex.org/W2017583800","https://openalex.org/W2027023890","https://openalex.org/W2030292647","https://openalex.org/W2045165780","https://openalex.org/W2046182783","https://openalex.org/W2049037588","https://openalex.org/W2057027768","https://openalex.org/W2058160057","https://openalex.org/W2075938204","https://openalex.org/W2076340825","https://openalex.org/W2077149270","https://openalex.org/W2081442068","https://openalex.org/W2081877186","https://openalex.org/W2086534263","https://openalex.org/W2087943529","https://openalex.org/W2088368520","https://openalex.org/W2089143024","https://openalex.org/W2103992594","https://openalex.org/W2106865625","https://openalex.org/W2109187406","https://openalex.org/W2114347909","https://openalex.org/W2116085039","https://openalex.org/W2128507275","https://openalex.org/W2137755374","https://openalex.org/W2138000140","https://openalex.org/W2155802193","https://openalex.org/W2160796054","https://openalex.org/W2170682601","https://openalex.org/W2184966207","https://openalex.org/W2286448385","https://openalex.org/W2326904022","https://openalex.org/W2390850449","https://openalex.org/W2554858171","https://openalex.org/W2562970611","https://openalex.org/W2573032076","https://openalex.org/W2605322593","https://openalex.org/W2607264992","https://openalex.org/W2617035740","https://openalex.org/W2732601320","https://openalex.org/W2735670013","https://openalex.org/W3123411076"],"related_works":["https://openalex.org/W2806840995","https://openalex.org/W4313415135","https://openalex.org/W2286448385","https://openalex.org/W2890440451","https://openalex.org/W6930444867","https://openalex.org/W2073404272","https://openalex.org/W2518819172","https://openalex.org/W4293171025","https://openalex.org/W2554858171","https://openalex.org/W2980312917"],"abstract_inverted_index":{"Development":[0],"of":[1,9,51,87,94,133,140,151,158,171],"a":[2,75],"safe":[3],"and":[4,38,56,183],"efficacious":[5],"filovirus":[6],"vaccine":[7],"is":[8,177,194],"high":[10],"importance":[11],"to":[12,179,196],"public":[13],"health.":[14],"In":[15],"this":[16],"study,":[17],"we":[18,67],"compared":[19],"immune":[20],"responses":[21,60,96],"induced":[22,53],"by":[23,97,119,137,155],"Ebola":[24],"virus":[25],"(EBOV)":[26],"glycoprotein":[27],"(GP)":[28],"subunit":[29,174],"vaccines":[30],"via":[31],"intradermal":[32],"immunization":[33],"with":[34,74,89],"microneedle":[35],"(MN)":[36],"patches":[37],"the":[39,116,145,162],"conventional":[40],"intramuscular":[41],"(IM)":[42],"injection":[43,157],"in":[44,72],"mice,":[45],"which":[46,176],"showed":[47,110],"that":[48,69,111,114,167,193],"MN":[49,84,98,120,138,168],"delivery":[50,139,170],"GP":[52,62,71,90,142,160,173],"higher":[54],"levels":[55],"longer":[57],"lasting":[58],"antibody":[59,95],"against":[61,190],"than":[63],"IM":[64,104,122,156,197],"injection.":[65,105],"Further,":[66,130],"found":[68],"EBOV":[70,128,172,191],"formulation":[73,118],"saponin-based":[76],"adjuvant,":[77],"Matrix-M,":[78],"can":[79,186],"be":[80],"efficiently":[81],"loaded":[82],"onto":[83],"patches.":[85],"Co-delivery":[86],"Matrix-M":[88],"significantly":[91],"enhanced":[92],"induction":[93],"delivery,":[99],"as":[100],"also":[101,143],"observed":[102],"for":[103],"Results":[106],"from":[107,126],"challenge":[108],"studies":[109],"all":[112],"mice":[113,135,153],"received":[115],"GP/adjuvant":[117],"or":[121],"immunizations":[123],"were":[124],"protected":[125],"lethal":[127],"challenge.":[129,163],"4":[131],"out":[132,150],"5":[134,152],"vaccinated":[136,154],"unadjuvanted":[141,159],"survived":[144,161],"challenge,":[146],"whereas":[147],"only":[148],"1":[149],"These":[164],"results":[165],"demonstrate":[166],"patch":[169],"vaccines,":[175],"expected":[178],"enable":[180],"improved":[181],"safety":[182],"thermal":[184],"stability,":[185],"confer":[187],"effective":[188],"protection":[189],"infection":[192],"superior":[195],"vaccination.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-08-03T00:00:00"}