{"id":"https://openalex.org/W2883399642","doi":"https://doi.org/10.1177/2040620718786437","title":"Leveraging JAK-STAT regulation in myelofibrosis to improve outcomes with allogeneic hematopoietic stem-cell transplant","display_name":"Leveraging JAK-STAT regulation in myelofibrosis to improve outcomes with allogeneic hematopoietic stem-cell transplant","publication_year":2018,"publication_date":"2018-07-16","ids":{"openalex":"https://openalex.org/W2883399642","doi":"https://doi.org/10.1177/2040620718786437","mag":"2883399642","pmid":"https://pubmed.ncbi.nlm.nih.gov/30210754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6130097"},"language":"en","primary_location":{"id":"doi:10.1177/2040620718786437","doi":"https://doi.org/10.1177/2040620718786437","is_oa":false,"landing_page_url":"https://doi.org/10.1177/2040620718786437","pdf_url":null,"source":{"id":"https://openalex.org/S2765068629","display_name":"Therapeutic Advances in Hematology","issn_l":"2040-6207","issn":["2040-6207","2040-6215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6130097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040815890","display_name":"Michael Thomas Byrne","orcid":"https://orcid.org/0000-0002-2966-4877","observed_orcids":["https://orcid.org/0000-0002-2966-4877"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Byrne","raw_affiliation_strings":["Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 777 Preston Research Building, 2200 Pierce Avenue, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology/Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 777 Preston Research Building, 2200 Pierce Avenue, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088962035","display_name":"Bipin N. Savani","orcid":"https://orcid.org/0000-0002-3304-9965","observed_orcids":["https://orcid.org/0000-0002-3304-9965"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bipin Savani","raw_affiliation_strings":["Vanderbilt-Ingram Cancer, Vanderbilt University School of Medicine, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt-Ingram Cancer, Vanderbilt University School of Medicine, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049400849","display_name":"Michael Robert Savona","orcid":"https://orcid.org/0000-0003-3763-5504","observed_orcids":["https://orcid.org/0000-0003-3763-5504"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Savona","raw_affiliation_strings":["Vanderbilt-Ingram Cancer, Vanderbilt University School of Medicine, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt-Ingram Cancer, Vanderbilt University School of Medicine, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049400849"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.1075,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.12832264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"9","first_page":"251","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-myelofibrosis","display_name":"primary myelofibrosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9670000076293945},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/steroid-refractory-gvhd","display_name":"steroid-refractory GVHD","score":0.7829999923706055},{"id":"https://openalex.org/keywords/spleen-volume","display_name":"spleen volume","score":0.6359999775886536},{"id":"https://openalex.org/keywords/extramedullary-hematopoiesis","display_name":"extramedullary hematopoiesis","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.9155008792877197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9045060873031616},{"id":"https://openalex.org/C2776112149","wikidata":"https://www.wikidata.org/wiki/Q7383611","display_name":"Ruxolitinib","level":4,"score":0.7916443347930908},{"id":"https://openalex.org/C2778080410","wikidata":"https://www.wikidata.org/wiki/Q5422215","display_name":"Extramedullary hematopoiesis","level":4,"score":0.572435200214386},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5219868421554565},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5200112462043762},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5086461305618286},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.507326066493988},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5043078660964966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5037545561790466},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.47733786702156067},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46229690313339233},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.433242529630661},{"id":"https://openalex.org/C2781107747","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative neoplasm","level":4,"score":0.4273771047592163},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4179608225822449},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.401790976524353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/2040620718786437","doi":"https://doi.org/10.1177/2040620718786437","is_oa":false,"landing_page_url":"https://doi.org/10.1177/2040620718786437","pdf_url":null,"source":{"id":"https://openalex.org/S2765068629","display_name":"Therapeutic Advances in Hematology","issn_l":"2040-6207","issn":["2040-6207","2040-6215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Hematology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5083812","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6130097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6130097","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6130097","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Adv Hematol","raw_type":"Text"},{"id":"pmid:30210754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30210754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in hematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5083812","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6130097","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1483308173","https://openalex.org/W1671779243","https://openalex.org/W1870543278","https://openalex.org/W1980568348","https://openalex.org/W1995410100","https://openalex.org/W2002782759","https://openalex.org/W2008799537","https://openalex.org/W2010527821","https://openalex.org/W2012686883","https://openalex.org/W2019931350","https://openalex.org/W2027613124","https://openalex.org/W2031782573","https://openalex.org/W2037845887","https://openalex.org/W2040002852","https://openalex.org/W2049145190","https://openalex.org/W2049477216","https://openalex.org/W2049965335","https://openalex.org/W2052014155","https://openalex.org/W2052033797","https://openalex.org/W2056777053","https://openalex.org/W2057360098","https://openalex.org/W2064453268","https://openalex.org/W2068160300","https://openalex.org/W2079645940","https://openalex.org/W2079681891","https://openalex.org/W2080877772","https://openalex.org/W2086469301","https://openalex.org/W2093158866","https://openalex.org/W2104830460","https://openalex.org/W2105414227","https://openalex.org/W2105949419","https://openalex.org/W2115351357","https://openalex.org/W2119160082","https://openalex.org/W2121743767","https://openalex.org/W2122395736","https://openalex.org/W2123633897","https://openalex.org/W2126532431","https://openalex.org/W2134919790","https://openalex.org/W2135679329","https://openalex.org/W2143775811","https://openalex.org/W2143777695","https://openalex.org/W2144664431","https://openalex.org/W2146505525","https://openalex.org/W2151734278","https://openalex.org/W2157694607","https://openalex.org/W2159595282","https://openalex.org/W2159659449","https://openalex.org/W2167739766","https://openalex.org/W2173500616","https://openalex.org/W2176681260","https://openalex.org/W2187320767","https://openalex.org/W2336835135","https://openalex.org/W2339658711","https://openalex.org/W2405712018","https://openalex.org/W2529473071","https://openalex.org/W2529648056","https://openalex.org/W2544907814","https://openalex.org/W2562839751","https://openalex.org/W2577962762","https://openalex.org/W2587685665","https://openalex.org/W2591510056","https://openalex.org/W2596279978","https://openalex.org/W2598185545","https://openalex.org/W2598479043","https://openalex.org/W2601742683","https://openalex.org/W2611028203","https://openalex.org/W2766949843","https://openalex.org/W2786216454","https://openalex.org/W2891720308"],"related_works":["https://openalex.org/W1979461781","https://openalex.org/W2093724620","https://openalex.org/W2334548251","https://openalex.org/W4224311929","https://openalex.org/W4389040648","https://openalex.org/W3097237398","https://openalex.org/W7161176660","https://openalex.org/W2138157242","https://openalex.org/W4310093705","https://openalex.org/W2974003682"],"abstract_inverted_index":{"Primary":[0],"myelofibrosis":[1],"(PMF)":[2],"is":[3,35,90,103,129],"a":[4,21,112,130],"disease":[5,41,47],"characterized":[6],"by":[7],"bone":[8],"marrow":[9],"fibrosis,":[10],"extramedullary":[11],"hematopoiesis,":[12],"risk":[13],"of":[14,28,57,65,84,115,136],"transformation":[15],"to":[16,52,96,101,123],"acute":[17],"myeloid":[18],"leukemia,":[19],"and":[20,43,62,72,78,141],"substantial":[22],"symptom":[23,79],"burden":[24],"with":[25,117,138],"diminished":[26],"quality":[27],"life.":[29],"Allogeneic":[30],"hematopoietic":[31],"cell":[32],"transplantation":[33],"(HCT)":[34],"the":[36,58,82,134],"only":[37],"curative":[38],"option;":[39],"however,":[40],"relapse":[42],"graft":[44],"versus":[45],"host":[46],"(GVHD)":[48],"are":[49],"significant":[50,73,113],"barriers":[51],"long-term":[53],"survival.":[54],"The":[55],"discovery":[56],"JAK2":[59],"V617F":[60],"mutation,":[61],"subsequent":[63],"development":[64],"JAK":[66,85,94,124],"inhibitors,":[67],"resulted":[68],"in":[69,75,133],"improved":[70],"survival":[71],"improvements":[74],"spleen":[76],"volumes":[77],"scores.":[80],"Though":[81],"effect":[83],"inhibition":[86,95],"on":[87],"transplant":[88],"outcome":[89],"poorly":[91],"understood,":[92],"using":[93],"achieve":[97],"maximal":[98],"response":[99],"prior":[100],"HCT":[102],"standard":[104],"practice":[105],"at":[106],"major":[107],"centers.":[108],"After":[109],"allogeneic":[110,143],"HCT,":[111],"proportion":[114],"patients":[116,137],"steroid-refractory":[118],"GVHD":[119],"have":[120],"clinical":[121],"responses":[122],"inhibition.":[125],"Targeting":[126],"this":[127],"pathway":[128],"key":[131],"component":[132],"management":[135],"PMF":[139],"before":[140],"after":[142],"HCT.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-08-03T00:00:00"}
