{"id":"https://openalex.org/W288337067","doi":null,"title":"Investigation of mechanisms and locus of neural change underlying stress-induced changes in affect","display_name":"Investigation of mechanisms and locus of neural change underlying stress-induced changes in affect","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W288337067","mag":"288337067"},"language":"en","primary_location":{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/2554","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14783/2554","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067457118","display_name":"Jacqueline J. Blundell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacqueline Blundell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067457118"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.14169999957084656,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.13920000195503235,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predator-stress","display_name":"predator stress","score":0.8339999914169312},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9570000171661377},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8220000267028809},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neural-transmission","display_name":"neural transmission","score":0.5550000071525574},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.9430000185966492},{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.7789999842643738},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/anxiogenic-behavior","display_name":"anxiogenic behavior","score":0.6460000276565552},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.5},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.5170000195503235},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.8291207551956177},{"id":"https://openalex.org/C2780451725","wikidata":"https://www.wikidata.org/wiki/Q4867818","display_name":"Basolateral amygdala","level":3,"score":0.7544295787811279},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6413049697875977},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.61544269323349},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.49956226348876953},{"id":"https://openalex.org/C205044023","wikidata":"https://www.wikidata.org/wiki/Q4778117","display_name":"Anxiogenic","level":4,"score":0.44807931780815125},{"id":"https://openalex.org/C2781069035","wikidata":"https://www.wikidata.org/wiki/Q1243765","display_name":"Periaqueductal gray","level":4,"score":0.4325689375400543},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.43131375312805176},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2723504304885864},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.21363773941993713},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.18944257497787476},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1443556845188141},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.14002519845962524},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/2554","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14783/2554","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master thesis"},{"id":"pmh:oai:research.library.mun.ca:1041","doi":null,"is_oa":false,"landing_page_url":"http://research.library.mun.ca/1041/3/Blundell_JacquelineJ.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:288337067","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/1041/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993432667","https://openalex.org/W2042734298","https://openalex.org/W2092268685","https://openalex.org/W2181055835","https://openalex.org/W2048103638","https://openalex.org/W1994455743","https://openalex.org/W2089031800","https://openalex.org/W1587608056","https://openalex.org/W2153062715","https://openalex.org/W2061092474"],"abstract_inverted_index":{"Stress":[0],"has":[1,74],"been":[2],"linked":[3],"to":[4,27,68,90,123,152,162,233,251,287,340,433],"a":[5,18,28,121,124,365],"variety":[6],"of":[7,59,78,86,113,132,344,346,361,367,387,408,437],"affective":[8,419],"disorders,":[9],"in":[10,63,66,97,100,105,140,192,201,218,221,243,290,301,311,318,327,356,369,380,394,397,413,418,425,441],"particular,":[11],"posttraumatic":[12],"stress":[13,116,191,198,231,246,352],"disorder":[14,22],"(PTSD).":[15],"PTSD":[16,64],"is":[17,34,47],"long-lasting,":[19],"chronic":[20],"psychological":[21],"that":[23,270],"results":[24,284,288],"from":[25],"exposure":[26],"life":[29],"threatening,":[30],"inescapable":[31],"stressor.":[32],"There":[33,390],"no":[35,392],"known":[36],"cure":[37],"or":[38,277],"adequate":[39],"treatment":[40],"for":[41,126],"this":[42,87,111,319],"disease.":[43],"In":[44,110,372,421],"addition,":[45,373,422],"there":[46,294],"little":[48],"information":[49],"regarding":[50],"its":[51],"cause.":[52],"Brain":[53],"imaging":[54],"studies":[55],"have":[56],"implicated":[57],"hyperexcitability":[58],"the":[60,76,79,147,153,163,193,202,223,259,281,302,342,357,362,370,375,381,388,398,406,409,435,438],"right":[61,235,253,358,439],"amygdala":[62,80,133,155,160,241,248,260],"and":[65,95,135,156,158,175,208,226,236,254,265,305,332,364,384,411,427],"response":[67],"traumatic":[69],"events.":[70],"Recent":[71],"animal":[72],"research":[73],"confirmed":[75],"role":[77,407],"during":[81],"severe":[82],"stress.":[83,109,183,442],"The":[84,335],"goal":[85],"study":[88],"was":[89,117,138,168,199,309,338],"identify":[91],"particular":[92,103],"neural":[93,219],"pathways":[94,137,144],"structures":[96],"which":[98],"changes":[99,104,214,272,417],"function":[101],"mediate":[102],"affect":[106],"following":[107],"predator":[108,115,182,190,245,414],"set":[112],"experiments,":[114],"achieved":[118],"by":[119],"exposing":[120],"rat":[122,376],"cat":[125,291,347,426],"five":[127],"minutes.":[128],"--":[129,212,298,350,402],"Neural":[130],"transmission":[131,220,250,271],"afferent":[134,240],"efferent":[136,249],"examined":[139,310],"Experiment":[141,312],"1.":[142],"Specifically,":[143],"studied":[145],"were":[146,215,316,391],"ventral":[148,306,385,399],"angular":[149,400],"bundle":[150],"input":[151],"basolateral":[154,159],"central":[157],"output":[161],"periaqueductal":[164],"gray":[165],"(PAG).":[166],"Transmission":[167],"investigated":[169],"one":[170],"day":[171],"(Day":[172,178],"1":[173,225],"study)":[174,180],"nine":[176],"days":[177,188],"9":[179,195,228],"after":[181],"Behavioral":[184],"testing":[185],"occurred":[186],"seven":[187],"post":[189,275],"Day":[194,224,227],"study.":[196],"Predator":[197,230,321,351],"anxiogenic":[200],"elevated":[203],"plus":[204],"maze,":[205],"light/dark":[206],"box":[207],"acoustic":[209],"startle":[210],"tests.":[211],"Lasting":[213],"also":[216],"observed":[217],"both":[222,252],"studies.":[229],"appeared":[232],"potentiate":[234],"depotentiate":[237],"left":[238,255,382],"hemisphere":[239,440],"transmission,":[242],"contrast,":[244],"potentiated":[247],"PAG,":[256],"depending":[257,279],"on":[258,280],"nucleus":[261],"stimulated.":[262],"Paired":[263],"pulse":[264],"intensity":[266,396],"series":[267],"analyses":[268],"suggest":[269],"may":[273],"be":[274],"synaptic":[276],"presynaptic,":[278],"pathway.":[282],"These":[283],"are":[285,295],"similar":[286],"found":[289],"studies,":[292],"but":[293],"species":[296],"differences.":[297],"PCREB":[299],"expression":[300,355,379],"amygdala,":[303],"PAG":[304,363,412],"medial":[307],"hypothalamus":[308],"2.":[313],"Three":[314],"groups":[315],"used":[317,326],"experiment:":[320],"stressed":[322],"(same":[323],"procedure":[324],"as":[325,423],"electrophysioiogy":[328],"study),":[329],"Handled":[330],"control":[331],"Restrained":[333],"control.":[334],"restrained":[336],"group":[337],"added":[339],"mimic":[341],"periods":[343],"immobility":[345],"exposed":[348],"rats.":[349],"increased":[353],"pCREB":[354,378,395],"lateral":[359,383],"column":[360],"subset":[366],"nuclei":[368],"amygdala.":[371],"restraining":[374],"reduced":[377],"columns":[386],"PAG.":[389],"differences":[393],"bundle.":[401],"Both":[403],"experiments":[404,431],"confirm":[405],"amydala":[410],"stress-":[415],"induced":[416],"behavior.":[420],"seen":[424],"human":[428],"data,":[429],"these":[430],"appear":[432],"support":[434],"importance":[436]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
