{"id":"https://openalex.org/W2883293133","doi":"https://doi.org/10.1055/s-0038-1652751","title":"Factor VIII/Von Willebrand Factor Protein Sensitivity Of Periodic Acid Schiff Stain To Carbohydrate Deficiency","display_name":"Factor VIII/Von Willebrand Factor Protein Sensitivity Of Periodic Acid Schiff Stain To Carbohydrate Deficiency","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2883293133","doi":"https://doi.org/10.1055/s-0038-1652751","mag":"2883293133"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1652751","doi":"https://doi.org/10.1055/s-0038-1652751","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0038-1652751","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1652751.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1652751.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111690341","display_name":"Harvey R. Gralnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Gralnick","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042666735","display_name":"G. Michael Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Jackson","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109122260","display_name":"Sybil B. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Williams","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046260297","display_name":"E Cregger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Cregger","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD USA","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9279999732971191},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.9300000071525574},{"id":"https://openalex.org/keywords/von-willebrand-disease","display_name":"von Willebrand disease","score":0.8460000157356262},{"id":"https://openalex.org/keywords/carbohydrate-deficiency","display_name":"carbohydrate deficiency","score":0.8669999837875366},{"id":"https://openalex.org/keywords/periodic-acid-schiff-staining","display_name":"PAS staining","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.8510000109672546},{"id":"https://openalex.org/keywords/desialylation","display_name":"desialylation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/glycosidase-treatment","display_name":"glycosidase treatment","score":0.777999997138977},{"id":"https://openalex.org/keywords/coomassie-brilliant-blue-staining","display_name":"Coomassie blue staining","score":0.7649999856948853},{"id":"https://openalex.org/keywords/screening-sensitivity","display_name":"screening sensitivity","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.8568605184555054},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.6732218861579895},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6576418876647949},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6570507287979126},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5726093649864197},{"id":"https://openalex.org/C75786782","wikidata":"https://www.wikidata.org/wiki/Q1391262","display_name":"Periodic acid\u2013Schiff stain","level":3,"score":0.5264678001403809},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5181761980056763},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.46009084582328796},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4265994131565094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42589110136032104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22821328043937683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17409726977348328},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.13910982012748718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08441469073295593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0038-1652751","doi":"https://doi.org/10.1055/s-0038-1652751","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0038-1652751","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1652751.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1055/s-0038-1652751","doi":"https://doi.org/10.1055/s-0038-1652751","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0038-1652751","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1652751.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883293133.pdf","grobid_xml":"https://content.openalex.org/works/W2883293133.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082697150","https://openalex.org/W2946579561","https://openalex.org/W2993021288","https://openalex.org/W2342796094","https://openalex.org/W2945868031","https://openalex.org/W1992257865","https://openalex.org/W2051108937","https://openalex.org/W2139376868","https://openalex.org/W1967882894","https://openalex.org/W2402168271"],"abstract_inverted_index":{"Carbohydrate":[0],"(C)":[1],"deficiency":[2],"of":[3,17,21,50,57,76,79,132,176,183,195,208,217,257,264,266,286,293,309],"the":[4,18,48,54,58,65,70,77,80,116,127,133,140,168,179,186,191,209,218,222,227,229,236,240,253,258,267,272,276,287,291,294,310],"factor":[5,8],"VUI/von":[6],"Willebrand":[7],"(f.":[9],"VIII/vWf)":[10],"protein":[11,61,67,137,163,261],"has":[12,36],"been":[13,37],"implicated":[14],"as":[15,39],"one":[16,110],"molecular":[19],"defects":[20],"von":[22],"Willebrand\u2019s":[23],"disease.":[24],"The":[25,159,245],"periodic":[26],"acid":[27,220,255],"Schiff":[28],"(PAS)":[29],"reaction":[30,52,75],"in":[31,167,202,226,235,297],"polyacrylamide":[32],"gel":[33],"electrophoresis":[34],"(PAGE)":[35],"used":[38],"a":[40,90,97],"screening":[41],"test":[42,304],"for":[43],"C":[44,55,206,223,230,241,268,307],"deficiency.":[45],"To":[46],"ascertain":[47,306],"sensitivity":[49],"this":[51],"to":[53,72,152,172,204,252,282,305],"content":[56,256,308],"f.":[59,135,161,187,211,259,288,311],"VIII/vWf":[60,136,162,188,212,260,289,312],"we":[62],"have":[63],"purified":[64],"normal":[66,173],"and":[68,86,89,104,115,120,142,185,234,262],"compared":[69,147,171],"Coomassie":[71,113,143],"PAS":[73,119,141,169,200,246,273,277,295],"staining":[74,126,201],"subunit":[78],"intact,":[81],"asialo":[82],"(neuraminidase-treated),":[83],"asialo-agalacto":[84,180,228],"(neuraminidase":[85],"\u03b2-galactosidase-treated)":[87],"derivatives":[88],"fourth":[91],"derivative":[92,181],"which":[93,100],"was":[94,231,242],"treated":[95,189],"with":[96,112,118,155,190],"mixed":[98,192,237],"glycosidase":[99,193],"included":[101],"neuraminidase,":[102],"\u03b2-galactosidase":[103],"N-acetyl-glucosaminidase.":[105],"Gels":[106],"were":[107,129],"run":[108],"simultaneously,":[109],"stained":[111],"blue":[114],"other":[117],"at":[121],"various":[122],"time":[123],"intervals":[124],"after":[125],"gels":[128],"scanned.":[130],"Studies":[131],"intact":[134],"revealed":[138,214],"that":[139,215],"stains":[144],"could":[145],"be":[146,301],"from":[148],"24":[149],"hours":[150],"up":[151],"7":[153],"days":[154],"no":[156],"significant":[157,283],"changes.":[158],"desialated":[160],"had":[164,197],"insignificant":[165],"differences":[166],"stain":[170,247,278,296],"(range":[174],"81-108%":[175],"intact).":[177],"However,":[178],"(36%":[182],"intact)":[184,196],"(24%":[194],"significantly":[198],"reduced":[199,221,232,243],"relation":[203],"normal.":[205],"analysis":[207],"different":[210],"proteins":[213],"removal":[216],"sialic":[219,254],"30%":[224,265],"while":[225],"47%":[233],"glycosidase-treated":[238],"material":[239],"78%.":[244],"is":[248,279],"not":[249,270,300],"very":[250],"sensitive":[251],"reduction":[263],"does":[269],"affect":[271],"stain.":[274],"Since":[275],"relatively":[280],"insensitive":[281],"carbohydrate":[284],"deficiencies":[285],"protein,":[290],"use":[292],"PAGE":[298],"may":[299],"an":[302],"adequate":[303],"protein.":[313]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2018-08-03T00:00:00"}
