{"id":"https://openalex.org/W2883020573","doi":"https://doi.org/10.1001/jamaoncol.2018.2178","title":"Monthly High-Dose Vitamin D Supplementation and Cancer Risk","display_name":"Monthly High-Dose Vitamin D Supplementation and Cancer Risk","publication_year":2018,"publication_date":"2018-07-20","ids":{"openalex":"https://openalex.org/W2883020573","doi":"https://doi.org/10.1001/jamaoncol.2018.2178","mag":"2883020573","pmid":"https://pubmed.ncbi.nlm.nih.gov/30027269","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6248079"},"language":"en","primary_location":{"id":"doi:10.1001/jamaoncol.2018.2178","doi":"https://doi.org/10.1001/jamaoncol.2018.2178","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2018.2178","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2687971/jamaoncology_scragg_2018_oi_180046.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2687971/jamaoncology_scragg_2018_oi_180046.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043043565","display_name":"Robert K.R. Scragg","orcid":"https://orcid.org/0000-0003-0013-2620","observed_orcids":["https://orcid.org/0000-0003-0013-2620"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Robert Scragg","raw_affiliation_strings":["School of Population Health, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Population Health, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040307802","display_name":"Kay\u2010Tee Khaw","orcid":"https://orcid.org/0000-0002-8802-2903","observed_orcids":["https://orcid.org/0000-0002-8802-2903"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kay-Tee Khaw","raw_affiliation_strings":["Department of Public Health, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035332078","display_name":"Les J Toop","orcid":"https://orcid.org/0000-0002-9375-8608","observed_orcids":["https://orcid.org/0000-0002-9375-8608"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Les Toop","raw_affiliation_strings":["Department of Public Health & General Practice, University of Otago, Christchurch, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health & General Practice, University of Otago, Christchurch, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026490021","display_name":"John Sluyter","orcid":"https://orcid.org/0000-0002-9722-139X","observed_orcids":["https://orcid.org/0000-0002-9722-139X"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"John Sluyter","raw_affiliation_strings":["School of Population Health, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Population Health, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015221304","display_name":"Carlene M.M. Lawes","orcid":"https://orcid.org/0000-0002-7140-1237","observed_orcids":["https://orcid.org/0000-0002-7140-1237"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Carlene M. M. Lawes","raw_affiliation_strings":["School of Population Health, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Population Health, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082373321","display_name":"Debbie Waayer","orcid":"https://orcid.org/0000-0003-4627-8342","observed_orcids":["https://orcid.org/0000-0003-4627-8342"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Debbie Waayer","raw_affiliation_strings":["School of Population Health, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Population Health, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038373228","display_name":"Edward L. Giovannucci","orcid":"https://orcid.org/0000-0002-6123-0219","observed_orcids":["https://orcid.org/0000-0002-6123-0219","https://orcid.org/0009-0003-9117-569X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Giovannucci","raw_affiliation_strings":["Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts","Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062152763","display_name":"Carlos A. Camargo","orcid":"https://orcid.org/0000-0002-5071-7654","observed_orcids":["https://orcid.org/0000-0002-5071-7654"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A. Camargo","raw_affiliation_strings":["Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043043565"],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":null,"apc_paid":null,"fwci":17.5983,"has_fulltext":true,"cited_by_count":167,"citation_normalized_percentile":{"value":0.99666247,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"4","issue":"11","first_page":"e182178","last_page":"e182178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.921999990940094},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cancer-mortality","display_name":"cancer mortality","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.3869999945163727},{"id":"https://openalex.org/keywords/high-dose-vitamin-d","display_name":"high-dose vitamin D","score":0.7049999833106995},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.8420000076293945},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6010000109672546},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":0.6919999718666077},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.48399999737739563},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.414000004529953},{"id":"https://openalex.org/keywords/community-dwelling-adults","display_name":"community-dwelling adults","score":0.6880000233650208},{"id":"https://openalex.org/keywords/new-zealand-population","display_name":"New Zealand population","score":0.41499999165534973},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.32499998807907104},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.941470742225647},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5731000900268555},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5519617199897766},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.537975013256073},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.53547203540802},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.5149295926094055},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.500967264175415},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43941444158554077},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.42815566062927246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4263015389442444},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.40966516733169556},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08030608296394348},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1001/jamaoncol.2018.2178","doi":"https://doi.org/10.1001/jamaoncol.2018.2178","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2018.2178","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2687971/jamaoncology_scragg_2018_oi_180046.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5593656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6248079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6248079","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6248079","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncol","raw_type":"Text"},{"id":"pmid:30027269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30027269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA oncology","raw_type":"Journal Article"},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/56506","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2292/56506","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1001/jamaoncol.2018.2178","doi":"https://doi.org/10.1001/jamaoncol.2018.2178","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2018.2178","pdf_url":"https://jamanetwork.com/journals/jamaoncology/articlepdf/2687971/jamaoncology_scragg_2018_oi_180046.pdf","source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4942257617","display_name":"The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population","funder_award_id":"MR/N003284/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5897142711","display_name":null,"funder_award_id":"14136","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6159928833","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0512-10114","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883020573.pdf","grobid_xml":"https://content.openalex.org/works/W2883020573.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1531229431","https://openalex.org/W1869666842","https://openalex.org/W1964611803","https://openalex.org/W1969278804","https://openalex.org/W1988664005","https://openalex.org/W1990859291","https://openalex.org/W1994163486","https://openalex.org/W2018866137","https://openalex.org/W2033476634","https://openalex.org/W2057301426","https://openalex.org/W2072975437","https://openalex.org/W2096150705","https://openalex.org/W2099665543","https://openalex.org/W2107100887","https://openalex.org/W2118426146","https://openalex.org/W2119959841","https://openalex.org/W2123346488","https://openalex.org/W2130462780","https://openalex.org/W2143183201","https://openalex.org/W2145798427","https://openalex.org/W2156394393","https://openalex.org/W2162069578","https://openalex.org/W2162139093","https://openalex.org/W2162459349","https://openalex.org/W2163674273","https://openalex.org/W2182400851","https://openalex.org/W2301143748","https://openalex.org/W2313524312","https://openalex.org/W2511017384","https://openalex.org/W2598825268","https://openalex.org/W2604629929","https://openalex.org/W2736841502","https://openalex.org/W2766993720","https://openalex.org/W4246889337"],"related_works":["https://openalex.org/W2922609171","https://openalex.org/W4408475692","https://openalex.org/W2916365527","https://openalex.org/W2792226184","https://openalex.org/W3175178946","https://openalex.org/W2598825268","https://openalex.org/W2980882548","https://openalex.org/W1990859291","https://openalex.org/W4220848229","https://openalex.org/W3176315146"],"abstract_inverted_index":{"Importance:":[0],"Previous":[1],"randomized":[2,123],"clinical":[3],"trials":[4],"have":[5],"reported":[6],"inconsistent":[7],"results":[8],"on":[9,16,225],"the":[10,43,59,149,201,220,231,236,238,259,284,298,304,335,345],"effect":[11],"of":[12,56,168,177,186,203,253,281,310,316,330,341,353],"vitamin":[13,24,126,161,299,336,365],"D":[14,25,61,271,288,300,337,366],"supplementation":[15,26,367],"cancer":[17,37,40,311,317],"incidence.":[18],"Objective:":[19],"To":[20],"examine":[21],"whether":[22],"high-dose":[23],"received":[27],"monthly,":[28],"without":[29,375],"calcium,":[30],"is":[31,51],"associated":[32],"with":[33,91,258],"a":[34,52,65,184,278,390],"reduction":[35],"in":[36,42,79,148,163,208,235,297,303,322,328,334,344],"incidence":[38],"and":[39,48,76,115,140,172,194,207,249,320,326,339,362],"mortality":[41],"general":[44],"population.":[45],"Design,":[46],"Setting,":[47],"Participants:":[49],"This":[50,381],"post":[53],"hoc":[54,197],"analysis":[55,153],"data":[57],"from":[58,73,83,112,117,217],"Vitamin":[60],"Assessment":[62],"(ViDA)":[63],"study,":[64],"randomized,":[66],"double-blind,":[67],"placebo-controlled":[68],"trial":[69],"that":[70,384],"recruited":[71],"participants":[72,121,137,233,332],"family":[74,113],"practices":[75,114],"community":[77,100,118],"groups":[78],"Auckland,":[80],"New":[81],"Zealand,":[82],"April":[84],"5,":[85],"2011,":[86],"through":[87],"November":[88],"6,":[89],"2012,":[90],"follow-up":[92,286],"completed":[93],"December":[94],"31,":[95,227],"2015.":[96,228],"Participants":[97],"were":[98,122,146,247,252],"adult":[99],"residents":[101],"aged":[102],"50":[103],"to":[104,124,157,372],"84":[105],"years.":[106],"Of":[107,230],"47":[108],"905":[109],"adults":[110],"invited":[111],"163":[116,340],"groups,":[119],"5110":[120],"receive":[125],"D3":[127],"(n":[128,133,143],"=":[129,134,144,359],"2558)":[130],"or":[131,181,255,263,386],"placebo":[132,182,305,346],"2552).":[135],"Two":[136],"withdrew":[138],"consent,":[139],"all":[141,204],"others":[142],"5108)":[145],"included":[147,234],"primary":[150,198,205,308],"analysis.":[151],"Data":[152],"was":[154,200,223,242,273,291],"by":[155,174],"intention":[156],"treat.":[158],"Interventions:":[159],"Oral":[160],"D3,":[162],"an":[164,349],"initial":[165],"bolus":[166],"dose":[167],"200":[169],"000":[170,179],"IU":[171],"followed":[173],"monthly":[175,369],"doses":[176],"100":[178],"IU,":[180],"for":[183,370,389],"median":[185],"3.3":[187],"years":[188,374],"(range,":[189],"2.5-4.2":[190],"years).":[191],"Main":[192],"Outcomes":[193],"Measures:":[195],"Post":[196],"outcome":[199,309],"number":[202],"invasive":[206,319],"situ":[209,323],"malignant":[210,324],"neoplasms":[211],"(excluding":[212],"nonmelanoma":[213],"skin":[214],"cancers)":[215],"diagnosed":[216],"randomization":[218],"until":[219],"study":[221,382],"medication":[222],"discontinued":[224],"July":[226],"Results:":[229],"5108":[232],"analysis,":[237],"mean":[239,285],"(SD)":[240,267],"age":[241],"65.9":[243],"(8.3)":[244],"years,":[245],"58.1%":[246],"male,":[248],"4253":[250],"(83.3%)":[251],"European":[254],"another":[256],"race/ethnicity,":[257],"remainder":[260],"being":[261],"Polynesian":[262],"South":[264],"Asian.":[265],"Mean":[266],"baseline":[268],"deseasonalized":[269],"25-hydroxyvitamin":[270,287],"concentration":[272,289],"26.5":[274],"(9.0)":[275],"ng/mL.":[276],"In":[277],"random":[279],"sample":[280],"438":[282],"participants,":[283],"consistently":[290],"greater":[292],"than":[293,302],"20":[294],"ng/mL":[295],"higher":[296],"group":[301,338],"group.":[306],"The":[307],"comprised":[312],"328":[313],"total":[314],"cases":[315],"(259":[318],"69":[321],"neoplasms)":[325],"occurred":[327],"165":[329],"2558":[331],"(6.5%)":[333],"2550":[342],"(6.4%)":[343],"group,":[347],"yielding":[348],"adjusted":[350],"hazard":[351],"ratio":[352],"1.01":[354],"(95%":[355],"CI,":[356],"0.81-1.25;":[357],"P":[358],".95).":[360],"Conclusions":[361],"Relevance:":[363],"High-dose":[364],"prescribed":[368],"up":[371],"4":[373],"calcium":[376],"may":[377,393],"not":[378],"prevent":[379],"cancer.":[380],"suggests":[383],"daily":[385],"weekly":[387],"dosing":[388],"longer":[391],"period":[392],"require":[394],"further":[395],"study.":[396],"Trial":[397],"Registration:":[398],"anzctr.org.au":[399],"Identifier:":[400],"ACTRN12611000402943.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":33},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-08-03T00:00:00"}