{"id":"https://openalex.org/W2882990748","doi":"https://doi.org/10.3389/fmicb.2018.01602","title":"Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet","display_name":"Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet","publication_year":2018,"publication_date":"2018-07-20","ids":{"openalex":"https://openalex.org/W2882990748","doi":"https://doi.org/10.3389/fmicb.2018.01602","mag":"2882990748","pmid":"https://pubmed.ncbi.nlm.nih.gov/30079055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6062601"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2018.01602","doi":"https://doi.org/10.3389/fmicb.2018.01602","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2018.01602","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2018.01602/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2018.01602/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100745693","display_name":"Ruirui Wang","orcid":"https://orcid.org/0000-0002-2766-9420","observed_orcids":["https://orcid.org/0000-0002-2766-9420"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruirui Wang","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041039715","display_name":"Hui Li","orcid":"https://orcid.org/0000-0001-6282-5559","observed_orcids":["https://orcid.org/0000-0001-6282-5559"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100655696","display_name":"Xin Yang","orcid":"https://orcid.org/0000-0001-7799-7425","observed_orcids":["https://orcid.org/0000-0001-7799-7425"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yang","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045492545","display_name":"Xinhe Xue","orcid":"https://orcid.org/0000-0001-5115-7022","observed_orcids":["https://orcid.org/0000-0001-5115-7022"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhe Xue","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053010349","display_name":"Liman Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liman Deng","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101434398","display_name":"Jian Shen","orcid":"https://orcid.org/0000-0002-5260-4872","observed_orcids":["https://orcid.org/0000-0002-5260-4872"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Shen","raw_affiliation_strings":["Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030856138","display_name":"Menghui H. Zhang","orcid":"https://orcid.org/0000-0002-9274-487X","observed_orcids":["https://orcid.org/0000-0002-9274-487X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghui Zhang","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089008822","display_name":"Liping Zhao","orcid":"https://orcid.org/0000-0001-9694-7140","observed_orcids":["https://orcid.org/0000-0001-9694-7140","https://orcid.org/0009-0009-1961-3820"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Liping Zhao","raw_affiliation_strings":["Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers New Jersey Institute for Food, Nutrition, and Health, Rutgers University-New Brunswick, New Brunswick, NJ, United States","Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China","State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers New Jersey Institute for Food, Nutrition, and Health, Rutgers University-New Brunswick, New Brunswick, NJ, United States","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005334123","display_name":"Chenhong Zhang","orcid":"https://orcid.org/0000-0002-4462-892X","observed_orcids":["https://orcid.org/0000-0002-4462-892X","https://orcid.org/0009-0009-3137-1123"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767884","display_name":"State Key Laboratory of Microbial Metabolism","ror":"https://ror.org/04t3q5q03","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenhong Zhang","raw_affiliation_strings":["State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005334123"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767884"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.4001,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.90237815,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"1602","last_page":"1602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8600000143051147},{"id":"https://openalex.org/keywords/genetic-obesity","display_name":"genetic obesity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.7099999785423279},{"id":"https://openalex.org/keywords/microbiota-transplantation","display_name":"microbiota transplantation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/liver-transcriptome","display_name":"liver transcriptome","score":0.7440000176429749},{"id":"https://openalex.org/keywords/dietary-weight-loss","display_name":"dietary weight loss","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hepatic-cholesterol","display_name":"liver cholesterol","score":0.6050000190734863},{"id":"https://openalex.org/keywords/hepatic-triglycerides","display_name":"hepatic triglycerides","score":0.7689999938011169},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fat-absorption","display_name":"fat absorption","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.8047134876251221},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.792866587638855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6574363708496094},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6562082767486572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6035791039466858},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5879987478256226},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5648859739303589},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.41586828231811523},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.41000494360923767},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3474244475364685},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29505234956741333},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17649590969085693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16442722082138062}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fmicb.2018.01602","doi":"https://doi.org/10.3389/fmicb.2018.01602","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2018.01602","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2018.01602/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5024283","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6062601","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6062601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6062601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:30079055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30079055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d0ed5ce3be8d406d88dddee30dfb5458","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d0ed5ce3be8d406d88dddee30dfb5458","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2018.01602","doi":"https://doi.org/10.3389/fmicb.2018.01602","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2018.01602","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2018.01602/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6100000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2034967606","display_name":"\u80a0\u9053\u529f\u80fd\u83cc\u4e0e\u8425\u517b\u4e92\u4f5c\u8bf1\u53d1\u4ee3\u8c22\u7efc\u5408\u5f81\u7684\u5206\u5b50\u751f\u6001\u5b66\u673a\u5236\u7814\u7a76","funder_award_id":"31330005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5178778503","display_name":null,"funder_award_id":"14YF1402200","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G6489150549","display_name":null,"funder_award_id":"81401141","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2882990748.pdf","grobid_xml":"https://content.openalex.org/works/W2882990748.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1541292363","https://openalex.org/W1803443273","https://openalex.org/W1969592147","https://openalex.org/W1984916935","https://openalex.org/W1993399595","https://openalex.org/W2002598396","https://openalex.org/W2017573476","https://openalex.org/W2023360692","https://openalex.org/W2032129662","https://openalex.org/W2037648723","https://openalex.org/W2042074642","https://openalex.org/W2042881415","https://openalex.org/W2059198752","https://openalex.org/W2072362233","https://openalex.org/W2072970694","https://openalex.org/W2089691332","https://openalex.org/W2099679330","https://openalex.org/W2100176567","https://openalex.org/W2102278945","https://openalex.org/W2104890139","https://openalex.org/W2110840202","https://openalex.org/W2116802952","https://openalex.org/W2121180999","https://openalex.org/W2121413434","https://openalex.org/W2125826054","https://openalex.org/W2128194105","https://openalex.org/W2128769815","https://openalex.org/W2134526812","https://openalex.org/W2135697832","https://openalex.org/W2136552678","https://openalex.org/W2146275270","https://openalex.org/W2151945971","https://openalex.org/W2156445392","https://openalex.org/W2167336969","https://openalex.org/W2176918678","https://openalex.org/W2178380008","https://openalex.org/W2179438025","https://openalex.org/W2204688218","https://openalex.org/W2259551399","https://openalex.org/W2289494545","https://openalex.org/W2431581641","https://openalex.org/W2460141262","https://openalex.org/W2561654350","https://openalex.org/W2569874320","https://openalex.org/W2766840884","https://openalex.org/W2774046712","https://openalex.org/W2911964244"],"related_works":["https://openalex.org/W2596009746","https://openalex.org/W3124102803","https://openalex.org/W1984916935","https://openalex.org/W4401489576","https://openalex.org/W2883563204","https://openalex.org/W2344484424","https://openalex.org/W2951606823","https://openalex.org/W3197204181","https://openalex.org/W3174494953","https://openalex.org/W4410174166"],"abstract_inverted_index":{"Dysbiotic":[0],"gut":[1,16,57,103,196,224],"microbiota":[2,17,27,104,197,225],"contributes":[3],"to":[4],"genetically":[5,30,200],"obese":[6,31,201],"phenotype":[7],"in":[8,64,105,127,140,173,217,231],"human.":[9],"However,":[10],"the":[11,65,144,150,159,182,204,232],"effect":[12],"of":[13,90,146,152,161,181,186,206,214,234],"genetic":[14],"obesity-associated":[15],"on":[18,73],"host":[19],"hepatic":[20,91,100,183,211],"metabolic":[21],"deteriorations":[22],"remains":[23],"largely":[24],"unknown.":[25],"Gut":[26],"from":[28,113,198],"a":[29,37,135,199,228],"human":[32,202],"donor":[33],"before":[34,158],"and":[35,52,61,93,107,116,149,155],"after":[36],"dietary":[38],"weight":[39],"loss":[40],"program":[41],"was":[42,110,117,171],"transplanted":[43],"into":[44],"germ-free":[45],"C57BL/6J":[46],"male":[47],"mice,":[48],"grouped":[49],"as":[50,178],"PreM":[51,80,106,132,174],"PostM":[53,96,108,130],"groups,":[54],"respectively.":[55],"The":[56,102],"microbiome,":[58],"liver":[59,83,141,162,207,237],"pathology":[60,160],"transcriptome":[62],"response":[63,139],"gnotobiotic":[66],"mice":[67],"were":[68],"evaluated.":[69],"After":[70],"being":[71],"fed":[72],"normal":[74,99],"chow":[75],"diet":[76],"for":[77],"4":[78],"weeks,":[79],"group":[81,97,133],"developed":[82],"macrovesicular":[84],"steatosis":[85,208],"accompanied":[86],"with":[87,120,129],"higher":[88],"concentrations":[89],"triglyceride":[92],"cholesterol,":[94],"while":[95],"exhibited":[98],"physiology.":[101],"groups":[109],"significantly":[111],"different":[112],"each":[114],"other":[115],"more":[118],"resembling":[119],"their":[121],"respective":[122],"donor.":[123],"RNA-sequencing":[124],"revealed":[125],"that,":[126],"comparison":[128],"group,":[131,175],"showed":[134],"foregoing":[136],"pro-steatotic":[137],"transcriptional":[138,184,212],"featuring":[142],"by":[143,209],"repression":[145],"lipid":[147,153,187,215],"beta-oxidation":[148],"activation":[151],"absorption":[154],"cholesterol":[156],"uptake":[157],"steatosis.":[163],"Moreover,":[164],"peroxisome":[165],"proliferator-activated":[166],"receptor":[167],"alpha":[168],"(PPAR\u03b1),":[169],"which":[170],"repressed":[172],"may":[176,226],"act":[177],"crucial":[179],"regulator":[180],"profile":[185,213],"metabolism":[188,216],"between":[189],"two":[190],"groups.":[191],"Our":[192],"results":[193],"show":[194],"that":[195,223],"promotes":[203],"onset":[205],"impacting":[210],"mice.":[218],"This":[219],"adds":[220],"new":[221],"evidence":[222],"play":[227],"causative":[229],"role":[230],"development":[233],"non-alcoholic":[235],"fatty":[236],"disease.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-08-03T00:00:00"}