{"id":"https://openalex.org/W28756939","doi":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","title":"Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution.","display_name":"Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution.","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W28756939","doi":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","mag":"28756939","pmid":"https://pubmed.ncbi.nlm.nih.gov/1710977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/452829"},"language":"en","primary_location":{"id":"doi:10.1002/j.1460-2075.1991.tb07683.x","doi":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","pdf_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1991.tb07683.x.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1991.tb07683.x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022939551","display_name":"Anne Volbeda","orcid":"https://orcid.org/0000-0002-6038-0979","observed_orcids":["https://orcid.org/0000-0002-6038-0979"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Volbeda","raw_affiliation_strings":["European Molecular Biology Laboratory, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000269292","display_name":"Armin Lahm","orcid":"https://orcid.org/0000-0002-2859-4379","observed_orcids":["https://orcid.org/0000-0002-2859-4379"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Lahm","raw_affiliation_strings":["European Molecular Biology Laboratory, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110003478","display_name":"Fumio Sakiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Sakiyama","raw_affiliation_strings":["European Molecular Biology Laboratory, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051705273","display_name":"Dietrich Suck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Suck","raw_affiliation_strings":["European Molecular Biology Laboratory, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Heidelberg, Germany","institution_ids":["https://openalex.org/I4210138560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210138560"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":4.1397,"has_fulltext":true,"cited_by_count":259,"citation_normalized_percentile":{"value":0.94828744,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"1607","last_page":"1618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillium-citrinum","display_name":"Penicillium citrinum","score":0.8849999904632568},{"id":"https://openalex.org/keywords/single-stranded-dna-cleavage","display_name":"single-stranded DNA cleavage","score":0.8769999742507935},{"id":"https://openalex.org/keywords/zinc-coordination","display_name":"zinc coordination","score":0.6359999775886536},{"id":"https://openalex.org/keywords/n-acetylglucosamine","display_name":"N-acetylglucosamine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cleavage-mechanism","display_name":"cleavage mechanism","score":0.7940000295639038},{"id":"https://openalex.org/keywords/protein-crystal-structure","display_name":"protein crystal structure","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6133808493614197},{"id":"https://openalex.org/C2776142995","wikidata":"https://www.wikidata.org/wiki/Q10622902","display_name":"Penicillium citrinum","level":2,"score":0.494886577129364},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.471934050321579},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.4679863452911377},{"id":"https://openalex.org/C2777166331","wikidata":"https://www.wikidata.org/wiki/Q17104122","display_name":"Molecular replacement","level":3,"score":0.4479670524597168},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3325444757938385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25017231702804565},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22790420055389404},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.1577155888080597},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14694476127624512},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07638123631477356}],"mesh":[{"descriptor_ui":"D000117","descriptor_name":"Acetylglucosamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001409","descriptor_name":"Bacillus cereus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010407","descriptor_name":"Penicillium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015719","descriptor_name":"Single-Strand Specific DNA and RNA Endonucleases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1460-2075.1991.tb07683.x","doi":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","pdf_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1991.tb07683.x.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:452829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/452829","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:1710977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1710977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/j.1460-2075.1991.tb07683.x","doi":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1991.tb07683.x","pdf_url":"https://link.springer.com/content/pdf/10.1002/j.1460-2075.1991.tb07683.x.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W28756939.pdf","grobid_xml":"https://content.openalex.org/works/W28756939.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W29362848","https://openalex.org/W1516459493","https://openalex.org/W1519899019","https://openalex.org/W1521900320","https://openalex.org/W1554378120","https://openalex.org/W1557518308","https://openalex.org/W1557525759","https://openalex.org/W1573005391","https://openalex.org/W1575704306","https://openalex.org/W1606011614","https://openalex.org/W1864506204","https://openalex.org/W1947219322","https://openalex.org/W1965648605","https://openalex.org/W1966041739","https://openalex.org/W1974618080","https://openalex.org/W1980624564","https://openalex.org/W1994204471","https://openalex.org/W2003286881","https://openalex.org/W2005766686","https://openalex.org/W2008708467","https://openalex.org/W2014694459","https://openalex.org/W2028659951","https://openalex.org/W2033168624","https://openalex.org/W2041701452","https://openalex.org/W2042812247","https://openalex.org/W2049902088","https://openalex.org/W2058475414","https://openalex.org/W2067031652","https://openalex.org/W2069843813","https://openalex.org/W2077483651","https://openalex.org/W2079943317","https://openalex.org/W2085791091","https://openalex.org/W2090538398","https://openalex.org/W2123242549","https://openalex.org/W2136830750","https://openalex.org/W2160336334","https://openalex.org/W2169202020","https://openalex.org/W2333477209","https://openalex.org/W4237484713","https://openalex.org/W4238638020","https://openalex.org/W4293253343"],"related_works":["https://openalex.org/W4233731975","https://openalex.org/W2041701452","https://openalex.org/W1992015671","https://openalex.org/W2069014517","https://openalex.org/W72979673","https://openalex.org/W1986334931","https://openalex.org/W2350426407","https://openalex.org/W2008891693","https://openalex.org/W4231178724","https://openalex.org/W2903029034"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}