{"id":"https://openalex.org/W287282316","doi":null,"title":"Charakterisierung der Funktionen der unterschiedlichen Isoformen des humanen Transkriptionsfaktors Grainyhead-like 3","display_name":"Charakterisierung der Funktionen der unterschiedlichen Isoformen des humanen Transkriptionsfaktors Grainyhead-like 3","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W287282316","mag":"287282316"},"language":"de","primary_location":{"id":"pmh:oai:docserv.uni-duesseldorf.de:23544","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=23544","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017577487","display_name":"Arne Mlynek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arne Mlynek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017577487"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7099999785423279},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.6970000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.8479999899864197},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8880000114440918},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.5799999833106995},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.47099998593330383},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6378698348999023},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49330559372901917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16349446773529053}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:docserv.uni-duesseldorf.de:23544","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=23544","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:287282316","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DerivateServlet/Derivate-25084","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W66006033","https://openalex.org/W125106425","https://openalex.org/W1541963905","https://openalex.org/W1577674435","https://openalex.org/W1581310431","https://openalex.org/W1607892649","https://openalex.org/W1678800844","https://openalex.org/W1881072801","https://openalex.org/W1887844619","https://openalex.org/W1963522352","https://openalex.org/W1966152350","https://openalex.org/W1976758368","https://openalex.org/W1976975022","https://openalex.org/W1980969801","https://openalex.org/W1984621921","https://openalex.org/W1987349361","https://openalex.org/W1989438369","https://openalex.org/W1989850563","https://openalex.org/W1992441650","https://openalex.org/W1994223434","https://openalex.org/W1998038367","https://openalex.org/W1998108444","https://openalex.org/W2000075945","https://openalex.org/W2001252075","https://openalex.org/W2003045225","https://openalex.org/W2003379664","https://openalex.org/W2003847336","https://openalex.org/W2004175200","https://openalex.org/W2004820783","https://openalex.org/W2006633406","https://openalex.org/W2007244655","https://openalex.org/W2010142538","https://openalex.org/W2010206624","https://openalex.org/W2011053169","https://openalex.org/W2013206077","https://openalex.org/W2015989606","https://openalex.org/W2018495872","https://openalex.org/W2023128560","https://openalex.org/W2024185487","https://openalex.org/W2024650410","https://openalex.org/W2025128457","https://openalex.org/W2028880044","https://openalex.org/W2029373728","https://openalex.org/W2031142693","https://openalex.org/W2031681500","https://openalex.org/W2031721857","https://openalex.org/W2032418919","https://openalex.org/W2033179718","https://openalex.org/W2037617759","https://openalex.org/W2040615118","https://openalex.org/W2044296969","https://openalex.org/W2049046201","https://openalex.org/W2051082229","https://openalex.org/W2051354345","https://openalex.org/W2054150424","https://openalex.org/W2060913542","https://openalex.org/W2065470651","https://openalex.org/W2065577350","https://openalex.org/W2070121449","https://openalex.org/W2071152217","https://openalex.org/W2076320536","https://openalex.org/W2082389145","https://openalex.org/W2087221897","https://openalex.org/W2095495393","https://openalex.org/W2099312302","https://openalex.org/W2100134733","https://openalex.org/W2100837269","https://openalex.org/W2101457798","https://openalex.org/W2104024903","https://openalex.org/W2104740310","https://openalex.org/W2104790006","https://openalex.org/W2106181213","https://openalex.org/W2107436171","https://openalex.org/W2107638340","https://openalex.org/W2118072900","https://openalex.org/W2118440238","https://openalex.org/W2124858681","https://openalex.org/W2128635872","https://openalex.org/W2128786825","https://openalex.org/W2132417094","https://openalex.org/W2133295224","https://openalex.org/W2134812217","https://openalex.org/W2137570167","https://openalex.org/W2137952489","https://openalex.org/W2138834926","https://openalex.org/W2139319526","https://openalex.org/W2145690501","https://openalex.org/W2146038402","https://openalex.org/W2146736971","https://openalex.org/W2147441759","https://openalex.org/W2150916276","https://openalex.org/W2151718749","https://openalex.org/W2152525228","https://openalex.org/W2153397085","https://openalex.org/W2156815362","https://openalex.org/W2156838463","https://openalex.org/W2157589212","https://openalex.org/W2157603347","https://openalex.org/W2160042367","https://openalex.org/W2164321835","https://openalex.org/W2168008823","https://openalex.org/W2169182236","https://openalex.org/W2170299197","https://openalex.org/W2170698318","https://openalex.org/W2388058617","https://openalex.org/W2407100760","https://openalex.org/W4313377105","https://openalex.org/W7098124190"],"related_works":["https://openalex.org/W2330364090","https://openalex.org/W1425042527","https://openalex.org/W2731270325","https://openalex.org/W2004820783","https://openalex.org/W4249007730","https://openalex.org/W2607405954","https://openalex.org/W3134494551","https://openalex.org/W2919140219","https://openalex.org/W2609143441","https://openalex.org/W1988820843"],"abstract_inverted_index":{"Epidemiologischen":[0],"Untersuchungen":[1,80],"zufolge":[2],"stellen":[3],"Kardiovaskulare":[4],"Erkrankungen":[5,17,26,331],"die":[6,25,27,70,95,111,142,172,183,199,201,216,277,293,323],"haufigste":[7],"Todesursache":[8],"in":[9,19,155,205,229,241,279,286],"westlichen":[10],"Industrienationen":[11],"dar.":[12],"Ihren":[13],"Ursprung":[14],"haben":[15,59],"diese":[16],"oftmals":[18],"endothelialer":[20,39],"Dysfunktion,":[21],"welche":[22,47],"genau":[23],"wie":[24],"sie":[28],"zur":[29],"Folge":[30],"hat,":[31],"mit":[32,49,82,246],"dem":[33,83],"Alter":[34],"zunimmt.":[35],"Ein":[36],"wichtiges":[37],"Kennzeichen":[38],"Dysfunktion":[40],"ist":[41],"eine":[42,260,313],"verringerte":[43],"Stickstoffmonoxid":[44],"(NO)":[45],"Bioverfugbarkeit,":[46],"einhergeht":[48],"erhohter":[50],"Apoptosesensitivitat":[51],"und":[52,76,124,137,141,159,168,177,191,231,237,274,296,303,328],"verringerter":[53],"Migrationsfahigkeit":[54],"der":[55,63,113,166,220,247,316,320],"Endothelzellen.":[56],"Vor":[57],"kurzem":[58],"wir":[60],"nachgewiesen,":[61],"dass":[62,152,215,259],"Transkriptionsfaktor":[64],"Grainyhead-like":[65],"3":[66,264,297],"(GRHL3)":[67],"Einfluss":[68,134],"auf":[69,135,179,198,219],"fur":[71],"Endothelzellen":[72,140,156,180,280],"essentiellen":[73],"Funktionen":[74,112],"Apoptose":[75,138,190],"Migration":[77,136],"hat.":[78],"Die":[79,225],"wurden":[81,239,289],"humanen":[84],"Homolog":[85],"des":[86,298],"murinen":[87],"GRHL3":[88,263,300],"durchgefuhrt.":[89],"Hierbei":[90],"handelt":[91],"es":[92,132],"sich":[93],"um":[94],"zweite":[96],"(GRHL3-2)":[97],"von":[98,139,174,226,262],"drei":[99],"im":[100,254,265],"Menschen":[101],"vorkommenden":[102],"Isoformen":[103,122,154,294,307],"dieses":[104],"Transkriptionsfaktors.":[105],"Im":[106],"Gegensatz":[107,266],"zu":[108,147,186,267,269],"GRHL3-2,":[109],"sind":[110],"beiden":[114,306],"aus":[115],"einem":[116],"Primartranskript":[117],"durch":[118,312],"alternatives":[119],"Spleisen":[120],"hervorgehenden":[121],"GRHL3-1":[123,175,196,227,268,317],"GRHL3-3":[125,184,208,321],"bisher":[126],"unbekannt.":[127],"Ziel":[128],"dieser":[129,284,305],"Arbeit":[130],"war":[131],"ihren":[133],"zugrunde":[143],"liegenden":[144],"molekularen":[145],"Mechanismen":[146],"charakterisieren.\r":[148],"Ich":[149],"konnte":[150,311],"zeigen,":[151],"beide":[153],"exprimiert":[157],"werden":[158,327],"transkriptionsaktivierend":[160],"wirken,":[161],"jedoch":[162],"gegensatzliche":[163],"Effekte":[164,210,218,283],"bei":[165],"Endothelzellmigration":[167],"-apoptose":[169],"hervorrufen.":[170],"Wahrend":[171],"Uberexpression":[173,185,261],"promigratorisch":[176],"antiapoptotisch":[178],"wirkt,":[181],"fuhrte":[182],"keinem":[187],"Schutz":[188],"vor":[189],"wirkte":[192,195],"migrationshemmend.":[193],"Zudem":[194],"aktivierend":[197],"eNOS,":[200],"wichtigste":[202],"NO":[203],"Quelle":[204],"Endothelzellen,":[206],"wohingegen":[207],"gegenteilige":[209],"zeigte.":[211],"Microarray":[212],"Analysen":[213],"zeigten,":[214,258],"gegenteiligen":[217],"Aktivierung":[221],"unterschiedlicher":[222],"Zielgene":[223,304],"beruhen.":[224],"regulierten,":[228],"promigratorische":[230],"antiapoptotische":[232],"Prozesse":[233],"involvierten":[234],"Gene":[235],"Mxi1":[236],"Akt2":[238],"zudem":[240],"Westernblot-Analysen":[242],"validiert.":[243],"In":[244,309],"Kooperation":[245],"National":[248],"University":[249],"of":[250],"Singapore":[251],"durchgefuhrte":[252],"Experimente":[253],"Zebrafisch":[255],"(Danio":[256],"rerio)":[257],"massiven":[270],"entwicklungsbiologischen":[271],"Defekten":[272],"fuhrt":[273],"bestatigten":[275],"damit":[276],"zuvor":[278],"nachgewiesenen":[281],"negativen":[282],"Isoform":[285],"vivo.\r":[287],"Zusammenfassend":[288],"zum":[290],"ersten":[291],"Mal":[292],"1":[295],"Transkriptionsfaktors":[299],"funktionell":[301],"charakterisiert":[302],"identifiziert.":[308],"Zukunft":[310],"gezielte":[314],"Aufregulation":[315],"und/oder":[318],"Herabregulation":[319],"Expression":[322],"Endothelzellintegritat":[324],"nachhaltig":[325],"verbessert":[326],"somit":[329],"kardiovaskularen":[330],"vorgebeugt":[332],"werden.":[333]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}