{"id":"https://openalex.org/W286799385","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.606.13","title":"Direct renin inhibition with Aliskiren lowers blood pressure and improves renal dysfunction in Ren2 rats","display_name":"Direct renin inhibition with Aliskiren lowers blood pressure and improves renal dysfunction in Ren2 rats","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W286799385","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.606.13","mag":"286799385"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.606.13","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.606.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.606.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026369769","display_name":"Ravi Nistala","orcid":"https://orcid.org/0000-0001-9577-8074","observed_orcids":["https://orcid.org/0000-0001-9577-8074"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi Nistala","raw_affiliation_strings":["Nephrology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084918480","display_name":"Javad Habibi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javad Habibi","raw_affiliation_strings":["Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013737413","display_name":"Alex A. Gutweiler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Gutweiler","raw_affiliation_strings":["Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060448803","display_name":"Jessica Jellison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Jellison","raw_affiliation_strings":["Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002260247","display_name":"Nathan Rehmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Rehmer","raw_affiliation_strings":["Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058451510","display_name":"Melvin Ray Hayden","orcid":"https://orcid.org/0000-0001-5178-4245","observed_orcids":["https://orcid.org/0000-0001-5178-4245"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melvin R Hayden","raw_affiliation_strings":["Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001968810","display_name":"James R. Sowers","orcid":"https://orcid.org/0000-0001-7938-7129","observed_orcids":["https://orcid.org/0000-0001-7938-7129"]},"institutions":[{"id":"https://openalex.org/I4210107726","display_name":"Harry S. Truman Memorial Veterans' Hospital","ror":"https://ror.org/01a4gqp27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210107726","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R Sowers","raw_affiliation_strings":["Harry S Truman VA Medical Center, Columbia, MO","Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harry S Truman VA Medical Center, Columbia, MO","institution_ids":["https://openalex.org/I4210107726"]},{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006212343","display_name":"Adam T. Whaley\u2010Connell","orcid":"https://orcid.org/0000-0001-8955-5560","observed_orcids":["https://orcid.org/0000-0001-8955-5560"]},"institutions":[{"id":"https://openalex.org/I4210107726","display_name":"Harry S. Truman Memorial Veterans' Hospital","ror":"https://ror.org/01a4gqp27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210107726","https://openalex.org/I4210165236"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Whaley\u2010Connell","raw_affiliation_strings":["Harry S Truman VA Medical Center, Columbia, MO","Medicine, University of Missouri-Columbia, Columbia, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harry S Truman VA Medical Center, Columbia, MO","institution_ids":["https://openalex.org/I4210107726"]},{"raw_affiliation_string":"Medicine, University of Missouri-Columbia, Columbia, MO","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02828187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aliskiren","display_name":"aliskiren","score":0.9629999995231628},{"id":"https://openalex.org/keywords/direct-renin-inhibition","display_name":"direct renin inhibition","score":0.9549999833106995},{"id":"https://openalex.org/keywords/renin","display_name":"renin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6119999885559082},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.9419999718666077},{"id":"https://openalex.org/keywords/renal-oxidative-stress","display_name":"renal oxidative stress","score":0.7329999804496765},{"id":"https://openalex.org/keywords/perivascular-fibrosis","display_name":"perivascular fibrosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glut4-translocation","display_name":"GLUT4 translocation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renin-receptor","display_name":"renin receptor","score":0.7540000081062317},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C2779838083","wikidata":"https://www.wikidata.org/wiki/Q414904","display_name":"Aliskiren","level":4,"score":0.9839614629745483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6851388216018677},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6774221062660217},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6727573871612549},{"id":"https://openalex.org/C2777425892","wikidata":"https://www.wikidata.org/wiki/Q409255","display_name":"Renin inhibitor","level":4,"score":0.6162741184234619},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5901613831520081},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.49276235699653625},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4575378894805908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43173861503601074},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.41499006748199463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35716718435287476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.606.13","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.606.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.606.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159120963","https://openalex.org/W3175305947","https://openalex.org/W3169441200","https://openalex.org/W3175337853","https://openalex.org/W2027087508","https://openalex.org/W2139757550","https://openalex.org/W2032937640","https://openalex.org/W2115229349","https://openalex.org/W3177235790","https://openalex.org/W2985912577"],"abstract_inverted_index":{"Renin":[0],"has":[1,60],"gained":[2],"notoriety":[3],"over":[4],"recent":[5],"times":[6],"regarding":[7],"its":[8],"involvement":[9],"and/or":[10],"facilitation":[11],"of":[12,19,21,54,94,188,190],"pro\u2010inflammatory":[13],"processes.":[14],"Investigations":[15],"into":[16],"the":[17,32,39,55,81,88,101,170],"mechanism":[18],"action":[20],"renin":[22,40,57,73,108],"have":[23,65],"revealed":[24],"that":[25,90,114],"this":[26,95],"enzyme":[27],"can":[28,35],"not":[29],"only":[30],"activate":[31],"RAAS":[33,191],"but":[34],"also":[36],"act":[37],"through":[38],"receptor":[41],"directly,":[42],"to":[43,64,99,169],"affect":[44],"kidney":[45,126,183],"function.":[46],"The":[47],"transgenic":[48,139],"Ren2":[49,138,145],"rat":[50],"harbors":[51],"stable":[52],"copies":[53],"mouse":[56,105],"gene":[58],"and":[59,69,83,131,165,192],"been":[61],"well":[62],"characterized":[63],"hypertension,":[66],"endothelial":[67],"dysfunction":[68],"insulin":[70,149,194],"resistance.":[71],"Mouse":[72],"transgene":[74],"is":[75,84,91],"expressed":[76],"at":[77],"high":[78],"levels":[79],"in":[80,137,155,159],"kidneys":[82],"likely":[85,185],"responsible":[86],"for":[87],"pathophysiology":[89],"so":[92],"characteristic":[93],"animal.":[96],"We":[97,112],"sought":[98],"reverse":[100],"pathology":[102],"with":[103,153],"a":[104],"specific":[106],"direct":[107],"inhibitor,":[109],"Aliskiren":[110,115,180],"(50mg/kg).":[111],"observed":[113],"lowered":[116,136],"blood":[117],"pressure":[118],"significantly":[119],"as":[120,151],"expected":[121],"(N=8,":[122],"p<0.05).":[123,142,175],"In":[124],"addition,":[125],"oxidative":[127],"stress,":[128],"perivascular":[129],"fibrosis":[130],"most":[132],"importantly":[133],"albuminuria":[134],"were":[135],"animals":[140],"(N=10,":[141],"Interestingly,":[143],"Aliskiren\u2010treated":[144],"rats":[146],"demonstrated":[147],"improved":[148,166,193],"signaling":[150],"measured":[152],"increase":[154],"total":[156],"IRS\u20101,":[157],"decrease":[158],"phosphorylated":[160],"Akt":[161],"(thr":[162],"308":[163],"),":[164],"GLUT4":[167],"translocation":[168],"plasma":[171],"membrane":[172],"fraction":[173],"(N=5,":[174],"Our":[176],"data":[177],"suggests":[178],"that,":[179],"treatment":[181],"improves":[182],"function":[184],"via":[186],"inhibition":[187],"overactivity":[189],"signaling.":[195]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}