{"id":"https://openalex.org/W286695657","doi":null,"title":"Comparative genetic analysis of VP4, VP1 and 3D gene regions of enterovirus 71 and coxsackievirus A16 circulating in Malaysia between 1997-2008.","display_name":"Comparative genetic analysis of VP4, VP1 and 3D gene regions of enterovirus 71 and coxsackievirus A16 circulating in Malaysia between 1997-2008.","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W286695657","mag":"286695657","pmid":"https://pubmed.ncbi.nlm.nih.gov/23018509"},"language":"en","primary_location":{"id":"pmid:23018509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23018509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical biomedicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018216071","display_name":"Yoke Fun Chan","orcid":"https://orcid.org/0000-0001-7089-0510","observed_orcids":["https://orcid.org/0000-0001-7089-0510"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]},{"id":"https://openalex.org/I4405268432","display_name":"Tropical Infectious Diseases Research & Education Centre","ror":"https://ror.org/00yaank91","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332","https://openalex.org/I4405268432"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Y F Chan","raw_affiliation_strings":["Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia. chanyf@um.edu.my"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia. chanyf@um.edu.my","institution_ids":["https://openalex.org/I33849332","https://openalex.org/I4405268432"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K L Wee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K L Wee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112024798","display_name":"Chun Wei Chiam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Chiam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019082416","display_name":"Chee\u2010Sieng Khor","orcid":"https://orcid.org/0000-0003-2883-3031","observed_orcids":["https://orcid.org/0000-0003-2883-3031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Khor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108596324","display_name":"S Y Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Y Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050098462","display_name":"M Z Amalina W","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Z Amalina W","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072385852","display_name":"I\u2010Ching Sam","orcid":"https://orcid.org/0000-0002-1296-7898","observed_orcids":["https://orcid.org/0000-0002-1296-7898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I C Sam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0272,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.73964918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"3","first_page":"451","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.40380001068115234,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterovirus-71","display_name":"enterovirus 71","score":0.9070000052452087},{"id":"https://openalex.org/keywords/coxsackievirus-a16","display_name":"coxsackievirus A16","score":1.0},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.671999990940094},{"id":"https://openalex.org/keywords/recombination","display_name":"recombination","score":0.8450000286102295},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.9409999847412109},{"id":"https://openalex.org/keywords/malaysia","display_name":"Malaysia","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9113261103630066},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7165003418922424},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.6924147605895996},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.6549707651138306},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5710147619247437},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5372185111045837},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.5117530822753906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4865761995315552},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.45606529712677},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4526866674423218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4369845390319824},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.43671658635139465},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4334193170070648},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.4300522208213806},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.40012887120246887},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.23826676607131958},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.07208764553070068},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004769","descriptor_name":"Enterovirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004769","descriptor_name":"Enterovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006232","descriptor_name":"Hand, Foot and Mouth Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006232","descriptor_name":"Hand, Foot and Mouth Disease","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008296","descriptor_name":"Malaysia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017720","descriptor_name":"Molecular Epidemiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029821","descriptor_name":"Enterovirus A, Human","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D029821","descriptor_name":"Enterovirus A, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029821","descriptor_name":"Enterovirus A, Human","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23018509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23018509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tropical biomedicine","raw_type":"Comparative Study"},{"id":"mag:286695657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23018509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W103217991","https://openalex.org/W175053650","https://openalex.org/W1843140515","https://openalex.org/W1964111270","https://openalex.org/W2020313443","https://openalex.org/W2024062560","https://openalex.org/W2042361543","https://openalex.org/W2062876847","https://openalex.org/W2083559305","https://openalex.org/W2088394825","https://openalex.org/W2100008113","https://openalex.org/W2122755078","https://openalex.org/W2123753779","https://openalex.org/W2128955222","https://openalex.org/W2130710544","https://openalex.org/W2132632499","https://openalex.org/W2137015675","https://openalex.org/W2140028978","https://openalex.org/W2140526135","https://openalex.org/W2146067302","https://openalex.org/W2153710955","https://openalex.org/W2157586119","https://openalex.org/W2157634796","https://openalex.org/W2158239139","https://openalex.org/W2169001784","https://openalex.org/W2189337529"],"related_works":["https://openalex.org/W2164927397","https://openalex.org/W2371845284","https://openalex.org/W2140526135","https://openalex.org/W4377138031","https://openalex.org/W1843140515","https://openalex.org/W2910401540","https://openalex.org/W2128955222","https://openalex.org/W2113315077","https://openalex.org/W3199253984","https://openalex.org/W2088394825"],"abstract_inverted_index":{"Three":[0],"genomic":[1,171],"regions,":[2],"VP4":[3],"capsid,":[4],"VP1":[5],"capsid":[6],"and":[7,16,36,59,73,91],"3D":[8,141],"RNA":[9,142],"polymerase":[10,143],"of":[11,26,33,48,66,129,148],"human":[12],"enterovirus":[13],"71":[14],"(EV-71)":[15],"coxsackievirus":[17],"A16":[18],"(CV-A16)":[19],"were":[20,43,61],"sequenced":[21],"to":[22,114,182],"understand":[23],"the":[24,46,82,92,100,127,140,158,169],"evolution":[25],"these":[27],"viruses":[28],"in":[29,63,106,125,139,150,157,168,186],"Malaysia.":[30,64],"A":[31],"total":[32],"42":[34],"EV-71":[35,50,133,160,174],"36":[37],"CV-A16":[38,163],"isolates":[39,135],"from":[40,75],"1997-":[41],"2008":[42],"sequenced.":[44,173],"Despite":[45],"presence":[47],"many":[49],"subgenotypes":[51,54,68,89],"worldwide,":[52],"only":[53,104],"B3,":[55],"B4,":[56],"B5,":[57],"C1":[58],"C2":[60],"present":[62,98],"Importation":[65],"other":[67,76],"such":[69],"as":[70],"C3,":[71],"C4/D":[72],"C5":[74],"countries":[77],"was":[78,86,97,155],"infrequent.":[79],"For":[80],"CV-A16,":[81],"earlier":[83],"subgenotype":[84],"B1":[85],"replaced":[87],"by":[88],"B2a":[90,96],"recent":[93],"B2c.":[94],"Subgenotype":[95],"throughout":[99],"study":[101],"while":[102],"B2c":[103],"emerged":[105],"2005.":[107],"No":[108],"genetic":[109,153,166],"signatures":[110],"could":[111],"be":[112],"attributed":[113],"viral":[115],"virulence":[116],"suggesting":[117],"that":[118,180],"host":[119],"factors":[120],"have":[121],"a":[122,183],"major":[123],"role":[124],"determining":[126],"outcome":[128],"infection.":[130],"Only":[131],"three":[132,170],"B3":[134],"showed":[136,164,175],"non-consistent":[137],"phylogeny":[138],"region":[144],"which":[145],"indicated":[146],"occurrence":[147],"recombination":[149],"EV-71.":[151],"High":[152],"diversity":[154,167],"observed":[156],"Malaysian":[159,162],"but":[161,179],"low":[165],"regions":[172],"strong":[176],"purifying":[177],"selection,":[178],"occurred":[181],"lesser":[184],"extent":[185],"CV-A16.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}