{"id":"https://openalex.org/W286601083","doi":null,"title":"Long-term cardiovascular effects of insulin sensitizer troglitazone on non-diabetic individuals with insulin resistance: double blind, prospective randomized study.","display_name":"Long-term cardiovascular effects of insulin sensitizer troglitazone on non-diabetic individuals with insulin resistance: double blind, prospective randomized study.","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W286601083","mag":"286601083","pmid":"https://pubmed.ncbi.nlm.nih.gov/12728539"},"language":"en","primary_location":{"id":"pmid:12728539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12728539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064014354","display_name":"Dimitrios Stakos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitrios A Stakos","raw_affiliation_strings":["Division of Cardiology, Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113772222","display_name":"Dara P. Schuster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dara P Schuster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109293962","display_name":"Elizabeth A. Sparks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A Sparks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113965754","display_name":"Charles F. Wooley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles F Wooley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106458693","display_name":"Kwame Osei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwame Osei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005862923","display_name":"Harisios K Boudoulas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harisios Boudoulas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7955,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73204277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"41","issue":"4","first_page":"183","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.4984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.4984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/troglitazone","display_name":"troglitazone","score":1.0},{"id":"https://openalex.org/keywords/insulin-sensitizers","display_name":"insulin sensitizers","score":0.8299999833106995},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.7110000252723694},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/aortic-stiffness","display_name":"aortic stiffness","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aortic-distensibility","display_name":"aortic distensibility","score":0.800000011920929},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.7639999985694885},{"id":"https://openalex.org/keywords/non-diabetic-individuals","display_name":"non-diabetic individuals","score":0.6639999747276306},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.3959999978542328},{"id":"https://openalex.org/keywords/brachial-blood-pressure","display_name":"brachial blood pressure","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2778150266","wikidata":"https://www.wikidata.org/wiki/Q7844989","display_name":"Troglitazone","level":4,"score":0.9078137874603271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8878701329231262},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7396146059036255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7028356790542603},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.6779816150665283},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5858332514762878},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.523322582244873},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4988059997558594},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4597054421901703},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4530954957008362},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44822388887405396},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.4402598738670349},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.07041963934898376},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077288","descriptor_name":"Troglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002839","descriptor_name":"Chromans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12728539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12728539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiology","raw_type":"Clinical Trial"},{"id":"mag:286601083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12728539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G2167661238","display_name":"ANTIDIABETIC DRUG INTERVENTION","funder_award_id":"R01DK048127","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8743965113","display_name":"General Clinical Research Center","funder_award_id":"M01RR000034","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1995934832","https://openalex.org/W2030973204","https://openalex.org/W2051625732","https://openalex.org/W2076709794","https://openalex.org/W2084038315","https://openalex.org/W2093576540","https://openalex.org/W2096073058","https://openalex.org/W2096237016","https://openalex.org/W2116404316","https://openalex.org/W2117129814","https://openalex.org/W2121083878","https://openalex.org/W2125914602","https://openalex.org/W2127283734","https://openalex.org/W2132631931","https://openalex.org/W2140603676","https://openalex.org/W2161924597","https://openalex.org/W2163007960","https://openalex.org/W2164634968","https://openalex.org/W2293035635","https://openalex.org/W2318002721","https://openalex.org/W2323262681","https://openalex.org/W2330505590","https://openalex.org/W2334309509","https://openalex.org/W2335922553","https://openalex.org/W2340586419","https://openalex.org/W2411117037","https://openalex.org/W2598089744"],"related_works":["https://openalex.org/W2090512679","https://openalex.org/W2117129814","https://openalex.org/W2079429899","https://openalex.org/W2410493839","https://openalex.org/W2130494432","https://openalex.org/W2054908811","https://openalex.org/W2025598065","https://openalex.org/W194371762","https://openalex.org/W2351007114","https://openalex.org/W2040855107"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,144],"study":[2],"was":[3,227],"undertaken":[4],"to":[5,54,79,105,155,221,259],"assess":[6],"the":[7,43,151,165,195,210,214,233,237,247],"long-term":[8,44],"cardiovascular":[9,34,45,250],"effects":[10,46],"of":[11,47,60,64,213,219,236,249],"troglitazone":[12,27,81,152,166,220,242],"on":[13,50],"non-diabetic":[14,37,51,222,253],"individuals":[15,38,52,254],"with":[16,26,39,69,206,224,229,241,255],"insulin":[17,40,74,225,256],"resistance.":[18,41],"BACKGROUND:":[19],"It":[20],"has":[21,258],"been":[22],"suggested":[23],"that":[24],"treatment":[25],"or":[28,87,243],"similar":[29,244],"insulin-sensitizing":[30],"agents":[31,49,245],"may":[32],"prevent":[33],"complications":[35,251],"in":[36,150,164,194,200,209,232,252],"However,":[42],"these":[48],"remain":[53],"be":[55,260],"defined.":[56],"METHODS:":[57],"A":[58],"total":[59],"137":[61],"African-American":[62],"offspring":[63],"type":[65],"2":[66],"diabetic":[67],"parents,":[68],"normal":[70],"glucose":[71],"tolerance":[72],"and":[73,112,116,123,125,133],"resistance,":[75],"were":[76,128,168],"randomly":[77],"divided":[78],"receive":[80],"200":[82],"mg/day":[83],"(n":[84,89],"=":[85,90,172,179],"40),":[86],"placebo":[88,156,196],"97)":[91],"for":[92,246],"24":[93,134,141,178],"months.":[94],"Brachial":[95],"artery":[96],"blood":[97,121],"pressure":[98],"(sphygmomanometry);":[99],"aortic":[100,118],"pulse":[101,145,189,201],"wave":[102,146,190,202],"velocity":[103,147,191,203],"(carotid":[104],"femoral":[106],"artery,":[107],"Doppler),":[108],"left":[109],"ventricular":[110],"diameters":[111],"mass":[113],"(echocardiography);":[114],"ascending":[115],"abdominal":[117],"distensibility":[119],"(echocardiography,":[120],"pressure);":[122],"metabolic":[124],"lipid":[126],"profile":[127],"assessed":[129],"at":[130],"baseline,":[131],"12,":[132,139],"months":[135],"after":[136],"randomization":[137],"(delta":[138,170],"delta":[140,177],"respectively).":[142],"RESULTS:":[143],"increased":[148],"significantly":[149],"group":[153,157,167],"compared":[154],"(p":[158],"<":[159,186],"0.05).":[160],"Changes":[161],"from":[162],"baseline":[163],"significant":[169],"12":[171],"1.09":[173],"+/-":[174,181],"0.36":[175],"m/sec,":[176,183],"2.08":[180],"0.45":[182],"ANOVA":[184],"p":[185],"0.001),":[187],"while":[188],"remained":[192],"unchanged":[193],"group.":[197],"This":[198],"increase":[199],"is":[204],"consistent":[205],"a":[207,230],"decrease":[208,231],"elastic":[211,234],"properties":[212,235],"aorta.":[215,238],"CONCLUSIONS:":[216],"Long-term":[217,239],"administration":[218],"African-Americans":[223],"resistance":[226,257],"associated":[228],"therapy":[240],"prevention":[248],"critically":[261],"evaluated.":[262]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
