{"id":"https://openalex.org/W2862962587","doi":"https://doi.org/10.1055/s-0038-1641928","title":"Insulin glargin 300 E/ml (Gla-300) zeigte eine verbesserte glyk\u00e4mische Kontrolle sowie ein niedrigeres Hypoglyk\u00e4mierisiko bei Typ-2-Diabetespatienten mit Reduktion der bisherigen oralen Antidiabetestherapie (OAD)","display_name":"Insulin glargin 300 E/ml (Gla-300) zeigte eine verbesserte glyk\u00e4mische Kontrolle sowie ein niedrigeres Hypoglyk\u00e4mierisiko bei Typ-2-Diabetespatienten mit Reduktion der bisherigen oralen Antidiabetestherapie (OAD)","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2862962587","doi":"https://doi.org/10.1055/s-0038-1641928","mag":"2862962587"},"language":"de","primary_location":{"id":"doi:10.1055/s-0038-1641928","doi":"https://doi.org/10.1055/s-0038-1641928","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1641928","pdf_url":null,"source":{"id":"https://openalex.org/S26605106","display_name":"Diabetologie und Stoffwechsel","issn_l":"1861-9002","issn":["1861-9002","1861-9010"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologie und Stoffwechsel","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037974997","display_name":"Dailey Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142769","display_name":"Scripps Whittier Diabetes Institute","ror":"https://ror.org/0422q5a32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210142769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GE Dailey","raw_affiliation_strings":["Scripps Whittier Diabetes Institute, San Diego, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Whittier Diabetes Institute, San Diego, CA, United States","institution_ids":["https://openalex.org/I4210142769"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Reid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314179348","display_name":"Mercy Health System","ror":"https://ror.org/008xr7e22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314179348"]},{"id":"https://openalex.org/I4210113060","display_name":"Sisters of Mercy Health System","ror":"https://ror.org/024zq6d87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210113060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Reid","raw_affiliation_strings":["Mercy Diabetes Center, Janesville, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercy Diabetes Center, Janesville, WI, United States","institution_ids":["https://openalex.org/I1314179348","https://openalex.org/I4210113060"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J White","raw_affiliation_strings":["Washington State University School of Pharmacy, Washington, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington State University School of Pharmacy, Washington, WA, United States","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Chao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Chao","raw_affiliation_strings":["Xinyi, Inc., Bridgewater, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinyi, Inc., Bridgewater, NJ, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015773281","display_name":"FL Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FL Zhou","raw_affiliation_strings":["Sanofi US, Inc., Bridgewater, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi US, Inc., Bridgewater, NJ, United States","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113564240","display_name":"Sachin Paranjape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Paranjape","raw_affiliation_strings":["Sanofi US, Inc., Bridgewater, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi US, Inc., Bridgewater, NJ, United States","institution_ids":["https://openalex.org/I4210111804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020648679","display_name":"Paulos Berhanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111804","display_name":"Sanofi (United States)","ror":"https://ror.org/027vj4x92","country_code":"US","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210111804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Berhanu","raw_affiliation_strings":["Sanofi US, Inc., Bridgewater, NJ, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi US, Inc., Bridgewater, NJ, United States","institution_ids":["https://openalex.org/I4210111804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18198874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.12809999287128448,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-insulin-initiation","display_name":"basal insulin initiation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.890999972820282},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.8529999852180481},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hypoglycemia-risk","display_name":"hypoglycemia risk","score":0.9369999766349792},{"id":"https://openalex.org/keywords/insulin-naive-patients","display_name":"insulin-naive patients","score":0.8560000061988831},{"id":"https://openalex.org/keywords/real-world-claims-data","display_name":"real-world claims data","score":0.8799999952316284},{"id":"https://openalex.org/keywords/glycemic-variability","display_name":"glycemic variability","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5527276396751404},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.45168620347976685}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0038-1641928","doi":"https://doi.org/10.1055/s-0038-1641928","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1641928","pdf_url":null,"source":{"id":"https://openalex.org/S26605106","display_name":"Diabetologie und Stoffwechsel","issn_l":"1861-9002","issn":["1861-9002","1861-9010"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologie und Stoffwechsel","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2893365476","https://openalex.org/W2332897570","https://openalex.org/W2341485252","https://openalex.org/W2338910640","https://openalex.org/W2322722073","https://openalex.org/W2336352293","https://openalex.org/W4286310464","https://openalex.org/W1981633674","https://openalex.org/W2341740589","https://openalex.org/W2952953486"],"abstract_inverted_index":{"Hintergrund":[0],"und":[1,38,55,65,251],"Ziele:":[2],"Viele":[3],"Typ-2-Diabetespatienten":[4],"mit":[5,19,101,222,238,252,256],"OAD-Therapie":[6,25],"ben\u00f6tigen":[7],"letztendlich":[8],"eine":[9,21,117,196],"Basalinsulintherapie.":[10],"Diese":[11,230],"Post-hoc-Analyse":[12],"untersuchte,":[13],"ob":[14],"Gla-300":[15,47,129,156,203,226,239],"bei":[16,225],"insulinnaiven":[17],"Patienten":[18,86,100,208],"OAD-Vortherapie":[20],"Reduktion":[22,197],"der":[23,30,62,68,85,153,198,207],"bisherigen":[24],"bewirken":[26],"kann,":[27],"ohne":[28,246],"dass":[29,235],"Einfluss":[31],"auf":[32,44,60],"den":[33],"HbA":[34,120,134],"1c":[35,121,135],"beeintr\u00e4chtigt":[36],"wird":[37],"unter":[39,146,155],"Wahrung":[40],"des":[41,75,133,148],"g\u00fcnstigen":[42],"Effekts":[43],"Hypoglyk\u00e4mien":[45,161,177,254],"von":[46,127,202],"versus":[48,92,109,167,183,214,227],"Insulin":[49],"glargin":[50],"100":[51],"E/ml":[52],"(Gla-100).":[53],"Studiendesign":[54],"Methoden:":[56],"Es":[57],"wurden":[58],"Daten":[59,67,231],"Patientenebene":[61],"randomisiert-kontrollierten":[63],"EDITION-3-Studie":[64],"anonymisierte":[66],"Clinformatics":[69],"Real-World-Claims-Datenbank":[70],"analysiert.":[71],"Ergebnisse:":[72],"Nach":[73],"Initiierung":[74,126,201],"Basalinsulins":[76],"wurde":[77,158],"die":[78,111,237,242,247],"OAD-Einnahme":[79,103,199,243],"in":[80],"EDITION-3":[81],"vielfach":[82],"reduziert":[83],"(49%":[84],"nahmen":[87,209],"2":[88,113,210],"OAD":[89,105,114,211],"zu":[90,106,212],"Beginn":[91,213],"8%":[93],"nach":[94,125,200,216],"6":[95,123,217],"Monaten":[96,218],"[N":[97,219],"=":[98,172,188,220],"875]).":[99],"reduzierter":[102],"(2":[104],"1":[107],"OAD)":[108],"Patienten,":[110],"weiterhin":[112],"nahmen,":[115],"zeigten":[116,193],"vergleichbare":[118],"signifikante":[119],"-Reduktion":[122],"Monate":[124],"entweder":[128],"oder":[130,204],"Gla-100":[131,205],"(\u00c4nderung":[132],"\u00b1":[136,139,143],"SD:":[137],"-1,4":[138,142],"1,05%":[140],"[Gla-300];":[141],"1,21%":[144],"[Gla-100])":[145],"Erhaltung":[147],"relativen":[149],"Schutzes":[150],"vor":[151],"Hypoglyk\u00e4mien,":[152],"zuvor":[154],"gezeigt":[157],"(dokumentierte":[159],"symptomatische":[160,175],"[\u226454":[162,178],"mg/dl]:":[163,179],"15":[164],"[8,5%;":[165],"Gla-300]":[166,182],"30":[168],"[18,6%;":[169],"Gla-100],":[170,186],"p":[171,187],"0,01;":[173],"dokumentierte":[174],"n\u00e4chtliche":[176],"4":[180],"[2,3%;":[181],"12":[184],"[7,5%;":[185],"0,001).":[189],"In":[190],"\u00dcbereinstimmung":[191],"damit":[192],"Real-World-Daten":[194],"ebenfalls":[195],"(39%":[206],"23%":[215],"6.430]),":[221],"geringerem":[223],"Hypoglyk\u00e4mierisiko":[224],"Gla-100.":[228,257],"Schlussfolgerung:":[229],"deuten":[232],"darauf":[233],"hin,":[234],"Typ-2-Diabetespatienten,":[236],"behandelt":[240],"wurden,":[241],"reduzieren":[244],"k\u00f6nnten":[245],"glyk\u00e4mische":[248],"Kontrolle":[249],"einzub\u00fc\u00dfen":[250],"weniger":[253],"als":[255],"Unterst\u00fctzt":[258],"durch":[259],"Sanofi.":[260]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-07-19T00:00:00"}