{"id":"https://openalex.org/W286185185","doi":null,"title":"Angiopoietins and their role in colon cancer angiogenesis.","display_name":"Angiopoietins and their role in colon cancer angiogenesis.","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W286185185","mag":"286185185","pmid":"https://pubmed.ncbi.nlm.nih.gov/12014866"},"language":"en","primary_location":{"id":"pmid:12014866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12014866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042341684","display_name":"Lee M. Ellis","orcid":"https://orcid.org/0000-0001-8082-4904","observed_orcids":["https://orcid.org/0000-0001-8082-4904"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee M Ellis","raw_affiliation_strings":["Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030-4009, USA. lellis@mdanderson.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030-4009, USA. lellis@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091876744","display_name":"Syed Ameen Ahmad","orcid":"https://orcid.org/0000-0002-6179-5252","observed_orcids":["https://orcid.org/0000-0002-6179-5252","https://orcid.org/0009-0005-5129-3864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Ahmad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Fan Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fan Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038218546","display_name":"Wenbiao Liu","orcid":"https://orcid.org/0000-0001-5271-2307","observed_orcids":["https://orcid.org/0000-0001-5271-2307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenbiao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Young Do Jung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Do Jung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007121961","display_name":"Oliver Stoeltzing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Stoeltzing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072753291","display_name":"Niels Reinmuth","orcid":"https://orcid.org/0000-0002-7369-4512","observed_orcids":["https://orcid.org/0000-0002-7369-4512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niels Reinmuth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013889334","display_name":"Alexander A. Parikh","orcid":"https://orcid.org/0000-0002-2730-2354","observed_orcids":["https://orcid.org/0000-0002-2730-2354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander A Parikh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5736,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.58154918,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"16","issue":"4 Suppl 3","first_page":"31","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":1.0},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/tie2-receptor","display_name":"Tie2 receptor","score":0.9079999923706055},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion","display_name":"endothelial cell adhesion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.9198808670043945},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.6799038648605347},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6235761046409607},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5315014719963074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.519626796245575},{"id":"https://openalex.org/C150710994","wikidata":"https://www.wikidata.org/wiki/Q18034921","display_name":"Vascular endothelial growth inhibitor","level":5,"score":0.48431769013404846},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.46351373195648193},{"id":"https://openalex.org/C85219853","wikidata":"https://www.wikidata.org/wiki/Q4763284","display_name":"Angiopoietin receptor","level":3,"score":0.46152418851852417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45905056595802307},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.4484090507030487},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.43183642625808716},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4281785488128662},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.4162357747554779},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37113505601882935},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3626962900161743},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1274852454662323},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1049204170703888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05203518271446228},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042683","descriptor_name":"Angiopoietin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042787","descriptor_name":"Receptor, TIE-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12014866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12014866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},{"id":"mag:286185185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12014866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W72110172","https://openalex.org/W75144673","https://openalex.org/W1970123993","https://openalex.org/W1978139448","https://openalex.org/W1985850927","https://openalex.org/W1986558615","https://openalex.org/W1990112424","https://openalex.org/W2000000541","https://openalex.org/W2003788548","https://openalex.org/W2066888615","https://openalex.org/W2068499444","https://openalex.org/W2081245927","https://openalex.org/W2151967532","https://openalex.org/W2161700314","https://openalex.org/W2167839699"],"related_works":["https://openalex.org/W2170201138","https://openalex.org/W2090645990","https://openalex.org/W3028817118","https://openalex.org/W4242450809","https://openalex.org/W1531163264","https://openalex.org/W2063535670","https://openalex.org/W2137596113","https://openalex.org/W2046001207","https://openalex.org/W4231199990","https://openalex.org/W2990762565"],"abstract_inverted_index":{"Tumor":[0],"angiogenesis":[1,29],"is":[2,7,77],"a":[3,15,113,144],"complicated":[4],"process":[5,22],"that":[6,36,120],"regulated":[8],"by":[9,142],"numerous":[10],"factors":[11,19],"simultaneously":[12],"and":[13,47,98],"in":[14,68,74,104],"coordinated":[16],"fashion.":[17],"Angiogenic":[18],"drive":[20],"the":[21,26,87],"of":[23,28,32],"neovascularization,":[24],"but":[25],"initiation":[27],"involves":[30],"priming":[31,106],"endothelial":[33,50,57,64,95,107,124,129],"cells":[34,108,130],"so":[35],"they":[37],"will":[38],"respond":[39],"to":[40,55,63,70,80,83,86,94,122,139],"mitogenic":[41,110],"stimuli.":[42,134],"The":[43],"angiopoietins":[44],"(Ang)":[45],"-1":[46],"-2":[48],"mediate":[49],"cell":[51,65,96,125],"stability":[52],"through":[53],"binding":[54],"their":[56],"cell-specific":[58],"receptor,":[59],"Tie-2.":[60],"Ang-1":[61],"leads":[62,93,121],"stability,":[66,126],"and,":[67],"vivo,":[69],"an":[71,101,149],"actual":[72],"decrease":[73],"angiogenesis.":[75],"This":[76,135],"likely":[78],"due":[79],"its":[81],"ability":[82],"enhance":[84],"adhesion":[85],"perivascular":[88],"tissues.":[89],"In":[90],"contrast,":[91],"Ang-2":[92],"instability":[97],"may":[99,117,136],"be":[100,118],"initiating":[102],"factor":[103],"angiogenesis,":[105],"for":[109],"signals.":[111],"Thus,":[112],"novel":[114],"antiangiogenic":[115],"strategy":[116],"one":[119],"enhanced":[123],"thereby":[127],"protecting":[128],"from":[131],"standard":[132],"angiogenic":[133],"ultimately":[137],"lead":[138],"tumor":[140,147],"dormancy":[141],"transforming":[143],"rapidly":[145],"growing":[146],"into":[148],"indolent":[150],"tumor.":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}