{"id":"https://openalex.org/W286136541","doi":null,"title":"Abstract 1411: Suppression of Insulin Signaling Attenuates Cardiac Aging in Mice","display_name":"Abstract 1411: Suppression of Insulin Signaling Attenuates Cardiac Aging in Mice","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W286136541","mag":"286136541"},"language":"en","primary_location":{"id":"mag:286136541","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/content/116/Suppl_16/II_290.2.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011381775","display_name":"Yasutaka Inuzuka","orcid":"https://orcid.org/0000-0002-2069-7963","observed_orcids":["https://orcid.org/0000-0002-2069-7963"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutaka Inuzuka","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":"https://orcid.org/0000-0002-2069-7963","affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113606841","display_name":"Tetsuo Shioi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Shioi","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042023852","display_name":"Takao Kato","orcid":"https://orcid.org/0000-0001-8213-7999","observed_orcids":["https://orcid.org/0000-0001-8213-7999"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Kato","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":"https://orcid.org/0000-0001-8213-7999","affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011534342","display_name":"Yodo Tamaki","orcid":"https://orcid.org/0000-0003-0217-6598","observed_orcids":["https://orcid.org/0000-0003-0217-6598"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yodo Tamaki","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":"https://orcid.org/0000-0003-0217-6598","affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041783254","display_name":"Tsuneaki Kawashima","orcid":"https://orcid.org/0009-0005-3531-4848","observed_orcids":["https://orcid.org/0009-0005-3531-4848"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneaki Kawashima","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053036137","display_name":"Yoshitaka Iwanaga","orcid":"https://orcid.org/0000-0002-1391-2864","observed_orcids":["https://orcid.org/0000-0002-1391-2864"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Iwanaga","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":"https://orcid.org/0000-0002-1391-2864","affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109115866","display_name":"Toru Kita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Kita","raw_affiliation_strings":["Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034422539","display_name":"Yuki Yoshida","orcid":"https://orcid.org/0000-0003-4706-1954","observed_orcids":["https://orcid.org/0000-0003-4706-1954"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Yoshida","raw_affiliation_strings":["Kitasato Univ Sch of Medicine, Sagamihara, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4706-1954","affiliations":[{"raw_affiliation_string":"Kitasato Univ Sch of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054140813","display_name":"Rie Kosugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rie Kosugi","raw_affiliation_strings":["Kitasato Univ Sch of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Univ Sch of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072409012","display_name":"Kayo Watanabe-Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kayo Watanabe-Maeda","raw_affiliation_strings":["Kitasato Univ Sch of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Univ Sch of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108440701","display_name":"Yoji Machida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoji Machida","raw_affiliation_strings":["Kitasato Univ Sch of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Univ Sch of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100826204","display_name":"Tohru Izumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Izumi","raw_affiliation_strings":["Kitasato Univ Sch of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kitasato Univ Sch of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7124000191688538,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.925000011920929},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.8159999847412109},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6610000133514404},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.703000009059906},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.6230000257492065},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7574495673179626},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7305116653442383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7289350628852844},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6087759733200073},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6081834435462952},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.559015691280365},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5376483201980591},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4894377291202545},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4312421679496765},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.41957664489746094},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4058529734611511},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4042462706565857},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.32687443494796753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20849508047103882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19006529450416565},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.18114644289016724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:286136541","doi":null,"is_oa":false,"landing_page_url":"http://circ.ahajournals.org/content/116/Suppl_16/II_290.2.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2027977549","https://openalex.org/W4289222504","https://openalex.org/W1998854730","https://openalex.org/W7100123424","https://openalex.org/W1972552757","https://openalex.org/W2145936440","https://openalex.org/W1981171493","https://openalex.org/W2105927334","https://openalex.org/W4282939243","https://openalex.org/W3175835761"],"abstract_inverted_index":{"Aging":[0],"is":[1,67,238],"a":[2,63,68,242],"major":[3,69],"risk":[4],"factor":[5],"for":[6],"heart":[7,76,99],"failure.":[8],"Suppression":[9],"of":[10,18,26,72,113,153,158,222,255],"the":[11,16,24,30,155,235,247,253],"insulin":[12,27,236,256],"signaling":[13,28,237,257],"pathway":[14],"increases":[15,185],"lifespan":[17],"model":[19],"organisms.":[20],"We":[21,34,74],"tested":[22],"whether":[23],"alteration":[25],"modifies":[29],"cardiac":[31,79,263],"aging":[32,248],"process.":[33],"analyzed":[35,75],"young":[36,52,126,170,217],"(12":[37],"week":[38,45],"old)":[39,46],"and":[40,51,53,98,107,129,173,189,252],"aged":[41,54,87,95,105,108,117,135,163,179,212,230],"(64":[42],"\u2013":[43],"80":[44],"wild":[47],"type":[48],"(WT)":[49],"mice,":[50,97,128,172],"transgenic":[55],"mice":[56,89,119,137,165,214],"that":[57,93,124,168,245],"expressed":[58],"dominant-negative":[59],"phosphoinositide-3-kinase":[60],"(dnPI3K)":[61],"in":[62,86,94,116,125,134,139,162,169,178,186,195,211,229,250,262],"heart-specific":[64],"manner.":[65],"PI3K":[66],"downstream":[70],"effector":[71],"insulin.":[73],"function":[77],"using":[78,201],"catheterization":[80],"under":[81],"dobutamine":[82],"infusion.":[83],"Max":[84],"dp/dt":[85],"dnPI3K":[88,109,136,180,196,231],"was":[90,101,120,132,160,176,209,226],"higher":[91],"than":[92,123],"WT":[96,106,118,127,164,171,213,218],"rate":[100],"not":[102],"different":[103],"between":[104],"mice.":[110,181,197,219,232],"The":[111,151,182,220],"extent":[112],"myocardial":[114],"fibrosis":[115],"significantly":[121,227],"greater":[122],"this":[130,174],"increase":[131,175],"attenuated":[133,177,194,258],"(area":[138],"%;":[140],"0.06":[141],"\u00b10.01":[142],"vs.":[143,146],"1.57":[144],"\u00b10.23":[145],"0.56":[147],"\u00b10.13,":[148],"mean":[149],"\u00b1SEM).":[150],"amount":[152],"p16,":[154],"representative":[156],"marker":[157],"aging,":[159],"increased":[161],"compared":[166,215],"to":[167,216,240],"age":[183],"associated":[184],"proinflammatory":[187],"cytokines":[188],"oxidative":[190],"stress":[191],"markers":[192],"were":[193],"Gene":[198],"expression":[199,208,221],"profiling":[200],"microarray":[202],"analyses":[203],"identified":[204],"157":[205],"genes":[206,225],"whose":[207],"decreased":[210],"these":[223],"down-regulated":[224],"preserved":[228],"In":[233],"conclusion,":[234],"likely":[239],"be":[241],"conserved":[243],"mechanism":[244],"regulates":[246],"process":[249],"mammals,":[251],"suppression":[254],"an":[259],"age-associated":[260],"decline":[261],"function.":[264]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2016-06-24T00:00:00"}
