{"id":"https://openalex.org/W28613617","doi":null,"title":"[Jentadueto, fixed combination of linagliptin plus metformin for the treatment of type 2 diabetes].","display_name":"[Jentadueto, fixed combination of linagliptin plus metformin for the treatment of type 2 diabetes].","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W28613617","mag":"28613617","pmid":"https://pubmed.ncbi.nlm.nih.gov/24180204"},"language":"fr","primary_location":{"id":"pmid:24180204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24180204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue medicale de Liege","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/handle/2268/161158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039563874","display_name":"Andr\u00e9 Jacques Scheen","orcid":"https://orcid.org/0000-0001-9743-4371","observed_orcids":["https://orcid.org/0000-0001-9743-4371"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"A J Scheen","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge, Service de Diab\u00e9tologie, Nutrition et Maladies metaboliques et Unit\u00e9 de Pharmacologie clinique, CHU de Li\u00e8ge"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge, Service de Diab\u00e9tologie, Nutrition et Maladies metaboliques et Unit\u00e9 de Pharmacologie clinique, CHU de Li\u00e8ge","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I4210134544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111609726","display_name":"Luc F. Van Gaal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L F Van Gaal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00327179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":"9","first_page":"479","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linagliptin","display_name":"linagliptin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.9169999957084656},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8180000185966492},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7720000147819519},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6169999837875366},{"id":"https://openalex.org/keywords/metformin-contraindication","display_name":"metformin contraindication","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2780031085","wikidata":"https://www.wikidata.org/wiki/Q909745","display_name":"Linagliptin","level":4,"score":0.9899219274520874},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.977236270904541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7906539440155029},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7196265459060669},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6002695560455322},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5232576131820679},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48163241147994995},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.44256168603897095},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4407981038093567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3895331621170044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31695741415023804},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069476","descriptor_name":"Linagliptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:24180204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24180204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revue medicale de Liege","raw_type":"English Abstract"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/161158","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/161158","pdf_url":"https://orbi.uliege.be/handle/2268/161158","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revue M\u00e9dicale de Li\u00e8ge, 68 (9), 479-85 (2013)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:2267669086","doi":null,"is_oa":false,"landing_page_url":"http://orbi.ulg.ac.be/handle/2268/161158","pdf_url":null,"source":{"id":"https://openalex.org/S2752738199","display_name":"RMLG. Revue m\u00e9dicale de Li\u00e8ge","issn_l":"0370-629X","issn":["0370-629X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4322632779","host_organization_name":"Faculte de medecine de l'Universite de Liege","host_organization_lineage":["https://openalex.org/P4322632779"],"host_organization_lineage_names":["Faculte de medecine de l'Universite de Liege"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"RMLG. Revue m\u00e9dicale de Li\u00e8ge","raw_type":null},{"id":"mag:28613617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24180204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/161158","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/161158","pdf_url":"https://orbi.uliege.be/handle/2268/161158","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revue M\u00e9dicale de Li\u00e8ge, 68 (9), 479-85 (2013)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W28613617.pdf","grobid_xml":"https://content.openalex.org/works/W28613617.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W1981713709","https://openalex.org/W2012340714"],"related_works":["https://openalex.org/W4246517324","https://openalex.org/W2108883607","https://openalex.org/W2067396601","https://openalex.org/W2492208984","https://openalex.org/W1443857991","https://openalex.org/W2323998396","https://openalex.org/W2097893376","https://openalex.org/W4406307266","https://openalex.org/W2087932518","https://openalex.org/W2406504737"],"abstract_inverted_index":{"In":[0],"case":[1],"of":[2,4,16,24,27,43,52,60,77,93,96,113,157,189,201],"failure":[3],"metformin":[5,64,164],"monotherapy,":[6,72],"several":[7,122],"pharmacological":[8],"strategies":[9],"may":[10,117,180],"be":[11,173,181],"considered":[12],"for":[13],"the":[14,22,28,50,94,146,184,187,199],"treatment":[15],"type":[17,82],"2":[18,83],"diabetes.":[19],"Among":[20],"these,":[21],"addition":[23],"an":[25],"inhibitor":[26,140],"dipeptidyl":[29],"peptidase-4":[30],"(DPP-4)":[31],"enzyme,":[32],"a":[33,61,104,109,137],"medication":[34],"commonly":[35],"named":[36],"as":[37],"gliptin,":[38],"is":[39,103,132,152],"increasingly":[40],"used":[41],"because":[42,92],"two":[44,155],"main":[45],"advantages":[46],"over":[47],"sulfonylureas,":[48],"i.e.":[49,159],"absence":[51],"both":[53],"hypoglycaemia":[54],"and":[55,63,144,165,171],"weight":[56],"gain.":[57],"The":[58,111,128],"combination":[59],"gliptin":[62],"further":[65],"improves":[66],"glycaemic":[67],"control":[68],"compared":[69],"to":[70,74],"either":[71],"due":[73],"complementary":[75],"mechanisms":[76],"action.":[78],"Most":[79],"patients":[80],"with":[81,89,154,177],"diabetes":[84],"are":[85,125],"treated":[86],"every":[87],"day":[88],"numerous":[90],"drugs":[91],"presence":[95,200],"comorbidities":[97],"so":[98],"that":[99],"poor":[100],"drug":[101],"compliance":[102,119],"major":[105],"concern":[106],"in":[107],"such":[108],"population.":[110],"use":[112,188],"fixed-dose":[114],"combinations":[115],"(FDCs)":[116],"improve":[118],"and,":[120],"therefore,":[121],"gliptin-metformin":[123],"FDCs":[124],"now":[126],"available.":[127],"most":[129],"recent":[130],"one":[131],"Jentadueto,":[133],"which":[134],"combines":[135],"linagliptin,":[136],"selective":[138],"DPP-4":[139],"without":[141],"renal":[142,185],"excretion,":[143],"metformin,":[145,158,170],"first-line":[147],"antidiabetic":[148],"compound.":[149],"This":[150],"FDC":[151,190],"commercialized":[153],"dosages":[156],"2.5":[160,166],"mg":[161,163,167,169],"linagliptin/850":[162],"linagliptin/1.000":[168],"should":[172,191],"administered":[174],"twice":[175],"daily":[176],"meal.While":[178],"linagliptin":[179],"prescribed":[182],"whatever":[183],"function,":[186],"take":[192],"into":[193],"account":[194],"classical":[195],"restrictions":[196],"imposed":[197],"by":[198],"metformin.":[202]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}