{"id":"https://openalex.org/W2857092597","doi":"https://doi.org/10.1155/2018/8234906","title":"High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells","display_name":"High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells","publication_year":2018,"publication_date":"2018-07-08","ids":{"openalex":"https://openalex.org/W2857092597","doi":"https://doi.org/10.1155/2018/8234906","mag":"2857092597","pmid":"https://pubmed.ncbi.nlm.nih.gov/30116634","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079449"},"language":"en","primary_location":{"id":"doi:10.1155/2018/8234906","doi":"https://doi.org/10.1155/2018/8234906","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/8234906","pdf_url":"http://downloads.hindawi.com/journals/joph/2018/8234906.pdf","source":{"id":"https://openalex.org/S198080574","display_name":"Journal of Ophthalmology","issn_l":"2090-004X","issn":["2090-004X","2090-0058"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://downloads.hindawi.com/journals/joph/2018/8234906.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000302114","display_name":"Jiajun Lu","orcid":"https://orcid.org/0000-0002-9918-8343","observed_orcids":["https://orcid.org/0000-0002-9918-8343"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajun Lu","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102428431","display_name":"Minjie Sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjie Sheng","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108201630","display_name":"Panpan Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Yao","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066576856","display_name":"Chaochao Ran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaochao Ran","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379172","display_name":"Li Chen","orcid":"https://orcid.org/0000-0001-7670-8062","observed_orcids":["https://orcid.org/0000-0001-7670-8062","https://orcid.org/0000-0001-9621-9231"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Chen","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448555","display_name":"Rui Liu","orcid":"https://orcid.org/0000-0002-8534-2071","observed_orcids":["https://orcid.org/0000-0002-8534-2071"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Liu","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100678868","display_name":"Bing Li","orcid":"https://orcid.org/0000-0002-8680-3319","observed_orcids":["https://orcid.org/0000-0002-8680-3319"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210166402","display_name":"Yangpu Hospital of Tongji University","ror":"https://ror.org/05cqn9380","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166402"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bing Li","raw_affiliation_strings":["Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China"],"raw_orcid":"https://orcid.org/0000-0002-8680-3319","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100678868"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210166402"],"apc_list":{"value":3040,"currency":"USD","value_usd":3040},"apc_paid":{"value":3040,"currency":"USD","value_usd":3040},"fwci":0.5834,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.55478824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2018","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.8769999742507935},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9599999785423279},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8399999737739563},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.972000002861023},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7200000286102295},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8982038497924805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8015325665473938},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6972708106040955},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6604437828063965},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6016392707824707},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.47725221514701843},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.45423051714897156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20639687776565552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07547840476036072},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2018/8234906","doi":"https://doi.org/10.1155/2018/8234906","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/8234906","pdf_url":"http://downloads.hindawi.com/journals/joph/2018/8234906.pdf","source":{"id":"https://openalex.org/S198080574","display_name":"Journal of Ophthalmology","issn_l":"2090-004X","issn":["2090-004X","2090-0058"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5039759","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6079449","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30116634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30116634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6079449","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6079449/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7519c62dbb9b4a00ba6a374ffbd5f856","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7519c62dbb9b4a00ba6a374ffbd5f856","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Ophthalmology, Vol 2018 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2018/8234906","doi":"https://doi.org/10.1155/2018/8234906","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/8234906","pdf_url":"http://downloads.hindawi.com/journals/joph/2018/8234906.pdf","source":{"id":"https://openalex.org/S198080574","display_name":"Journal of Ophthalmology","issn_l":"2090-004X","issn":["2090-004X","2090-0058"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2257868408","display_name":null,"funder_award_id":"81400373","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2857092597.pdf","grobid_xml":"https://content.openalex.org/works/W2857092597.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1968271902","https://openalex.org/W1987115582","https://openalex.org/W1993597268","https://openalex.org/W1996968267","https://openalex.org/W2001610514","https://openalex.org/W2001703253","https://openalex.org/W2006198113","https://openalex.org/W2015227787","https://openalex.org/W2032146310","https://openalex.org/W2040105447","https://openalex.org/W2049270721","https://openalex.org/W2060893621","https://openalex.org/W2063616319","https://openalex.org/W2074511932","https://openalex.org/W2078593792","https://openalex.org/W2084753468","https://openalex.org/W2088940641","https://openalex.org/W2090489112","https://openalex.org/W2102221077","https://openalex.org/W2111600026","https://openalex.org/W2118773140","https://openalex.org/W2125591289","https://openalex.org/W2132249975","https://openalex.org/W2141952686","https://openalex.org/W2153935171","https://openalex.org/W2163070021","https://openalex.org/W2317534840","https://openalex.org/W2731349674"],"related_works":["https://openalex.org/W2997791918","https://openalex.org/W7096876721","https://openalex.org/W2151943707","https://openalex.org/W2035295230","https://openalex.org/W2371770690","https://openalex.org/W2406297434","https://openalex.org/W2385183376","https://openalex.org/W2006728188","https://openalex.org/W4407796289","https://openalex.org/W4299740705"],"abstract_inverted_index":{"Objective.":[0],"To":[1],"investigate":[2],"the":[3,25,29,57,81,97,102,112,120,125,131,162,165,174,182,192,200,210,216,220,228,231,237,259,264,267,279,289,292,302,319,350,363,366],"effect":[4],"of":[5,8,32,50,59,68,104,128,137,154,164,195,213,219,223,234,241,248,263,270,282,295,315,321,353,365],"high":[6,132,152,193,221,232,268,293,307,351],"concentration":[7,123,133,153,194,202,212,222,233,269,281,294,314,352],"glucose":[9,51,122,138,155,196,214,224,235,271,283,296,308,316,354],"on":[10,111],"reactive":[11,340],"oxygen":[12,109,341],"species":[13],"(ROS)":[14],"production":[15,58,148],"in":[16,130,191,230,266,274,278,291,331,349],"rabbit":[17],"corneal":[18],"epithelial":[19],"cells":[20,229,243,265,290],"(RECEs)":[21],"and":[22,37,55,73,80,167,181,184,328,333],"explore":[23],"whether":[24],"increased":[26,142,169,273],"ROS":[27,60,129,147,322],"initiates":[28],"apoptosis":[30,99,261,304],"process":[31],"RECEs":[33,44,332],"through":[34],"oxidative":[35,326],"stress":[36,41,327,330],"endoplasmic":[38],"reticulum":[39],"(ER)":[40],"pathway.":[42],"Methods.":[43],"were":[45,75,115],"treated":[46],"by":[47,63,77,86,151],"different":[48],"concentrations":[49],"for":[52,362],"a":[53,346],"while,":[54],"then":[56],"was":[61,84,93,140,149,244],"detected":[62],"flow":[64,254],"cytometry.":[65],"The":[66,253,339],"expressions":[67,163,186],"PERK,":[69],"p-PERK,":[70],"Akt,":[71],"p-Akt,":[72],"CHOP":[74,168],"determined":[76],"western":[78],"blot,":[79],"cell":[82,217,238,303,337],"viability":[83],"measured":[85],"Cell":[87],"Counting":[88],"Kit-8":[89],"(CCK-8).":[90],"Flow":[91],"cytometry":[92,255],"used":[94],"to":[95,199,325,336],"detect":[96],"early":[98,260],"rate.":[100],"Meanwhile,":[101],"effects":[103],"N-acetyl-L-cysteine":[105],"(NAC),":[106],"an":[107],"active":[108],"inhibitor,":[110,342],"experimental":[113],"results":[114,205,256,357],"observed.":[116],"Results.":[117],"Compared":[118],"with":[119,209,276,298],"normal":[121,201,211,280],"group,":[124,215,236],"fluorescence":[126],"intensity":[127],"(1":[134],"mM":[135],"glucose)":[136],"group":[139,197,225,272,284,297],"significantly":[141,170,190],"(":[143,156,171,178,250,285,309],"P<0.05":[144,157,172,179,251,286,310],").":[145,252,287,311],"NAC-inhibited":[146],"induced":[150],").Western":[158],"blot":[159],"demonstrated":[160],"that":[161,207,247,258,277],"p-PERK":[166],"),":[173,180],"p-Akt":[175],"expression":[176],"decreased":[177],"PERK":[183],"Akt":[185],"did":[187],"not":[188],"change":[189],"compared":[198,208],"group.":[203],"CCK-8":[204],"revealed":[206],"activity":[218],"decreased.":[226],"For":[227],"survival":[239],"rate":[240,262],"NAC-treated":[242],"higher":[245],"than":[246],"untreated":[249],"indicated":[257],"contrast":[275],"Treating":[288],"NAC":[299],"could":[300],"reduce":[301],"resulted":[305],"from":[306],"Conclusions.":[312],"High":[313],"may":[317],"induce":[318],"formation":[320],"which":[323],"leads":[324,335],"ER":[329],"even":[334],"apoptosis.":[338],"NAC,":[343],"can":[344],"play":[345],"protective":[347],"character":[348],"environment.":[355],"These":[356],"might":[358],"provide":[359],"theoretical":[360],"basis":[361],"study":[364],"diabetes-related":[367],"dry":[368],"eye.":[369]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-07-19T00:00:00"}
