{"id":"https://openalex.org/W2851289650","doi":"https://doi.org/10.1371/journal.pcbi.1006335","title":"Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection","display_name":"Modelling how responsiveness to interferon improves interferon-free treatment of hepatitis C virus infection","publication_year":2018,"publication_date":"2018-07-12","ids":{"openalex":"https://openalex.org/W2851289650","doi":"https://doi.org/10.1371/journal.pcbi.1006335","mag":"2851289650","pmid":"https://pubmed.ncbi.nlm.nih.gov/30001324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6057683"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006335","doi":"https://doi.org/10.1371/journal.pcbi.1006335","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006335","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006335&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006335&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034461451","display_name":"Vishnu Venugopal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishnu Venugopal","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064694971","display_name":"Pranesh Padmanabhan","orcid":"https://orcid.org/0000-0001-5569-8731","observed_orcids":["https://orcid.org/0000-0001-5569-8731"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pranesh Padmanabhan","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039150326","display_name":"Rubesh Raja","orcid":"https://orcid.org/0000-0002-3204-0061","observed_orcids":["https://orcid.org/0000-0002-3204-0061"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rubesh Raja","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009087944","display_name":"Narendra M. Dixit","orcid":"https://orcid.org/0000-0002-2145-9828","observed_orcids":["https://orcid.org/0000-0002-2145-9828"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narendra M. Dixit","raw_affiliation_strings":["Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India","Department of Chemical Engineering, Indian Institute of Science, Bangalore, India"],"raw_orcid":"https://orcid.org/0000-0002-2145-9828","affiliations":[{"raw_affiliation_string":"Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bangalore, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009087944"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.9182,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74113045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"7","first_page":"e1006335","last_page":"e1006335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interferon-responsiveness","display_name":"interferon responsiveness","score":0.7910000085830688},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7580000162124634},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.9210000038146973},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/viral-dynamics","display_name":"viral dynamics","score":0.7910000085830688},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.6800000071525574},{"id":"https://openalex.org/keywords/multiscale-mathematical-model","display_name":"multiscale mathematical model","score":0.8119999766349792},{"id":"https://openalex.org/keywords/spontaneous-viral-clearance","display_name":"spontaneous viral clearance","score":0.6759999990463257},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8199999928474426},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.4740000069141388},{"id":"https://openalex.org/keywords/response-guided-therapy","display_name":"response-guided therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6930273771286011},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6008595824241638},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5683227181434631},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.553486168384552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5494914054870605},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5197655558586121},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.519273042678833},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.46852347254753113},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45264744758605957},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.45180004835128784},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.44650745391845703},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4175242781639099},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3947654664516449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2509937882423401},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006335","doi":"https://doi.org/10.1371/journal.pcbi.1006335","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006335","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006335&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5025614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6057683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6057683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6057683","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmid:30001324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30001324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.iisc.ac.in:60491","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/60491/1/plo_Com_Bio_14-7_2018.pdf","pdf_url":"http://eprints.iisc.ac.in/60491/1/plo_Com_Bio_14-7_2018.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:779f40c2c40b44dca06f51eb6b4e0be6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/779f40c2c40b44dca06f51eb6b4e0be6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 7, p e1006335 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/6810113","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Modelling_how_responsiveness_to_interferon_improves_interferon-free_treatment_of_hepatitis_C_virus_infection/6810113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006335","doi":"https://doi.org/10.1371/journal.pcbi.1006335","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006335","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006335&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1231717707","display_name":"Computational design of drugs, vaccines and optimal intervention strategies against rapidly evolving pathogens","funder_award_id":"IA/S/14/1/501307","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"},{"id":"https://openalex.org/G3629620881","display_name":null,"funder_award_id":"IA/S/14/1/501307","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5897988762","display_name":null,"funder_award_id":"Senior Fellowship IA/S/14/1/501307","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2851289650.pdf","grobid_xml":"https://content.openalex.org/works/W2851289650.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W955126711","https://openalex.org/W1488236888","https://openalex.org/W1505788137","https://openalex.org/W1826210767","https://openalex.org/W1879700306","https://openalex.org/W1967080996","https://openalex.org/W1973327273","https://openalex.org/W1975553990","https://openalex.org/W1979862324","https://openalex.org/W1981385281","https://openalex.org/W1985982900","https://openalex.org/W1987057202","https://openalex.org/W1987890574","https://openalex.org/W1989062739","https://openalex.org/W1995565071","https://openalex.org/W1995591620","https://openalex.org/W2013863441","https://openalex.org/W2018446644","https://openalex.org/W2022687771","https://openalex.org/W2026381741","https://openalex.org/W2026560201","https://openalex.org/W2035914469","https://openalex.org/W2038163209","https://openalex.org/W2043519223","https://openalex.org/W2049330606","https://openalex.org/W2050963689","https://openalex.org/W2054896384","https://openalex.org/W2055090323","https://openalex.org/W2060441409","https://openalex.org/W2061146727","https://openalex.org/W2062371742","https://openalex.org/W2064309760","https://openalex.org/W2068700454","https://openalex.org/W2078646756","https://openalex.org/W2085202049","https://openalex.org/W2089138082","https://openalex.org/W2095206832","https://openalex.org/W2106378149","https://openalex.org/W2108035402","https://openalex.org/W2129186628","https://openalex.org/W2129736881","https://openalex.org/W2132492420","https://openalex.org/W2141982925","https://openalex.org/W2145234555","https://openalex.org/W2151063300","https://openalex.org/W2152803686","https://openalex.org/W2154129261","https://openalex.org/W2156112450","https://openalex.org/W2158562498","https://openalex.org/W2164211111","https://openalex.org/W2167213467","https://openalex.org/W2168579451","https://openalex.org/W2185218296","https://openalex.org/W2216865272","https://openalex.org/W2261124144","https://openalex.org/W2286811631","https://openalex.org/W2314791685","https://openalex.org/W2340138588","https://openalex.org/W2346961068","https://openalex.org/W2405439543","https://openalex.org/W2413213127","https://openalex.org/W2415630662","https://openalex.org/W2479444737","https://openalex.org/W2496525917","https://openalex.org/W2523085454","https://openalex.org/W2537546890","https://openalex.org/W2557197752","https://openalex.org/W2559922559","https://openalex.org/W2584795971","https://openalex.org/W2593188656","https://openalex.org/W2614854323","https://openalex.org/W2616674837","https://openalex.org/W2624137195","https://openalex.org/W2729180194","https://openalex.org/W2749874612","https://openalex.org/W2777870076","https://openalex.org/W2784040935","https://openalex.org/W2800948940","https://openalex.org/W3147276859","https://openalex.org/W4211243282","https://openalex.org/W4246918801"],"related_works":["https://openalex.org/W2885999569","https://openalex.org/W2904795451","https://openalex.org/W2545496429","https://openalex.org/W2147466801","https://openalex.org/W2175811755","https://openalex.org/W2407216011","https://openalex.org/W1921162995","https://openalex.org/W1983951850","https://openalex.org/W1977507572","https://openalex.org/W2968631112"],"abstract_inverted_index":{"Direct-acting":[0],"antiviral":[1,39,252],"agents":[2,253],"(DAAs)":[3,254],"for":[4,231],"hepatitis":[5,237],"C":[6,238],"treatment":[7,51,69,99,222],"tend":[8,285],"to":[9,18,21,65,91,117,122,157,167,207,278,286,289],"fare":[10],"better":[11,280],"in":[12,119,171,202,281],"individuals":[13,145,214,282],"who":[14,146,283],"are":[15],"also":[16,284],"likely":[17],"respond":[19,156,166,287],"well":[20,288],"interferon-alpha":[22],"(IFN),":[23],"a":[24,37,44,76,172,197,225,228,244],"surprising":[25],"correlation":[26],"given":[27],"that":[28,186,213],"DAAs":[29,66,118,276],"target":[30,261],"specific":[31,262],"viral":[32,54,62,86],"proteins":[33],"whereas":[34],"IFN":[35,123],"triggers":[36],"generic":[38],"immune":[40,267],"response.Here,":[41],"we":[42,74],"posit":[43],"causal":[45,183],"relationship":[46,184],"between":[47],"IFN-responsiveness":[48,81,217],"and":[49,67,88,98,160,178,227],"DAA":[50],"outcome.IFN-responsiveness":[52],"restricts":[53],"replication,":[55],"which":[56],"would":[57,218],"prevent":[58],"the":[59,83,95,102,131,141,182],"growth":[60],"of":[61,143,175,181,188,199,236],"variants":[63],"resistant":[64],"improve":[68],"outcome.To":[70],"test":[71],"this":[72],"hypothesis,":[73],"developed":[75],"multiscale":[77],"mathematical":[78],"model":[79],"integrating":[80],"at":[82,94,101],"cellular":[84],"level,":[85,97],"kinetics":[87],"evolution":[89],"leading":[90],"drug":[92],"resistance":[93],"individual":[96],"outcome":[100],"population":[103,230],"level.Model":[104],"predictions":[105,133],"quantitatively":[106],"captured":[107],"data":[108],"from":[109],"over":[110],"50":[111],"clinical":[112,138],"trials":[113],"demonstrating":[114],"poorer":[115],"response":[116,268],"previous":[120],"non-responders":[121],"than":[124],"treatment-na\u00efve":[125],"individuals,":[126],"presenting":[127,224],"strong":[128],"evidence":[129],"supporting":[130],"hypothesis.Model":[132],"additionally":[134],"described":[135],"several":[136],"unexplained":[137],"observations,":[139],"viz.,":[140],"percentages":[142],"infected":[144,154],"1)":[147],"spontaneously":[148],"clear":[149],"HCV,":[150],"2)":[151],"get":[152],"chronically":[153],"but":[155,165],"IFN-based":[158,163],"therapy,":[159,169],"3)":[161],"fail":[162],"therapy":[164],"DAA-based":[168,189,221],"resulting":[170],"comprehensive":[173],"understanding":[174],"HCV":[176,263],"infection":[177,241],"treatment.An":[179],"implication":[180,211],"is":[185,212,242],"failure":[187],"treatments":[190,257],"may":[191],"be":[192],"averted":[193],"by":[194],"adding":[195],"IFN,":[196],"strategy":[198],"potential":[200],"use":[201],"settings":[203],"with":[204,215,247],"limited":[205],"access":[206],"DAAs.A":[208],"second,":[209],"wider":[210],"greater":[216],"require":[219],"shorter":[220],"durations,":[223],"basis":[226],"promising":[229],"response-guided":[232],"therapy.":[233],"Author":[234],"summaryTreatment":[235],"virus":[239],"(HCV)":[240],"seeing":[243],"paradigm":[245],"shift":[246],"powerful":[248],"drugs":[249],"called":[250],"direct-acting":[251],"replacing":[255],"earlier":[256],"involving":[258],"interferon":[259],"(IFN).DAAs":[260],"proteins.IFN":[264],"stimulates":[265],"our":[266],"against":[269],"HCV.The":[270],"two":[271],"should":[272],"thus":[273],"work":[274,279],"independently.Surprisingly,":[275],"appear":[277],"IFN.We":[290],"hypothesized":[291],"here":[292]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-19T00:00:00"}