{"id":"https://openalex.org/W284306532","doi":null,"title":"General Transcription Factors Play Dual Roles In Initiation And Termination","display_name":"General Transcription Factors Play Dual Roles In Initiation And Termination","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W284306532","mag":"284306532"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2018","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048572637","display_name":"Scott Medler","orcid":"https://orcid.org/0000-0002-7778-0928","observed_orcids":["https://orcid.org/0000-0002-7778-0928"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Scott Medler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7778-0928","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048572637"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-termination","display_name":"transcription termination","score":0.9200000166893005},{"id":"https://openalex.org/keywords/general-transcription-factors","display_name":"general transcription factors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tfiib","display_name":"TFIIB","score":0.996999979019165},{"id":"https://openalex.org/keywords/tfiih","display_name":"TFIIH","score":0.984000027179718},{"id":"https://openalex.org/keywords/ssu72","display_name":"Ssu72","score":0.878000020980835},{"id":"https://openalex.org/keywords/poly-a-polymerase","display_name":"poly(A) polymerase","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5109445452690125},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2018","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},{"id":"mag:284306532","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wayne.edu/cgi/viewcontent.cgi?article=2018&context=oa_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wayne.edu:oa_dissertations-2018","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","pdf_url":"https://digitalcommons.wayne.edu/oa_dissertations/1019","source":{"id":"https://openalex.org/S171990522","display_name":"Human Biology","issn_l":"0018-7143","issn":["0018-7143","1534-6617"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","erih-plus","jufo-1","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316469","host_organization_name":"Wayne State University Press","host_organization_lineage":["https://openalex.org/P4310316469"],"host_organization_lineage_names":["Wayne State University Press"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wayne State University Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W284306532.pdf","grobid_xml":"https://content.openalex.org/works/W284306532.grobid-xml"},"referenced_works_count":304,"referenced_works":["https://openalex.org/W183746846","https://openalex.org/W914334466","https://openalex.org/W1489207129","https://openalex.org/W1494025475","https://openalex.org/W1496884580","https://openalex.org/W1507700987","https://openalex.org/W1509346032","https://openalex.org/W1509357297","https://openalex.org/W1513276314","https://openalex.org/W1522856214","https://openalex.org/W1539101364","https://openalex.org/W1544116588","https://openalex.org/W1555065911","https://openalex.org/W1569390933","https://openalex.org/W1574785618","https://openalex.org/W1579500886","https://openalex.org/W1601315441","https://openalex.org/W1656358829","https://openalex.org/W1821994922","https://openalex.org/W1835943565","https://openalex.org/W1894654019","https://openalex.org/W1911817655","https://openalex.org/W1923175844","https://openalex.org/W1938794721","https://openalex.org/W1963600172","https://openalex.org/W1963604994","https://openalex.org/W1964337986","https://openalex.org/W1965582387","https://openalex.org/W1966695149","https://openalex.org/W1966821177","https://openalex.org/W1967667723","https://openalex.org/W1967969318","https://openalex.org/W1969670694","https://openalex.org/W1970069184","https://openalex.org/W1972137518","https://openalex.org/W1973182477","https://openalex.org/W1973498182","https://openalex.org/W1974481647","https://openalex.org/W1974595249","https://openalex.org/W1974865922","https://openalex.org/W1975948611","https://openalex.org/W1976561164","https://openalex.org/W1977788714","https://openalex.org/W1977894101","https://openalex.org/W1981232162","https://openalex.org/W1981915772","https://openalex.org/W1982003542","https://openalex.org/W1982161126","https://openalex.org/W1982588923","https://openalex.org/W1983164018","https://openalex.org/W1983412356","https://openalex.org/W1983603366","https://openalex.org/W1984583080","https://openalex.org/W1985235553","https://openalex.org/W1986427733","https://openalex.org/W1986853146","https://openalex.org/W1989967763","https://openalex.org/W1991965823","https://openalex.org/W1992223935","https://openalex.org/W1992428272","https://openalex.org/W1993712998","https://openalex.org/W1993786968","https://openalex.org/W1994330689","https://openalex.org/W1994342611","https://openalex.org/W1995733973","https://openalex.org/W1997490792","https://openalex.org/W2001013988","https://openalex.org/W2001406822","https://openalex.org/W2002900988","https://openalex.org/W2003002984","https://openalex.org/W2003676968","https://openalex.org/W2004636267","https://openalex.org/W2004919102","https://openalex.org/W2005054126","https://openalex.org/W2005744558","https://openalex.org/W2006276690","https://openalex.org/W2006277271","https://openalex.org/W2007219863","https://openalex.org/W2007346514","https://openalex.org/W2007782974","https://openalex.org/W2008616402","https://openalex.org/W2008619144","https://openalex.org/W2009444548","https://openalex.org/W2010026543","https://openalex.org/W2012084175","https://openalex.org/W2012120921","https://openalex.org/W2013235095","https://openalex.org/W2013535834","https://openalex.org/W2013930082","https://openalex.org/W2014213102","https://openalex.org/W2015881243","https://openalex.org/W2016786878","https://openalex.org/W2017777009","https://openalex.org/W2018133293","https://openalex.org/W2018494368","https://openalex.org/W2020363034","https://openalex.org/W2020412443","https://openalex.org/W2020774845","https://openalex.org/W2023077619","https://openalex.org/W2024093804","https://openalex.org/W2024095538","https://openalex.org/W2024265832","https://openalex.org/W2024352544","https://openalex.org/W2025571437","https://openalex.org/W2026574531","https://openalex.org/W2026592511","https://openalex.org/W2026715418","https://openalex.org/W2027534342","https://openalex.org/W2028735905","https://openalex.org/W2028898630","https://openalex.org/W2030556411","https://openalex.org/W2031073218","https://openalex.org/W2031847922","https://openalex.org/W2032071916","https://openalex.org/W2032742580","https://openalex.org/W2033244618","https://openalex.org/W2033244846","https://openalex.org/W2033673020","https://openalex.org/W2033997324","https://openalex.org/W2036238731","https://openalex.org/W2037686178","https://openalex.org/W2038543938","https://openalex.org/W2038630278","https://openalex.org/W2040583957","https://openalex.org/W2040922291","https://openalex.org/W2041348045","https://openalex.org/W2042031939","https://openalex.org/W2044085514","https://openalex.org/W2044690677","https://openalex.org/W2045454780","https://openalex.org/W2045474344","https://openalex.org/W2045755743","https://openalex.org/W2046186543","https://openalex.org/W2049017158","https://openalex.org/W2049174301","https://openalex.org/W2049858249","https://openalex.org/W2050721857","https://openalex.org/W2050766639","https://openalex.org/W2050872197","https://openalex.org/W2051231585","https://openalex.org/W2053323016","https://openalex.org/W2054603310","https://openalex.org/W2056273035","https://openalex.org/W2056304859","https://openalex.org/W2056638188","https://openalex.org/W2058122977","https://openalex.org/W2058262378","https://openalex.org/W2058411330","https://openalex.org/W2059297143","https://openalex.org/W2059380466","https://openalex.org/W2059691911","https://openalex.org/W2061040019","https://openalex.org/W2061970520","https://openalex.org/W2062204772","https://openalex.org/W2063296736","https://openalex.org/W2065264095","https://openalex.org/W2065679706","https://openalex.org/W2065943045","https://openalex.org/W2066780692","https://openalex.org/W2067058481","https://openalex.org/W2067953727","https://openalex.org/W2068479879","https://openalex.org/W2070312296","https://openalex.org/W2071340829","https://openalex.org/W2071674961","https://openalex.org/W2071984045","https://openalex.org/W2071984843","https://openalex.org/W2072021660","https://openalex.org/W2073131665","https://openalex.org/W2073350644","https://openalex.org/W2073894791","https://openalex.org/W2074206760","https://openalex.org/W2074252380","https://openalex.org/W2074304165","https://openalex.org/W2077786562","https://openalex.org/W2078036317","https://openalex.org/W2079255995","https://openalex.org/W2080365558","https://openalex.org/W2080914451","https://openalex.org/W2080993511","https://openalex.org/W2081290562","https://openalex.org/W2084145961","https://openalex.org/W2084619201","https://openalex.org/W2084622414","https://openalex.org/W2087732988","https://openalex.org/W2088343433","https://openalex.org/W2088345878","https://openalex.org/W2088389307","https://openalex.org/W2088454058","https://openalex.org/W2089032456","https://openalex.org/W2090687602","https://openalex.org/W2091452413","https://openalex.org/W2091727198","https://openalex.org/W2092558918","https://openalex.org/W2092644213","https://openalex.org/W2093522880","https://openalex.org/W2094184203","https://openalex.org/W2094972443","https://openalex.org/W2095254687","https://openalex.org/W2095771622","https://openalex.org/W2097621806","https://openalex.org/W2099138453","https://openalex.org/W2099872833","https://openalex.org/W2100649212","https://openalex.org/W2101424708","https://openalex.org/W2104099674","https://openalex.org/W2104400758","https://openalex.org/W2104531065","https://openalex.org/W2105721989","https://openalex.org/W2106448802","https://openalex.org/W2106502118","https://openalex.org/W2107042278","https://openalex.org/W2107624922","https://openalex.org/W2108259296","https://openalex.org/W2109054128","https://openalex.org/W2110032982","https://openalex.org/W2111057236","https://openalex.org/W2111578933","https://openalex.org/W2111656172","https://openalex.org/W2114302771","https://openalex.org/W2115659144","https://openalex.org/W2115948084","https://openalex.org/W2116117181","https://openalex.org/W2116287534","https://openalex.org/W2116384789","https://openalex.org/W2116447934","https://openalex.org/W2118306133","https://openalex.org/W2120027714","https://openalex.org/W2120434953","https://openalex.org/W2120478300","https://openalex.org/W2120836430","https://openalex.org/W2121649903","https://openalex.org/W2122000770","https://openalex.org/W2122460472","https://openalex.org/W2123603532","https://openalex.org/W2124458647","https://openalex.org/W2125624608","https://openalex.org/W2126567129","https://openalex.org/W2126742226","https://openalex.org/W2127024810","https://openalex.org/W2127201083","https://openalex.org/W2128987469","https://openalex.org/W2129656350","https://openalex.org/W2131997929","https://openalex.org/W2133102806","https://openalex.org/W2133452708","https://openalex.org/W2133912711","https://openalex.org/W2134555383","https://openalex.org/W2135068917","https://openalex.org/W2135969650","https://openalex.org/W2137314346","https://openalex.org/W2140036659","https://openalex.org/W2141325621","https://openalex.org/W2142379668","https://openalex.org/W2142644202","https://openalex.org/W2142731245","https://openalex.org/W2143462761","https://openalex.org/W2144688273","https://openalex.org/W2145049521","https://openalex.org/W2146866475","https://openalex.org/W2148195122","https://openalex.org/W2148624148","https://openalex.org/W2149168187","https://openalex.org/W2149920358","https://openalex.org/W2150125096","https://openalex.org/W2150639242","https://openalex.org/W2151082116","https://openalex.org/W2151546588","https://openalex.org/W2151763919","https://openalex.org/W2155254243","https://openalex.org/W2156566553","https://openalex.org/W2156736748","https://openalex.org/W2157887747","https://openalex.org/W2158574257","https://openalex.org/W2159274422","https://openalex.org/W2159422462","https://openalex.org/W2160658820","https://openalex.org/W2160720092","https://openalex.org/W2160871692","https://openalex.org/W2162042193","https://openalex.org/W2163537612","https://openalex.org/W2164564454","https://openalex.org/W2165608108","https://openalex.org/W2165652801","https://openalex.org/W2166760304","https://openalex.org/W2166829841","https://openalex.org/W2167125772","https://openalex.org/W2167331352","https://openalex.org/W2167653615","https://openalex.org/W2167659128","https://openalex.org/W2167956098","https://openalex.org/W2168365185","https://openalex.org/W2170698318","https://openalex.org/W2170778160","https://openalex.org/W2171119496","https://openalex.org/W2171171901","https://openalex.org/W2171711481","https://openalex.org/W2174609832","https://openalex.org/W2235281118","https://openalex.org/W2281470818","https://openalex.org/W2328569883","https://openalex.org/W2409667009","https://openalex.org/W2417900220","https://openalex.org/W2654488637"],"related_works":["https://openalex.org/W1983412356","https://openalex.org/W2768638443","https://openalex.org/W1973498182","https://openalex.org/W3211679876","https://openalex.org/W4392190226","https://openalex.org/W4387767206","https://openalex.org/W4311598732","https://openalex.org/W7098887497","https://openalex.org/W4401412546","https://openalex.org/W2126742226"],"abstract_inverted_index":{"Gene":[0],"looping,":[1],"defined":[2],"as":[3,20],"the":[4,7,10,53,66,106,119,133,137,149,181,209,248,255,274,294,301,310,322,326,333,341,350,364],"interaction":[5],"of":[6,13,30,56,62,69,91,109,136,208,216,276,291,298,304,328,335,344],"promoter":[8,31,227],"and":[9,79,102,151,168,180,199,218,337,369],"terminator":[11,120,365],"regions":[12],"a":[14,57,70,89,112,125,158,189,226,235,268,285,307,345],"gene":[15,23,71,346,367],"during":[16,36,122,366],"transcription,":[17],"is":[18,38,72,271,279,347],"emerging":[19],"an":[21,141,371],"important":[22],"regulatory":[24],"mechanism":[25],"in":[26,111,140,157,184,229,234,247,254,264,289,312,325,349,361,374],"eukaryotes.":[27],"The":[28,59,74,205,241],"role":[29,61,286,308,373],"bound":[32,224],"general":[33,75],"transcription":[34,76,113,123,278,375],"factors":[35,49,64,77,221,359],"initiation":[37,48,63,358],"well":[39],"established.":[40],"However,":[41],"recent":[42],"studies":[43],"have":[44,81],"revealed":[45],"that":[46,100,174,215,263,317,357],"some":[47],"also":[50,146],"interact":[51,85],"with":[52,87,132,148,177,238,363],"3'":[54,67,93,153,302,342],"end":[55,68,94,154,303,343],"gene.":[58],"biological":[60],"at":[65,118,300,340],"unknown.":[73],"TFIIB":[78,101,116,129,175,288],"TFIIH":[80,103,145,217,299,351],"been":[82],"found":[83,99,233],"to":[84,105,187,196,202],"genetically":[86],"Ssu72,":[88],"component":[90],"CPF":[92,152,338],"processing":[95,155],"complex.":[96,128,191],"Accordingly,":[97,314],"we":[98,172,315],"localize":[104],"distal":[107],"ends":[108],"genes":[110,305],"dependent":[114,143,296],"manner.":[115,144],"localization":[117],"region":[121],"requires":[124],"functional":[126],"CF1":[127,138,150,182,336],"physically":[130],"interacts":[131,147],"all":[134],"subunits":[135,339],"complex":[139,183,193,211,237,243,270],"activator":[142],"complexes":[156],"manner":[159],"depending":[160],"on":[161,225],"its":[162],"kinase":[163,295,330,352],"activity.":[164,331],"Employing":[165],"affinity":[166],"chromatography":[167],"glycerol":[169],"gradient":[170],"centrifugation,":[171],"show":[173,262,316],"associates":[176],"poly(A)":[178],"polymerase":[179],"yeast":[185],"cells":[186],"form":[188],"holo-TFIIB":[190,210,236,242,269],"This":[192],"was":[194,212,244],"resistant":[195],"MNase":[197],"digestion":[198],"brief":[200],"exposure":[201],"high":[203],"salt.":[204],"sedimentation":[206],"coefficient":[207],"intermediate":[213],"between":[214],"TFIID.":[219],"Initiation":[220],"which":[222],"remain":[223],"scaffold":[228],"vitro,":[230],"were":[231],"not":[232,253,272],"termination":[239,290,323],"factors.":[240],"observed":[245],"only":[246],"looping":[249,256,368],"competent":[250],"strains,":[251],"but":[252],"defective":[257,353],"sua7-1":[258,265],"strain.":[259],"We":[260,355],"further":[261],"cells,":[266],"where":[267],"formed,":[273],"kinetics":[275],"activated":[277],"altered.":[280],"These":[281],"results":[282],"strongly":[283],"suggest":[284],"for":[287,309],"transcription.":[292],"Similarly,":[293],"presence":[297],"suggested":[306],"factor":[311],"termination.":[313,376],"RNAP":[318],"II":[319],"read":[320],"through":[321],"signal":[324],"absence":[327],"Kin28":[329],"Furthermore,":[332],"recruitment":[334],"impaired":[348],"mutant.":[354],"propose":[356],"are":[360],"contact":[362],"play":[370],"active":[372]},"counts_by_year":[],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-06-24T00:00:00"}