{"id":"https://openalex.org/W2826748633","doi":"https://doi.org/10.3389/fphys.2018.00337","title":"Ticagrelor Improves Endothelial Function by Decreasing Circulating Epidermal Growth Factor (EGF)","display_name":"Ticagrelor Improves Endothelial Function by Decreasing Circulating Epidermal Growth Factor (EGF)","publication_year":2018,"publication_date":"2018-04-06","ids":{"openalex":"https://openalex.org/W2826748633","doi":"https://doi.org/10.3389/fphys.2018.00337","mag":"2826748633","pmid":"https://pubmed.ncbi.nlm.nih.gov/29686623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5900783"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2018.00337","doi":"https://doi.org/10.3389/fphys.2018.00337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2018.00337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00337/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00337/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047177904","display_name":"Francesco Vieceli Dalla Sega","orcid":"https://orcid.org/0000-0003-3445-3983","observed_orcids":["https://orcid.org/0000-0003-3445-3983"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]},{"id":"https://openalex.org/I4210100680","display_name":"Maria Cecilia Hospital","ror":"https://ror.org/01wxb8362","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210100680"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Vieceli Dalla Sega","raw_affiliation_strings":["Department of Medical Sciences, University of Ferrara, Ferrara, Italy","Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy","institution_ids":["https://openalex.org/I4210100680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004474802","display_name":"Francesca Fortini","orcid":"https://orcid.org/0000-0003-0807-3792","observed_orcids":["https://orcid.org/0000-0003-0807-3792"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]},{"id":"https://openalex.org/I4210100680","display_name":"Maria Cecilia Hospital","ror":"https://ror.org/01wxb8362","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210100680"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Fortini","raw_affiliation_strings":["Department of Medical Sciences, University of Ferrara, Ferrara, Italy","Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy","institution_ids":["https://openalex.org/I4210100680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050017272","display_name":"Giorgio Aquila","orcid":"https://orcid.org/0000-0002-3936-8895","observed_orcids":["https://orcid.org/0000-0002-3936-8895"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]},{"id":"https://openalex.org/I4210100680","display_name":"Maria Cecilia Hospital","ror":"https://ror.org/01wxb8362","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210100680"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Aquila","raw_affiliation_strings":["Department of Medical Sciences, University of Ferrara, Ferrara, Italy","Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy","institution_ids":["https://openalex.org/I4210100680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030325105","display_name":"Rita Pavasini","orcid":"https://orcid.org/0000-0002-1763-9711","observed_orcids":["https://orcid.org/0000-0002-1763-9711"]},"institutions":[{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita Pavasini","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038121881","display_name":"Simone Biscaglia","orcid":"https://orcid.org/0000-0001-6074-2370","observed_orcids":["https://orcid.org/0000-0001-6074-2370"]},"institutions":[{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Biscaglia","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108819115","display_name":"Davide Bernucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Bernucci","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018374677","display_name":"Annamaria Del Franco","orcid":"https://orcid.org/0000-0003-1405-9436","observed_orcids":["https://orcid.org/0000-0003-1405-9436"]},"institutions":[{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annamaria Del Franco","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040177700","display_name":"Elisabetta Tonet","orcid":"https://orcid.org/0000-0003-0257-1272","observed_orcids":["https://orcid.org/0000-0003-0257-1272"]},"institutions":[{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Tonet","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003974616","display_name":"Paola Rizzo","orcid":"https://orcid.org/0000-0001-7174-9674","observed_orcids":["https://orcid.org/0000-0001-7174-9674"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Rizzo","raw_affiliation_strings":["Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Laboratory for Technologies of Advanced Therapies, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727528","display_name":"Roberto Ferrari","orcid":"https://orcid.org/0000-0003-2046-9175","observed_orcids":["https://orcid.org/0000-0003-2046-9175"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]},{"id":"https://openalex.org/I4210100680","display_name":"Maria Cecilia Hospital","ror":"https://ror.org/01wxb8362","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210100680"]},{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Ferrari","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]},{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]},{"raw_affiliation_string":"Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy","institution_ids":["https://openalex.org/I4210100680"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075033637","display_name":"Gianluca Calogero Campo","orcid":"https://orcid.org/0000-0002-5150-188X","observed_orcids":["https://orcid.org/0000-0002-5150-188X"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]},{"id":"https://openalex.org/I4210126260","display_name":"Arcispedale Sant'Anna","ror":"https://ror.org/026yzxh70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210126260"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianluca Campo","raw_affiliation_strings":["Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy","institution_ids":["https://openalex.org/I4210126260"]},{"raw_affiliation_string":"Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy","institution_ids":["https://openalex.org/I201324441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075033637"],"corresponding_institution_ids":["https://openalex.org/I201324441","https://openalex.org/I4210126260"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.6482,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.9092573,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"337","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ticagrelor","display_name":"ticagrelor","score":1.0},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9929999709129333},{"id":"https://openalex.org/keywords/p2y12-inhibitors","display_name":"P2Y12 inhibitors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.875},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9559999704360962},{"id":"https://openalex.org/keywords/platelet-reactivity","display_name":"platelet reactivity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/enos-activation","display_name":"eNOS activation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2780890252","wikidata":"https://www.wikidata.org/wiki/Q420542","display_name":"Ticagrelor","level":4,"score":0.8699749708175659},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.8605173230171204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6878892779350281},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5833340883255005},{"id":"https://openalex.org/C49059817","wikidata":"https://www.wikidata.org/wiki/Q14916330","display_name":"P2Y12","level":4,"score":0.5268731713294983},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5189354419708252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5066660046577454},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.5050848126411438},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.43553197383880615},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4339723289012909},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37483853101730347},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3589778244495392},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3413839340209961},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.1735016107559204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16597256064414978},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14269056916236877},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.13166505098342896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13139048218727112},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.06125876307487488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fphys.2018.00337","doi":"https://doi.org/10.3389/fphys.2018.00337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2018.00337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00337/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4836900","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5900783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5900783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5900783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:29686623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29686623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2d6e48e690c84e028278f5da620c9a80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2d6e48e690c84e028278f5da620c9a80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 9 (2018)","raw_type":"article"},{"id":"pmh:oai:sfera.unife.it:11392/2390487","doi":null,"is_oa":true,"landing_page_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00337/full","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2018.00337","doi":"https://doi.org/10.3389/fphys.2018.00337","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2018.00337","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00337/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2826748633.pdf","grobid_xml":"https://content.openalex.org/works/W2826748633.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W36192329","https://openalex.org/W179729331","https://openalex.org/W614494813","https://openalex.org/W1596261235","https://openalex.org/W1961374519","https://openalex.org/W1963690717","https://openalex.org/W1966135833","https://openalex.org/W1992786080","https://openalex.org/W1993565704","https://openalex.org/W1996289114","https://openalex.org/W2019849215","https://openalex.org/W2023793692","https://openalex.org/W2030078522","https://openalex.org/W2031122447","https://openalex.org/W2035601759","https://openalex.org/W2038922683","https://openalex.org/W2050340471","https://openalex.org/W2051645126","https://openalex.org/W2055592575","https://openalex.org/W2068078905","https://openalex.org/W2069786094","https://openalex.org/W2098118614","https://openalex.org/W2136433300","https://openalex.org/W2158795842","https://openalex.org/W2160267184","https://openalex.org/W2259865807","https://openalex.org/W2271240637","https://openalex.org/W2282450682","https://openalex.org/W2553347576","https://openalex.org/W2601011645","https://openalex.org/W2611883203","https://openalex.org/W2751669791","https://openalex.org/W2783046021","https://openalex.org/W2790781247"],"related_works":["https://openalex.org/W4292970210","https://openalex.org/W3037324036","https://openalex.org/W2601011645","https://openalex.org/W2803544712","https://openalex.org/W2597396786","https://openalex.org/W4224244400","https://openalex.org/W3036305517","https://openalex.org/W2869051460","https://openalex.org/W2791690421","https://openalex.org/W6902825297"],"abstract_inverted_index":{"Ticagrelor":[0],"is":[1,41,75,123],"one":[2,65],"of":[3,46,78,82,94,112,126,199],"the":[4,47,54,61,79,113,131,152,197,202],"most":[5],"powerful":[6],"P2Y12":[7],"inhibitor.":[8],"We":[9],"have":[10],"recently":[11],"reported":[12],"that,":[13,59],"in":[14,60,91,102,133,151,163,165,175,196,201],"patients":[15,114],"with":[16,35,43,68,72,97,110,116,120],"concomitant":[17],"Stable":[18],"Coronary":[19],"Artery":[20],"Disease":[21,27],"(SCAD)":[22],"and":[23,87,135,147,158],"Chronic":[24],"Obstructive":[25],"Pulmonary":[26],"(COPD)":[28],"undergoing":[29],"percutaneous":[30],"coronary":[31],"intervention":[32],"(PCI),":[33],"treatment":[34,67],"ticagrelor,":[36,69,117],"as":[37],"compared":[38],"to":[39],"clopidogrel,":[40,73],"associated":[42],"an":[44,124,142],"improvement":[45],"endothelial":[48,106,188],"function":[49,189],"(Clinical":[50],"Trial":[51],"NCT02519608).":[52],"In":[53],"present":[55],"study,":[56],"we":[57,140,168],"showed":[58,169],"same":[62],"population,":[63],"after":[64,138],"month":[66],"but":[70,118],"not":[71,119],"there":[74,122],"a":[76,176],"decrease":[77],"circulating":[80,92,192],"levels":[81,93,137],"epidermal":[83],"growth":[84],"factor":[85],"(EGF":[86],"that":[88,170,185,194],"these":[89],"changes":[90,132,149],"EGF":[95,134,148,157,171,193],"correlate":[96],"on-treatment":[98],"platelet":[99],"reactivity.":[100],"Furthermore,":[101],"human":[103],"umbilical":[104],"vein":[105],"cells":[107],"(HUVEC)":[108],"incubated":[109],"sera":[111],"treated":[115],"clopidogrel":[121],"increase":[125],"p-eNOS":[127,136,146],"levels.":[128],"Finally,":[129],"analyzing":[130],"treatment,":[139],"observed":[141],"inverse":[143],"correlation":[144],"between":[145,156],"only":[150],"ticagrelor":[153,186],"group.":[154],"Causality":[155],"eNOS":[159,173,200],"activation":[160,198],"was":[161],"assessed":[162],"vitro":[164],"HUVEC":[166],"where":[167],"decreases":[172],"activity":[174],"dose":[177],"dependent":[178],"manner.":[179],"Taken":[180],"together":[181],"our":[182],"data":[183],"indicate":[184],"improves":[187],"by":[190],"lowering":[191],"results":[195],"vascular":[203],"endothelium.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-07-19T00:00:00"}
