{"id":"https://openalex.org/W28264501","doi":null,"title":"Inhibition of liver and bone marrow derived dendritic cell maturation and function by Interleukin-6 activation of Signal Transducer and Activator of Transcription-3","display_name":"Inhibition of liver and bone marrow derived dendritic cell maturation and function by Interleukin-6 activation of Signal Transducer and Activator of Transcription-3","publication_year":2007,"publication_date":"2007-12-07","ids":{"openalex":"https://openalex.org/W28264501","mag":"28264501"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9482","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9482/1/Lunz10_16_2007.pdf","pdf_url":"https://d-scholarship.pitt.edu/9482/1/Lunz10_16_2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030014458","display_name":"Lunz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lunz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"John E. George","orcid":"https://orcid.org/0000-0003-3216-9823","observed_orcids":["https://orcid.org/0000-0003-3216-9823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John E. George","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3216-9823","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00315642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.09139999747276306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.902999997138977},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9679999947547913},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/liver-dendritic-cells","display_name":"liver dendritic cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.7369999885559082},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gut-commensal-bacteria","display_name":"gut commensal bacteria","score":0.8510000109672546},{"id":"https://openalex.org/keywords/innate-immune-tolerance","display_name":"innate immune tolerance","score":0.5830000042915344},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.3779999911785126},{"id":"https://openalex.org/keywords/il-6-deficient-mice","display_name":"IL-6-deficient mice","score":0.6069999933242798},{"id":"https://openalex.org/keywords/stat3-inhibition","display_name":"STAT3 inhibition","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.7150728106498718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5867582559585571},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5527672171592712},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5079107880592346},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5001182556152344},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.46422526240348816},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44832199811935425},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43992921710014343},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43742144107818604},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.43308937549591064},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.42248812317848206},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.4222719669342041},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.41520124673843384},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32692813873291016},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26160603761672974},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1356753408908844},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.11939859390258789},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9482","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9482/1/Lunz10_16_2007.pdf","pdf_url":"https://d-scholarship.pitt.edu/9482/1/Lunz10_16_2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:28264501","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9482/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":331,"referenced_works":["https://openalex.org/W11321320","https://openalex.org/W14741340","https://openalex.org/W60070512","https://openalex.org/W69440101","https://openalex.org/W109291748","https://openalex.org/W157721590","https://openalex.org/W159439519","https://openalex.org/W163630733","https://openalex.org/W167148815","https://openalex.org/W167571371","https://openalex.org/W239481043","https://openalex.org/W248089139","https://openalex.org/W301350266","https://openalex.org/W347895934","https://openalex.org/W1491342045","https://openalex.org/W1496109170","https://openalex.org/W1497797754","https://openalex.org/W1498929362","https://openalex.org/W1499740591","https://openalex.org/W1503899313","https://openalex.org/W1514412416","https://openalex.org/W1515725948","https://openalex.org/W1516719898","https://openalex.org/W1539584528","https://openalex.org/W1541585193","https://openalex.org/W1562592996","https://openalex.org/W1577284202","https://openalex.org/W1578157386","https://openalex.org/W1583209620","https://openalex.org/W1585321597","https://openalex.org/W1594523905","https://openalex.org/W1633418194","https://openalex.org/W1661544713","https://openalex.org/W1668039320","https://openalex.org/W1743711678","https://openalex.org/W1761831931","https://openalex.org/W1825344511","https://openalex.org/W1838497045","https://openalex.org/W1851677105","https://openalex.org/W1857552597","https://openalex.org/W1892344960","https://openalex.org/W1898195399","https://openalex.org/W1906591077","https://openalex.org/W1928772928","https://openalex.org/W1939561089","https://openalex.org/W1945216762","https://openalex.org/W1960538598","https://openalex.org/W1960585934","https://openalex.org/W1965847911","https://openalex.org/W1966259152","https://openalex.org/W1968141301","https://openalex.org/W1968587886","https://openalex.org/W1969893909","https://openalex.org/W1971309107","https://openalex.org/W1972264376","https://openalex.org/W1972346208","https://openalex.org/W1972809211","https://openalex.org/W1972932855","https://openalex.org/W1973890327","https://openalex.org/W1975463463","https://openalex.org/W1975762173","https://openalex.org/W1975773833","https://openalex.org/W1976320059","https://openalex.org/W1977812921","https://openalex.org/W1978530585","https://openalex.org/W1980123888","https://openalex.org/W1980138671","https://openalex.org/W1980794669","https://openalex.org/W1981817625","https://openalex.org/W1981969796","https://openalex.org/W1982875532","https://openalex.org/W1983357853","https://openalex.org/W1983985556","https://openalex.org/W1984748165","https://openalex.org/W1987110376","https://openalex.org/W1987116953","https://openalex.org/W1987150557","https://openalex.org/W1988662791","https://openalex.org/W1989944445","https://openalex.org/W1990069486","https://openalex.org/W1990236675","https://openalex.org/W1991130140","https://openalex.org/W1992439632","https://openalex.org/W1993520606","https://openalex.org/W1993544422","https://openalex.org/W1994016440","https://openalex.org/W1994262539","https://openalex.org/W1995744610","https://openalex.org/W1995997868","https://openalex.org/W1997047331","https://openalex.org/W1997708871","https://openalex.org/W1998435868","https://openalex.org/W1998525935","https://openalex.org/W1998755899","https://openalex.org/W1998769740","https://openalex.org/W1999023229","https://openalex.org/W2000768335","https://openalex.org/W2001281185","https://openalex.org/W2001740313","https://openalex.org/W2002076761","https://openalex.org/W2004465286","https://openalex.org/W2004650098","https://openalex.org/W2006182190","https://openalex.org/W2006772331","https://openalex.org/W2007000374","https://openalex.org/W2007022287","https://openalex.org/W2007304845","https://openalex.org/W2007710827","https://openalex.org/W2008267385","https://openalex.org/W2008399822","https://openalex.org/W2008596165","https://openalex.org/W2009008191","https://openalex.org/W2009067699","https://openalex.org/W2009225001","https://openalex.org/W2011573876","https://openalex.org/W2014035331","https://openalex.org/W2014732115","https://openalex.org/W2014820340","https://openalex.org/W2014965697","https://openalex.org/W2015085911","https://openalex.org/W2015141049","https://openalex.org/W2015199158","https://openalex.org/W2016147511","https://openalex.org/W2016478391","https://openalex.org/W2016498524","https://openalex.org/W2016550600","https://openalex.org/W2018207594","https://openalex.org/W2018434369","https://openalex.org/W2019050142","https://openalex.org/W2019965911","https://openalex.org/W2020649104","https://openalex.org/W2023545075","https://openalex.org/W2024282024","https://openalex.org/W2025173334","https://openalex.org/W2025203327","https://openalex.org/W2026578487","https://openalex.org/W2028207476","https://openalex.org/W2028958732","https://openalex.org/W2029206179","https://openalex.org/W2030624761","https://openalex.org/W2031451107","https://openalex.org/W2032221109","https://openalex.org/W2032634323","https://openalex.org/W2033220681","https://openalex.org/W2034498308","https://openalex.org/W2035505806","https://openalex.org/W2036112796","https://openalex.org/W2036452124","https://openalex.org/W2037090825","https://openalex.org/W2037128355","https://openalex.org/W2037555606","https://openalex.org/W2038106655","https://openalex.org/W2040605376","https://openalex.org/W2040807303","https://openalex.org/W2041713168","https://openalex.org/W2042005033","https://openalex.org/W2042218061","https://openalex.org/W2042411369","https://openalex.org/W2043765645","https://openalex.org/W2044212200","https://openalex.org/W2044269184","https://openalex.org/W2045263076","https://openalex.org/W2045956714","https://openalex.org/W2046491426","https://openalex.org/W2047297118","https://openalex.org/W2047376937","https://openalex.org/W2047971908","https://openalex.org/W2048073154","https://openalex.org/W2048143404","https://openalex.org/W2049025940","https://openalex.org/W2050624944","https://openalex.org/W2052151802","https://openalex.org/W2052241455","https://openalex.org/W2052798287","https://openalex.org/W2052988201","https://openalex.org/W2053560045","https://openalex.org/W2054117091","https://openalex.org/W2054538838","https://openalex.org/W2056110767","https://openalex.org/W2056461632","https://openalex.org/W2057087204","https://openalex.org/W2058228117","https://openalex.org/W2058554371","https://openalex.org/W2058584950","https://openalex.org/W2059207468","https://openalex.org/W2060373504","https://openalex.org/W2062632117","https://openalex.org/W2063214912","https://openalex.org/W2063219998","https://openalex.org/W2063407488","https://openalex.org/W2064662152","https://openalex.org/W2065086280","https://openalex.org/W2065479473","https://openalex.org/W2066336766","https://openalex.org/W2067597016","https://openalex.org/W2067761476","https://openalex.org/W2068349733","https://openalex.org/W2069668308","https://openalex.org/W2070500465","https://openalex.org/W2073716326","https://openalex.org/W2074991167","https://openalex.org/W2075816687","https://openalex.org/W2076182160","https://openalex.org/W2076610281","https://openalex.org/W2077931779","https://openalex.org/W2078296217","https://openalex.org/W2078450673","https://openalex.org/W2078610347","https://openalex.org/W2081936911","https://openalex.org/W2082573533","https://openalex.org/W2082615180","https://openalex.org/W2082644007","https://openalex.org/W2082892689","https://openalex.org/W2083672604","https://openalex.org/W2085279940","https://openalex.org/W2085366465","https://openalex.org/W2086038987","https://openalex.org/W2086387065","https://openalex.org/W2086840459","https://openalex.org/W2087013294","https://openalex.org/W2087143957","https://openalex.org/W2087195110","https://openalex.org/W2087967325","https://openalex.org/W2088763689","https://openalex.org/W2089004438","https://openalex.org/W2089327657","https://openalex.org/W2089467722","https://openalex.org/W2090425412","https://openalex.org/W2090640877","https://openalex.org/W2092151512","https://openalex.org/W2093534424","https://openalex.org/W2095672355","https://openalex.org/W2096147746","https://openalex.org/W2096745640","https://openalex.org/W2097750522","https://openalex.org/W2098100304","https://openalex.org/W2098708829","https://openalex.org/W2100117872","https://openalex.org/W2100475731","https://openalex.org/W2101492664","https://openalex.org/W2101596544","https://openalex.org/W2102689053","https://openalex.org/W2104414795","https://openalex.org/W2104428586","https://openalex.org/W2105700807","https://openalex.org/W2106153959","https://openalex.org/W2106219094","https://openalex.org/W2108311157","https://openalex.org/W2108707397","https://openalex.org/W2109133986","https://openalex.org/W2110365405","https://openalex.org/W2111034338","https://openalex.org/W2111220263","https://openalex.org/W2112916314","https://openalex.org/W2115421342","https://openalex.org/W2115914792","https://openalex.org/W2119596771","https://openalex.org/W2121266814","https://openalex.org/W2121730308","https://openalex.org/W2123538811","https://openalex.org/W2125543544","https://openalex.org/W2126755143","https://openalex.org/W2127036601","https://openalex.org/W2127466319","https://openalex.org/W2127642399","https://openalex.org/W2128305305","https://openalex.org/W2128822995","https://openalex.org/W2128846699","https://openalex.org/W2131678280","https://openalex.org/W2131761283","https://openalex.org/W2132286068","https://openalex.org/W2132929600","https://openalex.org/W2134180983","https://openalex.org/W2134653497","https://openalex.org/W2135322609","https://openalex.org/W2135712089","https://openalex.org/W2137590150","https://openalex.org/W2139250003","https://openalex.org/W2141137217","https://openalex.org/W2141575322","https://openalex.org/W2142196461","https://openalex.org/W2142356948","https://openalex.org/W2144032514","https://openalex.org/W2145110660","https://openalex.org/W2145736817","https://openalex.org/W2147474072","https://openalex.org/W2147911026","https://openalex.org/W2148178789","https://openalex.org/W2148222156","https://openalex.org/W2149057253","https://openalex.org/W2149597372","https://openalex.org/W2150594596","https://openalex.org/W2151296838","https://openalex.org/W2152172202","https://openalex.org/W2152506648","https://openalex.org/W2152765064","https://openalex.org/W2153050742","https://openalex.org/W2154874607","https://openalex.org/W2155779547","https://openalex.org/W2156150500","https://openalex.org/W2156831625","https://openalex.org/W2157069655","https://openalex.org/W2159451122","https://openalex.org/W2159768658","https://openalex.org/W2161354474","https://openalex.org/W2161792071","https://openalex.org/W2164967233","https://openalex.org/W2165466482","https://openalex.org/W2166630199","https://openalex.org/W2166676682","https://openalex.org/W2167366928","https://openalex.org/W2167937185","https://openalex.org/W2168478794","https://openalex.org/W2168822788","https://openalex.org/W2170293184","https://openalex.org/W2170832326","https://openalex.org/W2227451033","https://openalex.org/W2286249299","https://openalex.org/W2319443468","https://openalex.org/W2332941313","https://openalex.org/W2336048928","https://openalex.org/W2396116692","https://openalex.org/W2411309565","https://openalex.org/W2416470840","https://openalex.org/W2418485954","https://openalex.org/W2419660941","https://openalex.org/W2421374971","https://openalex.org/W2422059616","https://openalex.org/W2474438279","https://openalex.org/W4255515401","https://openalex.org/W4313377040"],"related_works":["https://openalex.org/W2008399822","https://openalex.org/W2152765064","https://openalex.org/W2514442211","https://openalex.org/W2390989137","https://openalex.org/W2049043684","https://openalex.org/W2138278652","https://openalex.org/W2124671153","https://openalex.org/W2081959434","https://openalex.org/W1999239244","https://openalex.org/W2075628450"],"abstract_inverted_index":{"Dendritic":[0],"cells(DC)":[1],"are":[2,126,213],"professional":[3],"antigen":[4],"presenting":[5],"cells":[6],"bridging":[7],"the":[8,51,80,91,275,311],"innate":[9,101,320],"and":[10,27,60,85,96,117,128,150,200,289],"adaptive":[11,323],"immune":[12,102,324,341],"systems":[13],"by":[14,143,298],"detecting":[15],"pathogen-":[16],"and-":[17],"damage":[18],"associated":[19],"molecular":[20],"pattern(PAMP,":[21],"DAMP)":[22],"molecules.":[23,277],"This":[24],"triggers":[25,318],"maturation":[26,167,223,245,268],"migration":[28],"to":[29,42,58,161,163,169,261,271,316,338],"regional":[30],"lymph":[31],"nodes":[32],"where":[33],"they":[34],"stimulate":[35,70],"T":[36],"lymphocytes.":[37],"In":[38,75],"tissues":[39],"normally":[40],"exposed":[41],"relatively":[43],"high":[44],"level":[45],"of":[46,87,94,185,274,281,286,319],"PAMP":[47,276],"molecules,":[48],"such":[49],"as":[50,141],"liver,":[52],"DC":[53,71,99,121,133,156,180,204,305,315],"have":[54,255],"a":[55],"higher":[56,113,279],"threshold":[57,93,312],"stimulation":[59,285],"therefore":[61,333],"maintain":[62],"an":[63,335],"immature":[64],"phenotype":[65],"under":[66],"conditions":[67],"that":[68,82,106],"would":[69],"at":[72],"other":[73,115],"sites.":[74],"these":[76,282],"studies":[77],"we":[78],"tested":[79],"hypothesis":[81],"interleukin-6(IL-6)/Signal":[83],"Transducer":[84],"Activation":[86],"Transcription-3(STAT3)":[88],"activity":[89,110,199,212,243,309,331],"increases":[90,244],"activation/maturation":[92],"hepatic":[95,300,304],"bone":[97],"marrow(BM)":[98],"towards":[100],"signals.":[103],"Results":[104],"show":[105],"liver":[107,155,171,179,203],"nuclear":[108],"STAT3":[109,137,211,242,258],"is":[111,118],"significantly":[112,201,215,266],"than":[114,132,218],"organs":[116],"IL-6-dependent.":[119],"Hepatic":[120],"in":[122,159,189,232,246,251,269],"normal":[123],"wild-type(IL-6+/+)":[124],"mice":[125,191],"phenotypically":[127],"functionally":[129],"less":[130,216],"mature":[131,217],"from":[134],"IL-6-deficient(IL-6-/-)":[135],"or":[136,329],"inhibited":[138],"IL-6+/+":[139,154,190,228,247,264,288],"mice,":[140],"determined":[142],"surface":[144],"marker":[145],"expression,":[146],"pro-inflammatory":[147],"cytokine":[148],"secretion,":[149],"allogenic":[151],"T-cell":[152],"stimulation.":[153],"produce":[157],"IL-6":[158,175,234,236],"response":[160,270],"exposure":[162],"PAMPs,":[164],"but":[165,249],"resist":[166],"compared":[168],"IL-6-/-":[170,178,219,252,262,290],"DC.":[172],"Conversely,":[173],"exogenous":[174],"inhibits":[176],"LPS-induced":[177],"maturation.":[181,205,240],"Oral":[182],"antibiotic":[183],"depletion":[184],"commensal":[186],"gut":[187,327],"bacteria":[188,328],"decreased":[192],"portal":[193],"blood":[194],"endotoxin":[195],"levels,":[196],"lowered":[197],"IL-6/STAT3":[198,301,308,330],"increased":[202,238],"BM":[206],"derived":[207],"IL-6+/+DC":[208],"with":[209],"elevated":[210,233],"also":[214],"BMDC.":[220],"The":[221],"reduced":[222],"was":[224],"especially":[225],"pronounced":[226],"when":[227,230],"BMDC":[229,239,248,265,291],"cultured":[231],"conditions.":[235],"neutralization":[237],"Blocking":[241],"not":[250],"BMDC,":[253,263],"which":[254],"low":[256,272],"basal":[257],"activity.":[259],"Compared":[260],"resisted":[267],"concentrations":[273,280],"At":[278],"same":[283],"ligands":[284],"both":[287],"induced":[292],"maturation.In":[293],"Conclusion,":[294],"gut-derived":[295],"bacterial":[296],"products,":[297],"stimulating":[299],"signaling,":[302],"inhibit":[303],"activation/maturation.":[306],"Elevated":[307],"raises":[310],"needed":[313],"for":[314],"translate":[317],"immunity":[321],"into":[322],"responses.":[325,342],"Manipulating":[326],"may":[332],"be":[334],"effective":[336],"strategy":[337],"alter":[339],"intra-hepatic":[340]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
