{"id":"https://openalex.org/W28253242","doi":"https://doi.org/10.1016/s0898-6568(99)00025-x","title":"Insulin Signalling","display_name":"Insulin Signalling","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W28253242","doi":"https://doi.org/10.1016/s0898-6568(99)00025-x","mag":"28253242","pmid":"https://pubmed.ncbi.nlm.nih.gov/10433517"},"language":"en","primary_location":{"id":"doi:10.1016/s0898-6568(99)00025-x","doi":"https://doi.org/10.1016/s0898-6568(99)00025-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0898-6568(99)00025-x","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060423672","display_name":"Fredrik Hans Nystr\u00f6m","orcid":"https://orcid.org/0000-0002-1680-1000","observed_orcids":["https://orcid.org/0000-0002-1680-1000"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredrik H Nystrom","raw_affiliation_strings":["Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1754, USA","Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1754, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1754, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1754, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035304169","display_name":"Michael J. Quon","orcid":"https://orcid.org/0000-0002-5289-3707","observed_orcids":["https://orcid.org/0000-0002-5289-3707"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael J Quon","raw_affiliation_strings":["Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 8C-103, 10 Center Drive MSC 1754, Bethesda, MD 20892-1754, USA","Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 8C-103, 10 Center Drive, MSC 1754, Bethesda, MD 20892-1754, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 8C-103, 10 Center Drive MSC 1754, Bethesda, MD 20892-1754, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"Hypertension-Endocrine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 8C-103, 10 Center Drive, MSC 1754, Bethesda, MD 20892-1754, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035304169"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.7054,"has_fulltext":false,"cited_by_count":182,"citation_normalized_percentile":{"value":0.58823529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"11","issue":"8","first_page":"563","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.8859999775886536},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":0.7559999823570251},{"id":"https://openalex.org/keywords/signaling-networks","display_name":"signaling networks","score":0.5109999775886536},{"id":"https://openalex.org/keywords/subcellular-compartmentalization","display_name":"subcellular compartmentalization","score":0.847000002861023},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.730583906173706},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6500688195228577},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6416690945625305},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6362131834030151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6043298244476318},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5567464828491211},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5547260642051697},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5071227550506592},{"id":"https://openalex.org/C2909831755","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Proto-Oncogene Proteins c-akt","level":4,"score":0.4785062372684479},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.44179412722587585},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.41905882954597473},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.22387412190437317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2012406885623932},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.08712196350097656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07760095596313477},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0898-6568(99)00025-x","doi":"https://doi.org/10.1016/s0898-6568(99)00025-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0898-6568(99)00025-x","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},{"id":"pmid:10433517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10433517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular signalling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W21490794","https://openalex.org/W169445797","https://openalex.org/W282548006","https://openalex.org/W1492329260","https://openalex.org/W1500165569","https://openalex.org/W1513126834","https://openalex.org/W1513217200","https://openalex.org/W1523684384","https://openalex.org/W1524240684","https://openalex.org/W1529141138","https://openalex.org/W1529636865","https://openalex.org/W1530493122","https://openalex.org/W1536598892","https://openalex.org/W1537820722","https://openalex.org/W1539281575","https://openalex.org/W1559597555","https://openalex.org/W1561809228","https://openalex.org/W1566025256","https://openalex.org/W1570667389","https://openalex.org/W1572696798","https://openalex.org/W1573534810","https://openalex.org/W1578504987","https://openalex.org/W1591177416","https://openalex.org/W1599478288","https://openalex.org/W1602750944","https://openalex.org/W1613040252","https://openalex.org/W1649021695","https://openalex.org/W1697523131","https://openalex.org/W1726652071","https://openalex.org/W1797396297","https://openalex.org/W1862633417","https://openalex.org/W1863238068","https://openalex.org/W1914672271","https://openalex.org/W1950758994","https://openalex.org/W1966831459","https://openalex.org/W1971571944","https://openalex.org/W1974159373","https://openalex.org/W1976040992","https://openalex.org/W1977795081","https://openalex.org/W1978279440","https://openalex.org/W1978329718","https://openalex.org/W1981647923","https://openalex.org/W1983185734","https://openalex.org/W1984633752","https://openalex.org/W1985113364","https://openalex.org/W1988753461","https://openalex.org/W1989294105","https://openalex.org/W1989324173","https://openalex.org/W1990361659","https://openalex.org/W1991710558","https://openalex.org/W1997460544","https://openalex.org/W2000745031","https://openalex.org/W2000790515","https://openalex.org/W2001736800","https://openalex.org/W2002908987","https://openalex.org/W2003288736","https://openalex.org/W2008223259","https://openalex.org/W2008940139","https://openalex.org/W2011318675","https://openalex.org/W2013408977","https://openalex.org/W2014129040","https://openalex.org/W2015543195","https://openalex.org/W2018926746","https://openalex.org/W2023090301","https://openalex.org/W2023145731","https://openalex.org/W2028966505","https://openalex.org/W2029722068","https://openalex.org/W2029911977","https://openalex.org/W2030338284","https://openalex.org/W2030884611","https://openalex.org/W2031504013","https://openalex.org/W2033429522","https://openalex.org/W2033575261","https://openalex.org/W2034920996","https://openalex.org/W2036467191","https://openalex.org/W2037267818","https://openalex.org/W2038371973","https://openalex.org/W2038628739","https://openalex.org/W2038973974","https://openalex.org/W2041925630","https://openalex.org/W2046774437","https://openalex.org/W2046933787","https://openalex.org/W2049875806","https://openalex.org/W2050751458","https://openalex.org/W2052308537","https://openalex.org/W2057724921","https://openalex.org/W2058390591","https://openalex.org/W2058418427","https://openalex.org/W2062154472","https://openalex.org/W2062292823","https://openalex.org/W2066052044","https://openalex.org/W2067252716","https://openalex.org/W2071981946","https://openalex.org/W2072117280","https://openalex.org/W2072265657","https://openalex.org/W2073128787","https://openalex.org/W2075796682","https://openalex.org/W2076186944","https://openalex.org/W2076822732","https://openalex.org/W2077642701","https://openalex.org/W2080238905","https://openalex.org/W2080415718","https://openalex.org/W2081698610","https://openalex.org/W2082449959","https://openalex.org/W2082611901","https://openalex.org/W2082706608","https://openalex.org/W2083043624","https://openalex.org/W2083433543","https://openalex.org/W2083547817","https://openalex.org/W2088021829","https://openalex.org/W2089113524","https://openalex.org/W2094068658","https://openalex.org/W2094104389","https://openalex.org/W2094314261","https://openalex.org/W2095024386","https://openalex.org/W2097369775","https://openalex.org/W2097595798","https://openalex.org/W2098601481","https://openalex.org/W2103043702","https://openalex.org/W2107905355","https://openalex.org/W2109300167","https://openalex.org/W2110137900","https://openalex.org/W2111718290","https://openalex.org/W2112009693","https://openalex.org/W2117483382","https://openalex.org/W2119744230","https://openalex.org/W2122000735","https://openalex.org/W2122567567","https://openalex.org/W2124306457","https://openalex.org/W2124615128","https://openalex.org/W2132382863","https://openalex.org/W2139907742","https://openalex.org/W2141743775","https://openalex.org/W2141795340","https://openalex.org/W2144984479","https://openalex.org/W2145545657","https://openalex.org/W2146157811","https://openalex.org/W2146573379","https://openalex.org/W2146989813","https://openalex.org/W2147207624","https://openalex.org/W2148258829","https://openalex.org/W2150032835","https://openalex.org/W2150158001","https://openalex.org/W2152479249","https://openalex.org/W2152931086","https://openalex.org/W2154713680","https://openalex.org/W2160421139","https://openalex.org/W2161316513","https://openalex.org/W2164682544","https://openalex.org/W2165259997","https://openalex.org/W2165742826","https://openalex.org/W2170917038","https://openalex.org/W2171424906","https://openalex.org/W2178538190","https://openalex.org/W2180005201","https://openalex.org/W2415256380","https://openalex.org/W2417837276","https://openalex.org/W4235195764","https://openalex.org/W4251494161","https://openalex.org/W4253418569"],"related_works":["https://openalex.org/W4211224368","https://openalex.org/W2335447520","https://openalex.org/W2121328410","https://openalex.org/W2046007718","https://openalex.org/W1532013136","https://openalex.org/W2089113524","https://openalex.org/W1978002465","https://openalex.org/W2062292823","https://openalex.org/W2012976199","https://openalex.org/W174752440"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}