{"id":"https://openalex.org/W28193069","doi":null,"title":"Chemiluminescence resulting from an interaction between imipramine and human polymorphonuclear leukocytes.","display_name":"Chemiluminescence resulting from an interaction between imipramine and human polymorphonuclear leukocytes.","publication_year":1977,"publication_date":"1977-12-01","ids":{"openalex":"https://openalex.org/W28193069","mag":"28193069","pmid":"https://pubmed.ncbi.nlm.nih.gov/928961"},"language":"en","primary_location":{"id":"pmid:928961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/928961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053583942","display_name":"M A Trush","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Trush","raw_affiliation_strings":["Bloomberg School of Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg School of Public Health","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073771160","display_name":"Van Dyke K","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Van Dyke","raw_affiliation_strings":["West Virginia University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University ,","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018979754","display_name":"Mary Edythe Wilson","orcid":"https://orcid.org/0000-0001-8680-7275","observed_orcids":["https://orcid.org/0000-0001-8680-7275"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Wilson","raw_affiliation_strings":["West Virginia University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University ,","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089738784","display_name":"Mark J. Reasor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Reasor","raw_affiliation_strings":["West Virginia University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University ,","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5242,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57513836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"4","first_page":"645","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chemiluminescence","display_name":"chemiluminescence","score":0.9670000076293945},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8220000267028809},{"id":"https://openalex.org/keywords/zymosan","display_name":"zymosan","score":0.9340000152587891},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8960000276565552},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.8320000171661377},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chronic-granulomatous-disease","display_name":"chronic granulomatous disease","score":0.8889999985694885},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7590000033378601},{"id":"https://openalex.org/keywords/drug-cell-interaction","display_name":"drug-cell interaction","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.9815682172775269},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.829015851020813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6436320543289185},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.640990138053894},{"id":"https://openalex.org/C145802702","wikidata":"https://www.wikidata.org/wiki/Q2931725","display_name":"Chemiluminescence","level":2,"score":0.5815151929855347},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5245116949081421},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.4905373454093933},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4439300000667572},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3110165596008301},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.177387535572052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17636385560035706},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.12234994769096375},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11198586225509644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006105","descriptor_name":"Granulomatous Disease, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007099","descriptor_name":"Imipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015054","descriptor_name":"Zymosan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:928961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/928961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research communications in chemical pathology and pharmacology","raw_type":"Journal Article"},{"id":"mag:28193069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/928961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2508870274","https://openalex.org/W2083117078","https://openalex.org/W2262766247","https://openalex.org/W2508709614","https://openalex.org/W2315744637","https://openalex.org/W1985105730","https://openalex.org/W2069734146","https://openalex.org/W2024275778","https://openalex.org/W1968372917","https://openalex.org/W4239333363","https://openalex.org/W2087774414","https://openalex.org/W2318272540","https://openalex.org/W4229743141","https://openalex.org/W2028240481","https://openalex.org/W2088946080","https://openalex.org/W1976680684","https://openalex.org/W2063028213","https://openalex.org/W2331560033","https://openalex.org/W2398135431","https://openalex.org/W2079450369","https://openalex.org/W2299773795","https://openalex.org/W2279763510","https://openalex.org/W2031851076","https://openalex.org/W2088964811","https://openalex.org/W2314324577","https://openalex.org/W2150551630","https://openalex.org/W2312499429","https://openalex.org/W2028195287","https://openalex.org/W2345288804","https://openalex.org/W2169821755","https://openalex.org/W2071534982","https://openalex.org/W1969808589","https://openalex.org/W2013607204","https://openalex.org/W1997028373","https://openalex.org/W1611854178","https://openalex.org/W2020540026","https://openalex.org/W2101463846","https://openalex.org/W2315670458","https://openalex.org/W2107869090","https://openalex.org/W780478847","https://openalex.org/W2525711083","https://openalex.org/W1968449697","https://openalex.org/W2159518181","https://openalex.org/W2024088832","https://openalex.org/W2394489651"],"related_works":["https://openalex.org/W2058454341","https://openalex.org/W2001943372","https://openalex.org/W2064601678","https://openalex.org/W2079438629","https://openalex.org/W2046138282","https://openalex.org/W2443381671","https://openalex.org/W2167904042","https://openalex.org/W2314602553","https://openalex.org/W2089750978","https://openalex.org/W2280765262"],"abstract_inverted_index":{"The":[0],"addition":[1,66,110],"of":[2,7,16,29,34,45,67,100,130,149],"imipramine":[3,52,68,104,150],"to":[4,38,69,78,89,111],"a":[5,30,73],"suspension":[6],"resting":[8],"polymorphonuclear":[9],"leukocytes":[10],"(PMNs)":[11],"resulted":[12],"in":[13,97,127,144],"the":[14,27,36,43,65,98,112,119,128,135,140,147],"generation":[15,129],"chemiluminescence":[17],"(CL)":[18],"(100,000":[19],"cpm":[20],"with":[21,48,92],"1":[22,49],"X":[23,50],"10(-4)M":[24],"imipramine).":[25],"In":[26],"presence":[28,99],"particle":[31],"(zymosan)":[32],"capable":[33],"activating":[35],"PMNs":[37,70,93],"generate":[39,90],"reactive":[40,153],"oxygen":[41,154],"species,":[42],"magnitude":[44],"CL":[46,61,91,108,131,141],"observed":[47],"10(4)M":[51],"was":[53,62],"greatly":[54],"enhanced":[55],"(greater":[56],"than":[57],"1,000,000":[58],"cpm).":[59],"No":[60],"detected":[63],"upon":[64,109],"isolated":[71,81],"from":[72,82,146],"chronic":[74],"granulomatous":[75],"child":[76],"or":[77,96],"alveolar":[79],"macrophages":[80],"rats.":[83],"Another":[84],"tricyclic":[85],"antidepressant,":[86],"amitriptyline,":[87],"failed":[88],"either":[94],"alone":[95],"zymosan;":[101],"however,":[102],"both":[103],"and":[105],"amitriptyline":[106],"generated":[107],"xanthine":[113],"oxidase-purine":[114],"superoxide":[115],"generating":[116],"system.":[117],"Although":[118],"mechanism":[120],"by":[121,151],"which":[122],"this":[123],"drug-cell":[124],"interaction":[125],"results":[126],"is":[132],"not":[133],"known,":[134],"observations":[136],"are":[137],"suggestive":[138],"that":[139],"may":[142],"originate,":[143],"part,":[145],"activation":[148],"some":[152],"state(s).":[155]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
