{"id":"https://openalex.org/W2815790","doi":null,"title":"The role of Lgl, aPKC, and Numb in Distinguishing Neural Stem Cells from progenitor cells in Drosophila.","display_name":"The role of Lgl, aPKC, and Numb in Distinguishing Neural Stem Cells from progenitor cells in Drosophila.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2815790","mag":"2815790"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/94007","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/94007","pdf_url":"https://hdl.handle.net/2027.42/94007","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/94007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083933899","display_name":"Jill M. Haenfler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jill M. Haenfler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083933899"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lethal-giant-larvae","display_name":"lethal giant larvae","score":0.7630000114440918},{"id":"https://openalex.org/keywords/atypical-protein-kinase-c","display_name":"atypical protein kinase C","score":0.9639999866485596},{"id":"https://openalex.org/keywords/numb","display_name":"Numb","score":0.9639999866485596},{"id":"https://openalex.org/keywords/asymmetric-cell-division","display_name":"asymmetric cell division","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neuroblasts","display_name":"neuroblasts","score":0.6039999723434448},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/progenitor-cells","display_name":"progenitor cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.722000002861023},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8349999785423279},{"id":"https://openalex.org/keywords/drosophila-larval-brain","display_name":"Drosophila larval brain","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2776746469","wikidata":"https://www.wikidata.org/wiki/Q18033185","display_name":"NUMB","level":2,"score":0.8222110271453857},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.758080244064331},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6967451572418213},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5773035883903503},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.5596019625663757},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5535767078399658},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48693597316741943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43478211760520935},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3340545892715454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14058494567871094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05198180675506592}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/94007","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/94007","pdf_url":"https://hdl.handle.net/2027.42/94007","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2815790","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/94007","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/94007","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/94007","pdf_url":"https://hdl.handle.net/2027.42/94007","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2790894084","display_name":"Michigan Medical Scientist Training Program","funder_award_id":"T32GM007863","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5264016259","display_name":"Cellular and Molecular Biology at Michigan","funder_award_id":"T32GM007315","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2815790.pdf","grobid_xml":"https://content.openalex.org/works/W2815790.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1482614157","https://openalex.org/W1502837338","https://openalex.org/W1515156981","https://openalex.org/W1573053105","https://openalex.org/W1623584754","https://openalex.org/W1646135266","https://openalex.org/W1790815665","https://openalex.org/W1966736198","https://openalex.org/W1969995228","https://openalex.org/W1970265615","https://openalex.org/W1970492716","https://openalex.org/W1974059924","https://openalex.org/W1976964790","https://openalex.org/W1980415397","https://openalex.org/W1981336776","https://openalex.org/W1983575387","https://openalex.org/W1994404140","https://openalex.org/W2002602524","https://openalex.org/W2004361537","https://openalex.org/W2012234882","https://openalex.org/W2014669694","https://openalex.org/W2019593540","https://openalex.org/W2021892293","https://openalex.org/W2024490989","https://openalex.org/W2026175377","https://openalex.org/W2026998481","https://openalex.org/W2028480293","https://openalex.org/W2030123913","https://openalex.org/W2036355011","https://openalex.org/W2039623436","https://openalex.org/W2041482422","https://openalex.org/W2043713099","https://openalex.org/W2045829749","https://openalex.org/W2046457668","https://openalex.org/W2046814313","https://openalex.org/W2050688574","https://openalex.org/W2051221246","https://openalex.org/W2060953620","https://openalex.org/W2063197874","https://openalex.org/W2063622603","https://openalex.org/W2064585727","https://openalex.org/W2066532877","https://openalex.org/W2069574891","https://openalex.org/W2072001338","https://openalex.org/W2073264516","https://openalex.org/W2075947758","https://openalex.org/W2076070951","https://openalex.org/W2077638073","https://openalex.org/W2080064943","https://openalex.org/W2083280774","https://openalex.org/W2088539039","https://openalex.org/W2092900311","https://openalex.org/W2093778390","https://openalex.org/W2094822054","https://openalex.org/W2097125495","https://openalex.org/W2098313605","https://openalex.org/W2100143950","https://openalex.org/W2101601043","https://openalex.org/W2104950425","https://openalex.org/W2107227145","https://openalex.org/W2108078547","https://openalex.org/W2121312322","https://openalex.org/W2125713094","https://openalex.org/W2126383647","https://openalex.org/W2126984698","https://openalex.org/W2132981456","https://openalex.org/W2139240348","https://openalex.org/W2141236652","https://openalex.org/W2144868620","https://openalex.org/W2150968671","https://openalex.org/W2151505117","https://openalex.org/W2151777177","https://openalex.org/W2152642445","https://openalex.org/W2154262793","https://openalex.org/W2157480976","https://openalex.org/W2160680240","https://openalex.org/W2161742674","https://openalex.org/W2164474108","https://openalex.org/W2168826080","https://openalex.org/W2171655106","https://openalex.org/W2187370769","https://openalex.org/W2336566078","https://openalex.org/W2478566859"],"related_works":["https://openalex.org/W2121312322","https://openalex.org/W2045829749","https://openalex.org/W1623584754","https://openalex.org/W2381076023","https://openalex.org/W3045970441","https://openalex.org/W2183102768","https://openalex.org/W2366842645","https://openalex.org/W7099616419","https://openalex.org/W2048047215","https://openalex.org/W2012234882"],"abstract_inverted_index":{"Asymmetric":[0],"cell":[1,35,47,76,81,136],"division":[2],"is":[3],"a":[4,128,134],"conserved":[5],"mechanism":[6],"for":[7],"distinguishing":[8],"cells":[9,18,55,91,94,101,155,265],"following":[10],"mitosis":[11],"in":[12,29,44,85,95,103,176,201,222],"order":[13,86],"to":[14,72,87,156],"produce":[15],"two":[16,213],"daughter":[17,129],"with":[19],"unique":[20],"functions":[21],"and":[22,40,69,78,119,131,167,172,198,254],"characteristics.":[23],"Significant":[24],"progress":[25],"has":[26],"been":[27],"made":[28],"understanding":[30],"how":[31,41,74],"proteins":[32,113],"at":[33,211],"the":[34,58,107,111,145,177,180,193,202,208,218,223,227,263,273],"cortex":[36,178],"become":[37],"asymmetrically":[38],"localized":[39],"determinants":[42],"function":[43,219],"establishing":[45],"distinct":[46],"fates.":[48],"Also,":[49],"recent":[50],"studies":[51,65],"have":[52],"shown":[53],"that":[54,164,249,257],"actively":[56],"maintain":[57],"fate":[59,82,142],"which":[60],"they":[61],"initially":[62],"acquired.":[63],"My":[64],"utilize":[66],"clonal":[67],"analysis":[68],"genetic":[70],"techniques":[71],"investigate":[73],"this":[75],"polarity":[77,112],"maintenance":[79],"of":[80,127,133,141,147,174,179,188,192,220,234,240,272],"are":[83],"linked":[84],"distinguish":[88],"neural":[89,99],"stem":[90,100],"from":[92],"progenitor":[93,135,154,224,264],"Drosophila.":[96],"In":[97,144],"mitotic":[98,181],"(neuroblasts)":[102],"fly":[104],"larval":[105],"brains,":[106],"antagonistic":[108],"interaction":[109],"between":[110,252],"Lethal":[114],"(2)":[115],"giant":[116],"larvae":[117],"(Lgl)":[118],"atypical":[120],"Protein":[121],"Kinase":[122],"C":[123],"(aPKC)":[124],"ensures":[125,256],"self-renewal":[126],"neuroblast":[130],"generation":[132],"by":[137,237,242,275],"regulating":[138],"asymmetric":[139,170,186],"segregation":[140,173],"determinants.":[143],"absence":[146],"lgl,":[148],"increased":[149],"cortical":[150],"aPKC":[151,168,184,255],"activity":[152],"triggers":[153],"revert":[157],"back":[158],"into":[159,262],"neuroblasts.":[160],"Additionally,":[161],"I":[162],"found":[163],"together":[165],"Lgl":[166,253],"ensure":[169],"localization":[171,187],"Numb":[175,189,221,238,258,267],"neuroblast.":[182],"Specifically,":[183],"regulates":[185],"via":[190],"phosphorylation":[191,209,241,274],"previously":[194],"undefined":[195],"serines":[196],"48":[197],"52":[199],"sites":[200,214],"novel":[203],"ACBD3":[204,228],"binding":[205,229],"region.":[206],"However,":[207],"status":[210],"these":[212],"does":[215],"not":[216],"affect":[217],"cells.":[225],"Finally,":[226],"region":[230],"exerts":[231],"neuroblast-specific":[232],"suppression":[233],"Notch":[235],"signaling":[236],"independently":[239],"aPKC.":[243,276],"Taken":[244],"together,":[245],"my":[246],"work":[247],"suggests":[248],"mutual":[250],"antagonism":[251],"properly":[259],"segregates":[260],"exclusively":[261],"where":[266],"maintains":[268],"limited":[269],"potential":[270],"irrespective":[271]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
