{"id":"https://openalex.org/W281542935","doi":"https://doi.org/10.1182/blood.v93.8.2721","title":"Induced Differentiation of U937 Cells by 1,25-dihydroxyvitamin D3 Involves Cell Cycle Arrest in G1 That Is Preceded by a Transient Proliferative Burst and an Increase in Cyclin Expression","display_name":"Induced Differentiation of U937 Cells by 1,25-dihydroxyvitamin D3 Involves Cell Cycle Arrest in G1 That Is Preceded by a Transient Proliferative Burst and an Increase in Cyclin Expression","publication_year":1999,"publication_date":"1999-04-15","ids":{"openalex":"https://openalex.org/W281542935","doi":"https://doi.org/10.1182/blood.v93.8.2721","mag":"281542935","pmid":"https://pubmed.ncbi.nlm.nih.gov/10194452"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v93.8.2721","doi":"https://doi.org/10.1182/blood.v93.8.2721","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.8.2721","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030678985","display_name":"Nynke Y. Rots","orcid":"https://orcid.org/0000-0002-7170-7826","observed_orcids":["https://orcid.org/0000-0002-7170-7826"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nynke Y. Rots","raw_affiliation_strings":["From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634","observed_orcids":["https://orcid.org/0000-0002-0683-4634"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057856447","display_name":"V. Carrie Bromleigh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia Bromleigh","raw_affiliation_strings":["From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033005779","display_name":"Leonard P. Freedman","orcid":"https://orcid.org/0009-0007-5726-150X","observed_orcids":["https://orcid.org/0009-0007-5726-150X","https://orcid.org/0000-0003-2352-4037"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard P. Freedman","raw_affiliation_strings":["From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cell Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":5.8997,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.96721666,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"93","issue":"8","first_page":"2721","last_page":"2729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.6179999709129333},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/myeloid-differentiation","display_name":"myeloid differentiation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7929999828338623},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cyclin-a","display_name":"cyclin A","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":1.0},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9139999747276306},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/p15","display_name":"p15","score":0.8370000123977661},{"id":"https://openalex.org/keywords/p18","display_name":"p18","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8740000128746033},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.902999997138977},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C2778298596","wikidata":"https://www.wikidata.org/wiki/Q17143494","display_name":"CDK inhibitor","level":5,"score":0.6722371578216553},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.6266390681266785},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6077090501785278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5829907655715942},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5809794664382935},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5641730427742004},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5508010983467102},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5356364250183105},{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.5090689063072205},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4920479953289032},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.44568386673927307},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4371088743209839},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.4224918484687805},{"id":"https://openalex.org/C2781403221","wikidata":"https://www.wikidata.org/wiki/Q5198273","display_name":"Cyclin D3","level":5,"score":0.41266536712646484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3816007375717163},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2882841229438782},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2520619034767151},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12276330590248108},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.060562849044799805},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v93.8.2721","doi":"https://doi.org/10.1182/blood.v93.8.2721","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.8.2721","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v93.8.2721.408k28_2721_2729","doi":"https://doi.org/10.1182/blood.v93.8.2721.408k28_2721_2729","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v93.8.2721.408k28_2721_2729","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10194452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10194452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G204343016","display_name":null,"funder_award_id":"DK45460","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G477994241","display_name":"Vitamin D3 inducible Genes Mediating Differentiation","funder_award_id":"R01DK052621","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1538686078","https://openalex.org/W1844339134","https://openalex.org/W1897751061","https://openalex.org/W1975324295","https://openalex.org/W1996413533","https://openalex.org/W2007772649","https://openalex.org/W2015066175","https://openalex.org/W2015519364","https://openalex.org/W2024868532","https://openalex.org/W2027558915","https://openalex.org/W2033156691","https://openalex.org/W2048743150","https://openalex.org/W2051316659","https://openalex.org/W2052651806","https://openalex.org/W2061863824","https://openalex.org/W2066848701","https://openalex.org/W2070061120","https://openalex.org/W2089218510","https://openalex.org/W2092104789","https://openalex.org/W2099786386","https://openalex.org/W2102824660","https://openalex.org/W2132045524","https://openalex.org/W2138852914","https://openalex.org/W2157438849","https://openalex.org/W2161378573","https://openalex.org/W2162741492","https://openalex.org/W2166529745","https://openalex.org/W2170331239","https://openalex.org/W2291630343","https://openalex.org/W2375468400"],"related_works":["https://openalex.org/W2162741492","https://openalex.org/W2117988483","https://openalex.org/W7096047332","https://openalex.org/W1975167498","https://openalex.org/W1525067662","https://openalex.org/W2530606963","https://openalex.org/W7455313","https://openalex.org/W2171414647","https://openalex.org/W2082198146","https://openalex.org/W2070692743"],"abstract_inverted_index":{"The":[0],"hormonal":[1],"form":[2],"of":[3,14,22,24,37,138,143,153,159,162,167,178,243,254],"vitamin":[4],"D,":[5],"1,25-dihydroxyvitamin":[6],"D3":[7],"[1,":[8],"25(OH)2D3],":[9],"is":[10,196],"a":[11,35,176,198],"potent":[12],"inhibitor":[13],"cellular":[15],"proliferation":[16,110,195],"as":[17,19,223],"well":[18],"an":[20,89,157,191],"inducer":[21],"differentiation":[23,63,188,239],"myeloid":[25,44],"leukemic":[26],"cells":[27,87,211,256],"to":[28],"macrophages.":[29],"We":[30,68,79],"have":[31],"previously":[32],"reported":[33],"that":[34,58,175,190,212,231],"number":[36],"genes":[38],"are":[39,64,181,213],"upregulated":[40],"by":[41,94,113,216,261],"1,25(OH)2D3":[42,217],"during":[43,130],"differentiation,":[45],"including":[46],"the":[47,72,132,151,160],"cyclin-dependent":[48],"kinase":[49],"(CDK)":[50],"inhibitors":[51,180],"p21,":[52],"p27,":[53,249],"15,":[54],"and":[55,62,77,97,119,124,135,169,187,189,235,240,246,248],"p18,":[56],"suggesting":[57,174],"cell":[59,139,251],"cycle":[60,252],"arrest":[61,186,253],"tightly":[65],"linked":[66],"processes.":[67],"further":[69],"explore":[70],"here":[71],"relationship":[73],"between":[74],"growth":[75,95,185,214,233],"inhibition":[76,96,137,237],"differentiation.":[78,99,202],"report":[80],"that,":[81],"upon":[82],"1,":[83],"25(OH)2D3":[84],"treatment,":[85],"U937":[86,148],"exhibited":[88],"early":[90,192],"proliferative":[91,133],"burst":[92,134],"followed":[93],"subsequent":[98,136,201,236],"Although":[100],"CDK":[101,179,264],"levels":[102,126],"remain":[103],"constant":[104],"throughout,":[105],"this":[106],"transient":[107],"increase":[108,193],"in":[109,115,147,150,156,194,210,263],"was":[111,208],"accompanied":[112],"increases":[114],"cyclin":[116],"A,":[117],"D1,":[118],"E":[120],"protein":[121],"levels.":[122],"p21":[123,144,247],"p27":[125,146],"were":[127],"also":[128],"elevated":[129],"both":[131,184,232,244],"growth.":[140],"Ectopic":[141],"overexpression":[142,166],"and/or":[145],"cells,":[149],"absence":[152],"hormone,":[154],"resulted":[155],"induction":[158,242],"expression":[161],"monocyte/macrophage-specific":[163],"markers,":[164],"whereas":[165,250],"p15":[168],"p18":[170],"had":[171],"no":[172,204],"effect,":[173],"subset":[177],"important":[182],"for":[183,200],"somehow":[197],"prerequisite":[199],"However,":[203],"such":[205,222],"biphasic":[206],"behavior":[207],"detected":[209],"inhibited":[215],"but":[218],"do":[219],"not":[220],"differentiate,":[221],"MCF-7":[224],"cells.":[225],"Taken":[226],"together,":[227],"these":[228],"results":[229],"indicate":[230],"stimulation":[234],"precede":[238],"involve":[241],"cyclins":[245],"differentiated":[255],"can":[257],"be":[258],"achieved":[259],"simply":[260],"elevations":[262],"inhibitors.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
