{"id":"https://openalex.org/W2815023697","doi":"https://doi.org/10.1038/s41598-018-28622-4","title":"Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines","display_name":"Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines","publication_year":2018,"publication_date":"2018-07-06","ids":{"openalex":"https://openalex.org/W2815023697","doi":"https://doi.org/10.1038/s41598-018-28622-4","mag":"2815023697","pmid":"https://pubmed.ncbi.nlm.nih.gov/30002384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6043481"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-018-28622-4","doi":"https://doi.org/10.1038/s41598-018-28622-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-28622-4","pdf_url":"https://www.nature.com/articles/s41598-018-28622-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-018-28622-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066725980","display_name":"Anne\u2010Laure Sennesael","orcid":"https://orcid.org/0000-0003-3499-1466","observed_orcids":["https://orcid.org/0000-0003-3499-1466"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Anne-Laure Sennesael","raw_affiliation_strings":["Clinical Pharmacy Research Group, Louvain Drug Research Institute, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium. anne-laure.sennesael@uclouvain.be","Department of Pharmacy, Namur Research Institute for LIfe Sciences, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Namur, Belgium. anne-laure.sennesael@uclouvain.be","Clinical Pharmacy Research Group, Louvain Drug Research Institute, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-3499-1466","affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Research Group, Louvain Drug Research Institute, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium. anne-laure.sennesael@uclouvain.be","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Department of Pharmacy, Namur Research Institute for LIfe Sciences, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Namur, Belgium. anne-laure.sennesael@uclouvain.be","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]},{"raw_affiliation_string":"Clinical Pharmacy Research Group, Louvain Drug Research Institute, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003662720","display_name":"Nadtha Panin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nadtha Panin","raw_affiliation_strings":["Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030917658","display_name":"Christelle Vancraeynest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christelle Vancraeynest","raw_affiliation_strings":["Department of Pharmacy, Namur Research Institute for LIfe Sciences, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Namur, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Research Institute for LIfe Sciences, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023392033","display_name":"Lionel Pochet","orcid":"https://orcid.org/0000-0002-2560-9555","observed_orcids":["https://orcid.org/0000-0002-2560-9555"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lionel Pochet","raw_affiliation_strings":["Department of Pharmacy, Namur Research Institute for LIfe Sciences, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2560-9555","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Namur Research Institute for LIfe Sciences, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112342165","display_name":"Anne Spinewine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093617","display_name":"CHU Dinant Godinne UCL Namur","ror":"https://ror.org/00ntbvq76","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210093617"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne Spinewine","raw_affiliation_strings":["Clinical Pharmacy Research Group, Louvain Drug Research Institute, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium","Department of Pharmacy, NTHC, CHU UCL Namur, Yvoir, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Research Group, Louvain Drug Research Institute, Universit\u00e9 catholique de Louvain (UCL), Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Department of Pharmacy, NTHC, CHU UCL Namur, Yvoir, Belgium","institution_ids":["https://openalex.org/I4210093617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051216300","display_name":"Vincent Haufroid","orcid":"https://orcid.org/0000-0001-5040-9806","observed_orcids":["https://orcid.org/0000-0001-5040-9806"]},"institutions":[{"id":"https://openalex.org/I1315288073","display_name":"Cliniques Universitaires Saint-Luc","ror":"https://ror.org/03s4khd80","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I1315288073"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Vincent Haufroid","raw_affiliation_strings":["Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, UCL, Brussels, Belgium","Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Cliniques Universitaires Saint-Luc, UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I1315288073"]},{"raw_affiliation_string":"Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057687580","display_name":"Laure Elens","orcid":"https://orcid.org/0000-0002-0039-3583","observed_orcids":["https://orcid.org/0000-0002-0039-3583"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laure Elens","raw_affiliation_strings":["Integrated PharmacoMetrics, PharmacoGenomics and PharmacoKinetics, Louvain Drug Research Institute, UCL, Brussels, Belgium","Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, UCL, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated PharmacoMetrics, PharmacoGenomics and PharmacoKinetics, Louvain Drug Research Institute, UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Louvain Centre for Toxicology and Applied Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, UCL, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066725980"],"corresponding_institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857","https://openalex.org/I95674353"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.5858,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.78125687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"10514","last_page":"10514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.2029999941587448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rivaroxaban","display_name":"rivaroxaban","score":0.9760000109672546},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8989999890327454},{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.8539999723434448},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.8140000104904175},{"id":"https://openalex.org/keywords/intracellular-accumulation","display_name":"intracellular accumulation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hek293-cells","display_name":"HEK293 cells","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6717227697372437},{"id":"https://openalex.org/C2778661090","wikidata":"https://www.wikidata.org/wiki/Q420262","display_name":"Rivaroxaban","level":4,"score":0.5698891282081604},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5691297054290771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4293931722640991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3491297662258148},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3472434878349304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34193435311317444},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3007590174674988},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2613053619861603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2534880042076111},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069552","descriptor_name":"Rivaroxaban","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000073537","descriptor_name":"Biological Variation, Population","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41598-018-28622-4","doi":"https://doi.org/10.1038/s41598-018-28622-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-28622-4","pdf_url":"https://www.nature.com/articles/s41598-018-28622-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4998201","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6043481","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30002384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30002384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6043481","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6043481/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:pure.unamur.be:openaire/4df55cbb-73af-4dd1-be56-334909d8b821","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.unamur.be/en/publications/4df55cbb-73af-4dd1-be56-334909d8b821","pdf_url":null,"source":{"id":"https://openalex.org/S4406922457","display_name":"Repository of the University of Namur","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sennesael, A L, Panin, N, Vancraeynest, C, Pochet, L, Spinewine, A, Haufroid, V & Elens, L 2018, 'Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines', Scientific Reports, vol. 8, no. 1, 10514, pp. 10514. https://doi.org/10.1038/s41598-018-28622-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:200208","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.1/200208","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific reports, Vol. 8, no. 1, p. 10514 (2018)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:220089","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/220089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol. 8, no. 1, p. 10514 [1-6] (2018)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:47aad6490fa646d7a3e3ca5b554558d5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/47aad6490fa646d7a3e3ca5b554558d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-018-28622-4","doi":"https://doi.org/10.1038/s41598-018-28622-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-018-28622-4","pdf_url":"https://www.nature.com/articles/s41598-018-28622-4.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2815023697.pdf","grobid_xml":"https://content.openalex.org/works/W2815023697.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1481471937","https://openalex.org/W1507788646","https://openalex.org/W1564607482","https://openalex.org/W2017582897","https://openalex.org/W2066251905","https://openalex.org/W2066731188","https://openalex.org/W2122667952","https://openalex.org/W2135700027","https://openalex.org/W2137151087","https://openalex.org/W2138426988","https://openalex.org/W2142688525","https://openalex.org/W2147787974","https://openalex.org/W2194419520","https://openalex.org/W2397510889","https://openalex.org/W2408914441","https://openalex.org/W2474810070","https://openalex.org/W2509795914","https://openalex.org/W2547585100","https://openalex.org/W2562806729","https://openalex.org/W2603123984","https://openalex.org/W2609511853","https://openalex.org/W2615510955","https://openalex.org/W2620945124","https://openalex.org/W2730172418","https://openalex.org/W2732053137","https://openalex.org/W2755598421","https://openalex.org/W2762490623","https://openalex.org/W2762670530","https://openalex.org/W2771949431","https://openalex.org/W2777982354","https://openalex.org/W2789359247","https://openalex.org/W2794347333"],"related_works":["https://openalex.org/W2559528249","https://openalex.org/W7084218990","https://openalex.org/W4411642285","https://openalex.org/W4400185964","https://openalex.org/W4409953676","https://openalex.org/W2909073103","https://openalex.org/W4290695258","https://openalex.org/W2912688339","https://openalex.org/W3158710362","https://openalex.org/W7120855693"],"abstract_inverted_index":{"Direct":[0],"oral":[1],"anticoagulants":[2],"(DOAC)":[3],"are":[4,187],"substrates":[5],"for":[6],"the":[7,25,49,59,64,82,91,102,119,131,136,142,163,171,178,184,192],"ABCB1":[8,17,68,84,103,116,134,143,179],"transporter":[9],"(also":[10],"called":[11],"P-glycoprotein),":[12],"an":[13],"active":[14,137],"efflux":[15],"pump.":[16],"polymorphisms":[18,71],"have":[19,41],"been":[20],"previously":[21],"reported":[22],"to":[23,48,100,126,170,189,191],"influence":[24,161],"pharmacokinetics":[26],"of":[27,63,122,133,139,166],"several":[28],"drugs":[29],"such":[30],"as":[31],"immunosuppressants":[32],"and":[33,81,152],"tyrosine":[34],"kinase":[35],"inhibitors.":[36],"Recently,":[37],"in":[38,52,60,135,183,195],"vivo":[39],"studies":[40],"suggested":[42],"that":[43,177],"genetic":[44],"variants":[45],"might":[46],"contribute":[47,190],"inter-individual":[50,193],"variability":[51,194],"DOAC":[53],"plasma":[54,197],"concentrations.":[55,198],"Therefore,":[56],"we":[57],"evaluated":[58],"vitro":[61],"effect":[62],"most":[65],"common":[66],"coding":[67,83,180],"single":[69],"nucleotide":[70],"(SNP),":[72],"1236":[73,144],"C":[74,145],">":[75,77,79,87,146,148,150,155],"T-2677G":[76,147],"T-3435C":[78,149],"T,":[80],"1199":[85,106,114,153],"G":[86,154],"A":[88,156],"SNP":[89],"on":[90,162],"transport":[92,138],"activity":[93],"towards":[94],"rivaroxaban.":[95,140],"HEK293":[96],"cells":[97],"were":[98],"transfected":[99],"overexpress":[101],"wild-type":[104,172],"(1236C-2677G-3435C,":[105],"G)":[107],"or":[108,113],"variant":[109],"proteins":[110],"(1236C-2677G-3435T,":[111],"1236T-2677T-3435T":[112],"A).":[115],"expression":[117],"decreased":[118],"intracellular":[120,164],"accumulation":[121,165],"rivaroxaban,":[123],"when":[124,168],"compared":[125,169],"control":[127],"cells.":[128],"This":[129],"confirms":[130],"involvement":[132],"However,":[141],"T":[151],"SNPs":[157,181],"had":[158],"no":[159],"significant":[160],"rivaroxaban":[167,196],"protein.":[173],"These":[174],"results":[175],"suggest":[176],"investigated":[182],"present":[185],"study":[186],"unlikely":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-07-19T00:00:00"}