{"id":"https://openalex.org/W2811800502","doi":"https://doi.org/10.1158/1538-7445.am2018-5346","title":"Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis","display_name":"Abstract 5346: Recurrent genomic copy alterations deregulate the transcriptome and key signaling networks in head and neck cancer cell lines and tumors with worse prognosis","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2811800502","doi":"https://doi.org/10.1158/1538-7445.am2018-5346","mag":"2811800502"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2018-5346","doi":"https://doi.org/10.1158/1538-7445.am2018-5346","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-5346","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075913282","display_name":"Hui Cheng","orcid":"https://orcid.org/0000-0001-9154-9282","observed_orcids":["https://orcid.org/0000-0001-9154-9282"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Cheng","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039402755","display_name":"Xinping Yang","orcid":"https://orcid.org/0000-0003-4086-4180","observed_orcids":["https://orcid.org/0000-0003-4086-4180"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinping Yang","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088864413","display_name":"Han Si","orcid":"https://orcid.org/0000-0001-5655-3374","observed_orcids":["https://orcid.org/0000-0001-5655-3374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han Si","raw_affiliation_strings":["2MedImmune, Gaithersburg, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MedImmune, Gaithersburg, MD;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025877720","display_name":"Anthony D. Saleh","orcid":"https://orcid.org/0009-0004-1141-9576","observed_orcids":["https://orcid.org/0009-0004-1141-9576"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Saleh","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079978766","display_name":"Wenming Xiao","orcid":"https://orcid.org/0000-0003-4096-9724","observed_orcids":["https://orcid.org/0000-0003-4096-9724"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenming Xiao","raw_affiliation_strings":["3U.S. Food and Drug Administration, Jefferson, AR;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3U.S. Food and Drug Administration, Jefferson, AR;","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024223068","display_name":"Jamie F. Coupar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Coupar","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011138786","display_name":"Susanne M. Gollin","orcid":"https://orcid.org/0000-0001-5438-6808","observed_orcids":["https://orcid.org/0000-0001-5438-6808"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne M. Gollin","raw_affiliation_strings":["4University of Pittsburgh, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University of Pittsburgh, Pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086074491","display_name":"Robert Louis Ferris","orcid":"https://orcid.org/0000-0001-6605-2071","observed_orcids":["https://orcid.org/0000-0001-6605-2071"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Ferris","raw_affiliation_strings":["5University of Pittsburgh Cancer Institute, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5University of Pittsburgh Cancer Institute, Pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000300151","display_name":"Natalia Issaeva","orcid":"https://orcid.org/0000-0001-5483-6610","observed_orcids":["https://orcid.org/0000-0001-5483-6610"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Issaeva","raw_affiliation_strings":["6Yale University Medical School, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Yale University Medical School, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001660012","display_name":"Wendell Gray Yarbrough","orcid":"https://orcid.org/0000-0003-0855-6444","observed_orcids":["https://orcid.org/0000-0003-0855-6444"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendell G. Yarbrough","raw_affiliation_strings":["6Yale University Medical School, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Yale University Medical School, New Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039039295","display_name":"Mark E. Prince","orcid":"https://orcid.org/0000-0002-1120-9008","observed_orcids":["https://orcid.org/0000-0002-1120-9008"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Prince","raw_affiliation_strings":["7University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076508788","display_name":"Thomas E. Carey","orcid":"https://orcid.org/0000-0002-5202-7518","observed_orcids":["https://orcid.org/0000-0002-5202-7518"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Carey","raw_affiliation_strings":["7University of Michigan, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7University of Michigan, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067960602","display_name":"Carter Van Waes","orcid":"https://orcid.org/0000-0002-9599-5113","observed_orcids":["https://orcid.org/0000-0002-9599-5113"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carter Van Waes","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100430425","display_name":"Zhong Chen","orcid":"https://orcid.org/0000-0003-2444-8216","observed_orcids":["https://orcid.org/0000-0003-2444-8216"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong Chen","raw_affiliation_strings":["1National Insts. of Health, Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Insts. of Health, Bethesda, MD;","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"13_Supplement","first_page":"5346","last_page":"5346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7739999890327454},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9660000205039978},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5600000023841858},{"id":"https://openalex.org/keywords/hpv-status","display_name":"HPV status","score":0.5690000057220459},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7279999852180481},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6660000085830688},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.5950000286102295},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.5979999899864197},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.906000018119812},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7491309642791748},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6872420907020569},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6567680835723877},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5785242319107056},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5326839089393616},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47918641567230225},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.4473775327205658},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.4389822483062744},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4197448194026947},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4142528474330902},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.41356271505355835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39599883556365967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3021153211593628},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.21209654211997986},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.20296907424926758},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19365110993385315},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.166215181350708},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09888041019439697}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2018-5346","doi":"https://doi.org/10.1158/1538-7445.am2018-5346","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2018-5346","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899200466","https://openalex.org/W2741612900","https://openalex.org/W4298199094","https://openalex.org/W1529436387","https://openalex.org/W2337417322","https://openalex.org/W2057009450","https://openalex.org/W2985613304","https://openalex.org/W1977291985","https://openalex.org/W2771674632","https://openalex.org/W2284185910"],"abstract_inverted_index":{"Abstract":[0],"Human":[1],"cancer":[2,321],"cell":[3,57,204,322],"lines":[4,98,105,323],"have":[5],"been":[6],"important":[7,65,186],"tools":[8],"for":[9,99,237,336],"biological":[10],"and":[11,14,21,30,41,50,54,92,114,129,138,162,175,179,184,189,212,218,228,233,240,313,319,324],"preclinical":[12,239],"investigation,":[13],"establishing":[15],"their":[16],"relationship":[17],"to":[18,61,83],"genomic":[19,40,148,220,307],"alterations":[20,87,149,221,309],"subtypes":[22,67],"found":[23,150],"in":[24,96,151,165,191,194,243,317],"tumors":[25,72,325],"could":[26],"further":[27],"accelerate":[28],"functional":[29],"therapeutic":[31,241],"discoveries.":[32],"We":[33,79],"conducted":[34],"an":[35],"integrated":[36],"analysis":[37],"of":[38,44,64,120,123,142,245,263,332],"the":[39,260,264,311,333],"transcriptomic":[42],"profiles":[43],"15":[45],"human":[46],"papillomavirus":[47],"negative":[48],"(HPV\u2212)":[49],"11":[51],"HPV(+)":[52],"head":[53,318],"neck":[55,320],"squamous":[56],"carcinoma":[58],"(HNSCC)":[59],"lines,":[60,232],"identify":[62],"models":[63,236],"molecular":[66],"uncovered":[68],"among":[69],"279":[70],"HNSCC":[71,97,104,154,231],"from":[73],"The":[74],"Cancer":[75,337,350],"Genome":[76],"Atlas":[77],"(TCGA).":[78],"developed":[80],"analytic":[81],"approaches":[82],"detect":[84],"copy":[85,308],"number":[86],"(CNAs)":[88],"driving":[89],"altered":[90],"expression":[91,119],"predict":[93],"deleterious":[94],"mutations":[95,141,180],"comparison":[100],"with":[101,136,170,226,247,326],"TCGA.":[102],"Strikingly,":[103],"displayed":[106],"recurrent":[107],"amplifications":[108],"on":[109,182],"chromosomes":[110],"3q22-29,":[111],"5p15,":[112],"11q13/22,":[113],"8p11":[115],"that":[116],"drive":[117],"increased":[118],"a":[121],"cluster":[122],"~100":[124],"mRNAs":[125],"encoding":[126],"multiple":[127],"known":[128],"understudied":[130],"candidate":[131],"oncogenes.":[132],"These":[133],"CNAs,":[134,177],"together":[135],"loss":[137],"under-expression":[139],"or":[140],"putative":[143],"tumor":[144,155],"suppressor":[145],"genes,":[146],"recapitulate":[147],"more":[152],"aggressive":[153],"subtypes.":[156],"Among":[157],"these,":[158],"concurrent":[159],"3q26.3":[160],"amplification":[161],"TP53":[163],"mutation":[164],"HPV(\u2212)":[166],"HNSCCs":[167,192,246],"is":[168],"associated":[169],"worse":[171,248,327],"overall":[172],"survival.":[173],"Common":[174],"distinctive":[176],"transcriptome,":[178],"converge":[181],"biologically":[183],"therapeutically":[185],"signal":[187],"pathways":[188],"functions":[190],"differing":[193],"HPV":[195],"status,":[196],"including":[197],"PI3K,":[198],"Hippo,":[199],"TGF-\u03b2,":[200],"Wnt/\u03b2-catenin,":[201],"TP63,":[202],"TP53/death,":[203],"cycle/mitosis,":[205],"stemness/differentiation,":[206],"chromatin":[207],"remodelling/DNA":[208],"replication,":[209],"post-transcriptional":[210],"regulation,":[211],"mitochondrial":[213],"biosynthesis.":[214],"Our":[215],"findings":[216],"elucidate":[217],"validate":[219],"underpinning":[222],"numerous":[223],"discoveries":[224],"made":[225],"historic":[227],"recently":[229],"derived":[230],"provide":[234],"valuable":[235],"future":[238],"studies":[242],"subsets":[244],"prognosis.":[249],"Supported":[250],"by":[251],"NIDCD/NIH":[252],"intramural":[253],"projects":[254],"ZIA-DC-000073,":[255],"ZIA-DC-000074.":[256],"This":[257],"work":[258],"utilized":[259],"computational":[261],"resources":[262],"NIH":[265],"HPC":[266],"Biowulf":[267],"cluster.":[268],"(http://hpc.nih.gov)":[269],"Citation":[270],"Format:":[271],"Hui":[272],"Cheng,":[273],"Xinping":[274],"Yang,":[275],"Han":[276],"Si,":[277],"Anthony":[278],"Saleh,":[279],"Wenming":[280],"Xiao,":[281],"Jamie":[282],"Coupar,":[283],"Susanne":[284],"M.":[285],"Gollin,":[286],"Robert":[287],"L.":[288],"Ferris,":[289],"Natalia":[290],"Issaeva,":[291],"Wendell":[292],"G.":[293],"Yarbrough,":[294],"Mark":[295],"E.":[296,299],"Prince,":[297],"Thomas":[298],"Carey,":[300],"Carter":[301],"Van":[302],"Waes,":[303],"Zhong":[304],"Chen.":[305],"Recurrent":[306],"deregulate":[310],"transcriptome":[312],"key":[314],"signaling":[315],"networks":[316],"prognosis":[328],"[abstract].":[329],"In:":[330],"Proceedings":[331],"American":[334],"Association":[335],"Research":[338],"Annual":[339],"Meeting":[340],"2018;":[341],"2018":[342],"Apr":[343],"14-18;":[344],"Chicago,":[345],"IL.":[346],"Philadelphia":[347],"(PA):":[348],"AACR;":[349],"Res":[351],"2018;78(13":[352],"Suppl):Abstract":[353],"nr":[354],"5346.":[355]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-07-19T00:00:00"}
