{"id":"https://openalex.org/W2811504268","doi":"https://doi.org/10.4088/jcp.17m11741","title":"Efficacy of Tianeptine 25\u201350 mg in Elderly Patients With Recurrent Major Depressive Disorder: An 8-Week Placebo- and Escitalopram-Controlled Study","display_name":"Efficacy of Tianeptine 25\u201350 mg in Elderly Patients With Recurrent Major Depressive Disorder: An 8-Week Placebo- and Escitalopram-Controlled Study","publication_year":2018,"publication_date":"2018-06-29","ids":{"openalex":"https://openalex.org/W2811504268","doi":"https://doi.org/10.4088/jcp.17m11741","mag":"2811504268","pmid":"https://pubmed.ncbi.nlm.nih.gov/29995359"},"language":"en","primary_location":{"id":"doi:10.4088/jcp.17m11741","doi":"https://doi.org/10.4088/jcp.17m11741","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.17m11741","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012421719","display_name":"Robin Alexander Emsley","orcid":"https://orcid.org/0000-0003-1250-6888","observed_orcids":["https://orcid.org/0000-0003-1250-6888"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Robin Emsley","raw_affiliation_strings":["Department of Psychiatry, Faculty of Medicine and Health Sciences, University of Stellenbosch, Clinical Bldg Fransie van Zyl Ave, Parow, Cape Town 8000 South Africa. rae@sun.ac.za","Department of Psychiatry, Faculty of Medicine and Health Sciences, University of Stellenbosch, Parow, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Faculty of Medicine and Health Sciences, University of Stellenbosch, Clinical Bldg Fransie van Zyl Ave, Parow, Cape Town 8000 South Africa. rae@sun.ac.za","institution_ids":["https://openalex.org/I26092322"]},{"raw_affiliation_string":"Department of Psychiatry, Faculty of Medicine and Health Sciences, University of Stellenbosch, Parow, Cape Town, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054514237","display_name":"Antti Ahokas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antti Ahokas","raw_affiliation_strings":["Mehil\u00e4inen Clinic, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mehil\u00e4inen Clinic, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aldo Suarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aldo Suarez","raw_affiliation_strings":["Estimulaci\u00f3n Magn\u00e9tica Transcraneal de M\u00e9xico S.C., Mexico City, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estimulaci\u00f3n Magn\u00e9tica Transcraneal de M\u00e9xico S.C., Mexico City, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112859519","display_name":"Drago\u0219 Marinescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dragos Marinescu","raw_affiliation_strings":["Clinica de Psihiatrie 1, Spitalul Clinic de Neuropsihiatrie, Craiova, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica de Psihiatrie 1, Spitalul Clinic de Neuropsihiatrie, Craiova, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020106582","display_name":"Ivan D\u00f3ci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109189","display_name":"Univerzitn\u00e1 Nemocnica Louisa Pasteura","ror":"https://ror.org/01rb2st83","country_code":"SK","type":"healthcare","lineage":["https://openalex.org/I4210109189"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Ivan D\u00f3ci","raw_affiliation_strings":["II. Psychiatrick\u00e1 Klinika Lek\u00e1rskej Fakulty UPJ\u0160 a Univerzitnej Nemocnice L. Pasteura, Ko\u0161ice, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"II. Psychiatrick\u00e1 Klinika Lek\u00e1rskej Fakulty UPJ\u0160 a Univerzitnej Nemocnice L. Pasteura, Ko\u0161ice, Slovakia","institution_ids":["https://openalex.org/I4210109189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038477509","display_name":"Andres Lehtmets","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andres Lehtmets","raw_affiliation_strings":["West-Tallinn Central Hospital Centre of Psychiatry, Tallinn, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West-Tallinn Central Hospital Centre of Psychiatry, Tallinn, Estonia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006825903","display_name":"Vihra Krumova Milanova","orcid":"https://orcid.org/0000-0002-6939-9107","observed_orcids":["https://orcid.org/0000-0002-6939-9107"]},"institutions":[{"id":"https://openalex.org/I2799356449","display_name":"Alexandrovska Hospital","ror":"https://ror.org/04b8y3f13","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I2799356449"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Vihra Milanova","raw_affiliation_strings":["Clinic of Psychiatry, University Hospital \"Alexandrovska,\" Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Psychiatry, University Hospital \"Alexandrovska,\" Sofia, Bulgaria","institution_ids":["https://openalex.org/I2799356449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109463133","display_name":"Min Soo Lee","orcid":"https://orcid.org/0009-0009-4915-1663","observed_orcids":["https://orcid.org/0009-0009-4915-1663"]},"institutions":[{"id":"https://openalex.org/I4405260934","display_name":"Korea University Anam Hospital","ror":"https://ror.org/04gjj3027","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405260934"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Soo Lee","raw_affiliation_strings":["Department of Psychiatry, Korea University Anam Hospital, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Korea University Anam Hospital, Seoul, Korea","institution_ids":["https://openalex.org/I4405260934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005399554","display_name":"Roy Didi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287167","display_name":"Centre Hospitalier La Chartreuse","ror":"https://ror.org/04a0jg243","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4405287167"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roy Didi","raw_affiliation_strings":["Psychiatrie G\u00e9n\u00e9rale Secteur, CHS La Chartreuse, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatrie G\u00e9n\u00e9rale Secteur, CHS La Chartreuse, Dijon, France","institution_ids":["https://openalex.org/I4405287167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018521649","display_name":"Aleksander Stanis\u0142aw Araszkiewicz","orcid":"https://orcid.org/0000-0003-4324-4112","observed_orcids":["https://orcid.org/0000-0003-4324-4112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksander Araszkiewicz","raw_affiliation_strings":["NZOZ Centrum Kultury, Higieny i Zdrowia Psychicznego, Bydgoszcz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NZOZ Centrum Kultury, Higieny i Zdrowia Psychicznego, Bydgoszcz, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058716290","display_name":"Ahmad Hatim Sulaiman","orcid":"https://orcid.org/0000-0002-8364-4594","observed_orcids":["https://orcid.org/0000-0002-8364-4594"]},"institutions":[{"id":"https://openalex.org/I1296788130","display_name":"University Malaya Medical Centre","ror":"https://ror.org/00vkrxq08","country_code":"MY","type":"healthcare","lineage":["https://openalex.org/I1296788130"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ahmad Hatim Sulaiman","raw_affiliation_strings":["Department of Psychological Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I1296788130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074212798","display_name":"Fran\u00e7oise Picarel-Blanchot","orcid":"https://orcid.org/0000-0001-8232-0793","observed_orcids":["https://orcid.org/0000-0001-8232-0793"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Picarel Blanchot","raw_affiliation_strings":["Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032044129","display_name":"V\u00e9ronique Crutel","orcid":"https://orcid.org/0000-0003-0261-0999","observed_orcids":["https://orcid.org/0000-0003-0261-0999"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Strijckmans Crutel","raw_affiliation_strings":["Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017672352","display_name":"Catherine Antoine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Antoine","raw_affiliation_strings":["Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033440471","display_name":"Pierre\u2010Fran\u00e7ois P\u00e9n\u00e9laud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Fran\u00e7ois Penelaud","raw_affiliation_strings":["Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012421719"],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":null,"apc_paid":null,"fwci":0.5885,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.61952206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"79","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tianeptine","display_name":"tianeptine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recurrent-major-depressive-disorder","display_name":"recurrent major depressive disorder","score":0.8519999980926514},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9800000190734863},{"id":"https://openalex.org/keywords/escitalopram","display_name":"escitalopram","score":0.9750000238418579},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/antidepressant-safety","display_name":"antidepressant safety","score":0.7229999899864197},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hamilton-depression-rating-scale","display_name":"Hamilton Depression Rating Scale","score":0.7160000205039978},{"id":"https://openalex.org/keywords/clinical-global-impression-scale","display_name":"Clinical Global Impression Scale","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.44200000166893005},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/geriatric-depression","display_name":"geriatric depression","score":0.656000018119812},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2776903192","wikidata":"https://www.wikidata.org/wiki/Q424260","display_name":"Tianeptine","level":4,"score":0.9765596389770508},{"id":"https://openalex.org/C2779583969","wikidata":"https://www.wikidata.org/wiki/Q423757","display_name":"Escitalopram","level":4,"score":0.9164882898330688},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.820890486240387},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6206372976303101},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5069608688354492},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4857485890388489},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.4660310447216034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4591142535209656},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.4562346935272217},{"id":"https://openalex.org/C2781210005","wikidata":"https://www.wikidata.org/wiki/Q6738337","display_name":"Major depressive episode","level":3,"score":0.41926151514053345},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4012198746204376},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.33068859577178955},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.11933177709579468},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013841","descriptor_name":"Thiazepines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013841","descriptor_name":"Thiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018687","descriptor_name":"Antidepressive Agents, Second-Generation","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4088/jcp.17m11741","doi":"https://doi.org/10.4088/jcp.17m11741","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.17m11741","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},{"id":"pmid:29995359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29995359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418338561","https://openalex.org/W2353192764","https://openalex.org/W1966280648","https://openalex.org/W1981094134","https://openalex.org/W2464252998","https://openalex.org/W2024870504","https://openalex.org/W2397639262","https://openalex.org/W2354861794","https://openalex.org/W1991525961","https://openalex.org/W2130453308"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,99,185,266],"present":[2,267],"placebo-controlled":[3],"study":[4,268],"evaluated":[5,119],"the":[6,104,121,178,228,247,250],"efficacy":[7],"and":[8,151,206,283],"safety":[9],"of":[10,13,52,57,127,140,196,237,249],"8":[11,97,136],"weeks":[12],"treatment":[14,154,275],"with":[15,48,227,257,277],"tianeptine":[16,83,278],"25-50":[17,279],"mg/d":[18,33],"in":[19,64,68,125,261,286],"elderly":[20],"patients":[21,288],"suffering":[22],"from":[23,71,130,263],"major":[24],"depressive":[25,116],"disorder":[26],"(MDD)":[27],"according":[28],"to":[29,54,74,81,134,153,201,217],"DSM-IV-TR.":[30],"Escitalopram":[31],"5-10":[32],"was":[34,103,189,254],"used":[35],"as":[36,118],"an":[37,273],"active":[38,229],"comparator.":[39],"METHODS:":[40],"Elderly":[41],"outpatients":[42],"aged":[43,289],"at":[44],"least":[45],"65":[46,290],"years":[47,291],"a":[49,148,171],"primary":[50,100],"diagnosis":[51],"moderate":[53],"severe":[55],"episode":[56],"recurrent":[58],"MDD":[59],"were":[60,78,224],"recruited":[61],"by":[62,120],"psychiatrists":[63],"44":[65],"clinical":[66],"centers":[67],"10":[69],"countries":[70],"October":[72],"2013":[73],"January":[75],"2016.":[76],"Patients":[77],"randomly":[79],"assigned":[80],"receive":[82],"(n":[84,88,93],"=":[85,89,94,161,165],"105),":[86],"placebo":[87],"107),":[90],"or":[91,292],"escitalopram":[92,231],"99)":[95],"for":[96,174,192,209],"weeks.":[98],"outcome":[101],"measure":[102],"17-item":[105],"Hamilton":[106],"Depression":[107],"Rating":[108],"Scale":[109],"(HDRS\u2081\u2087)":[110],"total":[111,123,183,233],"score.":[112],"RESULTS:":[113],"Tianeptine":[114,253],"improved":[115],"symptoms,":[117],"HDRS\u2081\u2087":[122],"score":[124,234],"terms":[126],"absolute":[128],"change":[129],"baseline":[131],"(week":[132],"0)":[133],"week":[135],"(placebo-tianeptine":[137],"difference":[138,187,236],"[SE]":[139,160],"3.84":[141],"[0.85]":[142],"points,":[143,241],"P":[144,164,203,219,242],"<":[145,204,220,243],".001,":[146],"using":[147,170],"last-observation-carried-forward":[149],"approach)":[150],"response":[152],"(tianeptine:":[155],"46.7%;":[156],"placebo:":[157],"34.0%,":[158],"estimate":[159],"12.70%":[162],"[6.70],":[163],".06).":[166],"A":[167],"sensitivity":[168,248],"analysis":[169],"mixed":[172],"model":[173],"repeated":[175],"measures":[176],"confirmed":[177],"main":[179],"results":[180,223],"on":[181],"HDRS":[182],"s\u200bcore.":[184],"placebo-tianeptine":[186],"(SE)":[188],"0.66":[190],"(0.15)":[191],"Clinical":[193,210],"Global":[194,211],"Impressions-Severity":[195],"Illness":[197],"(95%":[198,214],"CI,":[199,215],"0.37":[200],"0.96;":[202],".001)":[205],"0.57":[207],"(0.14)":[208],"Impressions-":[212],"Improvement":[213],"0.30":[216],"0.83;":[218],".001).":[221],"Positive":[222],"also":[225],"obtained":[226],"control":[230],"(HDRS\u2081\u2087":[232],"placebo-escitalopram":[235],"4.09":[238],"\u00b1":[239],"0.86":[240],".001),":[244],"therefore":[245],"validating":[246],"studied":[251],"population.":[252],"well":[255,284],"tolerated,":[256],"only":[258],"minimal":[259],"differences":[260],"tolerability":[262],"placebo.":[264],"CONCLUSIONS:":[265],"provides":[269],"robust":[270],"evidence":[271],"that":[272],"8-week":[274],"period":[276],"mg":[280],"is":[281],"efficacious":[282],"tolerated":[285],"depressed":[287],"older.":[293],"TRIAL":[294],"REGISTRATION:":[295],"EudraCT":[296],"identifier:":[297],"2012-005612-26\u200b.":[298]},"counts_by_year":[{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-07-10T00:00:00"}