{"id":"https://openalex.org/W2811441998","doi":"https://doi.org/10.1051/jbio/2018015","title":"Approches haut d\u00e9bit pour l\u2019\u00e9tude des s\u00e9quences cis-r\u00e9gulatrices","display_name":"Approches haut d\u00e9bit pour l\u2019\u00e9tude des s\u00e9quences cis-r\u00e9gulatrices","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2811441998","doi":"https://doi.org/10.1051/jbio/2018015","mag":"2811441998","pmid":"https://pubmed.ncbi.nlm.nih.gov/29956654"},"language":"fr","primary_location":{"id":"doi:10.1051/jbio/2018015","doi":"https://doi.org/10.1051/jbio/2018015","is_oa":false,"landing_page_url":"https://doi.org/10.1051/jbio/2018015","pdf_url":null,"source":{"id":"https://openalex.org/S179448173","display_name":"Biologie Aujourd hui","issn_l":"2105-0678","issn":["2105-0678","2105-0686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologie Aujourd'hui","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biologie-journal.org/10.1051/jbio/2018015/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034676253","display_name":"Alexandre P. Espa\u00f1a","orcid":"https://orcid.org/0000-0003-2021-9950","observed_orcids":["https://orcid.org/0000-0003-2021-9950"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre P. Espa\u00f1a","raw_affiliation_strings":["Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025574366","display_name":"David Santiago\u2010Algarra","orcid":"https://orcid.org/0000-0003-4697-7047","observed_orcids":["https://orcid.org/0000-0003-4697-7047"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Santiago-Algarra","raw_affiliation_strings":["Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053206145","display_name":"Lydie C. Pradel","orcid":"https://orcid.org/0000-0001-6385-5127","observed_orcids":["https://orcid.org/0000-0001-6385-5127"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lydie Pradel","raw_affiliation_strings":["Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091488339","display_name":"Salvatore Spicuglia","orcid":"https://orcid.org/0000-0002-8101-7108","observed_orcids":["https://orcid.org/0000-0002-8101-7108"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210112918","display_name":"Theories and Approaches of Genomic Complexity","ror":"https://ror.org/025sfbe73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Salvatore Spicuglia","raw_affiliation_strings":["Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France - \u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, INSERM, TAGC, UMR 1090, 13288 Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767","https://openalex.org/I4210112918"]},{"raw_affiliation_string":"\u00c9quipe Labellis\u00e9e Ligue Contre le Cancer, Laboratoire TAGC, INSERM U1090, Aix-Marseille Universit\u00e9, Parc Scientifique de Luminy, 163 avenue de Luminy, 13288 Marseille Cedex 09, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1948,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.49373972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"211","issue":"4","first_page":"271","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cis-regulatory-sequences","display_name":"cis-regulatory sequences","score":0.8730000257492065},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/reporter-gene-assay","display_name":"reporter gene assay","score":0.6740000247955322},{"id":"https://openalex.org/keywords/enhancer-mutations","display_name":"enhancer mutations","score":0.625},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.713360071182251},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49838709831237793},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42728447914123535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42247068881988525},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.30292025208473206},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.22280019521713257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16797158122062683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10198205709457397},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1051/jbio/2018015","doi":"https://doi.org/10.1051/jbio/2018015","is_oa":false,"landing_page_url":"https://doi.org/10.1051/jbio/2018015","pdf_url":null,"source":{"id":"https://openalex.org/S179448173","display_name":"Biologie Aujourd hui","issn_l":"2105-0678","issn":["2105-0678","2105-0686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologie Aujourd'hui","raw_type":"journal-article"},{"id":"pmid:29956654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29956654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologie aujourd'hui","raw_type":"Journal Article"},{"id":"pmh:oai:edpsciences.org:dkey/10.1051/jbio/2018015","doi":null,"is_oa":true,"landing_page_url":"https://www.biologie-journal.org/10.1051/jbio/2018015/pdf","pdf_url":"https://www.biologie-journal.org/10.1051/jbio/2018015/pdf","source":{"id":"https://openalex.org/S4306400744","display_name":"Springer Link (Chiba Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8488066","host_organization_name":"Chiba Institute of Technology","host_organization_lineage":["https://openalex.org/I8488066"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1051/jbio/2018015","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:edpsciences.org:dkey/10.1051/jbio/2018015","doi":null,"is_oa":true,"landing_page_url":"https://www.biologie-journal.org/10.1051/jbio/2018015/pdf","pdf_url":"https://www.biologie-journal.org/10.1051/jbio/2018015/pdf","source":{"id":"https://openalex.org/S4306400744","display_name":"Springer Link (Chiba Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8488066","host_organization_name":"Chiba Institute of Technology","host_organization_lineage":["https://openalex.org/I8488066"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1051/jbio/2018015","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2811441998.pdf","grobid_xml":"https://content.openalex.org/works/W2811441998.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W587085329","https://openalex.org/W622583719","https://openalex.org/W655818288","https://openalex.org/W655820313","https://openalex.org/W1501807279","https://openalex.org/W1721542075","https://openalex.org/W1855348513","https://openalex.org/W1988760117","https://openalex.org/W1989004527","https://openalex.org/W2001528153","https://openalex.org/W2007694108","https://openalex.org/W2008047506","https://openalex.org/W2011202006","https://openalex.org/W2023386301","https://openalex.org/W2025127209","https://openalex.org/W2029492292","https://openalex.org/W2029949273","https://openalex.org/W2077874719","https://openalex.org/W2091533196","https://openalex.org/W2091688007","https://openalex.org/W2096261947","https://openalex.org/W2107596936","https://openalex.org/W2107866789","https://openalex.org/W2118646732","https://openalex.org/W2132366130","https://openalex.org/W2133727333","https://openalex.org/W2159664283","https://openalex.org/W2161671616","https://openalex.org/W2170739826","https://openalex.org/W2174466696","https://openalex.org/W2254864826","https://openalex.org/W2270544154","https://openalex.org/W2272131637","https://openalex.org/W2344602241","https://openalex.org/W2412481123","https://openalex.org/W2413629639","https://openalex.org/W2424483111","https://openalex.org/W2524507363","https://openalex.org/W2529467427","https://openalex.org/W2540381357","https://openalex.org/W2553600202","https://openalex.org/W2566468970","https://openalex.org/W2581818460","https://openalex.org/W2604130415","https://openalex.org/W2606434976","https://openalex.org/W2606796272","https://openalex.org/W2618105201","https://openalex.org/W2621774891","https://openalex.org/W2725576187","https://openalex.org/W2761527879","https://openalex.org/W2769418303","https://openalex.org/W2772841828","https://openalex.org/W2787240693","https://openalex.org/W2801850745","https://openalex.org/W2903823332","https://openalex.org/W7073543238"],"related_works":["https://openalex.org/W6940772531","https://openalex.org/W2628869990","https://openalex.org/W2588686165","https://openalex.org/W2016015848","https://openalex.org/W6926630796","https://openalex.org/W7147194174","https://openalex.org/W1987645791","https://openalex.org/W6987327609","https://openalex.org/W7147016381","https://openalex.org/W2475217470"],"abstract_inverted_index":{"La":[0],"r\u00e9gulation":[1,136,145],"de":[2,25,55,62,85,96,120,130,133,135],"la":[3,26,49,121,128,144],"transcription":[4,27],"des":[5,80,89,92,123,140],"g\u00e8nes":[6],"chez":[7],"les":[8,38,75],"eucaryotes":[9],"sup\u00e9rieurs":[10],"implique":[11],"l\u2019action":[12],"d\u2019\u00e9l\u00e9ments":[13],"r\u00e9gulateurs":[14],"proximaux":[15],"(promoteurs)":[16],"ou":[17,20],"distaux":[18],"(amplificateurs":[19],"enhancers)":[21],"du":[22],"site":[23],"d\u2019initiation":[24],"(Transcription":[28],"Start":[29],"Site,":[30],"TSS).":[31],"Il":[32],"est":[33],"aujourd\u2019hui":[34],"bien":[35],"connu":[36],"que":[37],"\u00e9l\u00e9ments":[39,57],"enhancers":[40,90,124,141],"jouent":[41],"un":[42],"r\u00f4le":[43],"essentiel":[44],"dans":[45],"le":[46,107],"d\u00e9veloppement":[47],"et":[48,73,137],"diff\u00e9renciation":[50],"cellulaire.":[51],"Les":[52],"alt\u00e9rations":[53],"g\u00e9n\u00e9tiques":[54],"ces":[56,113],"sont":[58],"une":[59,117],"cause":[60],"majeure":[61],"pathologies":[63],"humaines.":[64],"De":[65],"nombreuses":[66],"strat\u00e9gies":[67],"ont":[68],"\u00e9t\u00e9":[69],"d\u00e9velopp\u00e9es":[70],"pour":[71,83],"identifier":[72],"caract\u00e9riser":[74],"enhancers.":[76],"Ici,":[77],"nous":[78],"discutons":[79],"progr\u00e8s":[81],"r\u00e9cents":[82],"\u00e9valuer":[84],"fa\u00e7on":[86],"syst\u00e9matique":[87],"l\u2019activit\u00e9":[88],"allant":[91],"approches":[93,114],"haut":[94],"d\u00e9bit":[95],"type":[97],"\u00ab":[98],"g\u00e8ne":[99],"rapporteur":[100],"\u00bb":[101],"aux":[102],"r\u00e9centes":[103],"technologies":[104],"bas\u00e9es":[105],"sur":[106],"syst\u00e8me":[108],"CRISPR/Cas9.":[109],"Nous":[110],"soulignons":[111],"comment":[112,138],"contribuent":[115],"\u00e0":[116,127],"meilleure":[118],"compr\u00e9hension":[119],"fonction":[122],"en":[125],"conduisant":[126],"d\u00e9couverte":[129],"nouveaux":[131],"types":[132],"s\u00e9quences":[134],"l\u2019alt\u00e9ration":[139],"peut":[142],"affecter":[143],"transcriptionnelle.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}