{"id":"https://openalex.org/W2811404035","doi":"https://doi.org/10.1530/erc-18-0115","title":"A unique model for SDH-deficient GIST: an endocrine-related cancer","display_name":"A unique model for SDH-deficient GIST: an endocrine-related cancer","publication_year":2018,"publication_date":"2018-07-02","ids":{"openalex":"https://openalex.org/W2811404035","doi":"https://doi.org/10.1530/erc-18-0115","mag":"2811404035","pmid":"https://pubmed.ncbi.nlm.nih.gov/29967109","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6097913"},"language":"en","primary_location":{"id":"doi:10.1530/erc-18-0115","doi":"https://doi.org/10.1530/erc-18-0115","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-18-0115","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/25/11/ERC-18-0115.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/25/11/ERC-18-0115.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073535028","display_name":"James F. Powers","orcid":"https://orcid.org/0000-0001-8422-3938","observed_orcids":["https://orcid.org/0000-0001-8422-3938"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James F Powers","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043413337","display_name":"Brent Cochran","orcid":"https://orcid.org/0000-0002-7598-5604","observed_orcids":["https://orcid.org/0000-0002-7598-5604"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent Cochran","raw_affiliation_strings":["Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue,, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue,, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070294838","display_name":"James Baleja","orcid":"https://orcid.org/0000-0003-4841-0247","observed_orcids":["https://orcid.org/0000-0003-4841-0247"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D Baleja","raw_affiliation_strings":["Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue,, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue,, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049698973","display_name":"Hadley D. Sikes","orcid":"https://orcid.org/0000-0002-7096-138X","observed_orcids":["https://orcid.org/0000-0002-7096-138X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hadley D Sikes","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445868","display_name":"Xue Zhang","orcid":"https://orcid.org/0000-0003-0940-037X","observed_orcids":["https://orcid.org/0000-0003-0940-037X","https://orcid.org/0000-0002-9015-0517"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Zhang","raw_affiliation_strings":["Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue,, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue,, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112555669","display_name":"Inna Lomakin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inna Lomakin","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068981328","display_name":"Troy F. Langford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy Langford","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075900136","display_name":"Kassi Taylor Stein","orcid":"https://orcid.org/0000-0002-1033-2899","observed_orcids":["https://orcid.org/0000-0002-1033-2899"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kassi Taylor Stein","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009606299","display_name":"Arthur S. Tischler","orcid":"https://orcid.org/0000-0002-9726-5739","observed_orcids":["https://orcid.org/0000-0002-9726-5739"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur S Tischler","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Box 802, Boston, Massachusetts 02111, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073535028"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"],"apc_list":null,"apc_paid":null,"fwci":3.0972,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91176114,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"11","first_page":"943","last_page":"954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/succinate-dehydrogenase-deficiency","display_name":"succinate dehydrogenase deficiency","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/paraganglioma","display_name":"paraganglioma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9089999794960022},{"id":"https://openalex.org/keywords/kras-g12d-mutation","display_name":"KRAS G12D mutation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hypoxia-signaling","display_name":"hypoxia signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7450000047683716},{"id":"https://openalex.org/keywords/autophagic-cell-death","display_name":"autophagic cell death","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-oxygenation","display_name":"tumor oxygenation","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2780744430","wikidata":"https://www.wikidata.org/wiki/Q14916125","display_name":"SDHB","level":5,"score":0.8283055424690247},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6864318251609802},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5856978297233582},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.5663872361183167},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4948243498802185},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4850570261478424},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4696865379810333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46912145614624023},{"id":"https://openalex.org/C2776734335","wikidata":"https://www.wikidata.org/wiki/Q581592","display_name":"Paraganglioma","level":2,"score":0.4639351963996887},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4633188247680664},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4191979169845581},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.33253243565559387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3053399920463562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2119951844215393},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20493683218955994},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.12322542071342468},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12261119484901428},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004701","descriptor_name":"Endocrine Gland Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004701","descriptor_name":"Endocrine Gland Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046152","descriptor_name":"Gastrointestinal Stromal Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1530/erc-18-0115","doi":"https://doi.org/10.1530/erc-18-0115","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-18-0115","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/25/11/ERC-18-0115.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},{"id":"pmid:29967109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29967109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-related cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5784140","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6097913","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6097913","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6097913","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Endocr Relat Cancer","raw_type":"Text"},{"id":"pmh:oai:dspace.mit.edu:1721.1/126194","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/126194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1530/erc-18-0115","doi":"https://doi.org/10.1530/erc-18-0115","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-18-0115","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/25/11/ERC-18-0115.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5472179756","display_name":"UPGRADE AND CRYOGENIC PROBE FOR A 600 MHZ NMR SYSTEM FOR BIOMEDICAL RESEARCH","funder_award_id":"1s10od020073-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2811404035.pdf","grobid_xml":"https://content.openalex.org/works/W2811404035.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W122110278","https://openalex.org/W1523693806","https://openalex.org/W1673653576","https://openalex.org/W1757334295","https://openalex.org/W1970101770","https://openalex.org/W1975984844","https://openalex.org/W1978631832","https://openalex.org/W1982640657","https://openalex.org/W1991952977","https://openalex.org/W2002836865","https://openalex.org/W2003670869","https://openalex.org/W2010023860","https://openalex.org/W2019411591","https://openalex.org/W2028664756","https://openalex.org/W2031505107","https://openalex.org/W2041489973","https://openalex.org/W2047841290","https://openalex.org/W2051902906","https://openalex.org/W2053385401","https://openalex.org/W2058311275","https://openalex.org/W2061662711","https://openalex.org/W2063960199","https://openalex.org/W2067596492","https://openalex.org/W2068542211","https://openalex.org/W2074888939","https://openalex.org/W2078377639","https://openalex.org/W2080333427","https://openalex.org/W2083954708","https://openalex.org/W2085696636","https://openalex.org/W2088590107","https://openalex.org/W2091755560","https://openalex.org/W2093711185","https://openalex.org/W2094964407","https://openalex.org/W2112521850","https://openalex.org/W2114104545","https://openalex.org/W2128016549","https://openalex.org/W2129273005","https://openalex.org/W2131271579","https://openalex.org/W2138207763","https://openalex.org/W2140729960","https://openalex.org/W2152877666","https://openalex.org/W2155317003","https://openalex.org/W2165575701","https://openalex.org/W2203317814","https://openalex.org/W2308064764","https://openalex.org/W2337267398","https://openalex.org/W2413625595","https://openalex.org/W2472987213","https://openalex.org/W2518439446","https://openalex.org/W2588657480","https://openalex.org/W2604757061","https://openalex.org/W2624447764","https://openalex.org/W2762670382","https://openalex.org/W2778954596","https://openalex.org/W2949425085"],"related_works":["https://openalex.org/W2126111386","https://openalex.org/W2068281867","https://openalex.org/W2327280362","https://openalex.org/W6910795582","https://openalex.org/W3014323273","https://openalex.org/W2990401818","https://openalex.org/W3193537697","https://openalex.org/W4214713665","https://openalex.org/W3134402725","https://openalex.org/W2128518955"],"abstract_inverted_index":{"We":[0],"describe":[1],"a":[2,19,67,99,149,178,200,230,240],"unique":[3],"patient-derived":[4],"xenograft":[5],"(PDX)":[6],"and":[7,32,64,72,98,113,125,165,175],"cell":[8,198,249],"culture":[9],"model":[10,36,144],"of":[11,58,93,131,162,183,189,212,236,243],"succinate":[12],"dehydrogenase-deficient":[13],"gastrointestinal":[14],"stromal":[15],"tumor":[16,22,50,63,132,153,173,197],"(SDH-deficient":[17],"GIST),":[18],"rare":[20,49],"mesenchymal":[21],"that":[23,86,154,172,214,245],"can":[24,155],"occur":[25],"in":[26,30,233],"association":[27],"with":[28,79,206],"paragangliomas":[29,117],"hereditary":[31],"non-hereditary":[33],"syndromes.":[34],"This":[35,142,208],"is":[37,84,145,204,239],"potentially":[38],"important":[39],"for":[40,139],"what":[41],"it":[42],"might":[43,246],"reveal":[44],"specifically":[45],"pertinent":[46],"to":[47,55,109,159],"this":[48],"type":[51,235],"and,":[52],"more":[53],"broadly,":[54],"other":[56],"types":[57],"SDH-deficient":[59,140,237],"tumors.":[60],"The":[61,104],"primary":[62],"xenografts":[65],"show":[66],"very":[68],"high":[69],"proliferative":[70],"fraction,":[71],"distinctive":[73],"morphology":[74],"characterized":[75],"by":[76],"tiny":[77],"cells":[78],"marked":[80],"autophagic":[81,248],"activity.":[82],"It":[83],"likely":[85],"these":[87],"characteristics":[88],"resulted":[89],"from":[90,148],"the":[91,94,146],"combination":[92],"germline":[95],"SDHB":[96,150],"mutation":[97],"somatic":[100],"KRAS":[101],"G12D":[102],"mutation.":[103],"most":[105],"broadly":[106],"relevant":[107],"findings":[108],"date":[110],"concern":[111],"oxygen":[112,163,194],"oxidative":[114,126,190,216],"stress.":[115,191],"In":[116,221],"harboring":[118],"SDH":[119],"x":[120],"mutations,":[121],"both":[122],"hypoxic":[123,184],"signaling":[124,185],"stress":[127,217],"are":[128,136],"putative":[129],"drivers":[130],"growth.":[133],"However,":[134],"there":[135],"no":[137],"models":[138],"paragangliomas.":[141],"related":[143],"first":[147],"-mutated":[151],"human":[152],"be":[156],"experimentally":[157],"manipulated":[158],"study":[160],"mechanisms":[161],"effects":[164,182,188],"novel":[166,219],"treatment":[167],"strategies.":[168],"Our":[169],"data":[170],"suggest":[171],"growth":[174],"survival":[176,202],"require":[177],"balance":[179],"between":[180],"protective":[181],"vs":[186],"deleterious":[187],"While":[192],"reduced":[193],"concentration":[195],"promotes":[196],"survival,":[199],"further":[201],"benefit":[203],"achieved":[205],"antioxidants.":[207],"suggests":[209],"potential":[210,241],"use":[211],"drugs":[213],"increase":[215],"as":[218,229],"therapies.":[220],"addition,":[222],"autophagy,":[223],"which":[224],"has":[225],"not":[226],"been":[227],"reported":[228],"major":[231],"finding":[232],"any":[234],"tumor,":[238],"target":[242],"agents":[244],"trigger":[247],"death.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-07-10T00:00:00"}