{"id":"https://openalex.org/W2811394247","doi":"https://doi.org/10.1111/1750-3841.14112","title":"Uptake and Transport Mechanism of Dihydromyricetin Across Human Intestinal Caco\u20102 Cells","display_name":"Uptake and Transport Mechanism of Dihydromyricetin Across Human Intestinal Caco\u20102 Cells","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W2811394247","doi":"https://doi.org/10.1111/1750-3841.14112","mag":"2811394247","pmid":"https://pubmed.ncbi.nlm.nih.gov/29969512"},"language":"en","primary_location":{"id":"doi:10.1111/1750-3841.14112","doi":"https://doi.org/10.1111/1750-3841.14112","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1750-3841.14112","pdf_url":null,"source":{"id":"https://openalex.org/S23579880","display_name":"Journal of Food Science","issn_l":"0022-1147","issn":["0022-1147","1750-3841"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101474555","display_name":"Dong Xiang","orcid":"https://orcid.org/0000-0001-8989-1476","observed_orcids":["https://orcid.org/0000-0001-8989-1476"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Xiang","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108207451","display_name":"Li Fan","orcid":"https://orcid.org/0000-0001-6044-4138","observed_orcids":["https://orcid.org/0000-0001-6044-4138"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Fan","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111462430","display_name":"Xiaolong Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao\u2010long Hou","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xiong","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chun\u2010yang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun\u2010yang Shi","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367799","display_name":"Wenqing Wang","orcid":"https://orcid.org/0000-0003-0703-9787","observed_orcids":["https://orcid.org/0000-0003-0703-9787"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen\u2010qing Wang","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046429925","display_name":"Jian\u2010guo Fang","orcid":"https://orcid.org/0000-0001-7083-5896","observed_orcids":["https://orcid.org/0000-0001-7083-5896"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian\u2010guo Fang","raw_affiliation_strings":["Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China"],"raw_orcid":"https://orcid.org/0000-0001-7083-5896","affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong Univ. of Science and Technology, Wuhan, 430030 China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046429925"],"corresponding_institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":1.2525,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.82558228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"7","first_page":"1941","last_page":"1947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.18700000643730164,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydromyricetin","display_name":"dihydromyricetin","score":1.0},{"id":"https://openalex.org/keywords/intestinal-absorption","display_name":"intestinal absorption","score":0.9890000224113464},{"id":"https://openalex.org/keywords/passive-diffusion","display_name":"passive diffusion","score":0.746999979019165},{"id":"https://openalex.org/keywords/bidirectional-transport","display_name":"bidirectional transport","score":0.777999997138977},{"id":"https://openalex.org/keywords/ph-dependent-uptake","display_name":"pH-dependent uptake","score":0.5699999928474426},{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.7979999780654907},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9670000076293945},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.921999990940094},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.8328999280929565},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7859957814216614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5162563323974609},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41704052686691284},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35765010118484497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2592281699180603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2341514229774475},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10748636722564697},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08167707920074463},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044948","descriptor_name":"Flavonols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/1750-3841.14112","doi":"https://doi.org/10.1111/1750-3841.14112","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1750-3841.14112","pdf_url":null,"source":{"id":"https://openalex.org/S23579880","display_name":"Journal of Food Science","issn_l":"0022-1147","issn":["0022-1147","1750-3841"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Science","raw_type":"journal-article"},{"id":"pmid:29969512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29969512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of food science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G933658148","display_name":null,"funder_award_id":"81503013","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W427409182","https://openalex.org/W636035323","https://openalex.org/W1556702215","https://openalex.org/W1963799213","https://openalex.org/W1971580443","https://openalex.org/W1981930609","https://openalex.org/W1984399292","https://openalex.org/W1990765461","https://openalex.org/W2019568527","https://openalex.org/W2030691662","https://openalex.org/W2039521152","https://openalex.org/W2043026248","https://openalex.org/W2060480383","https://openalex.org/W2063887815","https://openalex.org/W2079737808","https://openalex.org/W2089865237","https://openalex.org/W2113498855","https://openalex.org/W2123745362","https://openalex.org/W2135194872","https://openalex.org/W2253150229","https://openalex.org/W2398752419","https://openalex.org/W2419389000","https://openalex.org/W2466224136","https://openalex.org/W2467750584","https://openalex.org/W2489350890","https://openalex.org/W2490332851","https://openalex.org/W2515008081","https://openalex.org/W2565481405","https://openalex.org/W2582420401","https://openalex.org/W2620413937"],"related_works":["https://openalex.org/W2743593955","https://openalex.org/W2154627751","https://openalex.org/W7099587465","https://openalex.org/W4299576748","https://openalex.org/W2027033329","https://openalex.org/W2163601154","https://openalex.org/W225177405","https://openalex.org/W2376191745","https://openalex.org/W7117540389","https://openalex.org/W787100497"],"abstract_inverted_index":{"A":[0],"variety":[1],"of":[2,23,29,40,83,137,155,171,198,204],"beneficial":[3],"pharmacological":[4],"activities":[5],"have":[6],"been":[7],"reported":[8],"for":[9,142,217],"dihydromyricetin":[10,156],"(DMY),":[11],"however,":[12],"its":[13,107,185],"oral":[14],"bioavailability":[15],"is":[16],"poor":[17],"and":[18,37,64,81,87,116,126,134,139,152,169,175,189,196,222],"the":[19,35,92,100,123,132,150,194,202,207,210],"intestinal":[20,44],"absorption":[21,203],"profiles":[22],"DMY":[24,41,47,70,84,101,124,138,158,172,181,205,219],"remains":[25],"unknown.":[26],"The":[27,79,167],"aim":[28],"this":[30],"study":[31,148,212],"was":[32,48,71,159],"to":[33,96],"investigate":[34],"uptake":[36,80,125,133,151,168,182,195],"transport":[38,82,127,135,153,170,197],"mechanism":[39],"in":[42,193,206],"human":[43],"Caco-2":[45],"cells.":[46],"detected":[49],"using":[50],"a":[51,75,163],"liquid":[52],"chromatography-tandem":[53],"mass":[54],"spectrometry":[55],"method.":[56],"Several":[57],"factors":[58],"including":[59],"time,":[60],"concentration,":[61],"pH,":[62],"temperature":[63],"efflux":[65],"transporters":[66],"were":[67,85,173,191],"systematically":[68],"evaluated.":[69],"poorly":[72,160],"absorbed":[73,161],"by":[74,162],"passive":[76,164],"diffusion":[77,165],"mechanism.":[78,166],"time":[86,174],"concentration":[88,176],"dependent.":[89,177],"Interestingly,":[90,178],"decreasing":[91],"pH":[93,179],"from":[94],"8.0":[95],"6.0":[97],"markedly":[98],"enhanced":[99],"uptake,":[102],"but":[103,183],"didn't":[104],"significantly":[105],"affect":[106],"bidirectional":[108,186],"transport.":[109,187],"Efflux":[110],"transporters,":[111],"multidrug":[112],"resistance":[113,119],"protein":[114,120],"2":[115],"breast":[117],"cancer":[118],"also":[121],"influenced":[122],"processes.":[128],"This":[129,147],"work":[130],"details":[131],"characteristics":[136,154],"provides":[140],"basis":[141],"future":[143],"study.":[144],"PRACTICAL":[145],"APPLICATION:":[146],"elucidated":[149],"(DMY).":[157],"affected":[180],"not":[184],"MRP2":[188],"BCRP":[190],"involved":[192],"DMY,":[199],"which":[200],"hindered":[201],"intestinal.":[208],"Thus,":[209],"present":[211],"may":[213],"provide":[214],"useful":[215],"information":[216],"designing":[218],"delivery":[220],"systems":[221],"avoiding":[223],"DMY-drug":[224],"interactions.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}