{"id":"https://openalex.org/W2811358158","doi":"https://doi.org/10.1039/c8cc03619e","title":"Translational opportunities for amyloid-targeting fluorophores","display_name":"Translational opportunities for amyloid-targeting fluorophores","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2811358158","doi":"https://doi.org/10.1039/c8cc03619e","mag":"2811358158","pmid":"https://pubmed.ncbi.nlm.nih.gov/29993065"},"language":"en","primary_location":{"id":"doi:10.1039/c8cc03619e","doi":"https://doi.org/10.1039/c8cc03619e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8cc03619e","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014891096","display_name":"Kevin Cao","orcid":"https://orcid.org/0000-0002-0226-7687","observed_orcids":["https://orcid.org/0000-0002-0226-7687"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Cao","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California","La Jolla","USA","Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California","institution_ids":[]},{"raw_affiliation_string":"La Jolla","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047600505","display_name":"Jerry Yang","orcid":"https://orcid.org/0000-0002-8423-7376","observed_orcids":["https://orcid.org/0000-0002-8423-7376","https://orcid.org/0009-0008-6372-2269"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerry Yang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California","La Jolla","USA","Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA"],"raw_orcid":"https://orcid.org/0000-0002-8423-7376","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California","institution_ids":[]},{"raw_affiliation_string":"La Jolla","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047600505"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.559,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.48255149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"54","issue":"66","first_page":"9107","last_page":"9118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-detection","display_name":"amyloid detection","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/presymptomatic-diagnosis","display_name":"presymptomatic diagnosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chemical-probes","display_name":"chemical probes","score":0.675000011920929},{"id":"https://openalex.org/keywords/clinical-diagnostics","display_name":"clinical diagnostics","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.545893132686615},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.5383971333503723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5225265026092529},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.4506722092628479},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4349018931388855},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3769426941871643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19363397359848022},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1708892285823822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14823263883590698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14331841468811035},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07480314373970032},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058227","descriptor_name":"Amyloidogenic Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c8cc03619e","doi":"https://doi.org/10.1039/c8cc03619e","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8cc03619e","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},{"id":"pmid:29993065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29993065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical communications (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W139130877","https://openalex.org/W235668762","https://openalex.org/W1037591319","https://openalex.org/W1532763771","https://openalex.org/W1599382280","https://openalex.org/W1773835491","https://openalex.org/W1813781971","https://openalex.org/W1848883975","https://openalex.org/W1925629371","https://openalex.org/W1964793333","https://openalex.org/W1967823816","https://openalex.org/W1971157165","https://openalex.org/W1971432346","https://openalex.org/W1973659432","https://openalex.org/W1974187431","https://openalex.org/W1977375832","https://openalex.org/W1979801224","https://openalex.org/W1981837445","https://openalex.org/W1982572468","https://openalex.org/W1984336002","https://openalex.org/W1985731048","https://openalex.org/W1986291736","https://openalex.org/W1986905524","https://openalex.org/W1991805750","https://openalex.org/W1996258924","https://openalex.org/W2001447241","https://openalex.org/W2001682320","https://openalex.org/W2001900513","https://openalex.org/W2006173748","https://openalex.org/W2006510253","https://openalex.org/W2007157911","https://openalex.org/W2009604591","https://openalex.org/W2009870816","https://openalex.org/W2010462701","https://openalex.org/W2010751802","https://openalex.org/W2018880174","https://openalex.org/W2020434254","https://openalex.org/W2023035838","https://openalex.org/W2024424098","https://openalex.org/W2027078803","https://openalex.org/W2027356620","https://openalex.org/W2027442107","https://openalex.org/W2028004114","https://openalex.org/W2033356866","https://openalex.org/W2038399240","https://openalex.org/W2039026859","https://openalex.org/W2041530428","https://openalex.org/W2047202120","https://openalex.org/W2048031945","https://openalex.org/W2050454006","https://openalex.org/W2050608687","https://openalex.org/W2051007768","https://openalex.org/W2053041274","https://openalex.org/W2054931962","https://openalex.org/W2057103900","https://openalex.org/W2057349526","https://openalex.org/W2060449610","https://openalex.org/W2066767743","https://openalex.org/W2067574216","https://openalex.org/W2067821383","https://openalex.org/W2070448139","https://openalex.org/W2072805367","https://openalex.org/W2073464277","https://openalex.org/W2075119726","https://openalex.org/W2076467891","https://openalex.org/W2078781576","https://openalex.org/W2080880751","https://openalex.org/W2081407214","https://openalex.org/W2085558649","https://openalex.org/W2091762456","https://openalex.org/W2096089327","https://openalex.org/W2096963202","https://openalex.org/W2097030000","https://openalex.org/W2097259690","https://openalex.org/W2099795098","https://openalex.org/W2103291816","https://openalex.org/W2103440561","https://openalex.org/W2116622558","https://openalex.org/W2117313690","https://openalex.org/W2121050713","https://openalex.org/W2122479346","https://openalex.org/W2127642254","https://openalex.org/W2132154794","https://openalex.org/W2138493935","https://openalex.org/W2141679195","https://openalex.org/W2142337553","https://openalex.org/W2145850622","https://openalex.org/W2146729934","https://openalex.org/W2147007028","https://openalex.org/W2148818050","https://openalex.org/W2151197773","https://openalex.org/W2151384687","https://openalex.org/W2151669689","https://openalex.org/W2155971051","https://openalex.org/W2157657208","https://openalex.org/W2159879659","https://openalex.org/W2160881867","https://openalex.org/W2162388879","https://openalex.org/W2162390982","https://openalex.org/W2162771723","https://openalex.org/W2166892529","https://openalex.org/W2167720733","https://openalex.org/W2167840686","https://openalex.org/W2171682279","https://openalex.org/W2257230315","https://openalex.org/W2299185849","https://openalex.org/W2307600746","https://openalex.org/W2322058873","https://openalex.org/W2329336071","https://openalex.org/W2336513583","https://openalex.org/W2373143539","https://openalex.org/W2435866579","https://openalex.org/W2730422203","https://openalex.org/W2750510345","https://openalex.org/W2755136466","https://openalex.org/W2765175830","https://openalex.org/W2769003964","https://openalex.org/W2807521104","https://openalex.org/W2885222125","https://openalex.org/W4211028926","https://openalex.org/W4248107770"],"related_works":["https://openalex.org/W3020576088","https://openalex.org/W4390111537","https://openalex.org/W4391576568","https://openalex.org/W7055771942","https://openalex.org/W2807521104","https://openalex.org/W2941088151","https://openalex.org/W2891094027","https://openalex.org/W3130915146","https://openalex.org/W7169772016","https://openalex.org/W2961517840"],"abstract_inverted_index":{"Advances":[0],"in":[1,22,66,121],"diagnostic":[2,87],"medicine":[3],"have":[4,27,71,97],"led":[5],"to":[6,37,45,74,132],"an":[7],"increased":[8],"awareness":[9],"and":[10,70,91,128],"heightened":[11],"concern":[12],"for":[13,89,142],"the":[14,23,54,115,122,134],"high":[15],"prevalence":[16],"of":[17,114,124,136],"amyloid-associated":[18],"neurodegenerative":[19,68],"diseases,":[20,69],"especially":[21],"elderly.":[24],"These":[25],"diseases":[26],"characteristic":[28],"late":[29],"stage":[30],"symptoms":[31,78],"that":[32,99],"often":[33],"make":[34],"it":[35],"possible":[36],"distinguish":[38],"one":[39],"disorder":[40],"from":[41],"another,":[42],"though":[43],"methods":[44],"diagnose":[46],"neurodegeneration":[47],"pre-symptomatically":[48],"remain":[49],"a":[50,84],"critical":[51],"challenge.":[52],"At":[53],"molecular":[55],"level,":[56],"misfolded":[57],"protein":[58],"aggregates":[59],"known":[60],"as":[61,139],"amyloids":[62],"are":[63],"ubiquitously":[64],"found":[65],"many":[67,95],"been":[72],"suggested":[73],"appear":[75],"before":[76],"clinical":[77,140],"manifest.":[79],"Amyloids":[80],"have,":[81],"thus,":[82],"become":[83],"valuable":[85],"potential":[86],"target":[88],"chemists,":[90],"recent":[92,130],"work":[93,117],"by":[94,105],"groups":[96],"shown":[98],"they":[100],"can":[101],"be":[102],"selectively":[103],"targeted":[104],"small":[106],"molecule":[107],"fluorescent":[108],"probes.":[109],"Here,":[110],"we":[111],"summarize":[112],"some":[113],"exciting":[116],"currently":[118],"under":[119],"investigation":[120],"area":[123],"fluorescence-based":[125],"amyloid":[126],"detection":[127],"highlight":[129],"efforts":[131],"expand":[133],"utility":[135],"amyloid-targeting":[137],"fluorophores":[138],"tools":[141],"disease":[143],"diagnostics.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-07-10T00:00:00"}