{"id":"https://openalex.org/W2811248243","doi":"https://doi.org/10.1039/c8mt00091c","title":"Calprotectin influences the aggregation of metal-free and metal-bound amyloid-\u03b2 by direct interaction","display_name":"Calprotectin influences the aggregation of metal-free and metal-bound amyloid-\u03b2 by direct interaction","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2811248243","doi":"https://doi.org/10.1039/c8mt00091c","mag":"2811248243","pmid":"https://pubmed.ncbi.nlm.nih.gov/30046785"},"language":"en","primary_location":{"id":"doi:10.1039/c8mt00091c","doi":"https://doi.org/10.1039/c8mt00091c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8mt00091c","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1721.1/128019","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027470004","display_name":"Hyuck Jin Lee","orcid":"https://orcid.org/0000-0001-8769-2967","observed_orcids":["https://orcid.org/0000-0001-8769-2967"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyuck Jin Lee","raw_affiliation_strings":["Daejeon 34141","Department of Chemistry","Korea Advanced Institute of Science and Technology (KAIST)","Republic of Korea","Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daejeon 34141","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology (KAIST)","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012864068","display_name":"Masha G. Savelieff","orcid":"https://orcid.org/0000-0001-5575-2494","observed_orcids":["https://orcid.org/0000-0001-5575-2494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masha G. Savelieff","raw_affiliation_strings":["Ann Arbor","SciGency Science Communications","USA","SciGency Science Communications, Ann Arbor, MI 48104, USA"],"raw_orcid":"https://orcid.org/0000-0001-5575-2494","affiliations":[{"raw_affiliation_string":"Ann Arbor","institution_ids":[]},{"raw_affiliation_string":"SciGency Science Communications","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"SciGency Science Communications, Ann Arbor, MI 48104, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111714469","display_name":"Juhye Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Juhye Kang","raw_affiliation_strings":["Daejeon 34141","Department of Chemistry","Korea Advanced Institute of Science and Technology (KAIST)","Republic of Korea","Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea","Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daejeon 34141","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology (KAIST)","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010063849","display_name":"Megan Brunjes Brophy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Brunjes Brophy","raw_affiliation_strings":["Cambridge","Department of Chemistry","Massachusetts Institute of Technology (MIT)","USA","Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology (MIT)","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035027059","display_name":"Toshiki G. Nakashige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshiki G. Nakashige","raw_affiliation_strings":["Cambridge","Department of Chemistry","Massachusetts Institute of Technology (MIT)","USA","Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology (MIT)","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077980720","display_name":"Shin Jung C. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Shin Jung C. Lee","raw_affiliation_strings":["Department of Chemistry","Republic of Korea","Ulsan 44919","Ulsan National Institute of Science and Technology (UNIST)","Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"Ulsan 44919","institution_ids":[]},{"raw_affiliation_string":"Ulsan National Institute of Science and Technology (UNIST)","institution_ids":["https://openalex.org/I48566637"]},{"raw_affiliation_string":"Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066305106","display_name":"Elizabeth M. Nolan","orcid":"https://orcid.org/0000-0002-6153-8803","observed_orcids":["https://orcid.org/0000-0002-6153-8803"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth M. Nolan","raw_affiliation_strings":["Cambridge","Department of Chemistry","Massachusetts Institute of Technology (MIT)","USA","Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA"],"raw_orcid":"https://orcid.org/0000-0002-6153-8803","affiliations":[{"raw_affiliation_string":"Cambridge","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology (MIT)","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008307832","display_name":"Mi Hee Lim","orcid":"https://orcid.org/0000-0003-3377-4996","observed_orcids":["https://orcid.org/0000-0003-3377-4996"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Mi Hee Lim","raw_affiliation_strings":["Daejeon 34141","Department of Chemistry","Korea Advanced Institute of Science and Technology (KAIST)","Republic of Korea","Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-3377-4996","affiliations":[{"raw_affiliation_string":"Daejeon 34141","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Korea Advanced Institute of Science and Technology (KAIST)","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008307832","https://openalex.org/A5066305106"],"corresponding_institution_ids":["https://openalex.org/I157485424","https://openalex.org/I63966007"],"apc_list":{"value":2653,"currency":"USD","value_usd":2653},"apc_paid":null,"fwci":1.1732,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73063348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"8","first_page":"1116","last_page":"1127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.42649999260902405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calprotectin","display_name":"calprotectin","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.75},{"id":"https://openalex.org/keywords/metal-ions","display_name":"metal ions","score":0.7329999804496765},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9399999976158142},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-40","display_name":"A\u03b240","score":0.777999997138977},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.9739999771118164},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.7189953327178955},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.6984726786613464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6336498260498047},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.6326257586479187},{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.5780642032623291},{"id":"https://openalex.org/C199164860","wikidata":"https://www.wikidata.org/wiki/Q6822745","display_name":"Metal ions in aqueous solution","level":3,"score":0.5625595450401306},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.5199710130691528},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4980504512786865},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.23560577630996704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18763846158981323},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18705406785011292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039841","descriptor_name":"Leukocyte L1 Antigen Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064568","descriptor_name":"S100 Calcium Binding Protein beta Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1039/c8mt00091c","doi":"https://doi.org/10.1039/c8mt00091c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8mt00091c","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},{"id":"pmid:30046785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30046785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics : integrated biometal science","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/128019","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/128019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prof. Nolan via Ye Li","raw_type":"Article"},{"id":"pmh:oai:scholarworks.unist.ac.kr:201301/24920","doi":null,"is_oa":false,"landing_page_url":"http://pubs.rsc.org/en/Content/ArticleLanding/2018/MT/C8MT00091C#!divAbstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306401118","display_name":"Scholarworks@UNIST (Ulsan National Institute of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I48566637","host_organization_name":"Ulsan National Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I48566637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"ARTICLE"}],"best_oa_location":{"id":"pmh:oai:dspace.mit.edu:1721.1/128019","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/128019","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Prof. Nolan via Ye Li","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1474371743","display_name":null,"funder_award_id":"NRF-2015HIA2A1030823","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1927737187","display_name":null,"funder_award_id":"NRF-2017R1A2B3002585","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G341208630","display_name":null,"funder_award_id":"NRF-2016R1A5A1009405","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320324161","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W165997145","https://openalex.org/W380069984","https://openalex.org/W1520284233","https://openalex.org/W1549271450","https://openalex.org/W1590561022","https://openalex.org/W1601964977","https://openalex.org/W1677883125","https://openalex.org/W1967549235","https://openalex.org/W1970413355","https://openalex.org/W1972637602","https://openalex.org/W1980605491","https://openalex.org/W1980825524","https://openalex.org/W1981387925","https://openalex.org/W1984223653","https://openalex.org/W1989810100","https://openalex.org/W1989948422","https://openalex.org/W1995272223","https://openalex.org/W1996916548","https://openalex.org/W1999967750","https://openalex.org/W2003470534","https://openalex.org/W2004837900","https://openalex.org/W2006961468","https://openalex.org/W2008433012","https://openalex.org/W2009174342","https://openalex.org/W2012031493","https://openalex.org/W2013801677","https://openalex.org/W2014538594","https://openalex.org/W2016292471","https://openalex.org/W2019511555","https://openalex.org/W2021439962","https://openalex.org/W2022830173","https://openalex.org/W2029119021","https://openalex.org/W2032642923","https://openalex.org/W2038425961","https://openalex.org/W2044992731","https://openalex.org/W2045751190","https://openalex.org/W2047898664","https://openalex.org/W2053288363","https://openalex.org/W2054702348","https://openalex.org/W2055775253","https://openalex.org/W2057709942","https://openalex.org/W2059050159","https://openalex.org/W2061381487","https://openalex.org/W2063197020","https://openalex.org/W2065100984","https://openalex.org/W2067224145","https://openalex.org/W2071713054","https://openalex.org/W2079323065","https://openalex.org/W2084280842","https://openalex.org/W2089491236","https://openalex.org/W2090950838","https://openalex.org/W2095360134","https://openalex.org/W2096103960","https://openalex.org/W2103491454","https://openalex.org/W2106301585","https://openalex.org/W2110249446","https://openalex.org/W2113107499","https://openalex.org/W2121735011","https://openalex.org/W2121753059","https://openalex.org/W2121963977","https://openalex.org/W2128003707","https://openalex.org/W2133610914","https://openalex.org/W2156193029","https://openalex.org/W2161888715","https://openalex.org/W2164365730","https://openalex.org/W2164371651","https://openalex.org/W2222001997","https://openalex.org/W2243723775","https://openalex.org/W2256555384","https://openalex.org/W2313725855","https://openalex.org/W2314116294","https://openalex.org/W2315760675","https://openalex.org/W2335327790","https://openalex.org/W2418725963","https://openalex.org/W2464863262","https://openalex.org/W2477558727","https://openalex.org/W2501073592","https://openalex.org/W2521624561","https://openalex.org/W2534771646","https://openalex.org/W2549799731","https://openalex.org/W2550762885","https://openalex.org/W2554405501","https://openalex.org/W2566269992","https://openalex.org/W2755705738","https://openalex.org/W2758663506","https://openalex.org/W2765175830","https://openalex.org/W2768746771","https://openalex.org/W2809675229","https://openalex.org/W3014251530","https://openalex.org/W4211028926"],"related_works":["https://openalex.org/W6963006815","https://openalex.org/W2945404218","https://openalex.org/W2810411548","https://openalex.org/W4404780963","https://openalex.org/W1982360614","https://openalex.org/W4313344980","https://openalex.org/W3204202807","https://openalex.org/W3110039925","https://openalex.org/W3013067162","https://openalex.org/W1882770623"],"abstract_inverted_index":{"Proteins":[0],"from":[1],"the":[2,18,26,49,52,59,71,88,96,107,125,141],"S100":[3],"family":[4],"perform":[5],"numerous":[6],"functions":[7],"and":[8,25,31,36,61,68,143],"may":[9],"contribute":[10],"to":[11],"Alzheimer's":[12],"disease":[13],"(AD).":[14],"Herein,":[15],"we":[16],"report":[17],"effects":[19],"of":[20,63,73,90,98,127,136,145],"S100A8/S100A9":[21],"heterooligomer":[22],"calprotectin":[23],"(CP)":[24],"S100B":[27,119],"homodimer":[28],"on":[29,124],"metal-free":[30],"metal-bound":[32],"amyloid-\u03b2":[33],"(A\u03b2;":[34],"A\u03b240":[35,56,93,101,103],"A\u03b242)":[37],"aggregation":[38,53,104,126],"in":[39,57,92,105,114,140,148],"vitro.":[40],"Studies":[41],"performed":[42],"with":[43,100,138],"CP-Ser":[44,99],"[S100A8(C42S)/S100A9(C3S)":[45],"oligomer]":[46],"indicate":[47],"that":[48],"protein":[50,108],"influences":[51],"profile":[54],"for":[55,87],"both":[58],"absence":[60,142],"presence":[62,144],"metal":[64,146],"ions":[65,147],"[i.e.,":[66],"Zn(ii)":[67],"Cu(ii)].":[69],"Moreover,":[70],"detection":[72],"A\u03b240-CP-Ser":[74],"complexes":[75],"by":[76],"mass":[77],"spectrometry":[78],"suggests":[79],"a":[80,84,121,133],"direct":[81],"interaction":[82,97],"as":[83],"possible":[85],"mechanism":[86],"involvement":[89],"CP":[91,137],"aggregation.":[94],"Although":[95],"impacts":[102],"vitro,":[106],"does":[109],"not":[110],"attenuate":[111],"A\u03b2-induced":[112],"toxicity":[113],"SH-SY5Y":[115],"cells.":[116],"In":[117],"contrast,":[118],"has":[120],"slight":[122],"effect":[123],"A\u03b2.":[128],"Overall,":[129],"this":[130],"work":[131],"supports":[132],"potential":[134],"association":[135],"A\u03b2":[139],"AD.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}