{"id":"https://openalex.org/W2811100230","doi":"https://doi.org/10.1210/jc.2018-01204","title":"Diagnosis of GH Deficiency as a Late Effect of Radiotherapy in Survivors of Childhood Cancers","display_name":"Diagnosis of GH Deficiency as a Late Effect of Radiotherapy in Survivors of Childhood Cancers","publication_year":2018,"publication_date":"2018-06-29","ids":{"openalex":"https://openalex.org/W2811100230","doi":"https://doi.org/10.1210/jc.2018-01204","mag":"2811100230","pmid":"https://pubmed.ncbi.nlm.nih.gov/29982753"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2018-01204","doi":"https://doi.org/10.1210/jc.2018-01204","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2018-01204","pdf_url":"https://academic.oup.com/jcem/article-pdf/103/8/2785/25408113/jc.2018-01204.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2811100230"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jcem/article-pdf/103/8/2785/25408113/jc.2018-01204.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014890509","display_name":"Jad G. Sfeir","orcid":"https://orcid.org/0000-0003-1576-1534","observed_orcids":["https://orcid.org/0000-0003-1576-1534"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jad G Sfeir","raw_affiliation_strings":["Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota","Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046230893","display_name":"Nana Esi Kittah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nana Esi N Kittah","raw_affiliation_strings":["Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029151495","display_name":"Shrikant U. Tamhane","orcid":"https://orcid.org/0000-0002-2007-5216","observed_orcids":["https://orcid.org/0000-0002-2007-5216"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shrikant U Tamhane","raw_affiliation_strings":["Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota","Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015511114","display_name":"Sina Jasim","orcid":"https://orcid.org/0000-0001-8984-3079","observed_orcids":["https://orcid.org/0000-0001-8984-3079"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sina Jasim","raw_affiliation_strings":["Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis, School of Medicine, St. Louis, Missouri","Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis, School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079717189","display_name":"Wassim Chemaitilly","orcid":"https://orcid.org/0000-0003-0717-5076","observed_orcids":["https://orcid.org/0000-0003-0717-5076"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wassim Chemaitilly","raw_affiliation_strings":["Department of Pediatric Medicine, Division of Endocrinology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Medicine, Division of Endocrinology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058339846","display_name":"Laurie E. Cohen","orcid":"https://orcid.org/0000-0002-8196-8800","observed_orcids":["https://orcid.org/0000-0002-8196-8800"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie E Cohen","raw_affiliation_strings":["Division of Endocrinology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054802858","display_name":"Mohammad Hassan Murad","orcid":"https://orcid.org/0000-0001-5502-5975","observed_orcids":["https://orcid.org/0000-0001-5502-5975"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M Hassan Murad","raw_affiliation_strings":["Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054802858"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.5854,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.50622877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"103","issue":"8","first_page":"2785","last_page":"2793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pediatric-cancer-survivors","display_name":"childhood cancer survivors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/late-radiation-effects","display_name":"late radiation effects","score":0.9549999833106995},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8339999914169312},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/insulin-tolerance-test","display_name":"insulin tolerance test","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ghrh-stimulation","display_name":"GHRH stimulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/arginine-stimulation","display_name":"arginine stimulation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.902999997138977},{"id":"https://openalex.org/keywords/hypothalamic-dysfunction","display_name":"hypothalamic dysfunction","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.828526496887207},{"id":"https://openalex.org/C2779952775","wikidata":"https://www.wikidata.org/wiki/Q369262","display_name":"Growth hormone deficiency","level":4,"score":0.5801782608032227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.518159031867981},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4762858748435974},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.43744656443595886},{"id":"https://openalex.org/C2779113265","wikidata":"https://www.wikidata.org/wiki/Q107525054","display_name":"Insulin tolerance test","level":5,"score":0.4257740378379822},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3806692361831665},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37497419118881226},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3626488745212555},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.26154083013534546},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2574843764305115},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1698375642299652},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.14109373092651367},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.11967605352401733},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073116","descriptor_name":"Cancer Survivors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003940","descriptor_name":"Diagnostic Techniques, Endocrine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/jc.2018-01204","doi":"https://doi.org/10.1210/jc.2018-01204","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2018-01204","pdf_url":"https://academic.oup.com/jcem/article-pdf/103/8/2785/25408113/jc.2018-01204.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:29982753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29982753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/jc.2018-01204","doi":"https://doi.org/10.1210/jc.2018-01204","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2018-01204","pdf_url":"https://academic.oup.com/jcem/article-pdf/103/8/2785/25408113/jc.2018-01204.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2811100230.pdf","grobid_xml":"https://content.openalex.org/works/W2811100230.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W43675721","https://openalex.org/W1558704041","https://openalex.org/W1966335217","https://openalex.org/W1968562633","https://openalex.org/W1981865861","https://openalex.org/W1984028172","https://openalex.org/W1990992726","https://openalex.org/W2004790755","https://openalex.org/W2035551059","https://openalex.org/W2039767017","https://openalex.org/W2039896009","https://openalex.org/W2048576559","https://openalex.org/W2053972537","https://openalex.org/W2060705510","https://openalex.org/W2066770264","https://openalex.org/W2070640693","https://openalex.org/W2082493729","https://openalex.org/W2086837347","https://openalex.org/W2090627812","https://openalex.org/W2098717833","https://openalex.org/W2100836119","https://openalex.org/W2106932077","https://openalex.org/W2107638293","https://openalex.org/W2125896595","https://openalex.org/W2133414814","https://openalex.org/W2150732091","https://openalex.org/W2155251048","https://openalex.org/W2169683366","https://openalex.org/W2170905294","https://openalex.org/W2174016676","https://openalex.org/W2214083791","https://openalex.org/W2223360032","https://openalex.org/W2312307539","https://openalex.org/W2419498424","https://openalex.org/W2441871146","https://openalex.org/W2548439690","https://openalex.org/W2555766993","https://openalex.org/W2585303145","https://openalex.org/W2605783173","https://openalex.org/W2760916783","https://openalex.org/W6660417436","https://openalex.org/W6664066199","https://openalex.org/W6672504325"],"related_works":["https://openalex.org/W7213885954","https://openalex.org/W2070640693","https://openalex.org/W2082493729","https://openalex.org/W2018480165","https://openalex.org/W2909006933","https://openalex.org/W2102885802","https://openalex.org/W2105158952","https://openalex.org/W2961486595","https://openalex.org/W2971585072","https://openalex.org/W2125896595"],"abstract_inverted_index":{"Background:":[0],"Limited":[1],"guidance":[2],"exists":[3],"for":[4,9,46,125,214],"selecting":[5],"a":[6,18,232],"laboratory":[7],"method":[8],"diagnosing":[10],"GH":[11,61,199],"deficiency":[12],"(GHD)":[13],"when":[14,144],"it":[15],"occurs":[16],"as":[17,224],"late":[19],"effect":[20],"of":[21,36,41,98,197,210],"radiotherapy":[22],"in":[23,102,115,148,172,216,226,239,246],"childhood":[24],"cancer":[25],"survivors":[26],"(CCSs).":[27],"Methods:":[28],"We":[29,65],"searched":[30],"Medline,":[31],"Embase,":[32],"Cochrane":[33],"Central":[34],"Register":[35],"Controlled":[37],"Trials":[38],"and":[39,44,72,86,162,182,242],"Database":[40],"Systematic":[42],"Reviews,":[43],"Scopus":[45],"studies":[47,68],"evaluating":[48],"GHD":[49,215],"that":[50],"used":[51,145],"IGF-1":[52,85,241],"or":[53,147,202],"IGF-binding":[54],"protein":[55],"3":[56],"(IGFBP-3)":[57],"measurements":[58],"compared":[59,185],"with":[60,129,150,176,186],"dynamic":[62,119,212],"testing.":[63],"Results:":[64],"included":[66],"15":[67],"[IGF-1":[69],"(8":[70],"studies)":[71],"IGFBP-3":[73,87,243],"(7":[74],"studies)]":[75],"enrolling":[76],"477":[77],"patients.":[78],"Comparator":[79],"tests":[80,100,120,213],"varied":[81],"widely.":[82],"Overall,":[83],"both":[84,99],"had":[88,179],"suboptimal":[89],"diagnostic":[90,110,208],"accuracy":[91,196,209],"but":[92],"were":[93,191],"strongly":[94],"correlated.":[95],"The":[96,131,207],"use":[97],"simultaneously":[101],"the":[103,109,116,122,139,169,187,195,221,235],"same":[104,222],"cohort":[105],"did":[106],"not":[107],"improve":[108],"accuracy.":[111],"Despite":[112],"high":[113],"variability":[114],"testing":[117,154,200],"protocols,":[118],"remained":[121],"most":[123,140],"accurate":[124],"appropriately":[126],"identifying":[127],"patients":[128],"GHD.":[130],"insulin":[132],"tolerance":[133],"test":[134,143],"(ITT)":[135],"appears":[136,218],"to":[137,168,193,219],"be":[138],"accepted":[141],"reference":[142],"alone":[146],"combination":[149],"arginine;":[151],"however,":[152,171],"standardized":[153],"strategies":[155],"among":[156],"practice":[157],"groups":[158],"are":[159],"absent.":[160],"GHRH":[161,175,229],"arginine":[163,177],"stimulation":[164,178,230],"performed":[165],"almost":[166],"similarly":[167],"ITT;":[170],"one":[173],"study":[174],"66%":[180],"sensitivity":[181],"88%":[183],"specificity":[184],"ITT.":[188],"Insufficient":[189],"data":[190],"available":[192],"assess":[194],"serial":[198],"(nocturnal":[201],"over":[203],"24":[204],"hours).":[205],"Conclusion:":[206],"various":[211],"CCSs":[217],"follow":[220],"patterns":[223],"those":[225],"non-CCSs.":[227],"Interpreting":[228],"is":[231],"challenge":[233],"given":[234],"primarily":[236],"hypothalamic":[237],"dysfunction":[238],"CCSs.":[240],"perform":[244],"poorly":[245],"this":[247],"population.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2018-07-10T00:00:00"}
