{"id":"https://openalex.org/W2811061908","doi":"https://doi.org/10.1042/cs20180060","title":"Adenylyl cyclase 6 is required for maintaining acid\u2013base homeostasis","display_name":"Adenylyl cyclase 6 is required for maintaining acid\u2013base homeostasis","publication_year":2018,"publication_date":"2018-06-25","ids":{"openalex":"https://openalex.org/W2811061908","doi":"https://doi.org/10.1042/cs20180060","mag":"2811061908","pmid":"https://pubmed.ncbi.nlm.nih.gov/29941522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512970"},"language":"en","primary_location":{"id":"doi:10.1042/cs20180060","doi":"https://doi.org/10.1042/cs20180060","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs20180060","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2811061908"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048999622","display_name":"S\u00f8ren Brandt Poulsen","orcid":"https://orcid.org/0000-0002-0082-3934","observed_orcids":["https://orcid.org/0000-0002-0082-3934"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"S\u00f8ren\u00a0Brandt Poulsen","raw_affiliation_strings":["InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark","VA San Diego Healthcare System, San Diego, CA 92161, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"VA San Diego Healthcare System, San Diego, CA 92161, U.S.A","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012680545","display_name":"Caralina Mar\u00edn de Evsikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caralina Marin De Evsikova","raw_affiliation_strings":["Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, U.S.A","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014335943","display_name":"Sathish Kumar Murali","orcid":"https://orcid.org/0000-0002-7056-9839","observed_orcids":["https://orcid.org/0000-0002-7056-9839"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Sathish\u00a0Kumar Murali","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, U.S.A","InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, U.S.A","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044035260","display_name":"Jeppe Pr\u00e6torius","orcid":"https://orcid.org/0000-0001-6109-247X","observed_orcids":["https://orcid.org/0000-0001-6109-247X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jeppe Praetorius","raw_affiliation_strings":["InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018776391","display_name":"Yijuang Chern","orcid":"https://orcid.org/0000-0002-5842-5429","observed_orcids":["https://orcid.org/0000-0002-5842-5429"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yijuang Chern","raw_affiliation_strings":["Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072279663","display_name":"Robert A. Fenton","orcid":"https://orcid.org/0000-0003-1623-199X","observed_orcids":["https://orcid.org/0000-0003-1623-199X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Robert\u00a0A. Fenton","raw_affiliation_strings":["InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058300732","display_name":"Timo Rieg","orcid":"https://orcid.org/0000-0001-6082-662X","observed_orcids":["https://orcid.org/0000-0001-6082-662X"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timo Rieg","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, U.S.A","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5058300732"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":1.6566,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81433297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"132","issue":"16","first_page":"1779","last_page":"1796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylyl-cyclase-6","display_name":"adenylyl cyclase 6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.9430000185966492},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/renal-tubules","display_name":"renal tubules","score":0.8640000224113464},{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.9649999737739563},{"id":"https://openalex.org/keywords/intercalated-cells","display_name":"intercalated cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.8320000171661377},{"id":"https://openalex.org/keywords/alkalosis","display_name":"alkalosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pendrin","display_name":"pendrin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anion-exchanger","display_name":"anion exchanger","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.6708207726478577},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6154627799987793},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.5082754492759705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4166802763938904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.303522527217865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26980823278427124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21485432982444763},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11294254660606384},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.055680155754089355},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025262","descriptor_name":"Vacuolar Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1042/cs20180060","doi":"https://doi.org/10.1042/cs20180060","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs20180060","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmh:oai:pure.atira.dk:openaire/44a4dba6-b2e9-4f15-a93e-f6465a5d180d","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512970","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poulsen, S B, Marin De Evsikova, C, Murali, S K, Praetorius, J, Chern, Y, Fenton, R A & Rieg, T 2018, 'Adenylyl cyclase 6 is required for maintaining acid-base homeostasis', Clinical Science, vol. 132, no. 16, pp. 1779-1796. https://doi.org/10.1042/CS20180060","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:29941522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29941522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5672764","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512970","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6512970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6512970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Sci (Lond)","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.usf.edu:mme_facpub-1089","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/mme_facpub/67","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Medicine Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire/44a4dba6-b2e9-4f15-a93e-f6465a5d180d","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512970","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poulsen, S B, Marin De Evsikova, C, Murali, S K, Praetorius, J, Chern, Y, Fenton, R A & Rieg, T 2018, 'Adenylyl cyclase 6 is required for maintaining acid-base homeostasis', Clinical Science, vol. 132, no. 16, pp. 1779-1796. https://doi.org/10.1042/CS20180060","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3464395539","display_name":"Role of Renal and Intestinal AC6 and NHE3 for Phosphate Homeostasis","funder_award_id":"R01DK110621","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5286542937","display_name":null,"funder_award_id":"NNF15OC0016342","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G5811030030","display_name":null,"funder_award_id":"R93-2011-8693","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G6386834545","display_name":null,"funder_award_id":"R233-2016-3759","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G7205944845","display_name":null,"funder_award_id":"NNF17OC0028812","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G7884623227","display_name":null,"funder_award_id":"NNF17OC0029724","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320310483","display_name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","ror":"https://ror.org/03ge1nb22"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1516172894","https://openalex.org/W1584979807","https://openalex.org/W1937078385","https://openalex.org/W1968374401","https://openalex.org/W1971318105","https://openalex.org/W1973574957","https://openalex.org/W1985745814","https://openalex.org/W1988758413","https://openalex.org/W1991724035","https://openalex.org/W1994965449","https://openalex.org/W2014194164","https://openalex.org/W2016935803","https://openalex.org/W2017633932","https://openalex.org/W2018227730","https://openalex.org/W2021941761","https://openalex.org/W2030524541","https://openalex.org/W2038531908","https://openalex.org/W2045419492","https://openalex.org/W2058124261","https://openalex.org/W2064391050","https://openalex.org/W2067581172","https://openalex.org/W2080882597","https://openalex.org/W2100179923","https://openalex.org/W2101340596","https://openalex.org/W2103105630","https://openalex.org/W2105421619","https://openalex.org/W2105712625","https://openalex.org/W2107039072","https://openalex.org/W2114047184","https://openalex.org/W2122944904","https://openalex.org/W2126323646","https://openalex.org/W2126636958","https://openalex.org/W2128741046","https://openalex.org/W2133200719","https://openalex.org/W2133487098","https://openalex.org/W2134664302","https://openalex.org/W2137964475","https://openalex.org/W2139019283","https://openalex.org/W2141218408","https://openalex.org/W2147556417","https://openalex.org/W2159068917","https://openalex.org/W2162275711","https://openalex.org/W2164190508","https://openalex.org/W2171005064","https://openalex.org/W2173906027","https://openalex.org/W2187378057","https://openalex.org/W2245041715","https://openalex.org/W2264092661","https://openalex.org/W2279700027","https://openalex.org/W2301858623","https://openalex.org/W2320589441","https://openalex.org/W2344012147","https://openalex.org/W2410762585","https://openalex.org/W2419572437","https://openalex.org/W2528309802","https://openalex.org/W2530276655","https://openalex.org/W2604318623","https://openalex.org/W2605277235","https://openalex.org/W4249469073","https://openalex.org/W6686461508","https://openalex.org/W6717257168"],"related_works":["https://openalex.org/W2889731283","https://openalex.org/W4389026394","https://openalex.org/W3175759582","https://openalex.org/W3166169665","https://openalex.org/W2805337901","https://openalex.org/W7160907159","https://openalex.org/W2193475846","https://openalex.org/W2126636958","https://openalex.org/W4388911141","https://openalex.org/W3169281563"],"abstract_inverted_index":{"Adenylyl":[0],"cyclase":[1],"(AC)":[2],"isoform":[3],"6":[4],"(AC6)":[5],"is":[6,133,223,238],"highly":[7],"expressed":[8,147],"throughout":[9],"the":[10,18,41,46,70,107,156,162,174,199],"renal":[11,28,71,104,236],"tubule":[12,72],"and":[13,22,73,101,139,161,166,230],"collecting":[14],"duct":[15],"(CD),":[16],"catalyzes":[17],"synthesis":[19],"of":[20,27,49,60,106,129,155,192],"cAMP":[21],"contributes":[23],"to":[24,51,82],"various":[25],"aspects":[26],"transport.":[29],"Several":[30],"proteins":[31],"involved":[32],"in":[33,69,79,94,123,148,168],"acid\u2013base":[34,53,228,241],"homeostasis":[35,229],"are":[36],"regulated":[37],"by":[38],"cAMP.":[39],"In":[40,111,173,196,220],"present":[42],"study,":[43],"we":[44],"assess":[45],"relative":[47,81],"contribution":[48],"AC6":[50,61,68,145,222,237],"overall":[52],"regulation":[54],"using":[55],"mice":[56,66,117,170,203],"with":[57,88,96,113,135,188,198],"global":[58],"deletion":[59],"(AC6\u2212/\u2212)":[62],"or":[63],"newly":[64],"generated":[65],"lacking":[67],"CD":[74],"(AC6loxloxPax8Cre).":[75],"Higher":[76],"energy":[77,231],"expenditure":[78],"AC6\u2212/\u2212":[80,116,169,175,200],"wild-type":[83],"(WT)":[84],"mice,":[85,115,176,201],"was":[86,146,171],"associated":[87,134],"lower":[89],"urinary":[90,124,206],"pH,":[91],"mild":[92],"alkalosis":[93],"conjunction":[95],"elevated":[97],"blood":[98,137,213],"HCO3\u2212":[99,130,140,182,214,218],"concentrations,":[100],"significantly":[102],"higher":[103,190,212],"abundance":[105],"H+-ATPase":[108,157,177],"B1":[109,158,178],"subunit.":[110],"contrast":[112,197],"WT":[114],"have":[118],"a":[119,189],"less":[120],"pronounced":[121],"increase":[122],"pH":[125,138,207],"after":[126,181,217],"8":[127],"days":[128],"challenge,":[131],"which":[132,186],"increased":[136],"concentrations.":[141],"Immunohistochemistry":[142],"demonstrated":[143],"that":[144],"intercalated":[149],"cells":[150],"(IC),":[151],"but":[152,211,243],"subcellular":[153],"distribution":[154],"subunit,":[159],"pendrin,":[160],"anion":[163],"exchangers":[164],"1":[165],"2":[167],"normal.":[172],"subunit":[179],"levels":[180],"challenge":[183],"were":[184],"greater,":[185],"correlated":[187],"number":[191],"type":[193],"A":[194],"IC.":[195],"AC6loxloxPax8Cre":[202],"had":[204],"normal":[205,227],"under":[208,246],"baseline":[209,234],"conditions":[210],"than":[215],"controls":[216],"challenge.":[219],"conclusion,":[221],"required":[224],"for":[225,240],"maintaining":[226],"expenditure.":[232],"Under":[233],"conditions,":[235],"redundant":[239],"balance":[242],"becomes":[244],"important":[245],"alkaline":[247],"conditions.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-07-10T00:00:00"}