{"id":"https://openalex.org/W2811019100","doi":"https://doi.org/10.1007/s00044-018-2209-6","title":"New histone deacetylase inhibitors from the twigs of Melanorrhoea usitata","display_name":"New histone deacetylase inhibitors from the twigs of Melanorrhoea usitata","publication_year":2018,"publication_date":"2018-06-23","ids":{"openalex":"https://openalex.org/W2811019100","doi":"https://doi.org/10.1007/s00044-018-2209-6","mag":"2811019100"},"language":"en","primary_location":{"id":"doi:10.1007/s00044-018-2209-6","doi":"https://doi.org/10.1007/s00044-018-2209-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-018-2209-6","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2811019100"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043474021","display_name":"Pakit Kumboonma","orcid":"https://orcid.org/0000-0002-4726-5191","observed_orcids":["https://orcid.org/0000-0002-4726-5191"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pakit Kumboonma","raw_affiliation_strings":["Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047663564","display_name":"Thanaset Senawong","orcid":"https://orcid.org/0000-0001-8788-5291","observed_orcids":["https://orcid.org/0000-0001-8788-5291","https://orcid.org/0000-0002-5094-0864"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Thanaset Senawong","raw_affiliation_strings":["Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078677383","display_name":"Somprasong Saenglee","orcid":"https://orcid.org/0000-0001-6950-0052","observed_orcids":["https://orcid.org/0000-0001-6950-0052"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Somprasong Saenglee","raw_affiliation_strings":["Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011025940","display_name":"Chavi Yenjai","orcid":"https://orcid.org/0000-0002-5803-0312","observed_orcids":["https://orcid.org/0000-0002-5803-0312"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chavi Yenjai","raw_affiliation_strings":["Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046997747","display_name":"Chanokbhorn Phaosiri","orcid":"https://orcid.org/0000-0002-0108-0204","observed_orcids":["https://orcid.org/0000-0002-0108-0204"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Chanokbhorn Phaosiri","raw_affiliation_strings":["Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-0108-0204","affiliations":[{"raw_affiliation_string":"Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand","institution_ids":["https://openalex.org/I179193067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046997747"],"corresponding_institution_ids":["https://openalex.org/I179193067"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.1561,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.40644517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"27","issue":"8","first_page":"2004","last_page":"2015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.10220000147819519,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hdac-isoform-selectivity","display_name":"HDAC isoform selectivity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hdac8","display_name":"HDAC8","score":1.0},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C25737173","wikidata":"https://www.wikidata.org/wiki/Q18042128","display_name":"HDAC8","level":5,"score":0.9424221515655518},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8998122215270996},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.7476330399513245},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.6888119578361511},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.6371505260467529},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.625576376914978},{"id":"https://openalex.org/C58793620","wikidata":"https://www.wikidata.org/wiki/Q21173206","display_name":"HDAC4","level":5,"score":0.5746796131134033},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5406067371368408},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5231562852859497},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47311732172966003},{"id":"https://openalex.org/C163111631","wikidata":"https://www.wikidata.org/wiki/Q1952454","display_name":"Carbon-13 NMR","level":2,"score":0.43404823541641235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4237882196903229},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4157225787639618},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10327857732772827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00044-018-2209-6","doi":"https://doi.org/10.1007/s00044-018-2209-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00044-018-2209-6","pdf_url":null,"source":{"id":"https://openalex.org/S36909932","display_name":"Medicinal Chemistry Research","issn_l":"1054-2523","issn":["1054-2523","1554-8120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G86707242","display_name":null,"funder_award_id":"571203 and 580403","funder_id":"https://openalex.org/F4320322335","funder_display_name":"Khon Kaen University"}],"funders":[{"id":"https://openalex.org/F4320322335","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1526205344","https://openalex.org/W1563624749","https://openalex.org/W1833434692","https://openalex.org/W1965608683","https://openalex.org/W1966059995","https://openalex.org/W1972380083","https://openalex.org/W1975223160","https://openalex.org/W1980200511","https://openalex.org/W1983094204","https://openalex.org/W1985107140","https://openalex.org/W1985515161","https://openalex.org/W1988503979","https://openalex.org/W1990861922","https://openalex.org/W1999260149","https://openalex.org/W1999499726","https://openalex.org/W2003681344","https://openalex.org/W2006742948","https://openalex.org/W2015838868","https://openalex.org/W2020074110","https://openalex.org/W2023271753","https://openalex.org/W2025973280","https://openalex.org/W2027619236","https://openalex.org/W2036951789","https://openalex.org/W2043424193","https://openalex.org/W2059914085","https://openalex.org/W2074636474","https://openalex.org/W2077505027","https://openalex.org/W2081675364","https://openalex.org/W2102324886","https://openalex.org/W2105668062","https://openalex.org/W2107040737","https://openalex.org/W2107733280","https://openalex.org/W2108547896","https://openalex.org/W2133367611","https://openalex.org/W2143278515","https://openalex.org/W2143981217","https://openalex.org/W2148718757","https://openalex.org/W2160824495","https://openalex.org/W2162537441","https://openalex.org/W2168368163","https://openalex.org/W2171330050","https://openalex.org/W2176188352","https://openalex.org/W2319213820","https://openalex.org/W2402484055","https://openalex.org/W2404368222","https://openalex.org/W2406709078","https://openalex.org/W2406990926","https://openalex.org/W2408743616","https://openalex.org/W2512733417","https://openalex.org/W2513333818","https://openalex.org/W2520540874","https://openalex.org/W2736042373","https://openalex.org/W2745508963","https://openalex.org/W2754166902","https://openalex.org/W2950806121","https://openalex.org/W4233036449"],"related_works":["https://openalex.org/W2994696278","https://openalex.org/W4382182408","https://openalex.org/W780923111","https://openalex.org/W2911276781","https://openalex.org/W1997409989","https://openalex.org/W2912912244","https://openalex.org/W4306153355","https://openalex.org/W3170654500","https://openalex.org/W3172321165"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2018-07-10T00:00:00"}