{"id":"https://openalex.org/W2810935337","doi":"https://doi.org/10.1007/s00784-018-2542-7","title":"The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system","display_name":"The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system","publication_year":2018,"publication_date":"2018-06-25","ids":{"openalex":"https://openalex.org/W2810935337","doi":"https://doi.org/10.1007/s00784-018-2542-7","mag":"2810935337","pmid":"https://pubmed.ncbi.nlm.nih.gov/29943369"},"language":"en","primary_location":{"id":"doi:10.1007/s00784-018-2542-7","doi":"https://doi.org/10.1007/s00784-018-2542-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00784-018-2542-7","pdf_url":null,"source":{"id":"https://openalex.org/S103663982","display_name":"Clinical Oral Investigations","issn_l":"1432-6981","issn":["1432-6981","1436-3771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Oral Investigations","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013940688","display_name":"Patrick W. McIntyre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick W. McIntyre","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073500533","display_name":"Jennifer L. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Wu","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061626627","display_name":"Rasika Kolte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasika Kolte","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100750683","display_name":"Ru Zhang","orcid":"https://orcid.org/0000-0003-3216-2787","observed_orcids":["https://orcid.org/0000-0003-3216-2787","https://orcid.org/0009-0003-4702-5926"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ru Zhang","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","Department of Endodontics, Beijing Stomatological Hospital, Capital Medical University, 4 Tiantan Xili, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Department of Endodontics, Beijing Stomatological Hospital, Capital Medical University, 4 Tiantan Xili, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044983589","display_name":"Richard L. Gregory","orcid":"https://orcid.org/0000-0002-4785-3620","observed_orcids":["https://orcid.org/0000-0002-4785-3620","https://orcid.org/0000-0002-1457-0587"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L. Gregory","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090297670","display_name":"Angela Bruzzaniti","orcid":"https://orcid.org/0000-0003-0389-4604","observed_orcids":["https://orcid.org/0000-0003-0389-4604"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Bruzzaniti","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027718782","display_name":"Ghaeth H. Yassen","orcid":"https://orcid.org/0000-0002-7841-5914","observed_orcids":["https://orcid.org/0000-0002-7841-5914"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ghaeth H. Yassen","raw_affiliation_strings":["Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA. gyassen@umail.iu.edu","Department of Endodontics, Case School of Dental Medicine, 2124 Cornell Rd, Cleveland, OH, 44106, USA. gyassen@umail.iu.edu","Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA. gyassen@umail.iu.edu","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Department of Endodontics, Case School of Dental Medicine, 2124 Cornell Rd, Cleveland, OH, 44106, USA. gyassen@umail.iu.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, 1121 W Michigan St, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027718782"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I58956616"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":3.3526,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.91204574,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"3","first_page":"1051","last_page":"1059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/double-antibiotic-paste","display_name":"double antibiotic paste","score":0.9049999713897705},{"id":"https://openalex.org/keywords/methylcellulose-hydrogel","display_name":"methylcellulose hydrogel","score":0.8989999890327454},{"id":"https://openalex.org/keywords/intracanal-medicaments","display_name":"intracanal medicaments","score":0.8949999809265137},{"id":"https://openalex.org/keywords/root-canal-disinfection","display_name":"root canal disinfection","score":0.6290000081062317},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.925000011920929},{"id":"https://openalex.org/keywords/prevotella-intermedia","display_name":"Prevotella intermedia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dual-species-biofilms","display_name":"dual-species biofilms","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dental-pulp-stem-cells","display_name":"dental pulp stem cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.921999990940094},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.7059999704360962},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/controlled-drug-delivery","display_name":"controlled drug delivery","score":0.7559999823570251},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.9073804616928101},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.8022189140319824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6600502133369446},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.6090272068977356},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6044381260871887},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.570999801158905},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5327534675598145},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5315974354743958},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.48310232162475586},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4315780997276306},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.37660500407218933},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32781603932380676},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2653580904006958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1729608178138733},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15753665566444397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09868472814559937},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08080118894577026},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012388","descriptor_name":"Root Canal Irrigants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00784-018-2542-7","doi":"https://doi.org/10.1007/s00784-018-2542-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00784-018-2542-7","pdf_url":null,"source":{"id":"https://openalex.org/S103663982","display_name":"Clinical Oral Investigations","issn_l":"1432-6981","issn":["1432-6981","1436-3771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Oral Investigations","raw_type":"journal-article"},{"id":"pmid:29943369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29943369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical oral investigations","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1824241537","https://openalex.org/W1939147375","https://openalex.org/W1962382246","https://openalex.org/W1969610055","https://openalex.org/W1969739545","https://openalex.org/W1979950212","https://openalex.org/W1991444257","https://openalex.org/W2017281071","https://openalex.org/W2024727739","https://openalex.org/W2025845360","https://openalex.org/W2027654288","https://openalex.org/W2028731993","https://openalex.org/W2042746082","https://openalex.org/W2059769954","https://openalex.org/W2081293261","https://openalex.org/W2081766342","https://openalex.org/W2084158448","https://openalex.org/W2092158479","https://openalex.org/W2102597480","https://openalex.org/W2107466663","https://openalex.org/W2116156424","https://openalex.org/W2134564961","https://openalex.org/W2138915147","https://openalex.org/W2197951783","https://openalex.org/W2300771567","https://openalex.org/W2412221498","https://openalex.org/W2412222866","https://openalex.org/W2464156560","https://openalex.org/W2466685065","https://openalex.org/W2521867406","https://openalex.org/W2525806127","https://openalex.org/W2567391438","https://openalex.org/W2588769861","https://openalex.org/W2615212818","https://openalex.org/W2735156606","https://openalex.org/W2742100710","https://openalex.org/W2751254124","https://openalex.org/W2757108345"],"related_works":["https://openalex.org/W4411931610","https://openalex.org/W7147684809","https://openalex.org/W2680886616","https://openalex.org/W3085381931","https://openalex.org/W4407971315","https://openalex.org/W4392606903","https://openalex.org/W4393185981","https://openalex.org/W7128991454","https://openalex.org/W2081293261","https://openalex.org/W4402535830"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2018-07-10T00:00:00"}
