{"id":"https://openalex.org/W2810799372","doi":"https://doi.org/10.4236/ojmn.2018.83021","title":"MALDI-TOF Mass Spectrometric Analysis of Brain Tumor Cyst Fluid Reveals a Protein Peak Corresponding to ApoC1 and LuzP6","display_name":"MALDI-TOF Mass Spectrometric Analysis of Brain Tumor Cyst Fluid Reveals a Protein Peak Corresponding to ApoC1 and LuzP6","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2810799372","doi":"https://doi.org/10.4236/ojmn.2018.83021","mag":"2810799372"},"language":"en","primary_location":{"id":"doi:10.4236/ojmn.2018.83021","doi":"https://doi.org/10.4236/ojmn.2018.83021","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojmn.2018.83021","pdf_url":"https://content.scirp.org/pdf/ojmn_2018062514545467.pdf","source":{"id":"https://openalex.org/S2764726287","display_name":"Open Journal of Modern Neurosurgery","issn_l":"2163-0569","issn":["2163-0569","2163-0585"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Modern Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://content.scirp.org/pdf/ojmn_2018062514545467.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mathias Groll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Groll","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110568731","display_name":"Jochen Frenzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Frenzel","raw_affiliation_strings":["Rudolf-Sch\u00f6nheimer-Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf-Sch\u00f6nheimer-Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065261639","display_name":"Matthias Krause","orcid":"https://orcid.org/0000-0002-7026-2837","observed_orcids":["https://orcid.org/0000-0002-7026-2837"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Krause","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032999874","display_name":"Anne Sch\u00e4nzer","orcid":"https://orcid.org/0000-0002-2014-2028","observed_orcids":["https://orcid.org/0000-0002-2014-2028"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Sch\u00e4nzer","raw_affiliation_strings":["Institute of Neuropathology, Justus Liebig University Giessen, Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuropathology, Justus Liebig University Giessen, Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109654830","display_name":"Wolf C. M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolf M\u00fcller","raw_affiliation_strings":["Institute of Neuropathology, University Hospital Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuropathology, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086851253","display_name":"Klaus Eschrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Eschrich","raw_affiliation_strings":["Rudolf-Sch\u00f6nheimer-Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rudolf-Sch\u00f6nheimer-Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031579123","display_name":"Ulf Nestler","orcid":"https://orcid.org/0000-0002-2963-4344","observed_orcids":["https://orcid.org/0000-0002-2963-4344"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ulf Nestler","raw_affiliation_strings":["Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031579123"],"corresponding_institution_ids":["https://openalex.org/I4210125843"],"apc_list":null,"apc_paid":null,"fwci":0.2022,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.36162973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"08","issue":"03","first_page":"251","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.5414999723434448,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.302700012922287,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.1264999955892563,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cancer-proteome","display_name":"tumor proteome","score":0.6809999942779541},{"id":"https://openalex.org/keywords/apoc1","display_name":"APOC1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/immunohistochemistry-of-tumor-tissue","display_name":"immunohistochemistry of tumor tissue","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6903982758522034},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6542717218399048},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.6493576169013977},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6015409827232361},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5934765338897705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5687975883483887},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.437005877494812},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.42388907074928284},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3520020842552185},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32549187541007996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27977219223976135},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22345781326293945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18801525235176086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0915517508983612}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/ojmn.2018.83021","doi":"https://doi.org/10.4236/ojmn.2018.83021","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojmn.2018.83021","pdf_url":"https://content.scirp.org/pdf/ojmn_2018062514545467.pdf","source":{"id":"https://openalex.org/S2764726287","display_name":"Open Journal of Modern Neurosurgery","issn_l":"2163-0569","issn":["2163-0569","2163-0585"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Modern Neurosurgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/ojmn.2018.83021","doi":"https://doi.org/10.4236/ojmn.2018.83021","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojmn.2018.83021","pdf_url":"https://content.scirp.org/pdf/ojmn_2018062514545467.pdf","source":{"id":"https://openalex.org/S2764726287","display_name":"Open Journal of Modern Neurosurgery","issn_l":"2163-0569","issn":["2163-0569","2163-0585"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Modern Neurosurgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810799372.pdf","grobid_xml":"https://content.openalex.org/works/W2810799372.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1984049269","https://openalex.org/W1998923065","https://openalex.org/W2002254025","https://openalex.org/W2022267557","https://openalex.org/W2036259521","https://openalex.org/W2056869265","https://openalex.org/W2058140056","https://openalex.org/W2061224512","https://openalex.org/W2064737647","https://openalex.org/W2074745266","https://openalex.org/W2101452274","https://openalex.org/W2164684917","https://openalex.org/W2171694243","https://openalex.org/W4237775567"],"related_works":["https://openalex.org/W2940380955","https://openalex.org/W2056869265","https://openalex.org/W6992637553","https://openalex.org/W6908525381","https://openalex.org/W3012612245","https://openalex.org/W6944829520","https://openalex.org/W4251396217","https://openalex.org/W36874382","https://openalex.org/W2138125837","https://openalex.org/W2166257899"],"abstract_inverted_index":{"Objectives:":[0],"SELDI-TOF":[1,31,127,137],"and":[2,39,72,102,109,124,146,154,162,273],"MALDI-TOF":[3,53,96,144,171,247],"mass":[4],"spectrometry":[5,172],"(MS)":[6],"are":[7],"laser":[8],"desorption":[9],"technologies":[10],"that":[11,221],"allow":[12],"for":[13,95,116],"proteomic":[14,194,264],"examination":[15,55],"of":[16,22,30,34,56,150,176,199,210,226,249],"molecular":[17],"masses":[18,108],"in":[19,36,167,203,228,241,259],"small":[20],"amounts":[21],"samples.":[23],"In":[24,46],"a":[25,92],"precedent":[26],"study,":[27,49],"the":[28,47,121,136,147,151,158,174,183,204,208,224,229,242,270],"feasibility":[29],"MS":[32,54,128,138,248],"assessment":[33],"proteins":[35,152,227,272],"cerebrospinal":[37,79],"fluid":[38,42,80,252],"tumor":[40,205,244,250,260],"cyst":[41,67,206,251],"had":[43],"been":[44],"shown.":[45],"present":[48],"we":[50],"analyzed":[51,115],"whether":[52],"these":[57],"fluids":[58,68],"leads":[59],"to":[60,126,157,179,223,233,268],"comparable":[61],"results.":[62],"Methods:":[63],"During":[64],"neurosurgical":[65],"intervention,":[66],"from":[69,82,135],"24":[70],"glioblastomas":[71],"15":[73],"metastases":[74],"were":[75,85,89,100,104,114],"collected.":[76],"As":[77],"control,":[78],"samples":[81,88],"23":[83,189],"patients":[84],"obtained.":[86],"The":[87,170,192],"prepared":[90],"using":[91],"protocol":[93],"optimized":[94],"MS.":[97],"Mass":[98],"spectra":[99],"recorded":[101],"peaks":[103,113,133,160],"extracted,":[105],"characterized":[106],"by":[107,143],"relative":[110],"intensities.":[111],"These":[112,231],"statistically":[117],"significant":[118],"differences":[119],"between":[120],"diagnosis":[122],"groups":[123],"compared":[125],"data.":[129],"Results:":[130],"41":[131],"protein":[132,159,200,254],"known":[134],"analysis":[139,177],"could":[140],"be":[141,234],"confirmed":[142],"MS,":[145],"cellular":[148],"expression":[149],"LuzP6":[153],"ApoC1,":[155],"corresponding":[156],"6433":[161],"6632,":[163],"was":[164],"shown":[165],"immunohistochemically":[166,236],"glioblas-toma":[168],"tissue.":[169,261],"extends":[173],"range":[175],"down":[178],"1.4":[180],"kDa,":[181],"whereas":[182],"upper":[184],"detection":[185],"limit":[186],"lies":[187],"below":[188],"kDa.":[190],"Discussion:":[191],"presented":[193],"approach":[195],"yields":[196],"an":[197],"inventory":[198],"masses,":[201],"found":[202],"at":[207],"time":[209],"puncture.":[211],"It":[212],"does":[213],"not":[214],"reveal":[215],"pathophysiologic,":[216],"metabolic":[217,274],"or":[218,237,257],"secretory":[219],"pathways":[220],"lead":[222],"presence":[225],"cyst.":[230],"have":[232],"assessed":[235],"on":[238],"mRNA":[239],"level":[240],"surrounding":[243],"cells.":[245],"Conclusion:":[246],"discloses":[253],"sizes,":[255],"overexpressed":[256],"lost":[258],"A":[262],"thorough":[263],"work-up":[265],"is":[266],"needed":[267],"identify":[269],"underlying":[271],"pathways.":[275]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}