{"id":"https://openalex.org/W2810745017","doi":"https://doi.org/10.1016/j.it.2018.05.005","title":"\u03b1\u03b2 T Cell Receptor Mechanosensing Forces out Serial Engagement","display_name":"\u03b1\u03b2 T Cell Receptor Mechanosensing Forces out Serial Engagement","publication_year":2018,"publication_date":"2018-07-04","ids":{"openalex":"https://openalex.org/W2810745017","doi":"https://doi.org/10.1016/j.it.2018.05.005","mag":"2810745017","pmid":"https://pubmed.ncbi.nlm.nih.gov/30060805"},"language":"en","primary_location":{"id":"doi:10.1016/j.it.2018.05.005","doi":"https://doi.org/10.1016/j.it.2018.05.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.it.2018.05.005","pdf_url":"http://www.cell.com/article/S147149061830108X/pdf","source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S147149061830108X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110565737","display_name":"Yinnian Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yinnian Feng","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013709830","display_name":"Ellis L. Reinherz","orcid":"https://orcid.org/0000-0003-1048-5526","observed_orcids":["https://orcid.org/0000-0003-1048-5526"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ellis L. Reinherz","raw_affiliation_strings":["Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Ellis_Reinherz@dfci.harvard.edu","Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Ellis_Reinherz@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044940094","display_name":"Matthew J. Lang","orcid":"https://orcid.org/0000-0002-8198-144X","observed_orcids":["https://orcid.org/0000-0002-8198-144X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew J. Lang","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37235, USA. Electronic address: matt.lang@vanderbilt.edu","Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA","Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37235, USA. Electronic address: matt.lang@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37235, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013709830","https://openalex.org/A5044940094"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I200719446","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":{"value":7030,"currency":"USD","value_usd":7030},"fwci":0.9433,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.6875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"39","issue":"8","first_page":"596","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.9129999876022339},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/peptide-mhc-complex","display_name":"peptide-MHC complex","score":0.5239999890327454},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cytoskeletal-motors","display_name":"cytoskeletal motors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9350000023841858},{"id":"https://openalex.org/keywords/t-cell-motility","display_name":"T cell motility","score":0.847000002861023},{"id":"https://openalex.org/keywords/single-molecule-force-measurement","display_name":"single-molecule force measurement","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7906310558319092},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.7733476161956787},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.595544695854187},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5897583365440369},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4843693673610687},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4508707523345947},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.44591429829597473},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44093775749206543},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.423240602016449},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.38086849451065063},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34066295623779297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32251641154289246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2885887026786804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2530008554458618},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23625871539115906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07803264260292053},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07403364777565002}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.it.2018.05.005","doi":"https://doi.org/10.1016/j.it.2018.05.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.it.2018.05.005","pdf_url":"http://www.cell.com/article/S147149061830108X/pdf","source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},{"id":"pmid:30060805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30060805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5100212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6154790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6154790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6154790","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trends Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.it.2018.05.005","doi":"https://doi.org/10.1016/j.it.2018.05.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.it.2018.05.005","pdf_url":"http://www.cell.com/article/S147149061830108X/pdf","source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2268269956","display_name":null,"funder_award_id":"DK-058404","funder_id":"https://openalex.org/F4320334532","funder_display_name":"Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center"},{"id":"https://openalex.org/G275963511","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309601","funder_display_name":"Vanderbilt-Ingram Cancer Center"},{"id":"https://openalex.org/G3153008248","display_name":null,"funder_award_id":"R56AI138489","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4370153136","display_name":"NMR and Computational Studies of Biomolecules","funder_award_id":"P01GM047467","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G725763919","display_name":null,"funder_award_id":"P30 CA 068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8979266933","display_name":"Mechanical basis of T cell receptor triggering","funder_award_id":"R01AI100643","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000862353","display_name":"Molecular and Cellular Basis for Digestive Diseases","funder_award_id":"P30DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309601","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320334532","display_name":"Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810745017.pdf"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W185827854","https://openalex.org/W1567219703","https://openalex.org/W1861250630","https://openalex.org/W1966474647","https://openalex.org/W1967359088","https://openalex.org/W1970594700","https://openalex.org/W1971221166","https://openalex.org/W1971376791","https://openalex.org/W1975503309","https://openalex.org/W1976059236","https://openalex.org/W1977672603","https://openalex.org/W1978879640","https://openalex.org/W1981565131","https://openalex.org/W1990109380","https://openalex.org/W1993369787","https://openalex.org/W1998415250","https://openalex.org/W2011584482","https://openalex.org/W2020010253","https://openalex.org/W2021673674","https://openalex.org/W2023293152","https://openalex.org/W2028682200","https://openalex.org/W2030214324","https://openalex.org/W2030720251","https://openalex.org/W2032169064","https://openalex.org/W2038870603","https://openalex.org/W2039206013","https://openalex.org/W2047519015","https://openalex.org/W2052192720","https://openalex.org/W2059813954","https://openalex.org/W2061394685","https://openalex.org/W2064253793","https://openalex.org/W2065681262","https://openalex.org/W2069308992","https://openalex.org/W2074321172","https://openalex.org/W2076171916","https://openalex.org/W2081589596","https://openalex.org/W2092424254","https://openalex.org/W2096234619","https://openalex.org/W2102300714","https://openalex.org/W2110148884","https://openalex.org/W2115294635","https://openalex.org/W2117612738","https://openalex.org/W2123029770","https://openalex.org/W2123590972","https://openalex.org/W2124186838","https://openalex.org/W2126496496","https://openalex.org/W2126745871","https://openalex.org/W2133240422","https://openalex.org/W2135935649","https://openalex.org/W2138197182","https://openalex.org/W2141109151","https://openalex.org/W2146074801","https://openalex.org/W2152645204","https://openalex.org/W2153520720","https://openalex.org/W2154589077","https://openalex.org/W2156393136","https://openalex.org/W2158208080","https://openalex.org/W2160648230","https://openalex.org/W2168167465","https://openalex.org/W2176758530","https://openalex.org/W2265605294","https://openalex.org/W2280722998","https://openalex.org/W2297959802","https://openalex.org/W2347077379","https://openalex.org/W2417253274","https://openalex.org/W2419594247","https://openalex.org/W2509070850","https://openalex.org/W2522267165","https://openalex.org/W2544486379","https://openalex.org/W2558984237","https://openalex.org/W2613004608","https://openalex.org/W2668309208","https://openalex.org/W2735069743","https://openalex.org/W2746240834","https://openalex.org/W2748062037","https://openalex.org/W2756114304","https://openalex.org/W2765605372","https://openalex.org/W2770254472","https://openalex.org/W4211178136","https://openalex.org/W6657636389"],"related_works":["https://openalex.org/W2917741599","https://openalex.org/W2001681139","https://openalex.org/W1974172409","https://openalex.org/W2011835836","https://openalex.org/W2378796985","https://openalex.org/W2972920064","https://openalex.org/W2089872551","https://openalex.org/W1973836350","https://openalex.org/W2038509173","https://openalex.org/W2136036540"],"abstract_inverted_index":{"T":[0,4,40,44,124],"lymphocytes":[1],"use":[2],"\u03b1\u03b2":[3],"cell":[5,41,45,75],"receptors":[6],"(TCRs)":[7],"to":[8,14,24,85],"recognize":[9],"sparse":[10],"antigenic":[11],"peptides":[12],"bound":[13],"MHC":[15],"molecules":[16],"(pMHCs)":[17],"arrayed":[18],"on":[19,56],"antigen-presenting":[20],"cells":[21],"(APCs).":[22],"Contrary":[23],"conventional":[25],"receptor-ligand":[26],"associations":[27],"exemplified":[28],"by":[29,70],"antigen-antibody":[30],"interactions,":[31],"forces":[32,52],"play":[33],"a":[34],"crucial":[35],"role":[36],"in":[37],"nonequilibrium":[38],"mechanosensor-based":[39],"activation.":[42],"Both":[43],"motility":[46],"and":[47,76,100,120],"local":[48],"cytoskeleton":[49],"machinery":[50],"exert":[51],"(i.e.,":[53,95],"generate":[54],"loads)":[55],"TCR-pMHC":[57],"bonds.":[58],"We":[59],"review":[60],"biological":[61],"features":[62],"of":[63,92,122],"the":[64,90,118],"load-dependent":[65],"activation":[66],"process":[67],"as":[68,105],"revealed":[69],"optical":[71],"tweezers":[72],"single":[73,86],"molecule/single":[74],"other":[77],"biophysical":[78],"measurements.":[79],"The":[80,111],"findings":[81],"link":[82],"pMHC-triggered":[83],"TCRs":[84],"cytoskeletal":[87],"motors;":[88],"define":[89],"importance":[91],"energized":[93],"anisotropic":[94],"force":[96],"direction":[97],"dependent)":[98],"activation;":[99],"characterize":[101],"immunological":[102],"synapse":[103],"formation":[104],"digital,":[106],"revealing":[107],"no":[108],"serial":[109],"requirement.":[110],"emerging":[112],"picture":[113],"suggests":[114],"new":[115],"approaches":[116],"for":[117],"monitoring":[119],"design":[121],"cytotoxic":[123],"lymphocyte":[125],"(CTL)-based":[126],"immunotherapy.":[127]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
