{"id":"https://openalex.org/W2810738494","doi":"https://doi.org/10.3389/fphys.2018.00820","title":"Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy","display_name":"Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy","publication_year":2018,"publication_date":"2018-07-13","ids":{"openalex":"https://openalex.org/W2810738494","doi":"https://doi.org/10.3389/fphys.2018.00820","mag":"2810738494","pmid":"https://pubmed.ncbi.nlm.nih.gov/30057551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6053590"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2018.00820","doi":"https://doi.org/10.3389/fphys.2018.00820","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2018.00820","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00820/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00820/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086776275","display_name":"Ana Raquel Santiago","orcid":"https://orcid.org/0000-0002-7541-7041","observed_orcids":["https://orcid.org/0000-0002-7541-7041"]},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana R. Santiago","raw_affiliation_strings":["Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal","CNC.IBILI, University of Coimbra, Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]},{"raw_affiliation_string":"CNC.IBILI, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002179389","display_name":"Raquel Boia","orcid":"https://orcid.org/0000-0002-0479-3066","observed_orcids":["https://orcid.org/0000-0002-0479-3066"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Raquel Boia","raw_affiliation_strings":["CNC.IBILI, University of Coimbra, Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC.IBILI, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078657053","display_name":"In\u00eas Dinis Aires","orcid":"https://orcid.org/0000-0001-8384-9648","observed_orcids":["https://orcid.org/0000-0001-8384-9648"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"In\u00eas D. Aires","raw_affiliation_strings":["CNC.IBILI, University of Coimbra, Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC.IBILI, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075909802","display_name":"Ant\u00f3nio Francisco Ambr\u00f3sio","orcid":"https://orcid.org/0000-0002-0477-1641","observed_orcids":["https://orcid.org/0000-0002-0477-1641"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio F. Ambr\u00f3sio","raw_affiliation_strings":["CNC.IBILI, University of Coimbra, Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC.IBILI, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024992223","display_name":"Rosa Fernandes","orcid":"https://orcid.org/0000-0001-7828-2296","observed_orcids":["https://orcid.org/0000-0001-7828-2296"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Rosa Fernandes","raw_affiliation_strings":["CNC.IBILI, University of Coimbra, Coimbra, Portugal","Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC.IBILI, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024992223"],"corresponding_institution_ids":["https://openalex.org/I76903346"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.7612,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.8625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"820","last_page":"820"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/retinal-endothelial-cells","display_name":"retinal endothelial cells","score":0.7720000147819519},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4300000071525574},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6679999828338623},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7253333330154419},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.570003867149353},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.46054571866989136},{"id":"https://openalex.org/C73282008","wikidata":"https://www.wikidata.org/wiki/Q1759895","display_name":"Coping (psychology)","level":2,"score":0.45699188113212585},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45191720128059387},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.4341808259487152},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38721007108688354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3577272593975067},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.22407454252243042},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19492965936660767}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fphys.2018.00820","doi":"https://doi.org/10.3389/fphys.2018.00820","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2018.00820","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00820/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5013560","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6053590","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30057551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30057551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6053590","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6053590/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmh:oai:estudogeral.uc.pt:10316/107638","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/107638","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/107638/1/Sweet%20Stress%20Coping%20with%20vascular%20dysfunction%20in%20diabetic%20retinopathy.pdf","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:160604315d5e41c2ae8f24fa0b53cd17","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/160604315d5e41c2ae8f24fa0b53cd17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 9 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2018.00820","doi":"https://doi.org/10.3389/fphys.2018.00820","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2018.00820","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2018.00820/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1300719884","display_name":null,"funder_award_id":"UID/NEU/04539/2013","funder_id":"https://openalex.org/F4320328601","funder_display_name":"Programa Operacional Regional do Centro"},{"id":"https://openalex.org/G1516346500","display_name":null,"funder_award_id":"01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1559341743","display_name":"Ativa\u00e7\u00e3o do recetor de adenosina usando implantes biodegrad\u00e1veis intraoculares como estrat\u00e9gia para o tratamento do glaucoma","funder_award_id":"PD/BD/114115/2015","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1577006909","display_name":null,"funder_award_id":"04539","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1578237752","display_name":null,"funder_award_id":"COMPETE","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1590170550","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER-000008)","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1763632427","display_name":null,"funder_award_id":"POCI-01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G196013823","display_name":null,"funder_award_id":"PO-CI-01-0145-FEDER-007440","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2737160601","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3840324753","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3907808495","display_name":"CNC. IBILI","funder_award_id":"UID/NEU/04539/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G440449987","display_name":"\"Deadly delivery: unraveling the contribuition of microglial exosomes to retinal degeneration in glaucoma\"","funder_award_id":"PD/BD/127821/2016","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5224927334","display_name":null,"funder_award_id":"POCI-01-","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5258554520","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-007440","funder_id":"https://openalex.org/F4320328601","funder_display_name":"Programa Operacional Regional do Centro"},{"id":"https://openalex.org/G6276858265","display_name":null,"funder_award_id":"CENTRO-01-0145-FEDER-000008","funder_id":"https://openalex.org/F4320328601","funder_display_name":"Programa Operacional Regional do Centro"}],"funders":[{"id":"https://openalex.org/F4320328601","display_name":"Programa Operacional Regional do Centro","ror":null},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810738494.pdf","grobid_xml":"https://content.openalex.org/works/W2810738494.grobid-xml"},"referenced_works_count":179,"referenced_works":["https://openalex.org/W121366921","https://openalex.org/W202493534","https://openalex.org/W1215756294","https://openalex.org/W1263018205","https://openalex.org/W1490372003","https://openalex.org/W1495997476","https://openalex.org/W1528177085","https://openalex.org/W1545837129","https://openalex.org/W1548418968","https://openalex.org/W1557190248","https://openalex.org/W1572772426","https://openalex.org/W1587360940","https://openalex.org/W1604412960","https://openalex.org/W1809981254","https://openalex.org/W1915008606","https://openalex.org/W1963552086","https://openalex.org/W1964058532","https://openalex.org/W1965220977","https://openalex.org/W1970037673","https://openalex.org/W1970730429","https://openalex.org/W1976353252","https://openalex.org/W1976412979","https://openalex.org/W1976988821","https://openalex.org/W1980549058","https://openalex.org/W1981122508","https://openalex.org/W1982042273","https://openalex.org/W1983786871","https://openalex.org/W1984984255","https://openalex.org/W1988533709","https://openalex.org/W1989454963","https://openalex.org/W1991064786","https://openalex.org/W1991587502","https://openalex.org/W1993762245","https://openalex.org/W1995945700","https://openalex.org/W1996952739","https://openalex.org/W1999137981","https://openalex.org/W2004135846","https://openalex.org/W2008277851","https://openalex.org/W2010903558","https://openalex.org/W2011026111","https://openalex.org/W2011477764","https://openalex.org/W2012747049","https://openalex.org/W2015027527","https://openalex.org/W2015316160","https://openalex.org/W2015436684","https://openalex.org/W2017666158","https://openalex.org/W2019432894","https://openalex.org/W2019895286","https://openalex.org/W2021108990","https://openalex.org/W2021460138","https://openalex.org/W2023497842","https://openalex.org/W2025036216","https://openalex.org/W2025799202","https://openalex.org/W2027868871","https://openalex.org/W2029188025","https://openalex.org/W2029258190","https://openalex.org/W2029542117","https://openalex.org/W2031418918","https://openalex.org/W2033450092","https://openalex.org/W2033919445","https://openalex.org/W2034060753","https://openalex.org/W2034426126","https://openalex.org/W2035334171","https://openalex.org/W2035640141","https://openalex.org/W2035899769","https://openalex.org/W2035985259","https://openalex.org/W2036688990","https://openalex.org/W2038631127","https://openalex.org/W2040503376","https://openalex.org/W2041137175","https://openalex.org/W2041857857","https://openalex.org/W2042068980","https://openalex.org/W2042080014","https://openalex.org/W2042789158","https://openalex.org/W2043243208","https://openalex.org/W2043808345","https://openalex.org/W2045228120","https://openalex.org/W2046039331","https://openalex.org/W2046433337","https://openalex.org/W2047640394","https://openalex.org/W2051066258","https://openalex.org/W2051893906","https://openalex.org/W2056043330","https://openalex.org/W2056843795","https://openalex.org/W2057328170","https://openalex.org/W2057683168","https://openalex.org/W2059088148","https://openalex.org/W2061356986","https://openalex.org/W2061988978","https://openalex.org/W2070001955","https://openalex.org/W2071466648","https://openalex.org/W2072020432","https://openalex.org/W2072690677","https://openalex.org/W2073453384","https://openalex.org/W2076821925","https://openalex.org/W2083274084","https://openalex.org/W2083355844","https://openalex.org/W2087149659","https://openalex.org/W2094935740","https://openalex.org/W2097325635","https://openalex.org/W2108337314","https://openalex.org/W2111076061","https://openalex.org/W2117568221","https://openalex.org/W2119711390","https://openalex.org/W2119745199","https://openalex.org/W2120276758","https://openalex.org/W2121162236","https://openalex.org/W2122386753","https://openalex.org/W2123105801","https://openalex.org/W2123634291","https://openalex.org/W2124011448","https://openalex.org/W2124736173","https://openalex.org/W2128188021","https://openalex.org/W2128631317","https://openalex.org/W2128783891","https://openalex.org/W2128895547","https://openalex.org/W2138386830","https://openalex.org/W2138480916","https://openalex.org/W2139123746","https://openalex.org/W2141170049","https://openalex.org/W2144443864","https://openalex.org/W2144776559","https://openalex.org/W2146172555","https://openalex.org/W2146738245","https://openalex.org/W2147457499","https://openalex.org/W2147656680","https://openalex.org/W2149528201","https://openalex.org/W2155144135","https://openalex.org/W2157757005","https://openalex.org/W2158855079","https://openalex.org/W2159205789","https://openalex.org/W2160121103","https://openalex.org/W2161509677","https://openalex.org/W2161908376","https://openalex.org/W2165344522","https://openalex.org/W2165592594","https://openalex.org/W2168261002","https://openalex.org/W2170593168","https://openalex.org/W2171651020","https://openalex.org/W2171994468","https://openalex.org/W2172142171","https://openalex.org/W2193621263","https://openalex.org/W2249574602","https://openalex.org/W2280898237","https://openalex.org/W2307184243","https://openalex.org/W2313838053","https://openalex.org/W2324588265","https://openalex.org/W2335563658","https://openalex.org/W2340643158","https://openalex.org/W2353199259","https://openalex.org/W2405624971","https://openalex.org/W2406832004","https://openalex.org/W2407450303","https://openalex.org/W2471605942","https://openalex.org/W2496215719","https://openalex.org/W2501854478","https://openalex.org/W2511446264","https://openalex.org/W2552476469","https://openalex.org/W2557321115","https://openalex.org/W2580500986","https://openalex.org/W2587570425","https://openalex.org/W2594873672","https://openalex.org/W2605619962","https://openalex.org/W2609199661","https://openalex.org/W2615239588","https://openalex.org/W2616524636","https://openalex.org/W2626442855","https://openalex.org/W2726694250","https://openalex.org/W2738996050","https://openalex.org/W2745265970","https://openalex.org/W2767261857","https://openalex.org/W4211205882","https://openalex.org/W4212945288","https://openalex.org/W4240304626","https://openalex.org/W4244017022","https://openalex.org/W4254778823","https://openalex.org/W6629168698","https://openalex.org/W6680524799","https://openalex.org/W6684540448"],"related_works":["https://openalex.org/W3049295013","https://openalex.org/W2892151967","https://openalex.org/W7118001970","https://openalex.org/W4231223779","https://openalex.org/W4386865190","https://openalex.org/W2375582959","https://openalex.org/W7171319214","https://openalex.org/W3098441039","https://openalex.org/W2805238712","https://openalex.org/W1994340065"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"plays":[2],"key":[3],"roles":[4],"in":[5,21,24,137,141,173],"the":[6,22,27,37,72,81,106,109,129,138,142,154,164],"pathogenesis":[7],"of":[8,39,54,68,74,99,108,111,128,146,167],"retinal":[9,59,85,112,155,189],"diseases,":[10],"such":[11],"as":[12],"diabetic":[13,116,174],"retinopathy.":[14],"Reactive":[15],"oxygen":[16],"species":[17],"(ROS)":[18],"are":[19],"increased":[20,63],"retina":[23,130],"diabetes":[25],"and":[26,66,88,97,124,144,158],"antioxidant":[28],"defense":[29],"system":[30],"is":[31,103],"also":[32],"compromised.":[33],"Increased":[34],"ROS":[35,55],"stimulate":[36],"release":[38],"pro-inflammatory":[40],"cytokines,":[41],"promoting":[42],"a":[43],"chronic":[44],"low-grade":[45],"inflammation":[46],"involving":[47],"various":[48],"signaling":[49],"pathways.":[50],"An":[51],"excessive":[52],"production":[53],"can":[56,152],"lead":[57],"to":[58,183],"endothelial":[60,86,122,171,184],"cell":[61,185],"injury,":[62],"microvascular":[64],"permeability,":[65],"recruitment":[67],"inflammatory":[69,133],"cells":[70,87,90,123,127,134,151],"at":[71],"site":[73],"inflammation.":[75],"Recent":[76],"studies":[77],"have":[78],"started":[79],"unraveling":[80],"complex":[82],"crosstalk":[83,102],"between":[84,121,149],"neuroglial":[89],"or":[91,131],"leukocytes,":[92],"via":[93],"both":[94],"cell-to-cell":[95],"contact":[96],"secretion":[98,143],"cytokines.":[100],"This":[101],"essential":[104],"for":[105,170],"maintenance":[107],"integrity":[110],"vascular":[113,156],"structure.":[114],"Under":[115],"conditions,":[117],"an":[118],"aberrant":[119],"interaction":[120],"other":[125,188],"resident":[126],"invading":[132],"takes":[135],"place":[136],"retina.":[139],"Impairment":[140],"flow":[145],"molecular":[147],"signals":[148],"different":[150],"compromise":[153],"architecture":[157],"trigger":[159],"angiogenesis.":[160],"In":[161],"this":[162],"review,":[163],"synergistic":[165],"contributions":[166],"redox-inflammatory":[168],"processes":[169],"dysfunction":[172],"retinopathy":[175],"will":[176],"be":[177],"examined,":[178],"with":[179,187],"particular":[180],"attention":[181],"paid":[182],"communication":[186],"cells.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-07-10T00:00:00"}