{"id":"https://openalex.org/W2810718432","doi":"https://doi.org/10.1371/journal.pone.0198827","title":"Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials","display_name":"Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials","publication_year":2018,"publication_date":"2018-07-03","ids":{"openalex":"https://openalex.org/W2810718432","doi":"https://doi.org/10.1371/journal.pone.0198827","mag":"2810718432","pmid":"https://pubmed.ncbi.nlm.nih.gov/29969448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6029752"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0198827","doi":"https://doi.org/10.1371/journal.pone.0198827","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0198827","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198827&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198827&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072471105","display_name":"Christopher A. Rice","orcid":"https://orcid.org/0000-0003-0672-9604","observed_orcids":["https://orcid.org/0000-0003-0672-9604"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]},{"id":"https://openalex.org/I868834043","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20","country_code":"GB","type":"education","lineage":["https://openalex.org/I868834043"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher A. Rice","raw_affiliation_strings":["Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom","Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-0672-9604","affiliations":[{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom","institution_ids":["https://openalex.org/I868834043"]},{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103725198","display_name":"Sara J. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I868834043","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20","country_code":"GB","type":"education","lineage":["https://openalex.org/I868834043"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sara J. Campbell","raw_affiliation_strings":["Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom","institution_ids":["https://openalex.org/I868834043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075753903","display_name":"Claudine Bisson","orcid":"https://orcid.org/0000-0002-9430-6822","observed_orcids":["https://orcid.org/0000-0002-9430-6822"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudine Bisson","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057174054","display_name":"Hayley J. Owen","orcid":"https://orcid.org/0000-0002-6274-0560","observed_orcids":["https://orcid.org/0000-0002-6274-0560"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hayley J. Owen","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110638997","display_name":"Svetlana E. Sedelnikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Svetlana E. Sedelnikova","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069798129","display_name":"Patrick J. Baker","orcid":"https://orcid.org/0000-0003-1995-5643","observed_orcids":["https://orcid.org/0000-0003-1995-5643"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick J. Baker","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029138719","display_name":"David W. Rice","orcid":"https://orcid.org/0000-0002-7811-0539","observed_orcids":["https://orcid.org/0000-0002-7811-0539"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David W. Rice","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010559786","display_name":"Fiona L. Henriquez","orcid":"https://orcid.org/0000-0002-5534-1019","observed_orcids":["https://orcid.org/0000-0002-5534-1019"]},"institutions":[{"id":"https://openalex.org/I868834043","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20","country_code":"GB","type":"education","lineage":["https://openalex.org/I868834043"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Fiona L. Henriquez","raw_affiliation_strings":["Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom","institution_ids":["https://openalex.org/I868834043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040139721","display_name":"Craig W. Roberts","orcid":"https://orcid.org/0000-0002-0653-835X","observed_orcids":["https://orcid.org/0000-0002-0653-835X"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Craig W. Roberts","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I181647926"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010559786","https://openalex.org/A5040139721"],"corresponding_institution_ids":["https://openalex.org/I181647926","https://openalex.org/I868834043"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5463,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.58649686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"7","first_page":"e0198827","last_page":"e0198827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.20080000162124634,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.10369999706745148,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acanthamoeba","display_name":"Acanthamoeba","score":0.996999979019165},{"id":"https://openalex.org/keywords/histidine-biosynthesis","display_name":"histidine biosynthesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/3-amino-1-2-4-triazole","display_name":"3-amino-1,2,4-triazole","score":0.9789999723434448},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.4320000112056732},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/antimicrobial-targets","display_name":"antimicrobial drug targets","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2778868110","wikidata":"https://www.wikidata.org/wiki/Q1152218","display_name":"Acanthamoeba","level":2,"score":0.8329247236251831},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.7520556449890137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.686896562576294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.576400637626648},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5594642162322998},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.49793267250061035},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4263220727443695},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.38677656650543213},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1263357400894165}],"mesh":[{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D000072756","descriptor_name":"Protein Conformation, alpha-Helical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000640","descriptor_name":"Amitrole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000640","descriptor_name":"Amitrole","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052818","descriptor_name":"Autotrophic Processes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052818","descriptor_name":"Autotrophic Processes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0198827","doi":"https://doi.org/10.1371/journal.pone.0198827","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0198827","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198827&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5005057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6029752","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29969448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29969448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6029752","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6029752/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:eprints.whiterose.ac.uk:133059","doi":null,"is_oa":false,"landing_page_url":"https://eprints.whiterose.ac.uk/133059/1/journal.pone.0198827.pdf","pdf_url":"https://eprints.whiterose.ac.uk/133059/1/journal.pone.0198827.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:strathprints.strath.ac.uk:64233","doi":null,"is_oa":true,"landing_page_url":"https://strathprints.strath.ac.uk/64233/","pdf_url":"https://strathprints.strath.ac.uk/64233/8/Rice_etal_PLoS_One_2018_Structural_and_functional_studies_of_histidine_biosynthesis_in_Acanthamoeba.pdf","source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:85ba507fe704463a900bf5c142dcff83","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/85ba507fe704463a900bf5c142dcff83","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 13, Iss 7, p e0198827 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/6737756","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Structural_and_functional_studies_of_histidine_biosynthesis_in_i_Acanthamoeba_i_spp_demonstrates_a_novel_molecular_arrangement_and_target_for_antimicrobials/6737756","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0198827","doi":"https://doi.org/10.1371/journal.pone.0198827","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0198827","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198827&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313096","display_name":"Diamond Light Source","ror":"https://ror.org/05etxs293"},{"id":"https://openalex.org/F4320320850","display_name":"University of the West of Scotland","ror":"https://ror.org/04w3d2v20"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810718432.pdf","grobid_xml":"https://content.openalex.org/works/W2810718432.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W271020424","https://openalex.org/W640680730","https://openalex.org/W1875627818","https://openalex.org/W1970534142","https://openalex.org/W1983561712","https://openalex.org/W1998017028","https://openalex.org/W2001641653","https://openalex.org/W2002251243","https://openalex.org/W2006922696","https://openalex.org/W2013890449","https://openalex.org/W2034767282","https://openalex.org/W2035622658","https://openalex.org/W2036598479","https://openalex.org/W2052283610","https://openalex.org/W2065220446","https://openalex.org/W2070697496","https://openalex.org/W2078101756","https://openalex.org/W2096064309","https://openalex.org/W2100457610","https://openalex.org/W2109613748","https://openalex.org/W2109841814","https://openalex.org/W2114622716","https://openalex.org/W2122661932","https://openalex.org/W2124026197","https://openalex.org/W2131367352","https://openalex.org/W2135307576","https://openalex.org/W2136794728","https://openalex.org/W2144998676","https://openalex.org/W2147874841","https://openalex.org/W2154714625","https://openalex.org/W2157468552","https://openalex.org/W2159211495","https://openalex.org/W2160034397","https://openalex.org/W2160873938","https://openalex.org/W2165583099","https://openalex.org/W2180229411","https://openalex.org/W2299699902","https://openalex.org/W2482918877","https://openalex.org/W2524746347","https://openalex.org/W2908703656"],"related_works":["https://openalex.org/W2008526592","https://openalex.org/W2063577650","https://openalex.org/W7070430256","https://openalex.org/W78979134","https://openalex.org/W4206093367","https://openalex.org/W7101180787","https://openalex.org/W2783720382","https://openalex.org/W73708903","https://openalex.org/W2247260543","https://openalex.org/W1970534142"],"abstract_inverted_index":{"Acanthamoeba":[0,37,80,126,154,204],"is":[1,81,94,106],"normally":[2],"free-living,":[3],"but":[4,85,105,180],"sometimes":[5],"facultative":[6],"and":[7,17,43,53,68,194],"occasionally":[8],"opportunistic":[9],"parasites.":[10],"Current":[11],"therapies":[12,52],"are,":[13],"by":[14,108,171,183],"necessity,":[15],"arduous":[16],"yet":[18],"poorly":[19],"effective":[20],"due":[21],"to":[22,25,33,54,89,96,196],"their":[23],"inabilities":[24],"kill":[26],"cyst":[27],"stages":[28],"or":[29],"in":[30,48,98,132,187,227],"some":[31],"cases":[32],"actually":[34],"induce":[35],"encystation.":[36],"can":[38],"therefore":[39],"survive":[40],"as":[41],"cysts":[42],"cause":[44],"disease":[45],"recurrence.":[46],"Herein,":[47],"pursuit":[49],"of":[50,58,72,120,125,143,152,174,192,200,203,221],"better":[51],"understand":[55],"the":[56,70,87,116,150,172,198,217,223],"biochemistry":[57],"this":[59,74,102],"understudied":[60],"organism,":[61],"we":[62],"characterize":[63],"its":[64],"histidine":[65,83,121,224],"biosynthesis":[66,225],"pathway":[67,226],"explore":[69],"potential":[71,218],"targeting":[73,222],"with":[75,86,134],"antimicrobials.":[76],"We":[77],"demonstrate":[78],"that":[79,111],"a":[82,138,157,207],"autotroph,":[84],"ability":[88,191],"scavenge":[90],"preformed":[91],"histidine.":[92],"It":[93],"able":[95],"grow":[97],"defined":[99],"media":[100],"lacking":[101],"amino":[103],"acid,":[104],"inhibited":[107,149],"3-amino-1,2,4-triazole":[109],"(3AT)":[110],"targets":[112],"Imidazoleglycerol-Phosphate":[113],"Dehydratase":[114],"(IGPD)":[115],"rate":[117],"limiting":[118],"step":[119],"biosynthesis.":[122],"The":[123,190],"structure":[124],"IGPD":[127],"has":[128],"also":[129],"been":[130],"determined":[131],"complex":[133],"2-hydroxy-3-(1,2,4-triazol-1-yl)":[135],"propylphosphonate":[136],"[(R)-C348],":[137],"recently":[139,208],"described":[140],"novel":[141],"inhibitor":[142],"Arabidopsis":[144],"thaliana":[145],"IGPD.":[146],"This":[147,166],"compound":[148],"growth":[151,199],"four":[153,201],"species,":[155],"having":[156],"50%":[158],"inhibitory":[159],"concentration":[160],"(IC50)":[161],"ranging":[162],"from":[163],"250-526":[164],"nM.":[165],"effect":[167],"could":[168],"be":[169],"ablated":[170],"addition":[173],"1":[175],"mM":[176],"exogenous":[177],"free":[178],"histidine,":[179],"importantly":[181],"not":[182,213],"physiological":[184],"concentrations":[185],"found":[186],"mammalian":[188],"tissues.":[189],"3AT":[193],"(R)-C348":[195],"restrict":[197],"strains":[202],"spp.":[205],"including":[206],"isolated":[209],"clinical":[210],"strain,":[211],"while":[212],"inducing":[214],"encystment,":[215],"demonstrates":[216],"therapeutic":[219],"utility":[220],"Acanthamoeba.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-07-10T00:00:00"}