{"id":"https://openalex.org/W2810714029","doi":"https://doi.org/10.12991/jrp.2018.90","title":"Development of a validated HPLC method for simultaneous determination of olanzapine and aripiprazole in human plasma","display_name":"Development of a validated HPLC method for simultaneous determination of olanzapine and aripiprazole in human plasma","publication_year":2018,"publication_date":"2018-07-02","ids":{"openalex":"https://openalex.org/W2810714029","doi":"https://doi.org/10.12991/jrp.2018.90","mag":"2810714029"},"language":"en","primary_location":{"id":"doi:10.12991/jrp.2018.90","doi":"https://doi.org/10.12991/jrp.2018.90","is_oa":true,"landing_page_url":"https://doi.org/10.12991/jrp.2018.90","pdf_url":"http://jrespharm.com/pdf.php?id=624","source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research in Pharmacy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2810714029"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://jrespharm.com/pdf.php?id=624","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032113699","display_name":"Sakine Atila Karaca","orcid":"https://orcid.org/0000-0002-9440-3438","observed_orcids":["https://orcid.org/0000-0002-9440-3438"]},"institutions":[{"id":"https://openalex.org/I133743585","display_name":"Anadolu University","ror":"https://ror.org/05nz37n09","country_code":"TR","type":"education","lineage":["https://openalex.org/I133743585"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sakine Atila Karaca","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey","institution_ids":["https://openalex.org/I133743585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072758293","display_name":"Duygu Yeniceli U\u011fur","orcid":"https://orcid.org/0000-0001-8765-4434","observed_orcids":["https://orcid.org/0000-0001-8765-4434"]},"institutions":[{"id":"https://openalex.org/I133743585","display_name":"Anadolu University","ror":"https://ror.org/05nz37n09","country_code":"TR","type":"education","lineage":["https://openalex.org/I133743585"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Duygu Yeniceli U\u011fur","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey","institution_ids":["https://openalex.org/I133743585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I133743585"],"apc_list":null,"apc_paid":null,"fwci":0.2333,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.39942489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"22","issue":"1","first_page":"162","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":1.0},{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":1.0},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8899999856948853},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.8759999871253967},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.949999988079071},{"id":"https://openalex.org/keywords/hplc-method-validation","display_name":"HPLC method validation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fractional-factorial-design","display_name":"fractional factorial design","score":0.7450000047683716},{"id":"https://openalex.org/keywords/box-behnken-design","display_name":"Box-Behnken design","score":0.9980000257492065},{"id":"https://openalex.org/keywords/monolithic-columns","display_name":"monoliths","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gradient-elution","display_name":"gradient elution","score":0.6230000257492065},{"id":"https://openalex.org/keywords/method-optimization","display_name":"method optimization","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.9666129946708679},{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.807874858379364},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.7411668300628662},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5814270377159119},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42755940556526184},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.419016569852829},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39514899253845215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2782171368598938},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.19846105575561523},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12210378050804138}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.12991/jrp.2018.90","doi":"https://doi.org/10.12991/jrp.2018.90","is_oa":true,"landing_page_url":"https://doi.org/10.12991/jrp.2018.90","pdf_url":"http://jrespharm.com/pdf.php?id=624","source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research in Pharmacy","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/1711866","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/jrespharm/article/1711866","pdf_url":null,"source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.12991/jrp.2018.90","doi":"https://doi.org/10.12991/jrp.2018.90","is_oa":true,"landing_page_url":"https://doi.org/10.12991/jrp.2018.90","pdf_url":"http://jrespharm.com/pdf.php?id=624","source":{"id":"https://openalex.org/S4210224330","display_name":"Journal of Research in Pharmacy","issn_l":"2630-6344","issn":["2630-6344"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Research in Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325357","display_name":"Anadolu \u00dcniversitesi","ror":"https://ror.org/05nz37n09"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810714029.pdf","grobid_xml":"https://content.openalex.org/works/W2810714029.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W31879179","https://openalex.org/W104921085","https://openalex.org/W143015570","https://openalex.org/W1963782308","https://openalex.org/W1986937661","https://openalex.org/W1993107786","https://openalex.org/W1999402957","https://openalex.org/W2023190148","https://openalex.org/W2038435127","https://openalex.org/W2044031888","https://openalex.org/W2053870335","https://openalex.org/W2066616619","https://openalex.org/W2068128033","https://openalex.org/W2071530550","https://openalex.org/W2077145825","https://openalex.org/W2079388151","https://openalex.org/W2082441632","https://openalex.org/W2089335027","https://openalex.org/W2090981029","https://openalex.org/W2091717367","https://openalex.org/W2094349703","https://openalex.org/W2114304645","https://openalex.org/W2570451540","https://openalex.org/W2611505834"],"related_works":["https://openalex.org/W3068085075","https://openalex.org/W2005247712","https://openalex.org/W1990500519","https://openalex.org/W2080303040","https://openalex.org/W2376344836","https://openalex.org/W2032593878","https://openalex.org/W1823580445","https://openalex.org/W1983425150","https://openalex.org/W4385199544"],"abstract_inverted_index":{"A":[0],"simple":[1],"and":[2,8,18,41,86,91,95,109,117,122,130,140,152],"rapid":[3],"HPLC":[4],"method":[5,99,126,151],"was":[6,52,72,100,127],"developed":[7],"validated":[9],"for":[10,107,111,115],"simultaneous":[11],"determination":[12],"of":[13,44,68,79,89,105,149,155],"two":[14],"antipsychotic":[15],"drugs,":[16],"olanzapine":[17,90,108,116],"aripiprazole,":[19],"in":[20,102],"spiked":[21],"human":[22],"plasma.Optimization":[23],"studies":[24],"were":[25,35,47,93,119,137,145,157],"performed":[26,73],"using":[27,37],"experimental":[28],"design":[29,40],"approach.The":[30],"most":[31],"important":[32],"analysis":[33],"parameters":[34,46],"selected":[36],"fractional":[38],"factorial":[39],"optimum":[42],"levels":[43],"these":[45],"determined":[48],"with":[49,64,74],"Box-Behnken":[50],"design.Separation":[51],"achieved":[53],"on":[54,133],"a":[55,65,75],"monolithic":[56],"column":[57],"(Rp-18,":[58],"100-4.6":[59],"mm)":[60],"set":[61],"at":[62],"35\u00b0C":[63],"flow":[66],"rate":[67],"0.8":[69],"ml/min.Gradient":[70],"elution":[71],"mobile":[76],"phase":[77],"consisting":[78],"phosphate":[80],"buffer":[81],"(pH":[82],"3.14,":[83],"20":[84],"mM)":[85],"acetonitrile.Retention":[87],"times":[88],"aripiprazole":[92,118],"2.34":[94],"6.90":[96],"minutes,":[97],"respectively.The":[98,125],"linear":[101],"the":[103,150,153],"range":[104],"0.125-50.0\u00b5g/ml":[106],"0.500-50.0\u00b5g/ml":[110],"aripiprazole.The":[112],"quantification":[113],"limits":[114],"found":[120,128],"0.069":[121],"0.498":[123],"\u00b5g/ml,":[124],"accurate":[129],"precise":[131],"based":[132],"recovery":[134],"values,":[135],"which":[136,144],"between":[138],"99-102%":[139],"relative":[141],"standard":[142],"deviations,":[143],"lower":[146],"than":[147],"2%.Robustness":[148],"stability":[154],"analytes":[156],"also":[158],"investigated.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2018-07-10T00:00:00"}