{"id":"https://openalex.org/W2810698763","doi":"https://doi.org/10.1002/jlb.3mr0218-079r","title":"MicroRNA miR-223 as regulator of innate immunity","display_name":"MicroRNA miR-223 as regulator of innate immunity","publication_year":2018,"publication_date":"2018-07-03","ids":{"openalex":"https://openalex.org/W2810698763","doi":"https://doi.org/10.1002/jlb.3mr0218-079r","mag":"2810698763","pmid":"https://pubmed.ncbi.nlm.nih.gov/29969525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6638550"},"language":"en","primary_location":{"id":"doi:10.1002/jlb.3mr0218-079r","doi":"https://doi.org/10.1002/jlb.3mr0218-079r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlb.3mr0218-079r","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6638550","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004618138","display_name":"Xiaoyi Yuan","orcid":"https://orcid.org/0000-0002-2898-6495","observed_orcids":["https://orcid.org/0000-0002-2898-6495"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaoyi Yuan","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090842322","display_name":"Nathaniel K. Berg","orcid":"https://orcid.org/0000-0002-2568-2867","observed_orcids":["https://orcid.org/0000-0002-2568-2867"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Berg","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045993973","display_name":"Jae Woong Lee","orcid":"https://orcid.org/0000-0001-7952-5544","observed_orcids":["https://orcid.org/0000-0001-7952-5544"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae Woong Lee","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110262397","display_name":"Thanh\u2010Thuy T. Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh-Thuy Le","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034888205","display_name":"Viola Neudecker","orcid":"https://orcid.org/0000-0003-3021-5523","observed_orcids":["https://orcid.org/0000-0003-3021-5523"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viola Neudecker","raw_affiliation_strings":["Department of Anesthesiology, Columbia University , New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Columbia University , New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107772286","display_name":"Na Jing","orcid":"https://orcid.org/0009-0009-8848-011X","observed_orcids":["https://orcid.org/0009-0009-8848-011X"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Na Jing","raw_affiliation_strings":["Department of Anesthesiology, China Medical University , Liaoning, P.R. China","Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, China Medical University , Liaoning, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001509341","display_name":"Holger K. Eltzschig","orcid":"https://orcid.org/0000-0002-5676-6473","observed_orcids":["https://orcid.org/0000-0002-5676-6473"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holger Eltzschig","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School , Houston, Texas, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004618138"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":2.1168,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.90279627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"104","issue":"3","first_page":"515","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-223","display_name":"miR-223","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9070000052452087},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myeloid-differentiation","display_name":"myeloid differentiation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"granulopoiesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.7789999842643738},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":1.0},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/microrna-therapy","display_name":"miRNA-based therapy","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.825170636177063},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.7559453845024109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7102963924407959},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.615415632724762},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5605394840240479},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5193222761154175},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.48486360907554626},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.477232962846756},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.4125870168209076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2765306234359741},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.254061222076416},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/jlb.3mr0218-079r","doi":"https://doi.org/10.1002/jlb.3mr0218-079r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlb.3mr0218-079r","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:29969525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29969525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5678556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6638550","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6638550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6638550/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Leukoc Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5678556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6638550","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1315163632","display_name":"Amphiregulin Signaling in Perioperative Cardio-Protection","funder_award_id":"R01HL119837","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4435849167","display_name":"MicroRNA Shuttling during Acute Respiratory Distress Syndrome","funder_award_id":"R01HL133900","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5954987108","display_name":"Hypoxic Adenosine Responses","funder_award_id":"P01HL114457","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6110008029","display_name":"Neuronally Active Proteins in IPF","funder_award_id":"R01HL109233","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6561444625","display_name":"Hypoxia-Inducible Factors in Acetaminophen-Induced Liver Injury","funder_award_id":"R01DK109574","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6659958009","display_name":"Proton Pump Inhibitors for Perioperative Acute Kidney Injury","funder_award_id":"R01DK097075","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1175760071","https://openalex.org/W1492262148","https://openalex.org/W1549250486","https://openalex.org/W1782841546","https://openalex.org/W1803784511","https://openalex.org/W1920303762","https://openalex.org/W1958284284","https://openalex.org/W1969430735","https://openalex.org/W1973847028","https://openalex.org/W1981859869","https://openalex.org/W1984127959","https://openalex.org/W1992710380","https://openalex.org/W1993324234","https://openalex.org/W1996441871","https://openalex.org/W2013953164","https://openalex.org/W2014974499","https://openalex.org/W2017249196","https://openalex.org/W2017762858","https://openalex.org/W2018045673","https://openalex.org/W2026051181","https://openalex.org/W2026570544","https://openalex.org/W2029614004","https://openalex.org/W2045402423","https://openalex.org/W2047456581","https://openalex.org/W2048251248","https://openalex.org/W2053391380","https://openalex.org/W2059266855","https://openalex.org/W2062757127","https://openalex.org/W2064039435","https://openalex.org/W2066213138","https://openalex.org/W2068854215","https://openalex.org/W2069009920","https://openalex.org/W2075860675","https://openalex.org/W2077327925","https://openalex.org/W2079625864","https://openalex.org/W2080595107","https://openalex.org/W2086809028","https://openalex.org/W2087966784","https://openalex.org/W2097617110","https://openalex.org/W2105312329","https://openalex.org/W2111861407","https://openalex.org/W2113546559","https://openalex.org/W2117293778","https://openalex.org/W2120111809","https://openalex.org/W2133449111","https://openalex.org/W2133810959","https://openalex.org/W2133968430","https://openalex.org/W2138664009","https://openalex.org/W2138708625","https://openalex.org/W2144893470","https://openalex.org/W2146027438","https://openalex.org/W2151114382","https://openalex.org/W2155227864","https://openalex.org/W2157503340","https://openalex.org/W2157916750","https://openalex.org/W2160467221","https://openalex.org/W2166903671","https://openalex.org/W2168314151","https://openalex.org/W2169825634","https://openalex.org/W2171106047","https://openalex.org/W2187244644","https://openalex.org/W2257965638","https://openalex.org/W2323793261","https://openalex.org/W2326472266","https://openalex.org/W2343364465","https://openalex.org/W2371948111","https://openalex.org/W2520825453","https://openalex.org/W2526341307","https://openalex.org/W2595165596","https://openalex.org/W2595741256","https://openalex.org/W2607819139","https://openalex.org/W2613151721","https://openalex.org/W2619677205","https://openalex.org/W2620241325","https://openalex.org/W2737081341","https://openalex.org/W2739342872","https://openalex.org/W2740390519","https://openalex.org/W2742348112","https://openalex.org/W2744149134","https://openalex.org/W2750765400","https://openalex.org/W2754374515","https://openalex.org/W2758762136","https://openalex.org/W2768403574","https://openalex.org/W2769831322","https://openalex.org/W2784799194","https://openalex.org/W2800499605","https://openalex.org/W3143447998","https://openalex.org/W4294183732","https://openalex.org/W7098400432"],"related_works":["https://openalex.org/W4200589812","https://openalex.org/W2014974499","https://openalex.org/W3176013631","https://openalex.org/W4382983997","https://openalex.org/W4220788436","https://openalex.org/W1969430735","https://openalex.org/W2750765400","https://openalex.org/W2163185014","https://openalex.org/W2363053768","https://openalex.org/W7097293979"],"abstract_inverted_index":{"MicroRNAs":[0],"were":[1],"discovered":[2],"more":[3],"than":[4],"2":[5],"decades":[6],"ago":[7],"and":[8,27,45,59,74,77,137,151],"have":[9,18],"profound":[10],"impact":[11],"on":[12],"diverse":[13],"biological":[14],"processes.":[15],"Specific":[16],"microRNAs":[17],"important":[19],"roles":[20],"in":[21,39,48,69,101,116,133,143,164],"modulating":[22],"the":[23,57,117,129],"innate":[24,113,184],"immune":[25,114,185],"response":[26],"their":[28],"dysregulation":[29],"has":[30,79,98],"been":[31,80],"demonstrated":[32],"to":[33,35,85,171,181],"contribute":[34],"inflammatory":[36,102,144,152,173],"diseases.":[37],"MiR-223":[38,83,104],"particular,":[40],"is":[41,175],"very":[42],"highly":[43],"expressed":[44],"tightly":[46],"regulated":[47],"hematopoietic":[49],"cells.":[50,63],"It":[51],"functions":[52,158],"as":[53,106,140,142,178],"key":[54],"modulator":[55],"for":[56],"differentiation":[58,76,87],"activation":[60,78,97],"of":[61,67,119,131,159,169],"myeloid":[62,70,86,96,120,134],"The":[64],"central":[65],"role":[66],"miR-223":[68,132,160,170],"cells,":[71],"especially":[72],"neutrophil":[73,136],"macrophage":[75,93,138],"studied":[81],"extensively.":[82],"contributes":[84],"by":[88],"enhancing":[89],"granulopoiesis":[90],"while":[91],"inhibiting":[92],"differentiation.":[94],"Uncontrolled":[95],"detrimental":[99],"consequences":[100],"disease.":[103,154],"serves":[105],"a":[107],"negative":[108],"feedback":[109],"mechanism":[110],"controlling":[111],"excessive":[112,183],"responses":[115,186],"maintenance":[118],"cell":[121],"homeostasis.":[122],"This":[123],"review":[124],"summarizes":[125],"several":[126],"topics":[127],"covering":[128],"function":[130],"differentiation,":[135],"functions,":[139],"well":[141],"diseases":[145],"including":[146],"acute":[147],"respiratory":[148],"distress":[149],"syndrome":[150],"bowel":[153],"In":[155],"addition,":[156],"nonmyeloid":[157],"are":[161],"also":[162,176],"discussed":[163],"this":[165],"review.":[166],"Therapeutic":[167],"enhancement":[168],"dampen":[172],"targets":[174],"highlighted":[177],"potential":[179],"treatment":[180],"control":[182],"during":[187],"mucosal":[188],"inflammation.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2018-07-10T00:00:00"}