{"id":"https://openalex.org/W2810136617","doi":"https://doi.org/10.1210/en.2018-00379","title":"Leptin Regulation of Cancer Stem Cells in Breast and Gynecologic Cancer","display_name":"Leptin Regulation of Cancer Stem Cells in Breast and Gynecologic Cancer","publication_year":2018,"publication_date":"2018-06-27","ids":{"openalex":"https://openalex.org/W2810136617","doi":"https://doi.org/10.1210/en.2018-00379","mag":"2810136617","pmid":"https://pubmed.ncbi.nlm.nih.gov/29955847","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6669812"},"language":"en","primary_location":{"id":"doi:10.1210/en.2018-00379","doi":"https://doi.org/10.1210/en.2018-00379","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2018-00379","pdf_url":"https://academic.oup.com/endo/article-pdf/159/8/3069/29115878/en.2018-00379.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/159/8/3069/29115878/en.2018-00379.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053750899","display_name":"Katie Crean-Tate","orcid":"https://orcid.org/0000-0003-2690-9063","observed_orcids":["https://orcid.org/0000-0003-2690-9063"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie K Crean-Tate","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Women\u2019s Health Institute, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Women\u2019s Health Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080606232","display_name":"Ofer Reizes","orcid":"https://orcid.org/0000-0003-0075-6871","observed_orcids":["https://orcid.org/0000-0003-0075-6871"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ofer Reizes","raw_affiliation_strings":["Case Comprehensive Cancer Center, Cleveland, Ohio","Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Cleveland, Ohio","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080606232"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I36373038","https://openalex.org/I4390039247","https://openalex.org/I4405287411","https://openalex.org/I58956616"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.9578,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.72674419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"159","issue":"8","first_page":"3069","last_page":"3080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.2070000022649765,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":1.0},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gynecologic-cancer","display_name":"gynecologic cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.46000000834465027},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6671447157859802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6652402281761169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6216160655021667},{"id":"https://openalex.org/C2994372414","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic cancer","level":4,"score":0.6074082851409912},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5886974930763245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5633943676948547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5432561039924622},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3367820978164673},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.24883604049682617},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.15400946140289307}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.2018-00379","doi":"https://doi.org/10.1210/en.2018-00379","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2018-00379","pdf_url":"https://academic.oup.com/endo/article-pdf/159/8/3069/29115878/en.2018-00379.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5627860","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6669812","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6669812","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6669812","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Text"},{"id":"pmid:29955847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29955847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/en.2018-00379","doi":"https://doi.org/10.1210/en.2018-00379","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2018-00379","pdf_url":"https://academic.oup.com/endo/article-pdf/159/8/3069/29115878/en.2018-00379.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2397272011","display_name":"Cell-cell communication in CSC self renewal and breast cancer progression","funder_award_id":"R21CA191263","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000862237","display_name":"Case Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA043703","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309680","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320309681","display_name":"Cleveland Clinic Foundation","ror":"https://ror.org/03xjacd83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810136617.pdf","grobid_xml":"https://content.openalex.org/works/W2810136617.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W161981488","https://openalex.org/W1128190356","https://openalex.org/W1580084546","https://openalex.org/W1608658514","https://openalex.org/W1631449371","https://openalex.org/W1778884454","https://openalex.org/W1874108458","https://openalex.org/W1876932774","https://openalex.org/W1933726946","https://openalex.org/W1971550840","https://openalex.org/W1983830583","https://openalex.org/W1992043203","https://openalex.org/W1996713062","https://openalex.org/W2006987457","https://openalex.org/W2011540227","https://openalex.org/W2017047594","https://openalex.org/W2020626901","https://openalex.org/W2027676433","https://openalex.org/W2028339783","https://openalex.org/W2028819093","https://openalex.org/W2029391384","https://openalex.org/W2029398685","https://openalex.org/W2029979230","https://openalex.org/W2035811939","https://openalex.org/W2037325146","https://openalex.org/W2041308494","https://openalex.org/W2042862016","https://openalex.org/W2048941674","https://openalex.org/W2050939102","https://openalex.org/W2052960217","https://openalex.org/W2057046277","https://openalex.org/W2062216607","https://openalex.org/W2062873246","https://openalex.org/W2062972159","https://openalex.org/W2069578030","https://openalex.org/W2071872930","https://openalex.org/W2072347219","https://openalex.org/W2072914828","https://openalex.org/W2076225576","https://openalex.org/W2077001746","https://openalex.org/W2077740357","https://openalex.org/W2080092303","https://openalex.org/W2081738005","https://openalex.org/W2082524242","https://openalex.org/W2082955357","https://openalex.org/W2084037325","https://openalex.org/W2088090787","https://openalex.org/W2091512107","https://openalex.org/W2095688781","https://openalex.org/W2101521676","https://openalex.org/W2101667330","https://openalex.org/W2102085111","https://openalex.org/W2106392968","https://openalex.org/W2106787323","https://openalex.org/W2109738877","https://openalex.org/W2111796479","https://openalex.org/W2111923039","https://openalex.org/W2114796974","https://openalex.org/W2118228359","https://openalex.org/W2126945850","https://openalex.org/W2130941707","https://openalex.org/W2135217300","https://openalex.org/W2136082576","https://openalex.org/W2143768482","https://openalex.org/W2150197335","https://openalex.org/W2151320729","https://openalex.org/W2151600171","https://openalex.org/W2160590419","https://openalex.org/W2163210258","https://openalex.org/W2164876587","https://openalex.org/W2167785811","https://openalex.org/W2170605129","https://openalex.org/W2170924429","https://openalex.org/W2184017553","https://openalex.org/W2312252916","https://openalex.org/W2341594612","https://openalex.org/W2342542764","https://openalex.org/W2345979257","https://openalex.org/W2411678126","https://openalex.org/W2476398566","https://openalex.org/W2484362226","https://openalex.org/W2531168605","https://openalex.org/W2531797293","https://openalex.org/W2552235514","https://openalex.org/W2589630485","https://openalex.org/W2605181377","https://openalex.org/W2620637833","https://openalex.org/W2620744966","https://openalex.org/W2734950004","https://openalex.org/W2738262645","https://openalex.org/W2740173227","https://openalex.org/W2740275539","https://openalex.org/W2743605511","https://openalex.org/W2750847959","https://openalex.org/W2752807922","https://openalex.org/W2753722921","https://openalex.org/W2756575490","https://openalex.org/W2765329136","https://openalex.org/W2766420394","https://openalex.org/W2772250549","https://openalex.org/W2781819665","https://openalex.org/W2788512864","https://openalex.org/W2788966729","https://openalex.org/W2790203249","https://openalex.org/W2794190696","https://openalex.org/W2801437236","https://openalex.org/W3023227769","https://openalex.org/W4254573998","https://openalex.org/W6608715015","https://openalex.org/W6659343912","https://openalex.org/W6777152624"],"related_works":["https://openalex.org/W2095688781","https://openalex.org/W2541384537","https://openalex.org/W239686473","https://openalex.org/W2060925449","https://openalex.org/W2050487267","https://openalex.org/W1848483485","https://openalex.org/W2922087164","https://openalex.org/W4307500027","https://openalex.org/W4389265301","https://openalex.org/W2985806909"],"abstract_inverted_index":{"It":[0],"is":[1,135],"well":[2],"established":[3],"that":[4,144],"obesity":[5,21,103,152],"increases":[6],"the":[7,11,29,163,169,183,229],"incidence":[8,160],"and":[9,45,51,88,113,130,149,161,197,213,236,245,259],"worsens":[10],"prognosis":[12],"of":[13,31,40,49,84,109,141,171,208],"women's":[14,262],"cancer.":[15,263],"For":[16],"breast":[17,235],"cancer,":[18,35,112,238],"women":[19,65],"with":[20,34,36,69,94,102,118,178,205],"exhibit":[22,104],"more":[23],"than":[24,53],"a":[25,37,70,89,105,125,156,175,206],"twofold":[26,106],"increase":[27,91,97,190,198],"in":[28,61,92,98,139,158,210,234,243,252,261],"odds":[30],"being":[32],"diagnosed":[33],"greater":[38,47,82],"risk":[39,48,83,108],"advanced":[41,119],"stage":[42,120],"at":[43],"diagnosis,":[44],"\u226440%":[46],"recurrence":[50,129],"death":[52],"their":[54],"normal-weight":[55],"counterparts.":[56],"These":[57,201],"findings":[58],"are":[59,67,116,203],"similar":[60],"gynecologic":[62,237],"cancers,":[63],"where":[64],"who":[66,115],"obese":[68,117],"body":[71],"mass":[72],"index":[73],"(BMI)":[74],">40":[75],"kg/m2":[76],"have":[77,123],"up":[78],"to":[79,128,189,255],"six":[80],"times":[81],"developing":[85],"endometrial":[86],"cancer":[87,122,159,218],"9.2%":[90],"mortality":[93],"every":[95],"10%":[96],"BMI.":[99],"Likewise,":[100],"patients":[101,114],"higher":[107],"premenopausal":[110],"ovarian":[111,121],"shown":[124,188],"shorter":[126],"time":[127],"poorer":[131],"overall":[132],"survival.":[133],"Obesity":[134],"accompanied":[136],"by":[137],"changes":[138],"expression":[140],"adipose":[142,164],"factors":[143],"act":[145],"on":[146,182,240],"local":[147],"tissues":[148],"systemically.":[150],"Once":[151],"was":[153],"recognized":[154],"as":[155,174,217],"factor":[157],"progression,":[162],"cytokine":[165],"(adipokine)":[166],"leptin":[167],"became":[168],"focus":[170],"intense":[172],"investigation":[173],"putative":[176],"link,":[177],"nearly":[179],"3000":[180],"publications":[181],"topic.":[184],"Leptin":[185],"has":[186],"been":[187],"cell":[191],"proliferation,":[192],"inhibit":[193],"apoptosis,":[194],"promote":[195],"angiogenesis,":[196],"therapeutic":[199],"resistance.":[200],"characteristics":[202],"associated":[204],"subset":[207],"cells":[209,220],"both":[211],"liquid":[212],"solid":[214],"tumors":[215],"known":[216],"stem":[219],"(CSCs),":[221],"or":[222],"tumor":[223,257],"initiating":[224],"cells.":[225],"We":[226],"will":[227],"review":[228],"literature":[230],"discussing":[231],"leptin's":[232],"role":[233,242],"focusing":[239],"its":[241],"CSCs,":[244],"consider":[246],"goals":[247],"for":[248],"targeting":[249],"future":[250],"therapy":[251],"this":[253],"arena":[254],"disrupt":[256],"initiation":[258],"progression":[260]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-07-10T00:00:00"}
