{"id":"https://openalex.org/W2809998292","doi":"https://doi.org/10.1042/bcj20180137","title":"Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism","display_name":"Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism","publication_year":2018,"publication_date":"2018-06-28","ids":{"openalex":"https://openalex.org/W2809998292","doi":"https://doi.org/10.1042/bcj20180137","mag":"2809998292","pmid":"https://pubmed.ncbi.nlm.nih.gov/29954845","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585447"},"language":"en","primary_location":{"id":"doi:10.1042/bcj20180137","doi":"https://doi.org/10.1042/bcj20180137","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bcj20180137","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585447","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042267819","display_name":"Albert G. Remacle","orcid":"https://orcid.org/0000-0003-1475-6346","observed_orcids":["https://orcid.org/0000-0003-1475-6346"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert G. Remacle","raw_affiliation_strings":["Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020318819","display_name":"Swathi K. Hullugundi","orcid":"https://orcid.org/0000-0003-0697-9988","observed_orcids":["https://orcid.org/0000-0003-0697-9988"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swathi K. Hullugundi","raw_affiliation_strings":["Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077814717","display_name":"Jennifer Dolkas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Dolkas","raw_affiliation_strings":["Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049104745","display_name":"Mila Angert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mila Angert","raw_affiliation_strings":["Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032185922","display_name":"Piotr Cieplak","orcid":"https://orcid.org/0000-0003-0700-5691","observed_orcids":["https://orcid.org/0000-0003-0700-5691"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr Cieplak","raw_affiliation_strings":["Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008199007","display_name":"David A. Scott","orcid":"https://orcid.org/0000-0002-8668-2449","observed_orcids":["https://orcid.org/0000-0002-8668-2449"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Scott","raw_affiliation_strings":["Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010121080","display_name":"Andrei V. Chernov","orcid":"https://orcid.org/0000-0002-3294-5418","observed_orcids":["https://orcid.org/0000-0002-3294-5418"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrei V. Chernov","raw_affiliation_strings":["Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026252325","display_name":"Veronica I. Shubayev","orcid":"https://orcid.org/0000-0003-2598-263X","observed_orcids":["https://orcid.org/0000-0003-2598-263X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica I. Shubayev","raw_affiliation_strings":["Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of California at San Diego, La Jolla, CA 92093, U.S.A","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013154347","display_name":"Alex Y. Strongin","orcid":"https://orcid.org/0000-0003-3765-3016","observed_orcids":["https://orcid.org/0000-0003-3765-3016"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alex Y. Strongin","raw_affiliation_strings":["Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A"],"raw_orcid":"https://orcid.org/0000-0003-3765-3016","affiliations":[{"raw_affiliation_string":"Infectious and Inflammatory Disease Center/Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013154347"],"corresponding_institution_ids":["https://openalex.org/I188891513"],"apc_list":null,"apc_paid":null,"fwci":0.0873,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.38466668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"475","issue":"14","first_page":"2355","last_page":"2376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelin-basic-protein","display_name":"myelin basic protein","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vdac1","display_name":"VDAC1","score":0.8370000123977661},{"id":"https://openalex.org/keywords/voltage-dependent-anion-channel","display_name":"voltage-dependent anion channel","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.6930000185966492},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9950000047683716},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.7260000109672546},{"id":"https://openalex.org/keywords/lrp1","display_name":"LRP1","score":0.3840000033378601},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.5070000290870667},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C200784783","wikidata":"https://www.wikidata.org/wiki/Q7940725","display_name":"Voltage-dependent anion channel","level":5,"score":0.7728003263473511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5687839984893799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5288551449775696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.503654420375824},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.481473833322525},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4607390761375427},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4559422731399536},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.39810773730278015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34838247299194336},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3330039978027344},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28771114349365234},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.10540899634361267},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0832955539226532},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050995","descriptor_name":"Voltage-Dependent Anion Channel 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050995","descriptor_name":"Voltage-Dependent Anion Channel 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bcj20180137","doi":"https://doi.org/10.1042/bcj20180137","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bcj20180137","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:29954845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29954845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5614557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6585447","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585447","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5614557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6585447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G326483370","display_name":"Myelin Autoantigens in Neuropathic Pain","funder_award_id":"R01DE022757","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8769330356","display_name":"UC San Diego Clinical and Translational Research Institute","funder_award_id":"UL1TR001442","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000864383","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA030199","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W24147571","https://openalex.org/W199440580","https://openalex.org/W419770941","https://openalex.org/W1482173390","https://openalex.org/W1501083576","https://openalex.org/W1560846896","https://openalex.org/W1623867342","https://openalex.org/W1718943240","https://openalex.org/W1852530796","https://openalex.org/W1914839904","https://openalex.org/W1967580434","https://openalex.org/W1969576719","https://openalex.org/W1971931055","https://openalex.org/W1975082755","https://openalex.org/W1975914956","https://openalex.org/W1980496535","https://openalex.org/W1980804643","https://openalex.org/W1982708244","https://openalex.org/W1983167566","https://openalex.org/W1985287567","https://openalex.org/W1989533700","https://openalex.org/W1989593508","https://openalex.org/W1991931009","https://openalex.org/W1997055993","https://openalex.org/W2002263141","https://openalex.org/W2002439304","https://openalex.org/W2006716437","https://openalex.org/W2008710537","https://openalex.org/W2008786641","https://openalex.org/W2008934166","https://openalex.org/W2009866554","https://openalex.org/W2010521881","https://openalex.org/W2013256991","https://openalex.org/W2014955142","https://openalex.org/W2017525816","https://openalex.org/W2018873526","https://openalex.org/W2019079031","https://openalex.org/W2019111347","https://openalex.org/W2019843278","https://openalex.org/W2024678580","https://openalex.org/W2026555011","https://openalex.org/W2027064576","https://openalex.org/W2028974980","https://openalex.org/W2033370948","https://openalex.org/W2035220900","https://openalex.org/W2035317322","https://openalex.org/W2042982552","https://openalex.org/W2045649071","https://openalex.org/W2045904225","https://openalex.org/W2052543023","https://openalex.org/W2055063491","https://openalex.org/W2055327656","https://openalex.org/W2055531243","https://openalex.org/W2060878129","https://openalex.org/W2061000482","https://openalex.org/W2061124081","https://openalex.org/W2064209588","https://openalex.org/W2068221097","https://openalex.org/W2069341142","https://openalex.org/W2072583622","https://openalex.org/W2073487229","https://openalex.org/W2077812123","https://openalex.org/W2077950512","https://openalex.org/W2081395451","https://openalex.org/W2083133991","https://openalex.org/W2084314658","https://openalex.org/W2086481114","https://openalex.org/W2089749528","https://openalex.org/W2093217806","https://openalex.org/W2096880567","https://openalex.org/W2097259163","https://openalex.org/W2097463188","https://openalex.org/W2100262552","https://openalex.org/W2102322990","https://openalex.org/W2105599853","https://openalex.org/W2106115645","https://openalex.org/W2112618201","https://openalex.org/W2112801815","https://openalex.org/W2113999599","https://openalex.org/W2123716968","https://openalex.org/W2125258716","https://openalex.org/W2127256767","https://openalex.org/W2129141040","https://openalex.org/W2134087185","https://openalex.org/W2135986226","https://openalex.org/W2136058929","https://openalex.org/W2138127628","https://openalex.org/W2140162407","https://openalex.org/W2143186704","https://openalex.org/W2144569256","https://openalex.org/W2145123477","https://openalex.org/W2153041190","https://openalex.org/W2156943914","https://openalex.org/W2158409776","https://openalex.org/W2161113946","https://openalex.org/W2162033191","https://openalex.org/W2166216415","https://openalex.org/W2167795547","https://openalex.org/W2170564629","https://openalex.org/W2300101139","https://openalex.org/W2315430776","https://openalex.org/W2345825909","https://openalex.org/W2404280981","https://openalex.org/W2473384226","https://openalex.org/W2517394834","https://openalex.org/W2517738370","https://openalex.org/W2552010861","https://openalex.org/W2589213388","https://openalex.org/W2620966663","https://openalex.org/W2732956904","https://openalex.org/W4241090263"],"related_works":["https://openalex.org/W1976990136","https://openalex.org/W4402368813","https://openalex.org/W3197461681","https://openalex.org/W2921446988","https://openalex.org/W2268157438","https://openalex.org/W2097463188","https://openalex.org/W7128044147","https://openalex.org/W4414536051","https://openalex.org/W2055971178","https://openalex.org/W2019568343"],"abstract_inverted_index":{"In":[0],"demyelinating":[1],"nervous":[2],"system":[3],"disorders,":[4],"myelin":[5,14],"basic":[6],"protein":[7],"(MBP),":[8],"a":[9,52,89],"major":[10],"component":[11],"of":[12,38,81,110,170,181,211],"the":[13,24,35,39,47,76,84,100,106,117,135,142,150,156,175,182,199,205,209,212],"sheath,":[15],"is":[16],"proteolyzed":[17],"and":[18,60,71,74,120,148,161],"its":[19,171],"fragments":[20],"are":[21],"released":[22,200],"in":[23,31,123,159,215],"neural":[25],"environment.":[26],"Here,":[27],"we":[28],"demonstrated":[29],"that,":[30,65],"contrast":[32],"with":[33,67,173],"MBP,":[34],"cellular":[36,137,183,189],"uptake":[37],"cryptic":[40,176],"84-104":[41],"epitope":[42],"(MBP84-104)":[43],"did":[44],"not":[45],"involve":[46],"low-density":[48],"lipoprotein":[49],"receptor-related":[50],"protein-1,":[51],"scavenger":[53],"receptor.":[54],"Our":[55],"pull-down":[56],"assay,":[57],"mass":[58],"spectrometry":[59],"molecular":[61],"modeling":[62,93],"studies":[63],"suggested":[64,94],"similar":[66],"many":[68],"other":[69],"unfolded":[70],"aberrant":[72],"proteins":[73],"peptides,":[75],"internalized":[77,203],"MBP84-104":[78,96,128,177,201],"was":[79],"capable":[80],"binding":[82],"to":[83,99,208],"voltage-dependent":[85],"anion-selective":[86],"channel-1":[87],"(VDAC-1),":[88],"mitochondrial":[90,118],"porin.":[91],"Molecular":[92],"that":[95,168,186,198],"directly":[97],"binds":[98],"N-terminal":[101],"\u03b1-helix":[102],"located":[103],"midway":[104],"inside":[105],"19":[107],"\u03b2-blade":[108],"barrel":[109],"VDAC-1.":[111],"These":[112],"interactions":[113,172],"may":[114],"have":[115],"affected":[116,134],"functions":[119],"energy":[121,184],"metabolism":[122,185],"multiple":[124,216],"cell":[125,131,194,217],"types.":[126,218],"Notably,":[127],"caused":[129],"neither":[130],"apoptosis":[132],"nor":[133],"total":[136],"ATP":[138],"levels,":[139],"but":[140],"repressed":[141],"aerobic":[143],"glycolysis":[144],"(lactic":[145],"acid":[146],"fermentation)":[147],"decreased":[149],"l-lactate/d-glucose":[151],"ratio":[152],"(also":[153],"termed":[154],"as":[155],"Warburg":[157],"effect)":[158],"normal":[160],"cancer":[162],"cells.":[163],"Overall,":[164],"our":[165],"findings":[166],"implied":[167],"because":[169],"VDAC-1,":[174],"peptide":[178],"invoked":[179],"reprogramming":[180,210],"favored":[187],"enhanced":[188],"activity,":[190],"rather":[191],"than":[192],"apoptotic":[193],"death.":[195],"We":[196],"concluded":[197],"peptide,":[202],"by":[204],"cells,":[206],"contributes":[207],"energy-generating":[213],"pathways":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}