{"id":"https://openalex.org/W2809951803","doi":"https://doi.org/10.1007/978-981-10-5526-3_8","title":"Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm","display_name":"Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2809951803","doi":"https://doi.org/10.1007/978-981-10-5526-3_8","mag":"2809951803","pmid":"https://pubmed.ncbi.nlm.nih.gov/29956196"},"language":"en","primary_location":{"id":"doi:10.1007/978-981-10-5526-3_8","doi":"https://doi.org/10.1007/978-981-10-5526-3_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-981-10-5526-3_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4301132515","display_name":"Developmental Origins of Health and Disease (DOHaD)"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102826451","display_name":"Ryuichi Kimura","orcid":"https://orcid.org/0000-0002-1090-7162","observed_orcids":["https://orcid.org/0000-0002-1090-7162"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichi Kimura","raw_affiliation_strings":["Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045365382","display_name":"Kaichi Yoshizaki","orcid":"https://orcid.org/0000-0002-2540-332X","observed_orcids":["https://orcid.org/0000-0002-2540-332X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaichi Yoshizaki","raw_affiliation_strings":["Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079222647","display_name":"Noriko Osumi","orcid":"https://orcid.org/0000-0003-0548-6452","observed_orcids":["https://orcid.org/0000-0003-0548-6452"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Noriko Osumi","raw_affiliation_strings":["Graduate School of Medicine, Tohoku University, Sendai, Japan. osumi@med.tohoku.ac.jp","Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Tohoku University, Sendai, Japan. osumi@med.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079222647"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":null,"apc_paid":null,"fwci":12.3793,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.98021434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"1012","issue":null,"first_page":"75","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-paternal-age","display_name":"advanced paternal age","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.8379999995231628},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8100000023841858},{"id":"https://openalex.org/keywords/sperm-epigenetics","display_name":"sperm epigenetics","score":0.6859999895095825},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/developmental-origins-of-health-and-disease","display_name":"developmental origins of health and disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.6949999928474426},{"id":"https://openalex.org/keywords/gametogenesis","display_name":"gametogenesis","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8218919634819031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6118527054786682},{"id":"https://openalex.org/C163949779","wikidata":"https://www.wikidata.org/wiki/Q507032","display_name":"Oogenesis","level":4,"score":0.5740237832069397},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5118042826652527},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47756415605545044},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.4752236008644104},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.42871007323265076},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.39954760670661926},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35915407538414},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3556424379348755},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3337953984737396},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.3225722312927246},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.30026668310165405},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2705792188644409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21978464722633362},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.1751997470855713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15138810873031616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11991149187088013},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005220","descriptor_name":"Fathers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010331","descriptor_name":"Paternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-981-10-5526-3_8","doi":"https://doi.org/10.1007/978-981-10-5526-3_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-981-10-5526-3_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:29956196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29956196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2102894216","display_name":"Elucidation of neuromolecular mechanisms of vocal communication deficits due to paternal aging","funder_award_id":"15K06694","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7440480705","display_name":"Sperm DNA methylation for a risk of offspring's disorder","funder_award_id":"17K17605","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1546691149","https://openalex.org/W1713509593","https://openalex.org/W1821797507","https://openalex.org/W1910049290","https://openalex.org/W1964444099","https://openalex.org/W1969235931","https://openalex.org/W1977388404","https://openalex.org/W1981750462","https://openalex.org/W1985148730","https://openalex.org/W2005820179","https://openalex.org/W2017507345","https://openalex.org/W2020331089","https://openalex.org/W2024663595","https://openalex.org/W2034219651","https://openalex.org/W2037818631","https://openalex.org/W2041662182","https://openalex.org/W2043070995","https://openalex.org/W2053184492","https://openalex.org/W2064313473","https://openalex.org/W2086795566","https://openalex.org/W2103410123","https://openalex.org/W2122345676","https://openalex.org/W2125288884","https://openalex.org/W2131104106","https://openalex.org/W2131165622","https://openalex.org/W2135660192","https://openalex.org/W2137330216","https://openalex.org/W2145098771","https://openalex.org/W2148521032","https://openalex.org/W2150099638","https://openalex.org/W2166194564","https://openalex.org/W2271134226","https://openalex.org/W2316811866","https://openalex.org/W4295915696"],"related_works":["https://openalex.org/W2754787709","https://openalex.org/W2128189777","https://openalex.org/W3039646386","https://openalex.org/W2253029043","https://openalex.org/W2584834954","https://openalex.org/W2793210507","https://openalex.org/W2537853357","https://openalex.org/W6995640884","https://openalex.org/W7117582266","https://openalex.org/W2053184492"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2018-07-10T00:00:00"}
