{"id":"https://openalex.org/W2809937135","doi":"https://doi.org/10.1080/15384101.2018.1486165","title":"The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks","display_name":"The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks","publication_year":2018,"publication_date":"2018-06-18","ids":{"openalex":"https://openalex.org/W2809937135","doi":"https://doi.org/10.1080/15384101.2018.1486165","mag":"2809937135","pmid":"https://pubmed.ncbi.nlm.nih.gov/29954236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6132960"},"language":"en","primary_location":{"id":"doi:10.1080/15384101.2018.1486165","doi":"https://doi.org/10.1080/15384101.2018.1486165","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384101.2018.1486165","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1486165?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1486165?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036281194","display_name":"Ting Hsiang Huang","orcid":"https://orcid.org/0000-0001-8739-0571","observed_orcids":["https://orcid.org/0000-0001-8739-0571"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting-Hsiang Huang","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-8739-0571","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023022347","display_name":"Zih-Jie Shen","orcid":"https://orcid.org/0000-0002-2530-4540","observed_orcids":["https://orcid.org/0000-0002-2530-4540"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zih-Jie Shen","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000388529","display_name":"Barry P. Sleckman","orcid":"https://orcid.org/0000-0001-8295-4462","observed_orcids":["https://orcid.org/0000-0001-8295-4462"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry P. Sleckman","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042369850","display_name":"Jessica K. Tyler","orcid":"https://orcid.org/0000-0001-9765-1659","observed_orcids":["https://orcid.org/0000-0001-9765-1659"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jessica K. Tyler","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042369850"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":0.3554,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.54340541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"12","first_page":"1413","last_page":"1424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asf1","display_name":"Asf1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/caf-1","display_name":"CAF-1","score":0.871999979019165},{"id":"https://openalex.org/keywords/histone-chaperone","display_name":"histone chaperone","score":0.7910000085830688},{"id":"https://openalex.org/keywords/atm-kinase-activation","display_name":"ATM kinase activation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9990000128746033},{"id":"https://openalex.org/keywords/h4k16ac","display_name":"H4K16ac","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hmof","display_name":"hMOF","score":0.8799999952316284},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chromatin-assembly","display_name":"chromatin assembly","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.7501123547554016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7438323497772217},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6837179660797119},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6565688252449036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6354758739471436},{"id":"https://openalex.org/C2779085176","wikidata":"https://www.wikidata.org/wiki/Q24721644","display_name":"Histone H4","level":4,"score":0.4843110144138336},{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.4556595981121063},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4464261531829834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42209142446517944},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.41244396567344666},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3697299063205719},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.3668956160545349},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3039323091506958},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2515150308609009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.166723370552063}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051747","descriptor_name":"DNA-Activated Protein Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056488","descriptor_name":"Histone Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1080/15384101.2018.1486165","doi":"https://doi.org/10.1080/15384101.2018.1486165","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384101.2018.1486165","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1486165?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5603433","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6132960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6132960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6132960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"Text"},{"id":"pmid:29954236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29954236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:figshare.com:article/6722861","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_Histone_Chaperone_ASF1_Regulates_the_Activation_of_ATM_and_DNA-PKcs_in_Response_to_DNA_Double-strand_Breaks/6722861","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.6722861.v2","doi":"https://doi.org/10.6084/m9.figshare.6722861.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.6722861.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1080/15384101.2018.1486165","doi":"https://doi.org/10.1080/15384101.2018.1486165","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384101.2018.1486165","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1486165?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1185003998","display_name":null,"funder_award_id":"CA 95641","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1222904578","display_name":"The Future of Cancer Research: Training Program for Basic and Translational Scientists","funder_award_id":"RP170067","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G2851422178","display_name":null,"funder_award_id":"RP170067","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G422466269","display_name":"ATM Function During V(D)J Recombination","funder_award_id":"R01AI074953","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4380169263","display_name":"Chromatin's Role in Repair of Radiation-induced Damage","funder_award_id":"R01CA095641","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4932020558","display_name":null,"funder_award_id":"RP170067","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2809937135.pdf","grobid_xml":"https://content.openalex.org/works/W2809937135.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1965341449","https://openalex.org/W1972345616","https://openalex.org/W1979583222","https://openalex.org/W1983218764","https://openalex.org/W1986830781","https://openalex.org/W1987369038","https://openalex.org/W1990103859","https://openalex.org/W1999031485","https://openalex.org/W2013571070","https://openalex.org/W2021029128","https://openalex.org/W2022811243","https://openalex.org/W2031574278","https://openalex.org/W2037508254","https://openalex.org/W2052130151","https://openalex.org/W2054881393","https://openalex.org/W2069328568","https://openalex.org/W2071457560","https://openalex.org/W2076284440","https://openalex.org/W2077436902","https://openalex.org/W2083707012","https://openalex.org/W2095934571","https://openalex.org/W2102326888","https://openalex.org/W2119091673","https://openalex.org/W2121846200","https://openalex.org/W2122680160","https://openalex.org/W2136399386","https://openalex.org/W2143629217","https://openalex.org/W2144171940","https://openalex.org/W2145929363","https://openalex.org/W2155318349","https://openalex.org/W2156063202","https://openalex.org/W2157172346","https://openalex.org/W2185296599","https://openalex.org/W2409457521","https://openalex.org/W2560749159","https://openalex.org/W2570296944","https://openalex.org/W2618807644","https://openalex.org/W2739914115","https://openalex.org/W2758084392"],"related_works":["https://openalex.org/W2766460563","https://openalex.org/W1965341449","https://openalex.org/W2180452931","https://openalex.org/W7099542415","https://openalex.org/W3134529082","https://openalex.org/W2787958170","https://openalex.org/W7006078568","https://openalex.org/W3177380296","https://openalex.org/W2025209634","https://openalex.org/W1718856170"],"abstract_inverted_index":{"The":[0],"Ataxia-telangiectasia":[1],"mutated":[2],"(ATM)":[3],"kinase":[4,9],"and":[5,114,124],"the":[6,24,32,46,91,130],"DNA-dependent":[7],"protein":[8],"catalytic":[10],"subunit":[11],"(DNA-PKcs)":[12],"are":[13],"activated":[14],"by":[15],"DNA":[16,64,117,134],"double-strand":[17],"breaks":[18],"(DSBs).":[19],"These":[20],"DSBs":[21],"occur":[22],"in":[23,61,68,127],"context":[25],"of":[26,34,45,105,133],"chromatin":[27,30,48,112],"but":[28],"how":[29],"influences":[31],"activation":[33],"these":[35],"kinases":[36],"is":[37,119],"not":[38],"known.":[39],"Here":[40],"we":[41],"show":[42],"that":[43,96],"loss":[44],"replication-dependent":[47],"assembly":[49,113],"factors":[50],"ASF1A/B":[51,69],"or":[52,70],"CAF-1":[53,71],"compromises":[54],"ATM":[55,86,123],"activation,":[56,60],"while":[57],"augmenting":[58],"DNA-PKcs":[59,106,125],"response":[62,128],"to":[63,84,102,107,121,129],"DSBs.":[65,108,135],"Cells":[66],"deficient":[67],"exhibit":[72],"reduced":[73],"histone":[74,81,92],"H4":[75],"lysine":[76],"16":[77],"acetylation":[78],"(H4K16ac),":[79],"a":[80],"mark":[82],"known":[83],"promote":[85],"activation.":[87],"ASF1A":[88,99],"interacts":[89],"with":[90],"acetyl":[93],"transferase,":[94],"hMOF":[95],"mediates":[97],"H4K16ac.":[98],"depletion":[100],"leads":[101],"increased":[103],"recruitment":[104],"We":[109],"propose":[110],"normal":[111],"H4K16ac":[115],"during":[116],"replication":[118],"required":[120],"regulate":[122],"activity":[126],"subsequent":[131],"induction":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-07-10T00:00:00"}
