{"id":"https://openalex.org/W2809821986","doi":"https://doi.org/10.1002/ptr.6130","title":"Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta\u2010analysis of clinical trials","display_name":"Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: A systematic review and meta\u2010analysis of clinical trials","publication_year":2018,"publication_date":"2018-06-27","ids":{"openalex":"https://openalex.org/W2809821986","doi":"https://doi.org/10.1002/ptr.6130","mag":"2809821986","pmid":"https://pubmed.ncbi.nlm.nih.gov/29947156"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.6130","doi":"https://doi.org/10.1002/ptr.6130","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.6130","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022138504","display_name":"Fariborz Mansour\u2010Ghanaei","orcid":"https://orcid.org/0000-0002-6264-0025","observed_orcids":["https://orcid.org/0000-0002-6264-0025","https://orcid.org/0000-0002-9197-0787","https://orcid.org/0000-0001-6747-0232"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Fariborz Mansour\u2010Ghanaei","raw_affiliation_strings":["Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran"],"raw_orcid":"https://orcid.org/0000-0002-9197-0787","affiliations":[{"raw_affiliation_string":"Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000739995","display_name":"Amir Hadi","orcid":"https://orcid.org/0000-0001-9952-6579","observed_orcids":["https://orcid.org/0000-0001-9952-6579"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amir Hadi","raw_affiliation_strings":["Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran"],"raw_orcid":"https://orcid.org/0000-0001-9952-6579","affiliations":[{"raw_affiliation_string":"Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084345017","display_name":"Makan Pourmasoumi","orcid":"https://orcid.org/0000-0001-9335-7276","observed_orcids":["https://orcid.org/0000-0001-9335-7276"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Makan Pourmasoumi","raw_affiliation_strings":["Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016468971","display_name":"Farahnaz Joukar","orcid":"https://orcid.org/0000-0001-8432-8879","observed_orcids":["https://orcid.org/0000-0001-8432-8879","https://orcid.org/0000-0003-0102-0575","https://orcid.org/0009-0005-3813-456X"]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farahnaz Joukar","raw_affiliation_strings":["Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caspian Digestive Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054481766","display_name":"Sahar Golpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204331812","display_name":"Guilan University of Medical Sciences","ror":"https://ror.org/04ptbrd12","country_code":"IR","type":"education","lineage":["https://openalex.org/I204331812","https://openalex.org/I4210110574"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sahar Golpour","raw_affiliation_strings":["Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences (GUMS), Rasht, Iran","institution_ids":["https://openalex.org/I204331812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000295058","display_name":"Ameneh Najafgholizadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799282979","display_name":"Islamic Azad University, Isfahan","ror":"https://ror.org/039zhhm92","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I2799282979"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ameneh Najafgholizadeh","raw_affiliation_strings":["Department of Microbiology, Naein Branch, Islamic Azad University Isfahan, Naein, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Naein Branch, Islamic Azad University Isfahan, Naein, Iran","institution_ids":["https://openalex.org/I2799282979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022138504"],"corresponding_institution_ids":["https://openalex.org/I204331812"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.9927,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.7,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"32","issue":"10","first_page":"1876","last_page":"1884"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-tea","display_name":"green tea","score":0.9850000143051147},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":1.0},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7850000262260437},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.871999979019165},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.7979999780654907},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.8218557834625244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7310429811477661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7208114266395569},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7025762796401978},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5763023495674133},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.509484589099884},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4964821934700012},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.47309544682502747},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4583120048046112},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44992199540138245},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.41121894121170044},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4019225239753723},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3379002511501312},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.17689752578735352},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16967695951461792}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013662","descriptor_name":"Tea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/ptr.6130","doi":"https://doi.org/10.1002/ptr.6130","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.6130","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:29947156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29947156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1182275475","https://openalex.org/W1523272844","https://openalex.org/W1574568906","https://openalex.org/W1971316445","https://openalex.org/W1972709924","https://openalex.org/W2001116603","https://openalex.org/W2009179732","https://openalex.org/W2018544685","https://openalex.org/W2019344222","https://openalex.org/W2027460686","https://openalex.org/W2029794241","https://openalex.org/W2035822315","https://openalex.org/W2079909358","https://openalex.org/W2106839236","https://openalex.org/W2107328434","https://openalex.org/W2108024349","https://openalex.org/W2110980511","https://openalex.org/W2114057457","https://openalex.org/W2122890697","https://openalex.org/W2125100006","https://openalex.org/W2130213180","https://openalex.org/W2136988701","https://openalex.org/W2139884256","https://openalex.org/W2143014690","https://openalex.org/W2146674712","https://openalex.org/W2157823046","https://openalex.org/W2204688218","https://openalex.org/W2205934650","https://openalex.org/W2227037929","https://openalex.org/W2284243468","https://openalex.org/W2291727371","https://openalex.org/W2318381126","https://openalex.org/W2483622726","https://openalex.org/W2515485628","https://openalex.org/W2531348994","https://openalex.org/W2578670173","https://openalex.org/W2618086403","https://openalex.org/W2652467780","https://openalex.org/W2727009873","https://openalex.org/W2743187300","https://openalex.org/W2744552086","https://openalex.org/W2754341706","https://openalex.org/W2779963293","https://openalex.org/W2803151742","https://openalex.org/W4362504902"],"related_works":["https://openalex.org/W2744552086","https://openalex.org/W2227037929","https://openalex.org/W3007506180","https://openalex.org/W2754341706","https://openalex.org/W4214806583","https://openalex.org/W2883661521","https://openalex.org/W4365512595","https://openalex.org/W2969993583","https://openalex.org/W2035822315","https://openalex.org/W2997977563"],"abstract_inverted_index":{"This":[0,175],"study":[1],"aimed":[2],"to":[3,32,36,81,91,114,122,131,142,160,173],"evaluate":[4],"the":[5,42],"efficacy":[6],"of":[7,23,60,68,99,166,180,189],"green":[8,69,100,190],"tea":[9,70,101,191],"supplementation":[10,71,192],"on":[11,41,105,150,193],"nonalcoholic":[12,194],"fatty":[13,195],"liver":[14,196],"disease":[15],"treatment.":[16],"Electronic":[17],"databases,":[18],"including":[19],"PubMed,":[20],"Scopus,":[21],"Web":[22],"Science,":[24],"and":[25,83,133,162,178],"Google":[26],"Scholar,":[27],"were":[28],"systematically":[29],"searched":[30],"up":[31],"October":[33],"30,":[34],"2017,":[35],"identify":[37],"eligible":[38],"trials":[39,182],"based":[40],"inclusion":[43],"criteria.":[44],"The":[45,58],"effect":[46,98,147],"size":[47],"was":[48,103,148],"presented":[49],"as":[50],"mean":[51],"difference":[52],"with":[53],"95%":[54,78,88,111,119,128,139,157,170],"confidence":[55],"intervals":[56],"(CI).":[57],"meta\u2010analysis":[59,179],"data":[61],"from":[62],"four":[63],"studies":[64],"indicated":[65],"significant":[66,146],"effects":[67],"in":[72],"altering":[73],"alanine":[74],"aminotransferases":[75,85],"(\u221212.81":[76],"U/L;":[77,87],"CI:":[79,89,112,120,129,140,158,171],"\u221218.17":[80],"\u22127.45)":[82],"aspartate":[84],"(\u221210.91":[86],"\u221219.66":[90],"\u22122.17)":[92],"blood":[93],"concentrations.":[94],"Likewise,":[95],"a":[96],"favorable":[97],"administration":[102],"observed":[104],"body":[106],"mass":[107],"index":[108],"(\u22122.08":[109],"kg/cm2;":[110],"\u22122.81":[113],"\u22121.36),":[115],"triacylglycerol":[116],"(\u221231.87":[117],"mg/dl;":[118,127,138,156],"\u221240.62":[121],"\u221223.12),":[123],"total":[124],"cholesterol":[125,136,153],"(\u221227.57":[126],"\u221236.17":[130],"\u221218.98),":[132],"low\u2010density":[134],"lipoprotein":[135,152],"(\u221214.15":[137],"\u221223.69":[141],"\u22124.60),":[143],"whereas":[144],"no":[145],"detected":[149],"high\u2010density":[151],"concentrations":[154],"(7.41":[155],"\u22121.49":[159],"16.30)":[161],"homeostasis":[163],"model":[164],"assessment":[165],"insulin":[167],"resistance":[168],"(\u22124.06;":[169],"\u221210.22":[172],"2.09).":[174],"systematic":[176],"review":[177],"available":[181],"suggests":[183],"that":[184],"there":[185],"are":[186],"potential":[187],"benefits":[188],"disease.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}