{"id":"https://openalex.org/W2809813558","doi":"https://doi.org/10.1038/s41594-018-0087-8","title":"The role of tubulin\u2013tubulin lattice contacts in the mechanism of microtubule dynamic instability","display_name":"The role of tubulin\u2013tubulin lattice contacts in the mechanism of microtubule dynamic instability","publication_year":2018,"publication_date":"2018-06-28","ids":{"openalex":"https://openalex.org/W2809813558","doi":"https://doi.org/10.1038/s41594-018-0087-8","mag":"2809813558","pmid":"https://pubmed.ncbi.nlm.nih.gov/29967541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6201834"},"language":"en","primary_location":{"id":"doi:10.1038/s41594-018-0087-8","doi":"https://doi.org/10.1038/s41594-018-0087-8","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41594-018-0087-8","pdf_url":null,"source":{"id":"https://openalex.org/S139253143","display_name":"Nature Structural & Molecular Biology","issn_l":"1545-9985","issn":["1545-9985","1545-9993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural &amp; Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6201834","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090338011","display_name":"Szymon W. Manka","orcid":"https://orcid.org/0000-0001-6733-146X","observed_orcids":["https://orcid.org/0000-0001-6733-146X"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Szymon W. Manka","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK. s.manka@mail.cryst.bbk.ac.uk","Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-6733-146X","affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK. s.manka@mail.cryst.bbk.ac.uk","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I98259816"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052607183","display_name":"Carolyn Ann Moores","orcid":"https://orcid.org/0000-0001-5686-6290","observed_orcids":["https://orcid.org/0000-0001-5686-6290"]},"institutions":[{"id":"https://openalex.org/I124357947","display_name":"University of London","ror":"https://ror.org/04cw6st05","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947"]},{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Carolyn A. Moores","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK. c.moores@mail.cryst.bbk.ac.uk","Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-5686-6290","affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK. c.moores@mail.cryst.bbk.ac.uk","institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I98259816"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UK","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I98259816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052607183","https://openalex.org/A5090338011"],"corresponding_institution_ids":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I98259816"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.5641,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.97605961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"25","issue":"7","first_page":"607","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule-dynamic-instability","display_name":"microtubule dynamic instability","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gtp-hydrolysis","display_name":"GTP hydrolysis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/gmpcpp","display_name":"GMPCPP","score":0.7279999852180481},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.7760000228881836},{"id":"https://openalex.org/keywords/doublecortin","display_name":"doublecortin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/microtubule-catastrophe","display_name":"microtubule catastrophe","score":0.8999999761581421},{"id":"https://openalex.org/keywords/microtubule-nucleation","display_name":"microtubule nucleation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.9157686829566956},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.8996956944465637},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5910081267356873},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.5467199683189392},{"id":"https://openalex.org/C207821765","wikidata":"https://www.wikidata.org/wiki/Q405372","display_name":"Instability","level":2,"score":0.5226947069168091},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.4604661166667938},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4535067081451416},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3475055694580078},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32478123903274536},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32408416271209717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3002127707004547},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.26034116744995117},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23007434606552124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13552320003509521},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000089622","descriptor_name":"Doublecortin Domain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41594-018-0087-8","doi":"https://doi.org/10.1038/s41594-018-0087-8","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41594-018-0087-8","pdf_url":null,"source":{"id":"https://openalex.org/S139253143","display_name":"Nature Structural & Molecular Biology","issn_l":"1545-9985","issn":["1545-9985","1545-9993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural &amp; Molecular Biology","raw_type":"journal-article"},{"id":"pmid:29967541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29967541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature structural & molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.bbk.ac.uk.oai2:22645","doi":null,"is_oa":false,"landing_page_url":"https://eprints.bbk.ac.uk/id/eprint/22645/1/22645.pdf","pdf_url":"https://eprints.bbk.ac.uk/id/eprint/22645/1/22645.pdf","source":{"id":"https://openalex.org/S4306400465","display_name":"BIROn (Birkbeck, University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98259816","host_organization_name":"Birkbeck, University of London","host_organization_lineage":["https://openalex.org/I98259816"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:5287951","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6201834","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6201834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6201834","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Struct Mol Biol","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10073511","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10073511/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Structural &amp; Molecular Biology , 25 (7) pp. 607-615. (2018)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5287951","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6201834","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3549659404","display_name":"Molecular reconstitution of cellular machinery essential for neuronal development","funder_award_id":"MR/J000973/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5786650183","display_name":"Building blocks of molecular complexity: the neuronal cytoskeleton in health and disease","funder_award_id":"MR/R000352/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1596852471","https://openalex.org/W1755456091","https://openalex.org/W1785817244","https://openalex.org/W1965404941","https://openalex.org/W1969245469","https://openalex.org/W1970611771","https://openalex.org/W1985249910","https://openalex.org/W1994345832","https://openalex.org/W2005308681","https://openalex.org/W2006158980","https://openalex.org/W2014528904","https://openalex.org/W2044820159","https://openalex.org/W2048826637","https://openalex.org/W2048982317","https://openalex.org/W2049684674","https://openalex.org/W2054770020","https://openalex.org/W2058997498","https://openalex.org/W2062470404","https://openalex.org/W2071451843","https://openalex.org/W2073949924","https://openalex.org/W2081531192","https://openalex.org/W2087130779","https://openalex.org/W2100343024","https://openalex.org/W2104234755","https://openalex.org/W2114083778","https://openalex.org/W2122755030","https://openalex.org/W2124026197","https://openalex.org/W2127334851","https://openalex.org/W2132629607","https://openalex.org/W2134443458","https://openalex.org/W2152562710","https://openalex.org/W2154714625","https://openalex.org/W2162785195","https://openalex.org/W2170600158","https://openalex.org/W2213042009","https://openalex.org/W2301478649","https://openalex.org/W2395604477","https://openalex.org/W2420436228","https://openalex.org/W2467404831","https://openalex.org/W2519303614","https://openalex.org/W2575108092","https://openalex.org/W2591669685","https://openalex.org/W2593511418","https://openalex.org/W2606253816","https://openalex.org/W2627078469","https://openalex.org/W2762278743"],"related_works":["https://openalex.org/W2162785195","https://openalex.org/W3081855866","https://openalex.org/W7165554861","https://openalex.org/W2072830954","https://openalex.org/W7161648108","https://openalex.org/W2093159855","https://openalex.org/W7130590960","https://openalex.org/W4239469583","https://openalex.org/W2103049504","https://openalex.org/W4319986611"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-07-10T00:00:00"}
