{"id":"https://openalex.org/W2809800261","doi":"https://doi.org/10.1002/jhet.3235","title":"Facile Synthesis of Pyrazolo[3,4\u2010c]pyrazoles Bearing Coumarine Ring as Anticancer Agents","display_name":"Facile Synthesis of Pyrazolo[3,4\u2010c]pyrazoles Bearing Coumarine Ring as Anticancer Agents","publication_year":2018,"publication_date":"2018-06-28","ids":{"openalex":"https://openalex.org/W2809800261","doi":"https://doi.org/10.1002/jhet.3235","mag":"2809800261"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.3235","doi":"https://doi.org/10.1002/jhet.3235","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.3235","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075917911","display_name":"Sobhi M. Gomha","orcid":"https://orcid.org/0000-0002-7739-2837","observed_orcids":["https://orcid.org/0000-0002-7739-2837"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Sobhi M. Gomha","raw_affiliation_strings":["Department of Chemistry, Faculty of Science University of Cairo Giza 12613 Egypt"],"raw_orcid":"https://orcid.org/0000-0002-7739-2837","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science University of Cairo Giza 12613 Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031324040","display_name":"Hassan M. Abdel\u2010aziz","orcid":"https://orcid.org/0000-0002-3440-2927","observed_orcids":["https://orcid.org/0000-0002-3440-2927"]},"institutions":[{"id":"https://openalex.org/I113643904","display_name":"Beni-Suef University","ror":"https://ror.org/05pn4yv70","country_code":"EG","type":"education","lineage":["https://openalex.org/I113643904"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hassan M. Abdel\u2010aziz","raw_affiliation_strings":["Department of Chemistry, Faculty of Science University of Bani Suef Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science University of Bani Suef Egypt","institution_ids":["https://openalex.org/I113643904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102833323","display_name":"Ahmed A. M. El\u2010Reedy","orcid":"https://orcid.org/0000-0002-3546-8047","observed_orcids":["https://orcid.org/0000-0002-3546-8047"]},"institutions":[{"id":"https://openalex.org/I2799409690","display_name":"Nahda University","ror":"https://ror.org/05s29c959","country_code":"EG","type":"education","lineage":["https://openalex.org/I2799409690"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed A. M. El\u2010Reedy","raw_affiliation_strings":["Department of Basic and Applied Science, Faculty of Oral and Dental Medicine Nahda University Beni-Suef Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Applied Science, Faculty of Oral and Dental Medicine Nahda University Beni-Suef Egypt","institution_ids":["https://openalex.org/I2799409690"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075917911"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":1.1746,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.72271713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"55","issue":"8","first_page":"1960","last_page":"1965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hydrazone-cyclization","display_name":"hydrazone cyclization","score":0.746999979019165},{"id":"https://openalex.org/keywords/phosphorus-oxychloride","display_name":"phosphorus oxychloride","score":0.6700000166893005},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9470000267028809},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9571675062179565},{"id":"https://openalex.org/C2780349576","wikidata":"https://www.wikidata.org/wiki/Q416007","display_name":"Hydrazone","level":2,"score":0.8180158734321594},{"id":"https://openalex.org/C2777682936","wikidata":"https://www.wikidata.org/wiki/Q408908","display_name":"Pyrazole","level":2,"score":0.6629756689071655},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5888117551803589},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.5681153535842896},{"id":"https://openalex.org/C171560689","wikidata":"https://www.wikidata.org/wiki/Q193086","display_name":"Halide","level":2,"score":0.46606284379959106},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.4597153663635254},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.44559338688850403},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40631043910980225},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3874216675758362},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.19972428679466248},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.07529741525650024},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jhet.3235","doi":"https://doi.org/10.1002/jhet.3235","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.3235","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1927206303","https://openalex.org/W1936375422","https://openalex.org/W1963551310","https://openalex.org/W1969589682","https://openalex.org/W1972258374","https://openalex.org/W1978395496","https://openalex.org/W1988935135","https://openalex.org/W1996617748","https://openalex.org/W2016922671","https://openalex.org/W2018447629","https://openalex.org/W2027358863","https://openalex.org/W2037179427","https://openalex.org/W2037203845","https://openalex.org/W2043966628","https://openalex.org/W2046055022","https://openalex.org/W2058788125","https://openalex.org/W2058814413","https://openalex.org/W2066398479","https://openalex.org/W2072412194","https://openalex.org/W2072845515","https://openalex.org/W2100793908","https://openalex.org/W2114524747","https://openalex.org/W2118832954","https://openalex.org/W2146262277","https://openalex.org/W2161955420","https://openalex.org/W2165751339","https://openalex.org/W2171347612","https://openalex.org/W2291562174","https://openalex.org/W2313898096","https://openalex.org/W2319596138","https://openalex.org/W2327508881","https://openalex.org/W2513773378","https://openalex.org/W2592905567","https://openalex.org/W2904633956","https://openalex.org/W2949539907","https://openalex.org/W2950084671","https://openalex.org/W2951417968","https://openalex.org/W2952538710","https://openalex.org/W2952926585","https://openalex.org/W2953368931","https://openalex.org/W2953390566","https://openalex.org/W4229688203","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2937861227","https://openalex.org/W2195561087","https://openalex.org/W2743365059","https://openalex.org/W2805397264","https://openalex.org/W2011483361","https://openalex.org/W2071233202","https://openalex.org/W2063855510","https://openalex.org/W2416915684","https://openalex.org/W4400894561","https://openalex.org/W2092554270"],"abstract_inverted_index":{"In":[0],"the":[1,24,30,37,44,70],"present":[2],"study,":[3],"2\u2010(2\u2010oxo\u20102H\u2010chromene\u20103\u2010carbonyl)\u20105\u2010phenyl\u20102,4\u2010dihydro\u20103H\u2010pyrazol\u20103\u2010one":[4],"was":[5],"prepared":[6],"and":[7,49,69,79,90],"reacted":[8],"with":[9,27,81],"various":[10],"hydrazonoyl":[11],"halides":[12],"to":[13],"give":[14],"a":[15],"series":[16],"of":[17,23,36,46,75],"2\u2010(2\u2010oxo\u20102H\u2010chromene\u20103\u2010carbonyl)\u20105\u2010phenyl\u20104\u2010((2\u2010phenylhydrazono)methyl)\u20102,4\u2010dihydro\u20103H\u2010pyrazol\u20103\u2010one":[18],"in":[19],"good":[20],"yield.":[21],"Cyclization":[22],"latter":[25],"hydrazone":[26],"POCl3":[28],"yielded":[29],"respective":[31],"3\u2010(3\u2010phenyl\u2010":[32],"4,6\u2010disubstituted\u20101,6\u2010dihydropyrazolo[3,4\u2010c]pyrazole\u20101\u2010carbonyl)\u20102H\u2010chromen\u20102\u2010ones.":[33],"The":[34,53],"structures":[35],"newly":[38,54],"synthesized":[39,55],"compounds":[40,56,76],"were":[41,57],"established":[42],"on":[43],"basis":[45],"spectroscopic":[47],"evidences":[48],"their":[50,60],"alternative":[51],"syntheses.":[52],"evaluated":[58],"for":[59],"antitumor":[61],"activities":[62,74],"against":[63],"hepatocellular":[64],"carcinoma":[65],"(HepG2)":[66],"cell":[67],"line":[68],"results":[71],"revealed":[72],"promising":[73],"4e,":[77],"4c,":[78],"4d":[80],"IC50":[82],"equal":[83],"0.92":[84],"\u00b1":[85,88,92],"0.22,":[86],"1.43":[87],"0.19,":[89],"2.17":[91],"0.21":[93],"\u03bcM,":[94],"respectively.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-07-10T00:00:00"}