{"id":"https://openalex.org/W2809726467","doi":"https://doi.org/10.1111/add.14373","title":"Moderation of baclofen response by a GABAB receptor polymorphism: results from the BacALD randomized controlled trial","display_name":"Moderation of baclofen response by a GABAB receptor polymorphism: results from the BacALD randomized controlled trial","publication_year":2018,"publication_date":"2018-07-03","ids":{"openalex":"https://openalex.org/W2809726467","doi":"https://doi.org/10.1111/add.14373","mag":"2809726467","pmid":"https://pubmed.ncbi.nlm.nih.gov/29968397"},"language":"en","primary_location":{"id":"doi:10.1111/add.14373","doi":"https://doi.org/10.1111/add.14373","is_oa":false,"landing_page_url":"https://doi.org/10.1111/add.14373","pdf_url":null,"source":{"id":"https://openalex.org/S70513841","display_name":"Addiction","issn_l":"0965-2140","issn":["0965-2140","1360-0443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004395530","display_name":"Kirsten C. Morley","orcid":"https://orcid.org/0000-0002-0868-9928","observed_orcids":["https://orcid.org/0000-0002-0868-9928"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Kirsten C. Morley","raw_affiliation_strings":["University of Sydney, Faculty of Medicine and Health, Central Clinical School, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0868-9928","affiliations":[{"raw_affiliation_string":"University of Sydney, Faculty of Medicine and Health, Central Clinical School, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108258702","display_name":"Natasha Luquin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natasha Luquin","raw_affiliation_strings":["Department of Medical Genomics, Royal Prince Alfred Hospital, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genomics, Royal Prince Alfred Hospital, NSW, Australia","institution_ids":["https://openalex.org/I2799732068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066682179","display_name":"Andrew Baillie","orcid":"https://orcid.org/0000-0003-3424-5703","observed_orcids":["https://orcid.org/0000-0003-3424-5703"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew Baillie","raw_affiliation_strings":["University of Sydney, Faculty of Health Sciences, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3424-5703","affiliations":[{"raw_affiliation_string":"University of Sydney, Faculty of Health Sciences, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113790026","display_name":"I.S. Fraser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Isabel Fraser","raw_affiliation_strings":["University of Sydney, Faculty of Medicine and Health, Central Clinical School, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sydney, Faculty of Medicine and Health, Central Clinical School, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111682207","display_name":"Ronald J. Trent","orcid":"https://orcid.org/0009-0009-1799-7904","observed_orcids":["https://orcid.org/0009-0009-1799-7904"]},"institutions":[{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ronald J. Trent","raw_affiliation_strings":["Department of Medical Genomics, Royal Prince Alfred Hospital, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genomics, Royal Prince Alfred Hospital, NSW, Australia","institution_ids":["https://openalex.org/I2799732068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090755202","display_name":"Glenys Dore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Glenys Dore","raw_affiliation_strings":["Herbert St Alcohol Clinic, Royal North Shore Hospital, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herbert St Alcohol Clinic, Royal North Shore Hospital, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000117403","display_name":"Nghi Phung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nghi Phung","raw_affiliation_strings":["Centre for Addiction Medicine, Westmead Hospital, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction Medicine, Westmead Hospital, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I2803024705"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071884095","display_name":"Paul Haber","orcid":"https://orcid.org/0000-0001-8915-8872","observed_orcids":["https://orcid.org/0000-0001-8915-8872"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul S. Haber","raw_affiliation_strings":["Royal Prince Alfred Hospital, NSW, Australia","University of Sydney, Faculty of Medicine and Health, Central Clinical School, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Prince Alfred Hospital, NSW, Australia","institution_ids":["https://openalex.org/I2799732068"]},{"raw_affiliation_string":"University of Sydney, Faculty of Medicine and Health, Central Clinical School, NHMRC Centre for Research Excellence in Mental Health and Substance Use, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004395530"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I42131985"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":2.6261,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89611946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"113","issue":"12","first_page":"2205","last_page":"2213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baclofen","display_name":"baclofen","score":1.0},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gabbr1","display_name":"GABBR1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6039999723434448},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.777999997138977},{"id":"https://openalex.org/keywords/alcohol-craving","display_name":"alcohol craving","score":0.5849999785423279},{"id":"https://openalex.org/keywords/heavy-drinking","display_name":"heavy drinking","score":0.5630000233650208},{"id":"https://openalex.org/keywords/abstinence","display_name":"abstinence","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2781201050","wikidata":"https://www.wikidata.org/wiki/Q413717","display_name":"Baclofen","level":4,"score":0.7943204641342163},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.6876686811447144},{"id":"https://openalex.org/C2779541405","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Craving","level":3,"score":0.6620677709579468},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6456838846206665},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6109123826026917},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6068106889724731},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5810403227806091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5539761185646057},{"id":"https://openalex.org/C2779436514","wikidata":"https://www.wikidata.org/wiki/Q4713263","display_name":"Alcohol dependence","level":3,"score":0.49881815910339355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49123114347457886},{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.4201836585998535},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.3969027101993561},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3642674684524536},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18946409225463867},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.13166698813438416},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11681026220321655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11515522003173828},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.10501089692115784},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071184","descriptor_name":"Pharmacogenomic Variants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001418","descriptor_name":"Baclofen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058786","descriptor_name":"GABA-B Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/add.14373","doi":"https://doi.org/10.1111/add.14373","is_oa":false,"landing_page_url":"https://doi.org/10.1111/add.14373","pdf_url":null,"source":{"id":"https://openalex.org/S70513841","display_name":"Addiction","issn_l":"0965-2140","issn":["0965-2140","1360-0443"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction","raw_type":"journal-article"},{"id":"pmid:29968397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29968397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Addiction (Abingdon, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1418857551","https://openalex.org/W1802167042","https://openalex.org/W1976153901","https://openalex.org/W1982373189","https://openalex.org/W1997520698","https://openalex.org/W2008504970","https://openalex.org/W2017475823","https://openalex.org/W2030868346","https://openalex.org/W2038015695","https://openalex.org/W2077625265","https://openalex.org/W2078357006","https://openalex.org/W2078594409","https://openalex.org/W2136006910","https://openalex.org/W2136475835","https://openalex.org/W2170979974","https://openalex.org/W2172137255","https://openalex.org/W2223458451","https://openalex.org/W2546673078","https://openalex.org/W2552950400","https://openalex.org/W2798811957","https://openalex.org/W2802163639","https://openalex.org/W2809575156"],"related_works":["https://openalex.org/W2031918347","https://openalex.org/W2029670706","https://openalex.org/W3195978238","https://openalex.org/W4299925910","https://openalex.org/W2904414284","https://openalex.org/W2080269795","https://openalex.org/W2139388477","https://openalex.org/W2118937212","https://openalex.org/W2496945893","https://openalex.org/W2546777102"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Baclofen":[3],"has":[4,29],"been":[5,30],"shown":[6],"to":[7,40,88,137,149,233,258],"reduce":[8],"alcohol":[9,27,109,198,240,264],"consumption":[10,110,199,241],"in":[11,19,50,99,104,260],"alcohol-dependent":[12,66],"individuals,":[13],"but":[14,237],"there":[15],"is":[16,42],"marked":[17],"heterogeneity":[18],"response.":[20],"An":[21],"association":[22],"between":[23],"GABBR1":[24,246],"rs29220":[25,247],"and":[26,68,92,101,122,142,175,207,221,235,253],"dependence":[28],"demonstrated":[31],"previously.":[32],"The":[33,245],"present":[34],"study":[35],"evaluated":[36],"whether":[37],"the":[38,51,155,159,177,226,261],"response":[39,252],"baclofen":[41,80,164,259],"moderated":[43],"by":[44],"a":[45,143,190],"single":[46],"nucleotide":[47],"polymorphism":[48,248],"(rs29220)":[49],"GABAB":[52],"receptor":[53],"subunit":[54],"1":[55],"gene":[56],"(GABBR1).":[57],"DESIGN:":[58],"Double-blind,":[59],"placebo-controlled":[60],"study.":[61],"SETTING:":[62],"Australia.":[63],"PARTICIPANTS:":[64],"Seventy-two":[65],"men":[67,100],"women":[69],"receiving":[70],"12":[71],"weeks":[72],"of":[73,76,118,217,263],"30":[74],"mg/day":[75],"baclofen,":[77],"75":[78],"mg":[79],"or":[81],"placebo.":[82],"MEASUREMENTS:":[83],"Primary":[84],"outcomes":[85],"included":[86],"time":[87,136,148,232],"lapse":[89,150,234],"(any":[90],"drinking)":[91],"relapse":[93,138,160,236],"(>":[94],"5":[95],"drinks":[96],"per":[97,114,201],"day":[98],">":[102],"4":[103],"women).":[105],"We":[106,127],"also":[107,189],"examined":[108],"at":[111,242],"follow-up":[112,197],"(drinks":[113,200],"drinking":[115,120,202,205],"day,":[116,203],"number":[117],"heavy":[119,204],"days":[121,124,206,208],"percentage":[123],"abstinent).":[125],"FINDINGS:":[126],"observed":[128],"significant":[129,191],"medication":[130,192,227],"\u00d7":[131,193,228],"genotype":[132,157,194,229],"interaction":[133,145,195],"effect":[134,146,230],"for":[135,147,163,176,196,214,231,239],"(P":[139,151,210],"=":[140,152,173,185,211],"0.049)":[141],"near-significant":[144],"0.055).":[153],"For":[154],"CC":[156],"group,":[158],"hazard":[161],"ratio":[162],"versus":[165],"placebo":[166],"was":[167,181,188],"0.32":[168],"[95%":[169],"confidence":[170],"interval":[171],"(CI)":[172],"0.14-0.75]":[174],"G-":[178],"group":[179],"it":[180],"1.07":[182],"(95%":[183],"CI":[184],"0.43-2.63).":[186],"There":[187],"abstinent)":[209],"0.02).":[212],"Covarying":[213],"baseline":[215],"levels":[216],"craving,":[218],"aspartate":[219],"aminotransferase":[220],"abstinence":[222],"before":[223],"enrolment":[224],"reduced":[225],"not":[238],"follow-up.":[243],"CONCLUSIONS:":[244],"may":[249],"influence":[250],"treatment":[251,262],"possibly":[254],"predict":[255],"adverse":[256],"effects":[257],"dependence.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-07-10T00:00:00"}